Evaluation of lead levels in children living near a Los Angeles county battery recycling facility.

abstract：:The fundamental problems in population monitoring for genetic effects are twofold: the binomialized nature of the data and the lower power due to small risk of finding positive results. The binomial character is artificial, even forced, and can with advantage be replaced by more refined analysis, and by a focus on all...

journal_title：Environmental health perspectives

authors： Murphy EA

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVE:This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. METHODS:We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at ter...

journal_title：Environmental health perspectives

authors： Lederman SA,Jones RL,Caldwell KL,Rauh V,Sheets SE,Tang D,Viswanathan S,Becker M,Stein JL,Wang RY,Perera FP

更新日期：2008-08-01 00:00:00

abstract：:The biopersistence of fibers and minerals in the respiratory tract is an important parameter in the toxicity of those materials. The biopersistence of respirable synthetic fibers and minerals in man can be most closely evaluated in an animal model. While acellular and in vitro systems are important for initial evaluat...

journal_title：Environmental health perspectives

authors： Bernstein DM,Mast R,Anderson R,Hesterberg TW,Musselman R,Kamstrup O,Hadley J

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledg...

journal_title：Environmental health perspectives

authors： Morin CW,Comrie AC,Ernst K

更新日期：2013-11-01 00:00:00

abstract：:It was considered that the fall in lung function seen after exposure to cotton dust may be attributable in part to the activity of arachidonic acid metabolites, such as leucotrienes as well as to the more established release of histamine by cotton dust. However, we found that cotton and barley dusts elicited poor rele...

journal_title：Environmental health perspectives

authors： Thomson TA,Edwards JH,Al-Zubaidy TS,Brown RC,Poole A,Nicholls PJ

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Ambient air ozone (O3) is a pulmonary irritant that has been associated with respiratory health effects including increased lung inflammation and permeability, airway hyperreactivity, respiratory symptoms, and decreased lung function. Estimation of O3 exposure is a complex task because the pollutant exhibits...

journal_title：Environmental health perspectives

authors： Adam-Poupart A,Brand A,Fournier M,Jerrett M,Smargiassi A

更新日期：2014-09-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are known as neurotoxic compounds that may modulate sex steroid hormones. Steroid hormones play a mediating role in brain development and may influence behaviors that show sex differences, such as childhood play behavior. In this study we evaluated the effects of perinatal ...

journal_title：Environmental health perspectives

authors： Vreugdenhil HJ,Slijper FM,Mulder PG,Weisglas-Kuperus N

更新日期：2002-10-01 00:00:00

abstract：:Nitrate contamination of drinking water implies a genotoxic risk to man due to the endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Thus far, epidemiological studies have presented conflicting results on the relation of drinking water nitrate levels with gastric cancer incidence. ...

journal_title：Environmental health perspectives

authors： Kleinjans JC,Albering HJ,Marx A,van Maanen JM,van Agen B,ten Hoor F,Swaen GM,Mertens PL

更新日期：1991-08-01 00:00:00

abstract：:On 15-16 September 1997, the U.S. Environmental Protection Agency sponsored the Conference on Preventable Causes of Cancer in Children. The conference was convened to examine rising trends in reported incidence of childhood cancer and the association of these trends with environmental exposures. This paper summarizes ...

journal_title：Environmental health perspectives

authors： Carroquino MJ,Galson SK,Licht J,Amler RW,Perera FP,Claxton LD,Landrigan PJ

更新日期：1998-06-01 00:00:00

abstract：:To elucidate problems with microfungal infestation in indoor environments, a multidisciplinary collaborative pilot study, supported by a grant from the Danish Ministry of Housing and Urban Affairs, was performed on 72 mold-infected building materials from 23 buildings. Water leakage through roofs, rising damp, and def...

journal_title：Environmental health perspectives

authors： Gravesen S,Nielsen PA,Iversen R,Nielsen KF

更新日期：1999-06-01 00:00:00

abstract：:Determination of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in fly ash and cinders collected from nine municipal incinerators in Japan was made. The concentrations of PCDDs and PCDFs in this study were generally in the same range as those in Europe and North America. However, t...

journal_title：Environmental health perspectives

authors： Wakimoto T,Tatsukawa R

更新日期：1985-02-01 00:00:00

abstract：:Descriptions of endocrine disruption have largely been associated with wildlife and driven by observations documenting estrogenic, androgenic, antiandrogenic, and antithyroid actions. These actions, in response to exposure to ecologically relevant concentrations of various environmental contaminants, have now been est...

journal_title：Environmental health perspectives

authors： Guillette LJ Jr

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are...

journal_title：Environmental health perspectives

authors： Bailey KA,Smith AH,Tokar EJ,Graziano JH,Kim KW,Navasumrit P,Ruchirawat M,Thiantanawat A,Suk WA,Fry RC

更新日期：2016-02-01 00:00:00

abstract：:We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...

