Genetic and molecular ecotoxicology: a research framework.

abstract：:The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency spon...

journal_title：Environmental health perspectives

authors： Kavlock RJ,Daston GP,DeRosa C,Fenner-Crisp P,Gray LE,Kaattari S,Lucier G,Luster M,Mac MJ,Maczka C,Miller R,Moore J,Rolland R,Scott G,Sheehan DM,Sinks T,Tilson HA

更新日期：1996-08-01 00:00:00

abstract：:Recent studies show that young children can be exposed to pesticides during normal oral exploration of their environment and their level of dermal contact with floors and other surfaces. Children living in agricultural areas may be exposed to higher pesticide levels than other children because of pesticides tracked in...

journal_title：Environmental health perspectives

authors： Eskenazi B,Bradman A,Castorina R

更新日期：1999-06-01 00:00:00

abstract：:There has been increased concern over health effects related to potential exposure of building occupants to bioaerosols. We report the case of a worker with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. We performed environmental tests to evaluate...

journal_title：Environmental health perspectives

authors： Trout D,Bernstein J,Martinez K,Biagini R,Wallingford K

更新日期：2001-06-01 00:00:00

abstract：:Methylcobalamin (methyl-B12) has been implicated in the biomethylation of the heavy metals (mercury, tin, platinum, gold, and thallium) as well as the metalloids (arsenic, selenium, tellurium and sulfur). In addition, methylcobalamin has been shown to react with lead, but the lead-alkyl product is unstable in water. D...

journal_title：Environmental health perspectives

authors： Ridley WP,Dizikes L,Cheh A,Wood JM

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:During May-June 2010, a childhood lead poisoning outbreak related to gold ore processing was confirmed in two villages in Zamfara State, Nigeria. During June-September of that year, villages with suspected or confirmed childhood lead poisoning continued to be identified in Zamfara State. OBJECTIVES:We inves...

journal_title：Environmental health perspectives

authors： Lo YC,Dooyema CA,Neri A,Durant J,Jefferies T,Medina-Marino A,de Ravello L,Thoroughman D,Davis L,Dankoli RS,Samson MY,Ibrahim LM,Okechukwu O,Umar-Tsafe NT,Dama AH,Brown MJ

更新日期：2012-10-01 00:00:00

abstract：:Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors dur...

journal_title：Environmental health perspectives

authors： Carlsen E,Giwercman A,Keiding N,Skakkebaek NE

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our fi...

journal_title：Environmental health perspectives

authors： Rehfuess E,Mehta S,Prüss-Ustün A

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE:We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whal...

journal_title：Environmental health perspectives

authors： Choi AL,Weihe P,Budtz-Jørgensen E,Jørgensen PJ,Salonen JT,Tuomainen TP,Murata K,Nielsen HP,Petersen MS,Askham J,Grandjean P

更新日期：2009-03-01 00:00:00

abstract：:The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP ...

journal_title：Environmental health perspectives

authors： Tindall DJ,Tash JS,Means AR

更新日期：1981-04-01 00:00:00

abstract：:Previously, we showed that diesel exhaust particles (DEPs) suppressed pulmonary clearance of Listeria monocytogenes (Listeria) and inhibited the phagocytosis of alveolar macrophages and their response to Listeria in the secretion of interleukin (IL)-1 beta, tumor necrosis factor alpha, and IL-12. In this report we exa...

journal_title：Environmental health perspectives

authors： Yin XJ,Schafer R,Ma JY,Antonini JM,Roberts JR,Weissman DN,Siegel PD,Ma JK

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. METHODS:We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at ter...

journal_title：Environmental health perspectives

authors： Lederman SA,Jones RL,Caldwell KL,Rauh V,Sheets SE,Tang D,Viswanathan S,Becker M,Stein JL,Wang RY,Perera FP

更新日期：2008-08-01 00:00:00

abstract：:The potential impact of an agent altering male reproductive function is greater for humans than for animals. Consequently, it is essential that sensitive criteria be used to look for effects on a multiplicity of target sites when an agent is evaluated using an animal model. No animal model has reproductive characteris...

journal_title：Environmental health perspectives

authors： Amann RP

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...

journal_title：Environmental health perspectives

authors： Lee WJ,Alavanja MC,Hoppin JA,Rusiecki JA,Kamel F,Blair A,Sandler DP

更新日期：2007-04-01 00:00:00

abstract：:The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...

journal_title：Environmental health perspectives

authors： Bourbigot MM,Hascoet MC,Levi Y,Erb F,Pommery N

更新日期：1986-11-01 00:00:00

abstract：:The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied. Selenium was found to affect the distribution of ethylmercury...

