Abstract:
:The effects of DEHP on sperm morphology and on peripheral blood micronuclei were studied for 12 weeks following five subacute IP injections of DEHP at 1/6, 1/12, and 1/60 of the LD50 per day. Sperm morphology was examined in both adult mice and rats, while peripheral blood micronuclei were scored in mice up to 4 weeks after treatment. In mice, DEHP at 1/6 LD50 significantly depressed body weight gain for up to 12 weeks after treatment, and reduced epididymal sperm number by 4 weeks. Numbers of morphologically abnormal sperm did not differ from controls in the 12 weeks following treatment. In addition, DEHP did not increase the numbers of peripheral blood micronuclei. Studies in the rat indicated that exposure to doses of 1/6 and 1/12 of the LD50 per day of DEHP resulted in a reduced gain in body weight compared to controls. Testis weight, sperm number, and numbers of morphologically abnormal sperm were unaffected by DEHP following treatment. In separate experiments, DEHP did not induce sister chromatid exchange (SCE) or DNA damage in Chinese hamster ovary (CHO) cells. Although DEHP is known to cause testicular atrophy in rats and to a lesser extent in mice, it did not cause an increase in abnormal sperm in either species. Together with the CHO and micronucleus data, these findings suggest that DEHP has a low probability of causing genetic damage capable of being transmitted through the male germ line.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Douglas GR,Hugenholtz AP,Blakey DHdoi
10.1289/ehp.8665255subject
Has Abstractpub_date
1986-03-01 00:00:00pages
255-62eissn
0091-6765issn
1552-9924journal_volume
65pub_type
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更新日期:2020-06-01 00:00:00
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更新日期:1996-05-01 00:00:00
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更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1984-04-01 00:00:00
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更新日期:2015-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1987-11-01 00:00:00
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更新日期:2006-01-01 00:00:00
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更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-06-01 00:00:00
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更新日期:2016-08-01 00:00:00
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1996-03-01 00:00:00
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更新日期:1995-09-01 00:00:00
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更新日期:2001-08-01 00:00:00
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更新日期:1993-07-01 00:00:00
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更新日期:1983-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/EHP39
更新日期:2017-04-01 00:00:00