journal_title：Environmental health perspectives

authors： Wilhelm M,Ritz B

更新日期：2005-09-01 00:00:00

abstract：:Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...

journal_title：Environmental health perspectives

authors： Valenzuela OL,Borja-Aburto VH,Garcia-Vargas GG,Cruz-Gonzalez MB,Garcia-Montalvo EA,Calderon-Aranda ES,Del Razo LM

更新日期：2005-03-01 00:00:00

abstract：:Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and lymphoproliferative malignancies and related disorders (HLD). In a follow-up study of 74,828 benzene-exposed workers and a...

journal_title：Environmental health perspectives

authors： Linet MS,Yin SN,Travis LB,Li CY,Zhang ZN,Li DG,Rothman N,Li GL,Chow WH,Donaldson J,Dosemeci M,Wacholder S,Blot WJ,Hayes RB

更新日期：1996-12-01 00:00:00

abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...

journal_title：Environmental health perspectives

authors： Maier A,Micka J,Miller K,Denko T,Chang CY,Nebert DW,Alvaro Puga

更新日期：1998-07-01 00:00:00

abstract：:Benzene has been known to be a bone marrow poison for almost a century. However, it was not until the last decade that benzene's carcinogenic potential was demonstrated by epidemiologic studies. The proposed regulation by the Occupational Safety and Health Administration (OSHA) to lower exposure levels of benzene in t...

journal_title：Environmental health perspectives

authors： Infante PF,White MC

更新日期：1983-10-01 00:00:00

abstract：:This report reviews the recent literature on the adverse effects of occupational factors on fertility and related reproductive outcomes. Few studies fulfill the criteria of good study design because of small sample size, insensitive measures of effect, selection, recall, and observation bias, weak if any control of co...

journal_title：Environmental health perspectives

authors： Baranski B

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Although patients with heart failure (HF) have been identified as particularly susceptible to the acute effects of air pollution, the effects of long-term exposure to air pollution on patients with this increasingly prevalent disease are largely unknown. OBJECTIVE:This study was designed to examine the mort...

journal_title：Environmental health perspectives

authors： Medina-Ramón M,Goldberg R,Melly S,Mittleman MA,Schwartz J

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:According to a wide variety of analyses and projections, the potential effects of global climate change on human health are large and diverse. The U.S. National Institutes of Health (NIH), through its basic, clinical, and population research portfolio of grants, has been increasing efforts to understand how ...

journal_title：Environmental health perspectives

authors： Jessup CM,Balbus JM,Christian C,Haque E,Howe SE,Newton SA,Reid BC,Roberts L,Wilhelm E,Rosenthal JP

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxyla...

journal_title：Environmental health perspectives

authors： Athanasiadou M,Cuadra SN,Marsh G,Bergman A,Jakobsson K

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:In an effort to decrease the rates of smoking conventional tobacco cigarettes, electronic cigarettes (e-cigarettes) have been proposed as an effective smoking cessation tool. However, little is known about their toxicological impacts. This is concerning given that e-cigarette use is perceived as less harmful...

journal_title：Environmental health perspectives

authors： Church JS,Chace-Donahue F,Blum JL,Ratner JR,Zelikoff JT,Schwartzer JJ

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a...

journal_title：Environmental health perspectives

authors： Liu Y,Wu F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...

journal_title：Environmental health perspectives

authors： Mills JN,Gage KL,Khan AS

更新日期：2010-11-01 00:00:00

abstract：:To set occupational exposure limits (OELs) for aerosol particles, dusts, or chemicals, one has to evaluate whether mechanistic considerations permit identification of a no observed effect level (NOEL). In the case of carcinogenic effects, this can be assumed if no genotoxicity is involved, and exposure is considered s...

journal_title：Environmental health perspectives

authors： Greim HA,Ziegler-Skylakakis K

更新日期：1997-09-01 00:00:00

abstract：:With the "graying of America," the prevalence of neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD) will make increasingly greater demands on Medicare/Medicaid resources, which will greatly strain the national economy. It is imperative that prevention and intervention strategies for t...

journal_title：Environmental health perspectives

authors：

更新日期：1999-07-01 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...

journal_title：Environmental health perspectives

authors： Johnson MD,Housey GM,O'Brian CA,Kirschmeier PT,Weinstein IB

更新日期：1987-12-01 00:00:00

abstract：:Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...

journal_title：Environmental health perspectives

authors： Nash JP,Kime DE,Van der Ven LT,Wester PW,Brion F,Maack G,Stahlschmidt-Allner P,Tyler CR

更新日期：2004-12-01 00:00:00

abstract：:Free-radical metabolites can be generated metabolically by a one-electron reductase-catalyzed reaction or a "peroxidase" catalyzed oxidation or by photoactivation of a wide variety of aromatic xenobiotics. Radicals may also be generated during lipid peroxidation. Some radicals can react with DNA or bind covalently or ...

journal_title：Environmental health perspectives

authors： O'Brien PJ

更新日期：1985-12-01 00:00:00