journal_title：Environmental health perspectives

authors： Brzeźnicka EA,Chmielnicka J

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:Lead (Pb) exposure has been associated with a host of pathological conditions in humans. In rodents Pb exposure has been shown to alter the hypothalamic-pituitary-adrenal (HPA) axis function. OBJECTIVE:We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor adm...

journal_title：Environmental health perspectives

authors： Fortin MC,Cory-Slechta DA,Ohman-Strickland P,Nwankwo C,Yanger TS,Todd AC,Moynihan J,Walton J,Brooks A,Fiedler N

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern. OBJECTIVES:We investigated the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease. METHODS:In an open randomized crossover trial, 98 patien...

journal_title：Environmental health perspectives

authors： Langrish JP,Li X,Wang S,Lee MM,Barnes GD,Miller MR,Cassee FR,Boon NA,Donaldson K,Li J,Li L,Mills NL,Newby DE,Jiang L

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure. The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event i...

journal_title：Environmental health perspectives

authors： Folkmann JK,Risom L,Jacobsen NR,Wallin H,Loft S,Møller P

更新日期：2009-05-01 00:00:00

abstract：:Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period...

journal_title：Environmental health perspectives

authors： Durant JL,Chen J,Hemond HF,Thilly WG

更新日期：1995-09-01 00:00:00

abstract：:Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wis...

journal_title：Environmental health perspectives

authors： Poirier MC,True B,Laishes BA

更新日期：1983-03-01 00:00:00

abstract：:Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

journal_title：Environmental health perspectives

authors： Smuckler EA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Air pollution data in Bangkok, Thailand, indicate that levels of particulate matter with aerodynamic diameter < or = 10 microm (PM(10)) are significantly higher than in most cities in North America and Western Europe, where the health effects of PM(10) are well documented. However, the pollution mix, seasona...

journal_title：Environmental health perspectives

authors： Vichit-Vadakan N,Vajanapoom N,Ostro B

更新日期：2008-09-01 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...

journal_title：Environmental health perspectives

authors： Johnson MD,Housey GM,O'Brian CA,Kirschmeier PT,Weinstein IB

更新日期：1987-12-01 00:00:00

abstract：:Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to ben...

journal_title：Environmental health perspectives

authors： Wan J,Shi J,Hui L,Wu D,Jin X,Zhao N,Huang W,Xia Z,Hu G

更新日期：2002-12-01 00:00:00

abstract：:It has been previously established that lung cancer could be induced in rats by exposure to radon and radon daughters. Although the oat-cell carcinomas that are common in humans were not found in rats, other histological types of lung carcinomas, especially squamous cell carcinomas and primitive lung adenocarcinomas, ...

journal_title：Environmental health perspectives

authors： Monchaux G,Morlier JP,Morin M,Chameaud J,Lafuma J,Masse R

更新日期：1994-01-01 00:00:00

abstract：:Human biomonitoring investigations have provided data on a wide array of chemicals in blood and urine and in other tissues and fluids such as hair and human milk. These data have prompted questions such as a) What is the relationship between levels of environmental chemicals in humans and external exposures? b) What i...

journal_title：Environmental health perspectives

authors： Bates MN,Hamilton JW,LaKind JS,Langenberg P,O'Malley M,Snodgrass W

更新日期：2005-11-01 00:00:00

abstract：:In this article we report a simple and efficient method for detecting nonsteroidal estrogens in a biologic sample. This method uses polyclonal antibodies to estradiol (E2) to immunoprecipitate these major biologically active steroidal estrogens, leaving behind the nonsteroidal estrogens, which are then detected in a c...

journal_title：Environmental health perspectives

authors： Natarajan K,Overstreet JW,Rogers JM,Denison MS,Chen J,Lohstroh PN,McConnell DS,Lasley BL

更新日期：2002-08-01 00:00:00

abstract：:The mammalian respiratory tract is densely innervated by autonomic and sensory nerves around airways and blood vessels. Subsets of these nerves contain a number of putative neurotransmitter peptides, such as substance P and calcitonin gene-related peptide (CGRP) in sensory nerves and vasoactive intestinal polypeptide ...

journal_title：Environmental health perspectives

authors： Springall DR,Edginton JA,Price PN,Swanston DW,Noel C,Bloom SR,Polak JM

更新日期：1990-04-01 00:00:00

abstract：:Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

journal_title：Environmental health perspectives

authors： Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

更新日期：1999-05-01 00:00:00

abstract：:An increase in both the numbers and types of tumors found in finfish and shellfish has been noted in the past several decades. In many cases, while the increase in tumor incidence can be correlated with increases in aquatic toxicant levels, causality cannot be definitively proven. One recent epidemiologic investigatio...

journal_title：Environmental health perspectives

authors： Van Beneden RJ

更新日期：1994-12-01 00:00:00