Abstract:
BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB groups with common actions or structure, 35 individual PCB congeners, and nine chlorinated pesticides. METHODS:Linear regression analysis was used to determine the relationships between blood pressure and serum levels of the various contaminants after adjustment for age, body mass index, sex, race, smoking, and exercise in 394 Anniston residents who were not taking antihypertensive medication. RESULTS:Other than age, total serum PCB concentration was the strongest determinant of blood pressure of the covariates studied. We found the strongest associations for those PCB congeners that had multiple ortho chlorines. We found the associations over the full range of blood pressure as well as in those subjects whose blood pressure was in the normal range. The chlorinated pesticides showed no consistent relationship to blood pressure. CONCLUSIONS:In this cross-sectional study, serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Goncharov A,Pavuk M,Foushee HR,Carpenter DO,Anniston Environmental Health Reseach Consortium.doi
10.1289/ehp.1002830subject
Has Abstractpub_date
2011-03-01 00:00:00pages
319-25issue
3eissn
0091-6765issn
1552-9924journal_volume
119pub_type
杂志文章abstract::Green turtle fibropapillomatosis (GTFP) is a growing threat to the survival of green turtle (Chelonia mydas) populations worldwide. Recent transmission studies point to an infectious etiology. Several field studies suggest that high GTFP prevalence is associated with marine habitats that have been impacted by agricult...
journal_title:Environmental health perspectives
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doi:10.1289/ehp.95103s427
更新日期:1995-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7823227
更新日期:1978-04-01 00:00:00
abstract::Beginning approximately 4 years after the Chernobyl nuclear accident a steady increase in the incidence of thyroid cancer was observed in children and adolescents of the Bryansk Oblast, which received the highest level of radionuclide contaminants in Russia. We examined the spatial relationship between the residence l...
journal_title:Environmental health perspectives
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doi:10.1289/ehp.97105s61491
更新日期:1997-12-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1994-11-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1977-12-01 00:00:00
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更新日期:1987-04-01 00:00:00
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更新日期:1996-12-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1986-11-01 00:00:00
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更新日期:1993-12-01 00:00:00
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更新日期:2006-02-01 00:00:00
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更新日期:1994-10-01 00:00:00
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更新日期:2002-03-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2011-10-01 00:00:00
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更新日期:2017-09-15 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1979-02-01 00:00:00
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更新日期:1975-12-01 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:2016-03-01 00:00:00
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更新日期:2003-07-01 00:00:00