Abstract:
:We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens. The yield of mutagens by the heating of food constituents is changed by the heating method. Effects of heating methods on the yield of amino-alpha-carbolines were studied in a series of experiments, and the results are shown in this paper. Additionally, it has been shown that by the heating of creatine-sugar mixtures imidazoquinoline or quinoxaline mutagens are formed.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Yoshida D,Matsumoto T,Okamoto H,Mizusaki S,Kushi A,Fukuhara Ydoi
10.1289/ehp.866755subject
Has Abstractpub_date
1986-08-01 00:00:00pages
55-8eissn
0091-6765issn
1552-9924journal_volume
67pub_type
杂志文章abstract::Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen. Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity. W...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104620
更新日期:1996-06-01 00:00:00
abstract::Human DNA adduct formation (covalent modification of DNA with chemical carcinogens) is a promising biomarker for elucidating the molecular epidemiology of cancer. Classes of compounds for which human DNA adducts have been observed include polycyclic aromatic hydrocarbons (PAHs), nitrosamines, mycotoxins, aromatic amin...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.96104s5883
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1289
更新日期:2018-01-11 00:00:00
abstract:BACKGROUND:Exposure to transportation noise is widespread and has been associated with obesity in some studies. However, the evidence from longitudinal studies is limited and little is known about effects of combined exposure to different noise sources. OBJECTIVES:The aim of this longitudinal study was to estimate the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1910
更新日期:2017-11-20 00:00:00
abstract::Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399129
更新日期:1993-03-01 00:00:00
abstract::Among the issues dealing with identifying potential adverse immunologic effects (i.e., suppression, hypersensitivity, or autoimmunity) associated with xenobiotic exposure, general agreement exists among the regulatory and pharmaceutical communities that predictive tests for autoimmunity are in most need of development...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.99107s5679
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Adverse cardiorespiratory health is associated with exposure to ambient particulate matter (PM). The highest PM concentrations in London occur in proximity to waste transfer stations (WTS), sites that experience high numbers of dust-laden, heavy-duty diesel vehicles transporting industrial and household wast...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901303
更新日期:2010-04-01 00:00:00
abstract::The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091145
更新日期:2001-11-01 00:00:00
abstract::Adults eating a Western diet digest and absorb ingested food containing approximately 100 g fat, 350 g carbohydrate, and 75 g protein daily. Normal fat absorption requires adequate gastric, pancreatic, liver-biliary, mucosal, and lymphatic function. Carbohydrate and protein absorption is much less dependent on liver-b...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7933101
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Ambient air ozone (O3) is a pulmonary irritant that has been associated with respiratory health effects including increased lung inflammation and permeability, airway hyperreactivity, respiratory symptoms, and decreased lung function. Estimation of O3 exposure is a complex task because the pollutant exhibits...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1306566
更新日期:2014-09-01 00:00:00
abstract::We have developed and applied a new measurement methodology to investigate dermal absorption of chloroform while bathing. Ten subjects bathed in chlorinated water while breathing pure air through a face mask. Their exhaled breath was delivered to a glow discharge source/ion trap mass spectrometer for continuous real-t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106337
更新日期:1998-06-01 00:00:00
abstract::The genetic toxicology databases for chemicals that have been tested extensively are generally composed of inconsistent responses from a diverse set of assays. Consequently, difficulties arise when the data are evaluated for classifying the agent or for assessing the chemical's hazard potential. Several years ago, the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9196101
更新日期:1991-12-01 00:00:00
abstract::As part of a detailed experimental study of the pathogenicity of disease of slate dust workers, the early biochemical changes in rat lung from 1 to 90 days after intratracheal inoculation of slate dust of particle size below 5 micron were investigated. A severalfold increase in free cell population (initially macropha...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8351305
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Cohort studies in North America and western Europe have reported increased risk of mortality associated with long-term exposure to fine particles (PM2.5), but to date, no such studies have been reported in China, where higher levels of exposure are experienced. OBJECTIVES:We estimated the association betwee...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1673
更新日期:2017-11-07 00:00:00
abstract::The physiological function of copper(I)-metallothionein is not well understood. The respiratory function of hemocyanin, a copper(I)-containing respiratory protein found in the hemolymph of many invertebrates, has been known a long time. However, the mechanism by which Cu(I) is inserted into the oxygen-binding site of ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866593
更新日期:1986-03-01 00:00:00
abstract::The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.814245
更新日期:1981-12-01 00:00:00
abstract::In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA d...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104744
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/EHP483
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:After Hurricane Katrina, many New Orleans homes remained flooded for weeks, promoting heavy microbial growth. OBJECTIVES:A small demonstration project was conducted November 2005-January 2006 aiming to recommend safe remediation techniques and safe levels of worker protection, and to characterize airborne m...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9258
更新日期:2006-12-01 00:00:00
abstract::Recent data from deep uranium mines in Czechoslovakia indicated that mines are exposed to other mutagenic factors in addition to radon daughter products. Mycotoxins were identified as a possible source of mutagens in these mines. Mycotoxins were examined in 38 samples from mines and in throat swabs taken from 116 mine...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.101-1521117
更新日期:1993-10-01 00:00:00
abstract::Basophilic hepatic foci, nodules, and trabecular hepatocellular carcinomas, collectively referred to as focal hepatic lesions, were induced by single injections of 5.0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice. Groups of eight experimental and eigh...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350149
更新日期:1983-04-01 00:00:00
abstract::Nitroaromatic compounds, ArNO2 have widespread actual or potential use in medicine and cancer therapy. There is direct proof that free-radical metabolites are involved in many applications, and an appreciation of the conceptual basis for their therapeutic differential; however, an understanding of the detailed mechani...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8564309
更新日期:1985-12-01 00:00:00
abstract::The in vivo micronucleus assay can be analyzed by comparing the number of micronuclei (MN) of several dose groups with those of a control group. In several publications, difficulties arose in estimating a suitable distribution for MN, even in the untreated historical control groups. Mitchell et al. described the prese...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s1121
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408847
更新日期:2015-12-01 00:00:00
abstract::1,3-Butadiene is a major monomer in the rubber and plastics industry and is one of the highest-production industrial chemicals in the United States. Although not highly acutely toxic to rodents, inhalation of concentrations as low as 6.25 ppm causes tumors in mice. Butadiene is oncogenic in rats, but much higher expos...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93101s6161
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects. OBJECTIVES:We sought to identify potential response-modifying factors to d...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1307541
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Recent policies attempting to reduce adverse effects of methylmercury exposure from fish consumption in the United States have targeted reductions in anthropogenic emissions from U.S. sources. OBJECTIVES:To analyze the prospects for future North American and international emissions controls, we assessed the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0900811
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard ide...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5672
更新日期:2019-12-01 00:00:00
abstract::During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokine...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104858
更新日期:1996-08-01 00:00:00
abstract:INTRODUCTION:Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children. DESIGN:Within a prospective birth cohort, we perfo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8741
更新日期:2006-07-01 00:00:00