Abstract:
:It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic variations in sperm counts within countries or regions, and analyses of North American data show that sperm counts have not decreased over the last 60 years. Analyses of records for hypospadias and cryptorchidism also show demographic differences in these disorders before 1985; however, since 1985 rates of hypospadias have not changed and cryptorchidism has actually declined. Temporal changes in sex ratios and fertility are minimal, whereas testicular cancer is increasing in most countries; however, in Scandinavia, the difference between high (Denmark) and low (Finland) incidence areas are not well understood and are unlikely to be correlated with differences in exposure to synthetic industrial chemicals. Results from studies on organochlorine contaminants (DDE/PCB) show that levels were not significantly different in breast cancer patients versus controls. Thus, many of the male and female reproductive tract problems linked to the endocrine-disruptor hypothesis have not increased and are not correlated with synthetic industrial contaminants. This does not exclude an endocrine-etiology for some adverse environmental effects or human problems associated with high exposures to some chemicals.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Safe SHdoi
10.1289/ehp.00108487subject
Has Abstractpub_date
2000-06-01 00:00:00pages
487-93issue
6eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
108pub_type
杂志文章,评审abstract::Minority populations face a wide variety of economic, institutional, and cultural barriers to health care. These barriers and low levels of education and income pose significant challenges for health professionals in developing cancer research and prevention-control strategies. It is suggested that specific segments o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s8287
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8870
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Studies estimating health effects of long-term air pollution exposure often use a two-stage approach: building exposure models to assign individual-level exposures, which are then used in regression analyses. This requires accurate exposure modeling and careful treatment of exposure measurement error. OBJEC...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206010
更新日期:2013-09-01 00:00:00
abstract::With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7467
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The upward trend in industrial nations in the incidence of male genitourinary (GU) conditions may be attributed to increased exposure to endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected endocrine disruptor. OBJECTIVE:We investigated the relationship be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800058
更新日期:2009-07-01 00:00:00
abstract::The toxicity of cadmium is determined by chelation reactions: in vivo, Cd2+ exists exclusively in coordination complexes with biological ligands, or with administered chelating agents. The Cd2+ ion has some soft character, but it is not a typical soft ion. It has a high degree of polarizability, and its complexes with...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8454249
更新日期:1984-03-01 00:00:00
abstract::Diffuse pulmonary fibrosis is associated with bleomycin administration to humans. The sequential reactions of lung cells to this drug have now been investigated in mice following injection of 20 mg/kg bleomycin twice per week for 4 to 8 weeks. Cytoplasmic and subendothelial edema was first observed in large vessels an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7616119
更新日期:1976-08-01 00:00:00
abstract::High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA) ] with no known historical cadmium contamination, we investiga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8763
更新日期:2006-06-01 00:00:00
abstract::A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106701
更新日期:1998-04-01 00:00:00
abstract::In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of pediatric disease in American children. We examined four categories of illness: lead poisoning, asthma, cancer, and neurobehavioral disorders. To estimate the proportion of each attrib...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110721
更新日期:2002-07-01 00:00:00
abstract::Dysmenorrhea is a common gynecologic disorder in women of reproductive age. Previous studies have found an association between current cigarette smoking and prevalence of dysmenorrhea. This study investigated the association between exposure to environmental tobacco smoke (ETS) and the occurrence of dysmenorrhea among...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081019
更新日期:2000-11-01 00:00:00
abstract::Free-radical metabolites can be generated metabolically by a one-electron reductase-catalyzed reaction or a "peroxidase" catalyzed oxidation or by photoactivation of a wide variety of aromatic xenobiotics. Radicals may also be generated during lipid peroxidation. Some radicals can react with DNA or bind covalently or ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8564219
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Aberrant histone acetylation has been observed in carcinogenesis and cellular transformation associated with arsenic exposure; however, the molecular mechanisms and cellular outcomes of such changes are poorly understood. OBJECTIVE:We investigated the impact of tolerated and toxic arsenic trioxide (As2O3) e...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408302
