Abstract：
BACKGROUND:Mercury is a pervasive environmental pollutant whose toxic effects have not been studied in sea turtles in spite of their threatened status and evidence of immunosuppression in diseased populations. OBJECTIVES:In the present study we investigate mercury toxicity in loggerhead sea turtles (Caretta caretta) by examining trends between blood mercury concentrations and various health parameters. METHODS:Blood was collected from free-ranging turtles, and correlations between blood mercury concentrations and plasma chemistries, complete blood counts, lysozyme, and lymphocyte proliferation were examined. Lymphocytes were also harvested from free-ranging turtles and exposed in vitro to methylmercury to assess proliferative responses. RESULTS:Blood mercury concentrations were positively correlated with hematocrit and creatine phosphokinase activity, and negatively correlated with lymphocyte cell counts and aspartate amino-transferase. Ex vivo negative correlations between blood mercury concentrations and B-cell proliferation were observed in 2001 and 2003 under optimal assay conditions. In vitro exposure of peripheral blood leukocytes to methylmercury resulted in suppression of proliferative responses for B cells (0.1 microg/g and 0.35 microg/g) and T cells (0.7 microg/g). CONCLUSIONS:The positive correlation between blood mercury concentration and hematocrit reflects the higher affinity of mercury species for erythrocytes than plasma, and demonstrates the importance of measuring hematocrit when analyzing whole blood for mercury. In vitro immunosuppression occurred at methylmercury concentrations that correspond to approximately 5% of the individuals captured in the wild. This observation and the negative correlation found ex vivo between mercury and lymphocyte numbers and mercury and B-cell proliferative responses suggests that subtle negative impacts of mercury on sea turtle immune function are possible at concentrations observed in the wild.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Day RD,Segars AL,Arendt MD,Lee AM,Peden-Adams MMdoi
10.1289/ehp.9918subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1421-8issue
10eissn
0091-6765issn
1552-9924journal_volume
115pub_type
杂志文章abstract：:Human health and aquatic animal health are organically related at three distinct interfaces. Aquatic animals serve as important contributors to the nutritional protein, lipid, and vitamin requirements of humans; as carriers and transmitters of many infectious and parasitic diseases to which humans are susceptible; and...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.9086245
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8870
更新日期：2007-02-01 00:00:00
abstract：:The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...
journal_title：Environmental health perspectives
pub_type： 历史文章,杂志文章
doi：10.1289/ehp.7544
更新日期：2005-05-01 00:00:00
abstract：:Inorganic particulate matter in foods and drugs is discussed from the standpoint of determination by optical microscopy, source, and regulatory significance. Some particulate matter may be generated as extraneous material and traced to specific operational practices during processing and production with excessive leve...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.749183
更新日期：1974-12-01 00:00:00
abstract：BACKGROUND:Environmental air pollutants are inhaled as complex mixtures, but the long dominant focus of monitoring and research on individual pollutants has provided modest insight into pollutant interactions that may be important to health. Trends toward managing multiple pollutants to maximize aggregate health gains ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.11654
更新日期：2009-01-01 00:00:00
abstract：:Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.99107s5743
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9961
更新日期：2007-09-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.9195157
更新日期：1991-11-01 00:00:00
abstract：:A brief overview is given of the sources, characteristics, and toxic constituents of municipal solid wastes. Several methods are presented for handling, treating, and disposal of solid wastes. Monitoring the landfill site is necessary; there has been a trend to recognize that municipal solid wastes may be hazardous an...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7827239
更新日期：1978-12-01 00:00:00
abstract：:The nasal cavity is susceptible to chemically induced injury as a result of exposure to inhaled irritants. Some responses of the nasal mucosa to inhaled toxicants are species specific. These species-related differences in response may be due to variations in structural, physiologic, and biochemical factors, such as gr...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.85-1568334
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Lead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors. OBJECTIVES:We examine...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1306931
更新日期：2014-10-01 00:00:00
abstract：:The significance of the environment for health is increasingly being recognized. There is a need for systematic approaches to assessment of environmental factors most relevant to health, health outcomes most influenced by the environment, and the relationships between them, as well as for approaches to representing th...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8321
更新日期：2006-03-01 00:00:00
abstract：:Recent data from deep uranium mines in Czechoslovakia indicated that mines are exposed to other mutagenic factors in addition to radon daughter products. Mycotoxins were identified as a possible source of mutagens in these mines. Mycotoxins were examined in 38 samples from mines and in throat swabs taken from 116 mine...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.101-1521117
更新日期：1993-10-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8221
更新日期：2006-02-01 00:00:00
abstract：:To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8982189
更新日期：1989-07-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8926
更新日期：2006-09-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.761457
更新日期：1976-04-01 00:00:00
abstract：BACKGROUND:The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied. OBJECTIVES:We investigated the prevalence, risk factors, and dri...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP5251
更新日期：2019-10-01 00:00:00
abstract：:Although para-nonylphenol (NP) is known as an endocrine disruptor, the immunologic effect of NP has been poorly analyzed. We found that NP from 5 to 50 microM caused a dose-dependent stimulatory effect on the generation of reactive oxygen species (ROS) in human blood neutrophils, which was measured by using a chemilum...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6584
更新日期：2004-04-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.5702
更新日期：2003-02-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.93101s663
更新日期：1993-12-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0900907
更新日期：2010-01-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP1937
更新日期：2017-10-16 00:00:00
abstract：:The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.81385
更新日期：1981-04-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP6652
更新日期：2020-11-01 00:00:00
abstract：:Exposure of the scallop Placopecten magellanicus to 20 ppb Cd2+ in seawater for 7 weeks results in a 7-fold increase in the kidney cytosol content of Cd and 5-fold increase in Zn. Sephadex G-75 column chromatography of the kidney cytosol showed that most of the Cd and Zn were bound to a protein complex with an estimat...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8665199
更新日期：1986-03-01 00:00:00
abstract：:The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application of the techniques for external measurements of exposure, microenvironmental and personal monitors, are placed in th...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.95103s335
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP396
更新日期：2017-04-01 00:00:00
abstract：:In this article we report a simple and efficient method for detecting nonsteroidal estrogens in a biologic sample. This method uses polyclonal antibodies to estradiol (E2) to immunoprecipitate these major biologically active steroidal estrogens, leaving behind the nonsteroidal estrogens, which are then detected in a c...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.02110791
更新日期：2002-08-01 00:00:00
abstract：:The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to interindividual variations in As metabolism that affect retention and distribution of toxic metabolites. To elucidate the role of genetic factors in As metabolism, we studied how polymorphisms in six genes affected the ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9734
更新日期：2007-04-01 00:00:00
