Current view of epidemiologic study designs for occupational and environmental lung diseases.

abstract：:Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activiti...

journal_title：Environmental health perspectives

authors： Fujiki H,Suganuma M,Yoshizawa S,Nishiwaki S,Winyar B,Sugimura T

更新日期：1991-06-01 00:00:00

abstract：:Acute exposures to isobutane, propane, F-12, and F-11 in concentrations of 250, 500, or 1000 ppm for periods of 1 min to 8 hr did not produce any untoward physiological effects as determined by the methods employed which included serial EKG's and continuous monitoring of modified V5 by telemetry during exposure. Repet...

journal_title：Environmental health perspectives

authors： Stewart RD,Newton PE,Baretta ED,Herrmann AA,Forster HV,Soto RJ

更新日期：1978-10-01 00:00:00

abstract：:Risk assessment is a process often divided into the following steps: a) hazard identification, b) dose-response assessment, c) exposure assessment, and d) risk characterization. Regulatory toxicity studies usually are aimed at providing data for the first two steps. Human case reports, environmental research, and in v...

journal_title：Environmental health perspectives

authors： Harry GJ,Billingsley M,Bruinink A,Campbell IL,Classen W,Dorman DC,Galli C,Ray D,Smith RA,Tilson HA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Tremor is one of the most common neurological signs, yet its etiology is poorly understood. Case-control studies suggest an association between blood lead and essential tremor, and that this association is modified by polymorphisms in the δ-aminolevulinic acid dehydrogenase (ALAD) gene. OBJECTIVE:We aimed t...

journal_title：Environmental health perspectives

authors： Ji JS,Power MC,Sparrow D,Spiro A 3rd,Hu H,Louis ED,Weisskopf MG

更新日期：2015-05-01 00:00:00

abstract：:Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...

journal_title：Environmental health perspectives

authors： Schreinemachers DM,Creason JP,Garry VF

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Pterygium is a fibrovascular growth of the bulbar conjunctiva and underlying subconjunctival tissue that may cause blindness. The mechanism of pterygium formation is not yet fully understood, but pterygium has some tumorlike features. OBJECTIVES:The objective of this study was to evaluate the association be...

journal_title：Environmental health perspectives

authors： Lin W,Wang SL,Wu HJ,Chang KH,Yeh P,Chen CJ,Guo HR

更新日期：2008-07-01 00:00:00

abstract：:In this study we examined the impact of weather variability and tides on the transmission of Barmah Forest virus (BFV) disease and developed a weather-based forecasting model for BFV disease in the Gladstone region, Australia. We used seasonal autoregressive integrated moving-average (SARIMA) models to determine the c...

journal_title：Environmental health perspectives

authors： Naish S,Hu W,Nicholls N,Mackenzie JS,McMichael AJ,Dale P,Tong S

更新日期：2006-05-01 00:00:00

abstract：:Inhaled asbestos fibers may contribute to three-fourths of malignant mesotheliomas diagnosed in men and almost 40% of cases diagnosed in women. Bans on the manufacture and sale of amphibole asbestos fibers are expected to reduce the incidence of mesothelioma, but the long latency period from initial exposure to clinic...

journal_title：Environmental health perspectives

authors： Tse LA,Yu IT,Goggins W,Clements M,Wang XR,Au JS,Yu KS

更新日期：2010-03-01 00:00:00

abstract：:Children and their parents in residences are often protected by insecticides from nuisance and disease-bearing mosquitoes. The annual worldwide consumption of the four major types of residential insecticide products--aerosols, mosquito coils, liquid vaporizers, and vaporizing mats--is in the billions of units. Mosquit...

journal_title：Environmental health perspectives

authors： Krieger RI,Dinoff TM,Zhang X

更新日期：2003-09-01 00:00:00

abstract：:Pesticides used in agriculture may cause adverse health effects among the population living near agricultural areas. However, identifying the populations most likely to be exposed is difficult. We conducted a feasibility study to determine whether satellite imagery could be used to reconstruct historical crop patterns...

journal_title：Environmental health perspectives

authors： Ward MH,Nuckols JR,Weigel SJ,Maxwell SK,Cantor KP,Miller RS

更新日期：2000-01-01 00:00:00

abstract：:The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...

journal_title：Environmental health perspectives

authors： Rosenkranz HS

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Recent policies attempting to reduce adverse effects of methylmercury exposure from fish consumption in the United States have targeted reductions in anthropogenic emissions from U.S. sources. OBJECTIVES:To analyze the prospects for future North American and international emissions controls, we assessed the...

journal_title：Environmental health perspectives

authors： Selin NE,Sunderland EM,Knightes CD,Mason RP

更新日期：2010-01-01 00:00:00

abstract：:Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

journal_title：Environmental health perspectives

authors： Smuckler EA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized. OBJECTIVES:In this study we evaluated the relationship between toxicants...

journal_title：Environmental health perspectives

authors： Schell LM,Gallo MV,Deane GD,Nelder KR,DeCaprio AP,Jacobs A,Akwesasne Task Force on the Environment.