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:We previously demonstrated that among 54 infants in neonatal intensive care units, exposure to polyvinyl chloride plastic medical devices containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) is associated with urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP) , a DEHP metabolite. In this f...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8926
更新日期:2006-09-01 00:00:00
abstract::Recent increases have been reported in industrial countries for several sites of cancer. The causes of these increases remain unknown. Efforts should proceed to identify those occupational groups with increases in the same sites, as these may indicate relevant exposures. Two analyses were undertaken: trends in cancer ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析
doi:10.1289/ehp.9310039
更新日期:1993-04-01 00:00:00
abstract::The pneumoconioses are associated with chronic inflammatory processes during which increased amounts of reactive oxygen species are formed in the lower respiratory tract. To characterize the effect(s) of these processes on the defense system against free radicals, we studied 91 individuals with long-term occupational ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9084165
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10108
更新日期:2007-11-01 00:00:00
abstract::Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.111-1241504
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies--and fewer epidemiologic investigations--have examined the potential effects of prenatal exposure. OBJECTIVES:We assessed the association between adverse birth outcomes and urinary biomarkers of prenatal atr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002775
更新日期:2011-07-01 00:00:00
abstract::This study investigated the association between biomarkers of fetal exposure to cigarette smoke at the end of pregnancy, cotinine in cord serum and in maternal and newborn urine samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 4...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081079
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Although many studies have examined the effects of air pollution on mortality, data limitations have resulted in fewer studies of both particulate matter with an aerodynamic diameter of
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800108
更新日期:2009-06-01 00:00:00
abstract::Health is defined as homeostasis of the cellular ecology, and a state where there has not been an inordinate loss, reversible or irreversible, of the structural and/or functional reserves of the body. An adverse health effect is defined as the causation, promotion, facilitation and/or exacerbation of a structural and/...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352177
更新日期:1983-10-01 00:00:00
abstract::Building-related illness ranges from mild rhinitis to potentially life-threatening hypersensitivity pneumonitis and legionellosis. Sick-building syndrome, consisting of headache, mucous membrane irritation, and fatigue, may be present in 30% of all office workers. Hypersensitivity pneumonitis, asthma, and legionellosi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.919567
更新日期:1991-11-01 00:00:00
abstract::The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350371
更新日期:1983-04-01 00:00:00
abstract::According to current data, the capacity to cause nonprogrammed or unscheduled cell proliferation in target tissues, a common characteristic of chemical carcinogens, may play a more important role in the development of tumors than does genotoxicity. This paper provides strong support for the validity of this conclusion...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9610440
更新日期:1996-01-01 00:00:00
abstract::Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.106-1533118
更新日期:1998-07-01 00:00:00
abstract:INTRODUCTION:Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children. DESIGN:Within a prospective birth cohort, we perfo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8741
更新日期:2006-07-01 00:00:00
abstract::The problem of byssinosis has plagued cotton textile mills for hundreds of years, and it is still a problem today. With the regulations on airborne raw cotton dust set by OSHA and the ACGIH, research regarding the measurement of cotton dust in lint fiber is a necessity. A procedure known as the mass concentration part...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8666167
更新日期:1986-04-01 00:00:00
abstract::To study the effect of processing on polybrominated biphenyl (PBB) levels, milk from four dairy herds containing less than 0.3 ppm (fat basis) of physiologically incorporated PBBs was presented individually into cream, skim milk, butter, and stirred curd cheese. Pasteurized and freeze-dried whole milk, skim milk, and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782337
更新日期:1978-04-01 00:00:00
abstract::The dose-response relationship of the benzene covalent interaction with biological macromolecules from rat organs was studied. The administered dose range was 3.6 x 10(7) starting from the highest dosage employed, 486 mg/kg, which is oncogenic for rodents, and included low and very low dosages. The present study was i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8982259
更新日期:1989-07-01 00:00:00