Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.

Abstract:

BACKGROUND:Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. OBJECTIVES:We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. METHODS:We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old. RESULTS:BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y. CONCLUSIONS:The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314.

authors

Philippat C,Nakiwala D,Calafat AM,Botton J,De Agostini M,Heude B,Slama R,EDEN Mother–Child Study Group.

doi

10.1289/EHP1314

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

097014

issue

9

eissn

0091-6765

issn

1552-9924

pii

EHP1314

journal_volume

125

pub_type

杂志文章
  • Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans.

    abstract::This paper describes quantitation of human hemoglobin and DNA adducts of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). NNK and NNN are believed to be involved in cancers of the lung, esophagus, oral cavity, and pancreas in people wh...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.939957

    authors: Hecht SS,Carmella SG,Foiles PG,Murphy SE,Peterson LA

    更新日期:1993-03-01 00:00:00

  • Thyroid Antagonists (Perchlorate, Thiocyanate, and Nitrate) and Childhood Growth in a Longitudinal Study of U.S. Girls.

    abstract:BACKGROUND:Perchlorate, thiocyanate, and nitrate are sodium/iodide symporter (NIS) inhibitors that block iodide uptake into the thyroid, thus affecting thyroid function. Thyroid dysfunction can adversely affect somatic growth and development in children. To our knowledge, no studies have examined effects of NIS inhibit...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409309

    authors: Mervish NA,Pajak A,Teitelbaum SL,Pinney SM,Windham GC,Kushi LH,Biro FM,Valentin-Blasini L,Blount BC,Wolff MS,Breast Cancer and Environment Research Project (BCERP).

    更新日期:2016-04-01 00:00:00

  • Infectious disease and worldwide declines of amphibian populations, with comments on emerging diseases in coral reef organisms and in humans.

    abstract::Many populations of amphibians are declining on all six continents on which they occur. Some causes of amphibian declines, such as habitat destruction, direct application of xenobiotics, and introduction of predators or competitors, are clearly attributable to human activities. Infectious disease appears to be the dir...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108s1143

    authors: Carey C

    更新日期:2000-03-01 00:00:00

  • Benzene and leukemia: an epidemiologic risk assessment.

    abstract::To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8982189

    authors: Rinsky RA

    更新日期:1989-07-01 00:00:00

  • Oncogenes and radiation carcinogenesis.

    abstract::Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistan...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.919345

    authors: Garte SJ,Burns FJ

    更新日期:1991-06-01 00:00:00

  • The utility of DNA microarrays for characterizing genotoxicity.

    abstract::Microarrays provide an unprecedented opportunity for comprehensive concurrent analysis of thousands of genes. The global analysis of the response of genes to a toxic insult (toxicogenomics), as opposed to the historical method of examining a few select genes, provides a more complete picture of toxicologically signifi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6709

    authors: Newton RK,Aardema M,Aubrecht J

    更新日期:2004-03-01 00:00:00

  • Prediction and assessment of the effects of mixtures of four xenoestrogens.

    abstract::The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108983

    authors: Payne J,Rajapakse N,Wilkins M,Kortenkamp A

    更新日期:2000-10-01 00:00:00

  • Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers.

    abstract::At picomolar concentrations, lead activates protein kinase C (PKC). This activation has been implicated in the neurotoxicity of lead. No prior study has evaluated the association of PKC activity with neurobehavioral function in humans. The purpose of this study was to determine whether PKC activity is associated with ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110133

    authors: Hwang KY,Lee BK,Bressler JP,Bolla KI,Stewart WF,Schwartz BS

    更新日期:2002-02-01 00:00:00

  • In vivo detection of radicals in biological reactions.

    abstract::In vivo detection of free radicals on a quantitative basis is essential for an establishment of their role in membrane, protein, and cell and tissue damage. This article compares optical methods, including chemiluminescence, electron paramagnetic resonance (EPR) and NMR methods for the study of free radicals and free ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102s1029

    authors: Chance B,Gao G

    更新日期:1994-12-01 00:00:00

  • A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures.

