U.S. cancer mortality 1950-1978: a strategy for analyzing spatial and temporal patterns.

abstract：:We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive...

journal_title：Environmental health perspectives

authors： Arcaro KF,Vakharia DD,Yang Y,Gierthy JF

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...

journal_title：Environmental health perspectives

authors： Everson TM,Punshon T,Jackson BP,Hao K,Lambertini L,Chen J,Karagas MR,Marsit CJ

更新日期：2018-01-22 00:00:00

abstract：:The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...

journal_title：Environmental health perspectives

authors： Bourbigot MM,Hascoet MC,Levi Y,Erb F,Pommery N

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited. OBJECTIVES:We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmenta...

journal_title：Environmental health perspectives

authors： Hudon Thibeault AA,Deroy K,Vaillancourt C,Sanderson JT

更新日期：2014-04-01 00:00:00

abstract：:Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...

journal_title：Environmental health perspectives

authors： Ryan US,Ryan JW

更新日期：1980-04-01 00:00:00

abstract：:In this study we investigated the potential impact of climate change in Portugal on heat-related mortality, air pollution-related health effects, and selected vectorborne diseases. The assessment used climate scenarios from two regional climate models for a range of future time periods. The annual heat-related death r...

journal_title：Environmental health perspectives

authors： Casimiro E,Calheiros J,Santos FD,Kovats S

更新日期：2006-12-01 00:00:00

abstract：:To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses ...

journal_title：Environmental health perspectives

authors： Goettsch W,Garssen J,Deijns A,de Gruijl FR,van Loveren H

更新日期：1994-03-01 00:00:00

abstract：:This report updates the risk assessment by Crump and Allen for benzene-induced leukemia that was based on a cohort exposed to benzene in the manufacture of Pliofilm. The present study derives new risk estimates using data from follow-up through 1987 (whereas the earlier assessment only had follow-up available through ...

journal_title：Environmental health perspectives

authors： Crump KS

更新日期：1996-12-01 00:00:00

abstract：:This paper describes quantitation of human hemoglobin and DNA adducts of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). NNK and NNN are believed to be involved in cancers of the lung, esophagus, oral cavity, and pancreas in people wh...

journal_title：Environmental health perspectives

authors： Hecht SS,Carmella SG,Foiles PG,Murphy SE,Peterson LA

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Although numerous epidemiologic studies now use models of intraurban exposure, there has been little systematic evaluation of the performance of different models. OBJECTIVES:In this present article we proposed a modeling framework for assessing exposure model performance and the role of spatial autocorrelat...

journal_title：Environmental health perspectives

authors： Molitor J,Jerrett M,Chang CC,Molitor NT,Gauderman J,Berhane K,McConnell R,Lurmann F,Wu J,Winer A,Thomas D

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledg...

journal_title：Environmental health perspectives

authors： Morin CW,Comrie AC,Ernst K

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) may accelerate the cognitive and motor dysfunction found in normal aging, but few studies have examined these outcomes and PCB exposure among older adults. OBJECTIVE:We evaluated neuropsychological status and low-level PCB exposure among older adults living along contaminate...

journal_title：Environmental health perspectives

authors： Fitzgerald EF,Belanger EE,Gomez MI,Cayo M,McCaffrey RJ,Seegal RF,Jansing RL,Hwang SA,Hicks HE

更新日期：2008-02-01 00:00:00

abstract：:The presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. In a recently published report, the National Academy of Sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-...

journal_title：Environmental health perspectives

authors： Crump KS,Gibbs JP

更新日期：2005-08-01 00:00:00

abstract：:Epidemiologic studies of the link between particulate matter (PM) concentrations and mortality rates have yielded a range of estimates, leading to disagreement about the magnitude of the relationship and the strength of the causal connection. Previous meta-analyses of this literature have provided pooled effect estima...

journal_title：Environmental health perspectives

authors： Levy JI,Hammitt JK,Spengler JD

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). OBJECTIVES:We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was associated with risk of PD. METHODS:We linked the U.S. Environmental Protection Agency (EPA)'s Air Toxi...

journal_title：Environmental health perspectives

authors： Palacios N,Fitzgerald K,Roberts AL,Hart JE,Weisskopf MG,Schwarzschild MA,Ascherio A,Laden F

更新日期：2014-09-01 00:00:00

abstract：:We examined 100 symptomatic Gulf War veterans (patients) and 100 controls for immunologic assays. The veterans and controls were compared for the percentage of T cells (CD3); B cells (CD19); helper:suppressor (CD4:CD8) ratio; natural killer (NK) cell activity; mitogenic response to phytohemagglutin (PHA) and pokeweed ...