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. OBJECTIVE:We investigated the relationship between phthalate exposure and preterm birth. METHODS:Within a large Mexic...

journal_title：Environmental health perspectives

authors： Meeker JD,Hu H,Cantonwine DE,Lamadrid-Figueroa H,Calafat AM,Ettinger AS,Hernandez-Avila M,Loch-Caruso R,Téllez-Rojo MM

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Green spaces have been associated with both health benefits and risks in children; however, available evidence simultaneously investigating these conflicting influences, especially in association with different types of greenness, is scarce. OBJECTIVES:We aimed to simultaneously evaluate health benefits and...

journal_title：Environmental health perspectives

authors： Dadvand P,Villanueva CM,Font-Ribera L,Martinez D,Basagaña X,Belmonte J,Vrijheid M,Gražulevičienė R,Kogevinas M,Nieuwenhuijsen MJ

更新日期：2014-12-01 00:00:00

abstract：:We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive...

journal_title：Environmental health perspectives

authors： Arcaro KF,Vakharia DD,Yang Y,Gierthy JF

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Previous studies indicate that the design of streets and sidewalks can influence physical activity among residents. Park features also influence park use and park-based physical activity. Although individuals can walk on streets and sidewalks, walking loops in parks offer a setting to walk in nature and to a...

journal_title：Environmental health perspectives

authors： Cohen DA,Han B,Evenson KR,Nagel C,McKenzie TL,Marsh T,Williamson S,Harnik P

更新日期：2017-02-01 00:00:00

abstract：:The marriage of toxicology and genomics has created not only opportunities but also novel informatics challenges. As with the larger field of gene expression analysis, toxicogenomics faces the problems of probe annotation and data comparison across different array platforms. Toxicogenomics studies are generally built ...

journal_title：Environmental health perspectives

authors： Mattes WB,Pettit SD,Sansone SA,Bushel PR,Waters MD

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies of postnatal PCB exposure and behavior have not reported consistent evidence of adverse associations, possibly because of challenges in exposure estimation. We previously developed a pharmacokinetic model to improve estimation of children's PCB exposure. OBJECTIVES:We aimed to assess w...

journal_title：Environmental health perspectives

authors： Verner MA,Hart JE,Sagiv SK,Bellinger DC,Altshul LM,Korrick SA

更新日期：2015-09-01 00:00:00

abstract：:Interleukin-3 (IL-3) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) are responsible for maintaining survival and stimulating growth of early dormant hematopoietic progenitor cells (HPC). These cytokines exhibit extensive overlap, with GM-CSF supporting growth and differentiation of myeloid HPC. A charac...

journal_title：Environmental health perspectives

authors： Irons RD,Stillman WS

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation. OBJECTIVES AND METHODS:We studied the disappearance of NPs from the epithelium by sequential lung retention and clearance and bronchoalveolar lavage (...

journal_title：Environmental health perspectives

authors： Semmler-Behnke M,Takenaka S,Fertsch S,Wenk A,Seitz J,Mayer P,Oberdörster G,Kreyling WG

更新日期：2007-05-01 00:00:00

abstract：:Animal studies and small studies in humans have shown that uranium is nephrotoxic. However, more information about its renal effects in humans following chronic exposure through drinking water is required. We measured uranium concentrations in drinking water and urine in 325 persons who had used drilled wells for drin...

journal_title：Environmental health perspectives

authors： Kurttio P,Auvinen A,Salonen L,Saha H,Pekkanen J,Mäkeläinen I,Väisänen SB,Penttilä IM,Komulainen H

更新日期：2002-04-01 00:00:00

abstract：:Chronic exposure of rodents to high dose levels of drugs, food additives and environmental chemicals frequently results in liver enlargement. Several of these compounds have been found to enhance the incidence of liver tumors in animals briefly exposed previously to hepatocarcinogens. Accordingly, it has been advanced...

journal_title：Environmental health perspectives

authors： Kunz HW,Tennekes HA,Port RE,Schwartz M,Lorke D,Schaude G

更新日期：1983-04-01 00:00:00

abstract：:The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, i...

journal_title：Environmental health perspectives

authors： Seed JL

更新日期：1982-11-01 00:00:00

abstract：:In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six ...

journal_title：Environmental health perspectives

authors： Vine MF,Stein L,Weigle K,Schroeder J,Degnan D,Tse CK,Hanchette C,Backer L

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Phthalates, known endocrine disruptors, may play a role in breast carcinogenesis. Few studies have examined phthalates in relation to breast cancer (BC), and, to our knowledge, none have considered survival following BC. OBJECTIVES:We examined 11 urinary phthalate metabolites, individually and as molar sum ...

journal_title：Environmental health perspectives

authors： Parada H Jr,Gammon MD,Chen J,Calafat AM,Neugut AI,Santella RM,Wolff MS,Teitelbaum SL

更新日期：2018-04-26 00:00:00

abstract：:Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitroge...

journal_title：Environmental health perspectives

authors： Last JA

更新日期：1989-02-01 00:00:00

abstract：:Background: Drinking water from natural sources in coastal Bangladesh has become contaminated by varying degrees of salinity due to saltwater intrusion from rising sea levels, cyclone and storm surges and upstream withdrawal of freshwater. Objective: Our objective was to estimate salt intake from drinking water source...

journal_title：Environmental health perspectives

authors： Khan AE,Ireson A,Kovats S,Mojumder SK,Khusru A,Rahman A,Vineis P

更新日期：2011-04-12 00:00:00

abstract：:Phthalates are a group of multifunctional chemicals used in consumer and personal care products, plastics, and medical devices. Laboratory studies show that some phthalates are reproductive and developmental toxicants. Recently, human studies have shown measurable levels of several phthalates in most of the U.S. gener...

journal_title：Environmental health perspectives

authors： Hauser R,Duty S,Godfrey-Bailey L,Calafat AM

更新日期：2004-05-01 00:00:00