    abstract:BACKGROUND:Exposure mixtures frequently occur in data across many domains, particularly in the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer questions about exposure mixtures, including methods such as weighted quantile sum (WQS) regression that estimate a joint effect o...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5838

    authors: Keil AP,Buckley JP,O'Brien KM,Ferguson KK,Zhao S,White AJ

    更新日期:2020-04-01 00:00:00

  • Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.

    abstract:BACKGROUND:Lead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors. OBJECTIVES:We examine...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1306931

    authors: Bakulski KM,Park SK,Weisskopf MG,Tucker KL,Sparrow D,Spiro A 3rd,Vokonas PS,Nie LH,Hu H,Weuve J

    更新日期:2014-10-01 00:00:00

  • Exploratory monitoring of air pollutants for mutagenicity activity with the Tradescantia stamen hair system.

    abstract::The Tradescantia genetic system developed by the late Dr. Arnold H. Sparrow for the study of effects of ionizing radiation is applicable to chemical mutagen detection. Early radiobiological data demonstrated that the stamen hairs were sensitive to as little as 0.25 rad of x-rays and that the number of cells showing a ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.782751

    authors: Schairer LA,Van't Hof J,Hayes CG,Burton RM,de Serres FJ

    更新日期:1978-12-01 00:00:00

  • What should be done to mitigate groundwater contamination?

    abstract::Groundwater contamination is a serious problem that is growing in the United States, but its true extent is not known and it is difficult to determine because of the complexities of contaminants, their transformation, and fate in groundwater systems. It is also difficult to predict their movement in groundwater. Since...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9086239

    authors: Patrick R

    更新日期:1990-06-01 00:00:00

  • Transformation of BALB/c-3T3 cells: III. Development of a co-culture clonal survival assay for quantification of chemical cytotoxicity in high-density cell cultures.

    abstract::A co-culture clonal survival assay was developed to measure the cytotoxicity of test chemical treatments to BALB/c-3T3 cells because the standard clonal survival assay using 200 wild type (WT) cells frequently overestimates chemical cytotoxicity when compared with identical treatment doses in high-density cultures. Th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s2311

    authors: Matthews EJ

    更新日期:1993-07-01 00:00:00

  • Agricultural exposures and cancer trends in developed countries.

    abstract::Recent increases have been reported in industrial countries for several sites of cancer. The causes of these increases remain unknown. Efforts should proceed to identify those occupational groups with increases in the same sites, as these may indicate relevant exposures. Two analyses were undertaken: trends in cancer ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,meta分析

    doi:10.1289/ehp.9310039

    authors: Davis DL,Blair A,Hoel DG

    更新日期:1993-04-01 00:00:00

  • Monitoring intracellular redox changes in ozone-exposed airway epithelial cells.

    abstract:BACKGROUND:The toxicity of many xenobiotic compounds is believed to involve oxidative injury to cells. Direct assessment of mechanistic events involved in xenobiotic-induced oxidative stress is not easily achievable. Development of genetically encoded probes designed for monitoring intracellular redox changes represent...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1206039

    authors: Gibbs-Flournoy EA,Simmons SO,Bromberg PA,Dick TP,Samet JM

    更新日期:2013-03-01 00:00:00

  • Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study.

    abstract:BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP39

    authors: Béranger R,Garlantézec R,Le Maner-Idrissi G,Lacroix A,Rouget F,Trowbridge J,Warembourg C,Monfort C,Le Gléau F,Jourdin M,Multigner L,Cordier S,Chevrier C

    更新日期:2017-04-01 00:00:00

  • Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables.

    abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1104802

    authors: Stapleton HM,Eagle S,Sjödin A,Webster TF

    更新日期:2012-07-01 00:00:00

  • Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland.

    abstract::Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organoc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.99107823

    authors: Dewailly E,Mulvad G,Pedersen HS,Ayotte P,Demers A,Weber JP,Hansen JC

    更新日期:1999-10-01 00:00:00

  • A proposed method for assembly and interpretation of short-term test data.

    abstract::The genetic toxicology databases for chemicals that have been tested extensively are generally composed of inconsistent responses from a diverse set of assays. Consequently, difficulties arise when the data are evaluated for classifying the agent or for assessing the chemical's hazard potential. Several years ago, the...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9196101

    authors: Brusick D

    更新日期:1991-12-01 00:00:00

  • Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines.