journal_title：Environmental health perspectives

authors： Vojdani A,Thrasher JD

更新日期：2004-06-01 00:00:00

abstract：:This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman)...

journal_title：Environmental health perspectives

authors： McClellan RO,Hesterberg TW

更新日期：1994-10-01 00:00:00

abstract：:Germ-line mutations of the mouse have for years comprised one class of biological markers for mammalian reproductive and developmental toxicology. Understanding the molecular nature of mutations and the mechanisms by which mutations are translated into specific (and often complex) phenotypes, however, still looms as a...

journal_title：Environmental health perspectives

authors： Rinchik EM

更新日期：1987-10-01 00:00:00

abstract：:Chromate is an established human carcinogen. There have been many studies of the reactivity of chromate aimed at improving understanding of chromate toxicity. In the present paper a number of conclusions of these studies are reviewed and considered in the light of new results obtained in our laboratories. A number of ...

journal_title：Environmental health perspectives

authors： O'Brien P,Kortenkamp A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and...

journal_title：Environmental health perspectives

authors： Liew Z,Luo J,Nohr EA,Bech BH,Bossi R,Arah OA,Olsen J

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Organophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. OBJECTIVES/METHODS:We administered diazinon (DZN) or parathion (PRT) to rats on postnatal days 14 at doses straddling the threshold for systemic signs of exposure and assessed the effects on he...

journal_title：Environmental health perspectives

authors： Adigun AA,Wrench N,Seidler FJ,Slotkin TA

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to t...

journal_title：Environmental health perspectives

authors： Zhang Y,Huang W,London SJ,Song G,Chen G,Jiang L,Zhao N,Chen B,Kan H

更新日期：2006-08-01 00:00:00

abstract：:Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to ris...

journal_title：Environmental health perspectives

authors： Thomas RS,Rank DR,Penn SG,Zastrow GM,Hayes KR,Hu T,Pande K,Lewis M,Jovanovich SB,Bradfield CA

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) in construction materials, such as caulking used around windows and expansion joints, may constitute a source of PCB contamination in the building interiors and in surrounding soil. Several studies of soil contamination have been conducted around buildings where the caulking ...

journal_title：Environmental health perspectives

authors： Herrick RF,Lefkowitz DJ,Weymouth GA

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA) is known to be biologically active in experimental models even at low levels of exposure. However, its impact on endometrial cancer remains unclear. OBJECTIVES:This study aimed to investigate whether lifelong exposure to different doses of BPA induced uterine abnormalities and molecular ch...

journal_title：Environmental health perspectives

authors： Leung YK,Biesiada J,Govindarajah V,Ying J,Kendler A,Medvedovic M,Ho SM

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:In a 1994 Ninth Circuit decision on the remand of Daubert v. Merrell Dow Pharmaceuticals, Inc., Judge Alex Kosinski wrote that science done for the purpose of litigation should be subject to more stringent standards of admissibility than other science. OBJECTIVES:We analyze this proposition by considering l...

journal_title：Environmental health perspectives

authors： Boden LI,Ozonoff D

更新日期：2008-01-01 00:00:00

abstract：:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...

journal_title：Environmental health perspectives

authors： Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Recent findings suggest that maternal smoking during pregnancy may play a role in the development of metabolic alterations in offspring during childhood. However, whether such exposure increases the risk of developing similar metabolic alterations during adulthood is uncertain. OBJECTIVE:We evaluated the as...

journal_title：Environmental health perspectives

authors： Cupul-Uicab LA,Skjaerven R,Haug K,Travlos GS,Wilson RE,Eggesbø M,Hoppin JA,Whitworth KW,Longnecker MP

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION:We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core paper...

journal_title：Environmental health perspectives

authors： Bonde JP,Toft G,Rylander L,Rignell-Hydbom A,Giwercman A,Spano M,Manicardi GC,Bizzaro D,Ludwicki JK,Zvyezday V,Bonefeld-Jørgensen EC,Pedersen HS,Jönsson BA,Thulstrup AM,INUENDO.

更新日期：2008-03-01 00:00:00

abstract：:The last decade has marked a radical change in the business of sustainability, say environmental activists and industrialists alike. On the wane are "greenwashing" campaigns in which corporations promote dubious environmental accomplishments to draw attention away from environmentally damaging practices. On the rise a...

journal_title：Environmental health perspectives

authors： Fields S

更新日期：2002-03-01 00:00:00