Abstract:
BACKGROUND:Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by concomitant ozone exposure remains unknown. OBJECTIVE:In this study we assessed the impact of O(3) and particulate matter exposure on HRV in humans. METHODS:In a crossover design, 50 subjects (19-48 years of age) were randomized to 2-hr controlled exposures to filtered air (FA), concentrated ambient particles (CAPs), O(3), or combined CAPs and ozone (CAPs + O(3)). The primary end point was change in HRV between the start and end of exposure. Secondary analyses included blood pressure (BP) responses, and effect modification by asthmatic status. RESULTS:Achieved mean CAPs and O(3) exposure concentrations were 121.6 +/- 48.0 microg/m(3) and 113.9 +/- 6.6 ppb, respectively. In a categorical analysis, exposure had no consistent effect on HRV indices. However, the dose-response relationship between CAPs mass concentration and HRV indices seemed to vary depending on the presence of O(3). This heterogeneity was statistically significant for the low-frequency component of HRV (p = 0.02) and approached significance for the high-frequency component and time-domain measures of HRV. Exposure to CAPs + O(3) increased diastolic BP by 2.0 mmHg (SE, 1.2; p = 0.02). No other statistically significant changes in BP were observed. Asthmatic status did not modify these effects. CONCLUSION:The potentiation by O(3) of CAPs effects on diastolic BP and possibly HRV is of small magnitude in young adults. Further studies are needed to assess potential effects in more vulnerable populations.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Fakhri AA,Ilic LM,Wellenius GA,Urch B,Silverman F,Gold DR,Mittleman MAdoi
10.1289/ehp.0900541subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1287-92issue
8eissn
0091-6765issn
1552-9924journal_volume
117pub_type
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.8497
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abstract::The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...
journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s4193
更新日期:1993-12-01 00:00:00
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abstract::Organophosphates in increasing amounts and wider varieties of molecular structure are being used to replace the organochlorine pesticides. It has been assumed that the organophosphates as a class would have a minimal chronic toxicity due to rapid hydrolysis and an unfavorable partitioning as regards to lipids. The phy...
journal_title:Environmental health perspectives
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pub_type: 杂志文章
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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更新日期:1988-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1977-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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更新日期:2003-02-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1985-09-01 00:00:00
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更新日期:2016-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1978-10-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2006-03-01 00:00:00
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更新日期:2006-11-01 00:00:00
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更新日期:1987-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1978-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
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更新日期:2020-04-01 00:00:00
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更新日期:2002-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1994-06-01 00:00:00
abstract::Many mammals methylate trivalent inorganic arsenic in liver to species that are released into the bloodstream and excreted in urine and feces. This study addresses how methylated arsenicals pass through cell membranes. We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomy...
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更新日期:2006-04-01 00:00:00
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更新日期:2013-07-01 00:00:00