Monitoring genotoxic exposure in uranium mines.

abstract：BACKGROUND:The widespread use of organophosphorus (OP) pesticides has led to frequent exposure in adults and children. Because such exposure may cause adverse health effects, particularly in children, the sources and patterns of exposure need to be studied further. OBJECTIVES:We assessed young urban/suburban children'...

journal_title：Environmental health perspectives

authors： Lu C,Barr DB,Pearson MA,Waller LA

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothe...

journal_title：Environmental health perspectives

authors： Chappell GA,Israel JW,Simon JM,Pott S,Safi A,Eklund K,Sexton KG,Bodnar W,Lieb JD,Crawford GE,Rusyn I,Furey TS

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:High-level occupational exposures to some industrial chemicals have been associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, the potential role of low-level environmental pollution on liver disease in the general population has not been evaluated. OBJECTIVE:We determ...

journal_title：Environmental health perspectives

authors： Cave M,Appana S,Patel M,Falkner KC,McClain CJ,Brock G

更新日期：2010-12-01 00:00:00

abstract：:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...

journal_title：Environmental health perspectives

authors： Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES:We aimed to a) determine whether BPA showed effects on the developin...

journal_title：Environmental health perspectives

authors： Montévil M,Acevedo N,Schaeberle CM,Bharadwaj M,Fenton SE,Soto AM

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. OBJECT...

journal_title：Environmental health perspectives

authors： Thankamony A,Lek N,Carroll D,Williams M,Dunger DB,Acerini CL,Ong KK,Hughes IA

更新日期：2014-02-01 00:00:00

abstract：:Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

journal_title：Environmental health perspectives

authors： Lee TC,Ho IC

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...

journal_title：Environmental health perspectives

authors： Bell ML,Kim JY,Dominici F

更新日期：2007-11-01 00:00:00

abstract：:Inspection of the available literature reveals that a detailed investigation of the aqueous organic chemistry of chlorine dioxide and systematic identification of products formed during water disinfection has not been considered. This must be done before an informed assessment can be made of the relative safety of usi...

journal_title：Environmental health perspectives

authors： Stevens AA

更新日期：1982-12-01 00:00:00

abstract：:In vivo bone lead measurement using K X-ray fluorescence (KXRF) has been used to estimate long-term lead exposure, especially in adults. Relatively few studies have been conducted on young subjects with this technique. To explore the measurement variability of KXRF bone lead measurements in young subjects, the tibiae ...

journal_title：Environmental health perspectives

authors： Hoppin JA,Aro A,Hu H,Ryan PB

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Drinking water contamination related to the use of aqueous film-forming foam (AFFF) has been documented at hundreds of military bases, airports, and firefighter training facilities. AFFF has historically contained high levels of long-chain per- and polyfluoroalkyl substances (PFAS), which pose serious health...

journal_title：Environmental health perspectives

authors： Annunziato KM,Doherty J,Lee J,Clark JM,Liang W,Clark CW,Nguyen M,Roy MA,Timme-Laragy AR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...

journal_title：Environmental health perspectives

authors： Lee WJ,Alavanja MC,Hoppin JA,Rusiecki JA,Kamel F,Blair A,Sandler DP

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Radon is the second-leading cause of lung cancer worldwide. Most indoor exposure occurs by diffusion of soil gas. Radon is also found in well water, natural gas, and ambient air. Pennsylvania has high indoor radon concentrations; buildings are often tested during real estate transactions, with results report...

journal_title：Environmental health perspectives

authors： Casey JA,Ogburn EL,Rasmussen SG,Irving JK,Pollak J,Locke PA,Schwartz BS

更新日期：2015-11-01 00:00:00

abstract：:Although chemical exposure has been associated with reduced reproduction in certain North American fish, reptiles, and mammals, definitive cause-and-effect data are lacking in many instances. Because the increasing use and global transport of industrial chemicals pose significant risk to successful reproduction, metho...

journal_title：Environmental health perspectives

authors： Hose JE,Guillette LJ

更新日期：1995-05-01 00:00:00

abstract：:In this paper we give some examples of using databases of genotoxicity and carcinogenicity for quantitative and qualitative correlation studies between short-term tests and carcinogenicity. The quality of the databases is obviously important, but one of the major deficiencies of present databases is that they are too ...

journal_title：Environmental health perspectives

authors： Parodi S,Malacarne D,Taningher M

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Few studies have examined the relationship between long-term exposure to ambient fine particulate matter (PM2.5) and nonaccidental mortality in rural populations. OBJECTIVE:We examined the relationship between PM2.5 and nonaccidental and cardiovascular mortality in the U.S. Agricultural Health Study cohort....

journal_title：Environmental health perspectives

authors： Weichenthal S,Villeneuve PJ,Burnett RT,van Donkelaar A,Martin RV,Jones RR,DellaValle CT,Sandler DP,Ward MH,Hoppin JA

