Abstract:
:In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six locations in Aberdeen, North Carolina, is associated with higher plasma organochlorine levels, immune suppression, or DNA damage. Each of 302 residents of Aberdeen and neighboring communities provided a blood specimen, underwent a skin test, and answered a questionnaire. Blood specimens were analyzed for organochlorine pesticides, immune markers, and micronuclei. Of 20 organochlorines tested, only DDE was detected in the blood of participants (except for one individual). Age-adjusted mean plasma DDE levels were 4.05 ppb for Aberdeen residents and 2.95 ppb (p = 0.01) for residents of neighboring communities. Residents of 40-59 years of age who lived within a mile of any site, but particularly the Farm Chemicals site, had higher plasma DDE levels than residents who lived farther away. Residents who lived near the Farm Chemicals site before versus after 1985 also had higher plasma DDE levels. Overall, there were few differences in immune markers between residents of Aberdeen and the neighboring communities. However, residents who lived closer to the dump sites had statistically significantly lower mitogen-induced lymphoproliferative activity than residents who lived farther away (p < 0.05). Residential location was not consistently associated with frequency of micronuclei or skin test responses. Although some statistically significant differences in immune markers were noted in association with residential location, the magnitude of effects are of uncertain clinical importance.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Vine MF,Stein L,Weigle K,Schroeder J,Degnan D,Tse CK,Hanchette C,Backer Ldoi
10.1289/ehp.001081113subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1113-24issue
12eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
108pub_type
杂志文章abstract::It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic varia...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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更新日期:1998-06-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:2008-04-01 00:00:00
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更新日期:2008-08-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-11 00:00:00