Abstract：
BACKGROUND:Organophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. OBJECTIVES/METHODS:We administered diazinon (DZN) or parathion (PRT) to rats on postnatal days 14 at doses straddling the threshold for systemic signs of exposure and assessed the effects on hepatic and cardiac cell signaling mediated through the adenylyl cyclase (AC) cascade. RESULTS:In the liver, DZN elicited global sensitization, characterized by parallel up-regulation of AC activity itself and of the responses to stimulants acting at beta-adrenergic receptors, glucagon receptors, or G-proteins. The effects intensified over the course from adolescence to adulthood. In contrast, PRT elicited up-regulation in adolescence that waned by adulthood. Superimposed on these general patterns were effects on glucagon receptor coupling to AC and on responses mediated through the Gi inhibitory protein. The effects on the liver were more substantial than those in the heart, which displayed only transient effects of DZN on AC function in adolescence and no significant effects of PRT. Furthermore, the hepatic effects were greater in magnitude than those in a brain region (cerebellum) that shares similar AC cascade elements. CONCLUSIONS:These findings indicate that OPs alter the trajectory of hepatic cell signaling in a manner consistent with the observed emergence of prediabetes-like metabolic dysfunction. Notably, the various OPs differ in their net impact on peripheral AC signaling, making it unlikely that the effects on signaling reflect their shared property as cholinesterase inhibitors.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Adigun AA,Wrench N,Seidler FJ,Slotkin TAdoi
10.1289/ehp.0901237subject
Has Abstractpub_date
2010-02-01 00:00:00pages
210-5issue
2eissn
0091-6765issn
1552-9924journal_volume
118pub_type
杂志文章abstract：BACKGROUND:Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. OBJECTIVES:We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a compo...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP1330
更新日期：2017-09-20 00:00:00
abstract：:This article reviews the epidemiologic studies of the association of ischemic heart disease risk and environmental tobacco smoke (ETS) exposure from a spouse who smokes. Seventeen studies (nine cohort, eight case-control) comprising more than 485,000 lifelong nonsmokers and 7,345 coronary heart disease (CHD) events we...
journal_title：Environmental health perspectives
pub_type： 杂志文章,meta分析
doi：10.1289/ehp.99107s6841
更新日期：1999-12-01 00:00:00
abstract：:Descriptions of endocrine disruption have largely been associated with wildlife and driven by observations documenting estrogenic, androgenic, antiandrogenic, and antithyroid actions. These actions, in response to exposure to ecologically relevant concentrations of various environmental contaminants, have now been est...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8045
更新日期：2006-04-01 00:00:00
abstract：:Much public health research has been directed to studies of cancer risks due to chemical agents. Recently, increasing attention has been given to adverse reproductive outcomes as another, shorter-term biologic indicator of public health impact. Further, several low-level ubiquitous physical agents have been implicated...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8981193
更新日期：1989-05-01 00:00:00
abstract：:To elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one concerning the possible association of broiled fish consumption with cancer and the other concerning the cancer mortality ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8667143
更新日期：1986-08-01 00:00:00
abstract：:The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.98106649
更新日期：1998-10-01 00:00:00
abstract：:We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6869
更新日期：2004-06-01 00:00:00
abstract：:The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...
