Abstract:
:Multiple factors, known and unknown, contribute to human breast cancer. Hereditary, hormonal, and reproductive factors are associated with risk of breast cancer. Environmental agents, including chemical carcinogens, are modifiable risk factors to which over 70% of breast cancers have been attributed. Polymorphisms of drug-metabolizing enzymes may influence risk of breast cancer from environmental chemicals, dietary agents, and endogenous steroids. The environmental factors discussed in this review include pollutants, occupational exposures, tobacco smoke, alcohol, and diet. Aromatic amines are discussed as potential mammary carcinogens, with a focus on heterocyclic amine food pyrolysis products. These compounds are excreted into the urine after consumption of meals containing cooked meats and have recently been detected in the breast milk of lactating women.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
DeBruin LS,Josephy PDdoi
10.1289/ehp.02110s1119subject
Has Abstractpub_date
2002-02-01 00:00:00pages
119-28eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
110 Suppl 1pub_type
杂志文章,评审abstract::This article summarizes the basic facts about the measurement of ionizing radiation, usually referred to as radiation dosimetry. The article defines the common radiation quantities and units; gives typical levels of natural radiation and medical exposures; and describes the most important biological effects of radiati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.919145
更新日期:1991-02-01 00:00:00
abstract::Neonatal treatment of female mice with diethystilbestrol (DES) is known to induce ovary-independent persistent proliferation and cornification of vaginal epithelium. This irreversibly changed vaginal epithelium persistently expressed higher levels of c-jun and c-fos mRNAs, which was not altered by postpubertal estroge...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s779
更新日期:1995-10-01 00:00:00
abstract::Potential public health effects associated with exposure to metal emissions from hazardous waste incinerators through noninhalation pathways were evaluated. Instead of relying on modeling the movement of toxicants through various environmental media, an approach based on estimating changes from baseline levels of expo...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102105
更新日期:1994-06-01 00:00:00
abstract::Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biol...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.85615
更新日期:1985-09-01 00:00:00
abstract::During the last three decades, the use of modern organic synthetic pesticides has increased about 40-fold. Total U.S. production, for domestic and expert use, in 1976 was about 1.4 million pounds. Crops receiving the most intensive application of various pesticides were cotton for insecticides, corn for herbicides, an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7827103
更新日期:1978-12-01 00:00:00
abstract::The main source of cadmium in the diet is cereal or meat, especially in liver and kidney. Since the cadmium in both liver and kidney is bound to metallothionein, a heat-stable protein, the gastrointestinal absorption and metabolism of cadmium metallothionein (CdMt) was studied in detail. The selective renal cadmium de...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7928127
更新日期:1979-02-01 00:00:00
abstract::The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum energy conformation that is within 1 or 2 kcal/mole of the global minimum. In favorable cases, state-of-the-art mole...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561111
更新日期:1985-09-01 00:00:00
abstract::Several examples of categorized data from epidemiological studies are analyzed to illustrate that more informative analysis than tests of independence can be performed by fitting models. All of the analyses fit into a unified conceptual framework that can be performed by weighted least squares. The methods presented s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7932169
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND:Pterygium is a fibrovascular growth of the bulbar conjunctiva and underlying subconjunctival tissue that may cause blindness. The mechanism of pterygium formation is not yet fully understood, but pterygium has some tumorlike features. OBJECTIVES:The objective of this study was to evaluate the association be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11111
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES:We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS:A total of 186 incide...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP157
更新日期:2016-10-01 00:00:00
abstract::In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s51121
更新日期:1997-09-01 00:00:00
abstract::In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081113
更新日期:2000-12-01 00:00:00
abstract::Naturally occurring radon is a relatively ubiquitous environmental carcinogen to which large numbers of people can be exposed over their lifetimes. The accumulation of radon in homes, therefore, has led to a large program to determine the effects of the densely ionizing alpha particles that are produced when radon dec...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s373
更新日期:1993-10-01 00:00:00
abstract::Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5799
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Although many studies have examined the effects of air pollution on mortality, data limitations have resulted in fewer studies of both particulate matter with an aerodynamic diameter of
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800108
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Although numerous epidemiologic studies now use models of intraurban exposure, there has been little systematic evaluation of the performance of different models. OBJECTIVES:In this present article we proposed a modeling framework for assessing exposure model performance and the role of spatial autocorrelat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9849
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:In an effort to decrease the rates of smoking conventional tobacco cigarettes, electronic cigarettes (e-cigarettes) have been proposed as an effective smoking cessation tool. However, little is known about their toxicological impacts. This is concerning given that e-cigarette use is perceived as less harmful...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6067
更新日期:2020-04-01 00:00:00
abstract::Millions of people worldwide are living in areas where ozone (O3) concentrations exceed health standards (an hourly average of 235 micrograms/m3/0.12 ppm, not to be exceeded more than once per year). Ozone induces acute nasal inflammatory responses and significant epithelial lesions in experimental animals and humans....
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.102-1567497
更新日期:1994-12-01 00:00:00
abstract::A review of the present understanding of asthma leads to the following conclusions: an elevated IgE is the principal risk factor in the development of childhood asthma; secondary exposure to a wide range of environmental agents (including indoor bioallergens) accounts for the variations in prevalence; prevalence (defi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s6243
更新日期:1995-09-01 00:00:00
abstract::The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.772179
更新日期:1977-12-01 00:00:00
abstract::To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102298
更新日期:1994-03-01 00:00:00
abstract::A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108595
更新日期:2000-07-01 00:00:00
abstract::The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091145
更新日期:2001-11-01 00:00:00
abstract::The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93101s59
更新日期:1993-12-01 00:00:00
abstract::The consideration of ethical issues relating to pediatric environmental health is a recent phenomenon. Discussions of biomedical ethics, research on children, and environmental health research have a longer history. In the late 1990s, researchers at the Kennedy Krieger Institute in Baltimore, Maryland, undertook a stu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9000
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. OBJECTIVE:We evaluated the olfactory neuroepithelium (OE) and brain regional respon...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP134
更新日期:2016-10-01 00:00:00
abstract::The capacity of in vitro bioassays to detect the potential carcinogenicity of metal compounds is reviewed. The in vitro bioassays discussed include: bacterial reversion analysis to determine the capacity of metal salts to revert Salmonella typhimurium histidine auxotrophs or to revert Escherichia coli WP 2 tryp- to tr...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8140163
更新日期:1981-08-01 00:00:00
abstract::The past and current EPA research and regulatory programs as they relate to non-regulated emissions from light-duty motor vehicles are reviewed. Provisions of Sections 202(a) and 211 of the 1970 Clean Air Act Amendments are discussed and their relationships to the nonregulated emissions issue detailed. The EPA positio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.75105
更新日期:1975-04-01 00:00:00
abstract::In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of pediatric disease in American children. We examined four categories of illness: lead poisoning, asthma, cancer, and neurobehavioral disorders. To estimate the proportion of each attrib...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110721
更新日期:2002-07-01 00:00:00
abstract::U.S. chemical plants currently have potentially catastrophic vulnerabilities as terrorist targets. The possible consequences of these vulnerabilities echo from the tragedies of the Bhopal incident in 1984 to the terrorist attacks on 11 September 2001 and, most recently, Hurricanes Katrina and Rita. Findings from a 200...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8762
更新日期:2006-09-01 00:00:00