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Agricultural use of antimicrobials in subtherapeutic concentrations is increasing in response to the rising demand for food animal products worldwide. In India, the use of antimicrobials in food animal production is unregulated. Research suggests that many clinically important antimicrobials are used indiscr...

journal_title：Environmental health perspectives

authors： Brower CH,Mandal S,Hayer S,Sran M,Zehra A,Patel SJ,Kaur R,Chatterjee L,Mishra S,Das BR,Singh P,Singh R,Gill JPS,Laxminarayan R

更新日期：2017-07-20 00:00:00

abstract：:Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular...

journal_title：Environmental health perspectives

authors： Krasavage WJ,Katz GV

更新日期：1984-08-01 00:00:00

abstract：:Mammalian cells in culture have been used to study the genetic effects of physical and chemical agents. We have used Chinese hamster ovary (CHO) cells, clone K1-BH4, to quantify mutations at the X-linked, large (35 kb) hypoxanthine-guanine phosphoribosyltransferase (hprt) locus (the CHO/HPRT assay) induced by environm...

journal_title：Environmental health perspectives

authors： Hsie AW,Xu Z,Yu Y,An J,Meltz ML,Schwartz JL,Hrelia P

更新日期：1993-10-01 00:00:00

abstract：:Two remote maritime populations were evaluated for their biological exposure to organochlorines in 1989-1990. Because of their high intake of seafood, these two populations have high biological levels. One hundred nine breast milk samples from Inuit women from Arctic Québec were analyzed to determine levels of polychl...

journal_title：Environmental health perspectives

authors： Dewailly E,Ryan JJ,Laliberté C,Bruneau S,Weber JP,Gingras S,Carrier G

更新日期：1994-01-01 00:00:00

abstract：:Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activiti...

journal_title：Environmental health perspectives

authors： Fujiki H,Suganuma M,Yoshizawa S,Nishiwaki S,Winyar B,Sugimura T

更新日期：1991-06-01 00:00:00

abstract：:In this study we investigated the risk of hearing loss among workers exposed to both toluene and noise. We recruited 58 workers at an adhesive materials manufacturing plant who were exposured to both toluene and noise [78.6-87.1 A-weighted decibels; dB(A)], 58 workers exposed to noise only [83.5-90.1 dB(A)], and 58 ad...

journal_title：Environmental health perspectives

authors： Chang SJ,Chen CJ,Lien CH,Sung FC

更新日期：2006-08-01 00:00:00

abstract：:Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various compounds can be classi...

journal_title：Environmental health perspectives

authors： Steiner G,Suter L,Boess F,Gasser R,de Vera MC,Albertini S,Ruepp S

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:The U.S. Environmental Protection Agency is working toward gaining a better understanding of the human health impacts of exposure to complex air pollutant mixtures and the key features that drive the toxicity of these mixtures, which can then be used for future scientific and risk assessments. DATA SOURCES:...

journal_title：Environmental health perspectives

authors： Johns DO,Stanek LW,Walker K,Benromdhane S,Hubbell B,Ross M,Devlin RB,Costa DL,Greenbaum DS

更新日期：2012-09-01 00:00:00

abstract：:Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...

journal_title：Environmental health perspectives

authors： Harbison RD

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:We have previously shown that adult male mice exposure to low doses of an ubiquitous endocrine disruptor, di(2-ethylhexyl) phthalate (DEHP), alters courtship behavior. OBJECTIVE:The effects of adult exposure to low doses of DEHP alone or in an environmental phthalate mixture on estrous cyclicity, reproducti...

journal_title：Environmental health perspectives

authors： Adam N,Brusamonti L,Mhaouty-Kodja S

更新日期：2021-01-01 00:00:00

abstract：:Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the...

journal_title：Environmental health perspectives

authors： Hart RW,Daniel FB,Kindig OR,Beach CA,Joseph LB,Wells RC

更新日期：1980-02-01 00:00:00

abstract：:With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...

journal_title：Environmental health perspectives

authors： Ogunseitan OA

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results. OBJECTIVE:We sought ...

journal_title：Environmental health perspectives

authors： Cardenas A,Gold DR,Hauser R,Kleinman KP,Hivert MF,Calafat AM,Ye X,Webster TF,Horton ES,Oken E

更新日期：2017-10-02 00:00:00

abstract：:The instrumentation and practical circuitry required for the detection of negative ions exiting the mass analysis section of a mass spectrometer is examined. The potentials needed to bias the electron multiplier when detecting negative ions from a low ion-energy mass spectrometer, e.g., a quadrupole, are contrasted wi...

journal_title：Environmental health perspectives

authors： McKeown M

更新日期：1980-06-01 00:00:00