Abstract:
:The dose-response relationship of the benzene covalent interaction with biological macromolecules from rat organs was studied. The administered dose range was 3.6 x 10(7) starting from the highest dosage employed, 486 mg/kg, which is oncogenic for rodents, and included low and very low dosages. The present study was initially performed with tritium-labeled benzene, administered by IP injection. In order to exclude the possibility that part of the detected radioactivity was due to tritium incorporated into DNA from metabolic processes, 14C-benzene was then also used following a similar experimental design. By HPLC analysis, a single adduct from benzene-treated DNA was detected; adduct identification will be attempted in the near future. Linear dose-response relationship was observed within most of the range of explored doses. Linearity was particularly evident within low and very low dosages. Saturation of benzene metabolism did occur at the highest dosages for most of the assayed macromolecules and organs, especially in rat liver. This finding could be considered as indicative of the dose-response relationship of tumor induction and could be used in risk assessment.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Mazzullo M,Bartoli S,Bonora B,Colacci A,Grilli S,Lattanzi G,Niero A,Turina MP,Parodi Sdoi
10.1289/ehp.8982259subject
Has Abstractpub_date
1989-07-01 00:00:00pages
259-66eissn
0091-6765issn
1552-9924journal_volume
82pub_type
杂志文章abstract::Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) fire...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399265
更新日期:1993-03-01 00:00:00
abstract::Elemental boron was isolated in 1808. It typically occurs in nature as borates hydrated with varying amounts of water. Important compounds are boric acid and borax. Boron compounds are also used in the production of metals, enamels, and glasses. In trace amounts, boron is essential for the growth of many plants, and i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s7113
更新日期:1994-11-01 00:00:00
abstract::Atlantic coast estuaries recently have experienced fish kills and fish with lesions attributed to Pfiesteria piscicida and related dinoflagellates. Human health effects have been reported from laboratory exposure and from a 1997 Maryland fish kill. North Carolina has recorded Pfiesteria-related fish kill events over t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0110921
更新日期:2001-01-01 00:00:00
abstract::Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation of these cells. This chapter examine...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.898025
更新日期:1989-03-01 00:00:00
abstract::The effects of DEHP on sperm morphology and on peripheral blood micronuclei were studied for 12 weeks following five subacute IP injections of DEHP at 1/6, 1/12, and 1/60 of the LD50 per day. Sperm morphology was examined in both adult mice and rats, while peripheral blood micronuclei were scored in mice up to 4 weeks...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8665255
更新日期:1986-03-01 00:00:00
abstract::Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.898243
更新日期:1989-07-01 00:00:00
abstract::Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107205
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:The upward trend in industrial nations in the incidence of male genitourinary (GU) conditions may be attributed to increased exposure to endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected endocrine disruptor. OBJECTIVE:We investigated the relationship be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800058
更新日期:2009-07-01 00:00:00
abstract::Most contemporary bioinsecticides are derived from scaled-up cultures of Bacillus thuringiensis subspecies israelensis (Bti) and kurstaki (Btk), whose particulate fractions contain mostly B. thuringiensis spores (> 10(12)/L) and proteinaceous aggregates, including crystal-like parasporal inclusion bodies (PIB). Based ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108919
更新日期:2000-10-01 00:00:00
abstract::Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8562423
更新日期:1985-10-01 00:00:00
abstract::In 1996 the U.S. Congress charged the U.S. Environmental Protection Agency to develop a screening program to test chemicals for their possible estrogenic and other endocrine effects. Shortly thereafter, the Chemical Guidelines Program of the Organisation for Economic Co-operation and Development's (OECD) Environmental...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s3363
更新日期:2002-06-01 00:00:00
abstract::The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.877689
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Pterygium is a fibrovascular growth of the bulbar conjunctiva and underlying subconjunctival tissue that may cause blindness. The mechanism of pterygium formation is not yet fully understood, but pterygium has some tumorlike features. OBJECTIVES:The objective of this study was to evaluate the association be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11111
更新日期:2008-07-01 00:00:00
abstract::The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contam...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7145
更新日期:2004-10-01 00:00:00