    abstract::The Lower North Shore region of the St. Lawrence River is home to a fish-eating population that displays an unusually high body burden of several organochlorines, including polychlorinated biphenyls (PCBs) and dioxin-like compounds (DLCs). We measured biomarkers indicative of liver enzyme induction and investigated th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7970

    authors: Ayotte P,Dewailly E,Lambert GH,Perkins SL,Poon R,Feeley M,Larochelle C,Pereg D

    更新日期:2005-10-01 00:00:00

  • Hypochlorous acid-activated carbon: an oxidizing agent capable of producing hydroxylated polychlorinated biphenyls.

    abstract::Granular activated carbon (GAC), in the presence of dilute aqueous hypochlorite solutions typical of those used in water treatment, was converted to a reagent capable of carrying out free-radical coupling reactions and other oxidations of dilute aqueous solutions of phenols. The products included biphenyls with chlori...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.866997

    authors: Voudrias EA,Larson RA,Snoeyink VL,Chen AS,Stapleton PL

    更新日期:1986-11-01 00:00:00

  • Additional thyroid dose factor from transportation sources in Russia after the Chernobyl disaster.

    abstract::Beginning approximately 4 years after the Chernobyl nuclear accident a steady increase in the incidence of thyroid cancer was observed in children and adolescents of the Bryansk Oblast, which received the highest level of radionuclide contaminants in Russia. We examined the spatial relationship between the residence l...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.97105s61491

    authors: Parshkov EM,Chebotareva IV,Sokolov VA,Dallas CE

    更新日期:1997-12-01 00:00:00

  • Mechanisms of action of okadaic acid class tumor promoters on mouse skin.

    abstract::Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activiti...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9193211

    authors: Fujiki H,Suganuma M,Yoshizawa S,Nishiwaki S,Winyar B,Sugimura T

    更新日期:1991-06-01 00:00:00

  • Outdoor Light at Night and Breast Cancer Incidence in the Nurses' Health Study II.

    abstract:BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP935

    authors: James P,Bertrand KA,Hart JE,Schernhammer ES,Tamimi RM,Laden F

    更新日期:2017-08-17 00:00:00

  • Priorities for development of research methods in occupational cancer.

    abstract::Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.111-1241299

    authors: Ward EM,Schulte PA,Bayard S,Blair A,Brandt-Rauf P,Butler MA,Dankovic D,Hubbs AF,Jones C,Karstadt M,Kedderis GL,Melnick R,Redlich CA,Rothman N,Savage RE,Sprinker M,Toraason M,Weston A,Olshan AF,Stewart P,Zahm SH,

    更新日期:2003-01-01 00:00:00

  • Distribution of metallothionein-bound cadmium and cadmium chloride in mice: preliminary studies.

    abstract::Metallothionein from livers of mice was isolated by gel chromatography and isoelectric focusing. One of two forms thus obtained contained 32 percent cysteine. This form, labeled in vitro with 109Cd, was injected intravenously in mice, and the distribution of 109Cd was studied. Animals killed after 4 hrs had over 80 pe...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7512103

    authors: Nordberg M,Nordberg GF

    更新日期:1975-12-01 00:00:00

  • Effects on the immune system associated with living near a pesticide dump site.

    abstract::In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.001081113

    authors: Vine MF,Stein L,Weigle K,Schroeder J,Degnan D,Tse CK,Hanchette C,Backer L

    更新日期:2000-12-01 00:00:00

  • Cancer mortality in U.S. counties with plastics and related industries.

    abstract::Counties in the United States have been identified with chemical establishments whose primary manufacturing processes use vinyl chloride. Site-specific cancer mortality comparisons have revealed an excess of multiple myeloma in males associated with two of the manufacturing categories, synthetic rubber and synthetic f...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.751179

    authors: Mason TJ

    更新日期:1975-06-01 00:00:00

  • Methylation study of a population environmentally exposed to arsenic in drinking water.

    abstract::Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen. Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity. W...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.96104620

    authors: Hopenhayn-Rich C,Biggs ML,Smith AH,Kalman DA,Moore LE

    更新日期:1996-06-01 00:00:00