Abstract:
OBJECTIVE:Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxylated metabolites, which not hitherto have been found retained in humans, could be detected. METHODS:We assessed PBDEs in pooled serum samples obtained in 2002 from children 11-15 years of age, working and sometimes also living at the municipal waste disposal site in Managua, and in nonworking urban children. The influence of fish consumption was evaluated in the children and in groups of women 15-44 years of age who differed markedly in their fish consumption. Hydroxylated PBDEs were assessed as their methoxylated derivates. The chemical analyses were performed by gas chromatography/mass spectrometry, using authentic reference substances. RESULTS:The children living and working at the waste disposal site showed very high levels of medium brominated diphenyl ethers. The levels observed in the referent children were comparable to contemporary observations in the United States. The exposure pattern was consistent with dust being the dominating source. The children with the highest PBDE levels also had the highest levels of hydroxylated metabolites. CONCLUSIONS:Unexpectedly, very high levels of PBDEs were found in children from an urban area in a developing country. Also, for the first time, hydroxylated PBDE metabolites were found to bioaccumulate in human serum.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Athanasiadou M,Cuadra SN,Marsh G,Bergman A,Jakobsson Kdoi
10.1289/ehp.10713subject
Has Abstractpub_date
2008-03-01 00:00:00pages
400-8issue
3eissn
0091-6765issn
1552-9924journal_volume
116pub_type
杂志文章abstract::We analyzed questionnaire and physician examination data for 1560 new immigrants from the former USSR divided into three groups by potential exposure to Chernobyl radiation. Two groups were chosen according to soil contamination by cesium-137 at former residences, as confirmed by our findings in a 137Cs body burden st...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103936
更新日期:1995-10-01 00:00:00
abstract::Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104s3489
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9297145
更新日期:1992-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399129
更新日期:1993-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307736
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.93101s5271
更新日期:1993-12-01 00:00:00
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doi:10.1289/ehp.1104034
更新日期:2012-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8035171
更新日期:1980-04-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.00108435
更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1289/ehp.919567
更新日期:1991-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.78231
更新日期:1978-04-01 00:00:00
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更新日期:2006-04-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.96104s51101
更新日期:1996-10-01 00:00:00
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更新日期:2003-02-01 00:00:00
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更新日期:1987-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93101s59
更新日期:1993-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1289/ehp.01109s4539
更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s263
更新日期:1995-03-01 00:00:00
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更新日期:1998-08-01 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1289/ehp.0900541
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.8034159
更新日期:1980-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP293
更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.1003348
更新日期:2011-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.4980
更新日期:2003-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.101-1521147
更新日期:1993-10-01 00:00:00