abstract::There are still many uncertainties regarding the risk of adverse pregnancy outcomes associated with exposure to drinking water disinfection by-products. In Montréal, Québec, Canada, we carried out a hospital-based case-control study including 493 cases of intrauterine growth restriction defined as birth weight below t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7003
更新日期:2004-08-01 00:00:00
abstract::Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7713
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Enteric illness arising from contaminated water and food is a major health concern worldwide, and tracking the incidences and severity of outbreaks is still a challenging task. Most developed and developing countries have administrative databases for medical visits and services maintained by the government a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9199
更新日期:2007-01-01 00:00:00
abstract::Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110411
更新日期:2002-04-01 00:00:00
abstract::The objective of this study was to provide a basis for effectively protecting nonsmokers from acute sensory impacts and for preventing deterioration of indoor air quality caused by environmental tobacco smoke (ETS) emissions. With an olfactory experiment we determined odor detection thresholds (OT) of sidestream ETS (...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091045
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104345
更新日期:2012-05-01 00:00:00
abstract::In the fall of 1976 Congress enacted the Resource Conservation and Recovery Act, commonly referred to as RCRA. The objective of the statute is to create an orderly system for the generation, handling and disposal of hazardous waste by means of a comprehensive tracking and record keeping mechanism. RCRA does not regula...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.834819
更新日期:1983-02-01 00:00:00
abstract::Mass poisonings, called yusho and yu-cheng, occurred in western Japan in 1968 and central Taiwan in 1979, respectively. These occurrences were separately caused by ingestion of rice oils contaminated with polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls. The tot...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560321
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:According to a wide variety of analyses and projections, the potential effects of global climate change on human health are large and diverse. The U.S. National Institutes of Health (NIH), through its basic, clinical, and population research portfolio of grants, has been increasing efforts to understand how ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1104518
更新日期:2013-04-01 00:00:00
abstract::The purpose of the investigation is to study whether an increased mortality from certain causes exists in an area around the Rönnskärsverken smelter works in northern Sweden. Founded in 1928, this metallurgical plant processing mainly nonferrous metals has since its initial operations been using ore with a high arseni...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7719133
更新日期:1977-08-01 00:00:00
abstract::Children may be more susceptible to exposures to environmental toxins than adults and may be more vulnerable to their effects. Because of this, the health care community and those responsible for children need to be alert to possible environmental factors in identifying and responding to the health problems of childre...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s613
更新日期:1995-09-01 00:00:00
abstract::New technologies are providing innovative ways to reduce sound levels in many areas. Aircraft engineers are finding ways to reduce the noise produced by jet engines, while road builders are using rubber-enhanced pavement to quiet highway noise. Indoor acoustics are benefiting from materials that transform sound waves ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.113-a46
更新日期:2005-01-01 00:00:00
abstract::A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9196239
更新日期:1991-12-01 00:00:00
abstract::Striking similarities have been observed in a number of extrapulmonary responses of rodents to seemingly disparate ambient pollutants. These responses are often characterized by primary decreases in important indices of cardiac and thermoregulatory function, along with secondary decreases in associated parameters. For...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.01109s4539
更新日期:2001-08-01 00:00:00
abstract::Outdoor ambient air pollutant exposures in communities are relevant to the acute exacerbation and possibly the onset of asthma. However, the complexity of pollutant mixtures and etiologic heterogeneity of asthma has made it difficult to identify causal components in those mixtures. Occupational exposures associated wi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s4573
更新日期:2002-08-01 00:00:00
abstract::A patient with massive exposure to tetrachloroethylene fumes presented with coma and severe pulmonary edema. Sequential blood gases, chest x-rays, and clinical findings showed dramatic improvement with conventional but aggressive management and the patient recovered completely. There was no evidence of permanent renal...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7721247
更新日期:1977-12-01 00:00:00