journal_title：Environmental health perspectives
pub_type： 历史文章,杂志文章
doi：10.1289/ehp.7544
更新日期：2005-05-01 00:00:00
abstract：:Africa is quickly becoming a destination for information technology in the form of tons of used computers, fax machines, cell phones, and other electronics. Although many of these machines can be repaired and resold, up to 75% of the electronics shipped to Africa is junk. This equipment, when dumped, may leach lead, m...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.114-a232
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Few studies have been conducted to identify risk factors for balance and vestibular dysfunction in general populations, but previous studies have reported evidence of adverse effects of lead and cadmium on balance control in high-risk groups. OBJECTIVE:We evaluated the relationship between blood lead and ca...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1103643
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE:We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respi...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.11491
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. OBJECTIVES:The primary goal of this research was to evaluate the dieta...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0900817
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.0901389
更新日期：2010-11-01 00:00:00
abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.98106s61263
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts. OBJE...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1002805
更新日期：2012-01-01 00:00:00
abstract：:We conducted a study to examine seasonal changes in residential dust lead content and its relationship to blood lead in preschool children. We collected blood and dust samples (floors, windowsills, and carpets) to assess lead exposure. The geometric mean blood lead concentrations are 10.77 and 7.66 microg/dL for the d...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.00108177
更新日期：2000-02-01 00:00:00
abstract：:Methyl parathion (MP), an organophosphate pesticide licensed only for agricultural uses, was sprayed illegally for pest control in Mississippi and Ohio residences. To evaluate the association between MP exposure and neurobehavioral development, we assessed children 6 years or younger at the time of the spraying and lo...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6430
更新日期：2004-01-01 00:00:00
abstract：:This paper summarizes the clinical phenomenology of multiple chemical sensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive am...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.97105s2457
更新日期：1997-03-01 00:00:00
abstract：:The lungs may be exposed to potentially toxic metabolites that are either formed in situ or which are present in the circulation. Therefore, pulmonary injury may be a prominent effect of certain classes of chemicals that undergo bioactivation in the body. The specific types of lung cells damaged may depend upon factor...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.845547
更新日期：1984-04-01 00:00:00
abstract：:A comprehensive environmental fate and effects testing program, sponsored by the Chemical Manufacturers Association (CMA) Phthalate Esters Program Panel, has been completed. Based on the results, a preliminary safety assessment has shown that all of the 14 commercially important phthalates tested have sufficiently hig...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8665337
更新日期：1986-03-01 00:00:00
abstract：:This paper examines recent risk assessments for benzene and observes a number of inconsistencies within the study and consistencies between studies that should effect the quantitative determination of the risk from benzene exposure. Comparisons across studies show that only acute myeloid leukemia (AML) is found to be ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8982289
更新日期：1989-07-01 00:00:00
abstract：:Minority populations face a wide variety of economic, institutional, and cultural barriers to health care. These barriers and low levels of education and income pose significant challenges for health professionals in developing cancer research and prevention-control strategies. It is suggested that specific segments o...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.95103s8287
更新日期：1995-11-01 00:00:00
abstract：:The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consideration is given to a...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.9195157
更新日期：1991-11-01 00:00:00
abstract：:Southwest metropolitan Mexico City (SWMMC) inhabitants have been exposed several hours per day for the last 6 years to photochemical smog, ozone being the most important oxidant pollutant. Subjects exposed to the SWMMC atmosphere develop several histopathological changes in their nasal mucosa: dysplasia is the most si...
journal_title：Environmental health perspectives
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1289/ehp.101-1519752
更新日期：1993-06-01 00:00:00
abstract：:Organophosphate (OP) pesticides are commonly used in the United States, and farmworkers are at risk for chronic exposure. Using a sample of 218 farmworkers in 24 communities and labor camps in eastern Washington State, we examined the association between agricultural crop and OP pesticide metabolite concentrations in ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8620
更新日期：2006-07-01 00:00:00
abstract：:A stratified version of nested case-control sampling which we call "countermatching" is presented. This design uses data available for all cohort members to obtain a sample for collecting additional information in a case-control substudy. Hitherto the only stratified sampling design for such studies has involved match...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.94102s847
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1104802
更新日期：2012-07-01 00:00:00
abstract：:Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.96104s2173
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:Population-based studies have estimated health risks of short-term exposure to fine particles using mass of PM(2.5) (particulate matter journal_title：Environmental health perspectives pub_type： 杂志文章 doi：10.1289/ehp.0800185 更新日期：2009-06-01 00:00:00
abstract：:We used an improved method for trapping carbon-centered radicals (.R) from the gas-phase to compare radical suites trapped from various tobacco smoke and model smoke systems. Using a nitroxide trap, 3-amino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (3AP), on solid support, we trapped radicals directly from the gas phase, ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.01109765
更新日期：2001-08-01 00:00:00
