Abstract:
:Food allergy affects between 5% and 7.5% of children and between 1% and 2% of adults. The greater prevalence of food allergy in children reflects both the increased predisposition of children to develop food allergies and the development of immunologic tolerance to certain foods over time. Immunoglobulin (Ig) E-mediated food allergies can be classified as those that persist indefinitely and those that are predominantly transient. Although there is overlap between the two groups, certain foods are more likely than others to be tolerated in late childhood and adulthood. The diagnosis of food allergy rests with the detection of food-specific IgE in the context of a convincing history of type I hypersensitivity-mediated symptoms after ingestion of the suspected food or by eliciting IgE-mediated symptoms after controlled administration of the suspected food. Presently, the only available treatment of food allergies is dietary vigilance and administration of self-injectable epinephrine.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Kagan RSdoi
10.1289/ehp.5702subject
Has Abstractpub_date
2003-02-01 00:00:00pages
223-5issue
2eissn
0091-6765issn
1552-9924journal_volume
111pub_type
杂志文章,评审abstract::Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various compounds can be classi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/txg.7036
更新日期:2004-08-01 00:00:00
abstract::Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known. We studied their effects on two main targets, the renal and dopaminergic systems, in > 800 children during a cross-sectional European survey. Control and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8202
更新日期:2006-04-01 00:00:00
abstract::Isolated rat and human hepatocytes in primary culture were shown to metabolize AAF to reactive intermediates which damaged hepatocyte DNA. A significant increase in unscheduled DNA synthesis was detectable by autoradiography in rat and human hepatocytes exposed to concentrations of AAF as low as 1 microM. When rat hep...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8349165
更新日期:1983-03-01 00:00:00
abstract::A wide range of fiber types was tested in two in vitro assays: toxicity to A549 epithelial cells, as detachment from substrate, and the production of the proinflammatory cytokine tumor necrosis factor (TNF) by rat alveolar macrophages. Three of the fibers were also studied in vivo, using short-term inhalation followed...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s51235
更新日期:1997-09-01 00:00:00
abstract::Pollen of Impatiens sultanii Hook F. germinates and forms tubes rapidly at 25 degrees C in a simple medium containing 111.0 ppm CaCl2, 13.6 ppm KH2PO4, and 1000 ppm boric acid. Calcium, potassium, and boron are essential for germination and tube growth, but sucrose is not required. Pollen tubes grow with equal rapidit...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.813795
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results. OBJECTIVE:We sought ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,随机对照试验
doi:10.1289/EHP1612
更新日期:2017-10-02 00:00:00
abstract::The Clean Air Act requires that sensitive subgroups of exposed populations be protected from adverse health effects of air pollution exposure. Hence, data suggesting the existence of sensitive subgroups can have an important impact on regulatory decisions. Some investigators have interpreted differences among individu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.90-1519500
更新日期:1991-01-01 00:00:00
abstract::To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102298
更新日期:1994-03-01 00:00:00
abstract::A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108595
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. OBJECTIVE:We studied prenatal lead exposure's impact on neurodevelopment using repeated measures of fetal dose as...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9067
更新日期:2006-11-01 00:00:00
abstract::A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108s2307
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Environmental air pollutants are inhaled as complex mixtures, but the long dominant focus of monitoring and research on individual pollutants has provided modest insight into pollutant interactions that may be important to health. Trends toward managing multiple pollutants to maximize aggregate health gains ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.11654
更新日期:2009-01-01 00:00:00
abstract::Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors dur...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s7137
更新日期:1995-10-01 00:00:00
abstract::In this article we summarize the results of a series of studies that measured the relative bioavailability (RBA) of lead in a variety of soil and soil-like test materials. Reference material (Pb acetate) or Pb-contaminated soils were administered orally to juvenile swine twice a day for 15 days. Blood samples were col...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8852
更新日期:2006-08-01 00:00:00
abstract::Toxicity testing in AS52 cells (24-hr exposures) gave LC50 values of 2 to 130 micrograms Ni/ml for particulate nickel compounds and 45 to 60 micrograms Ni/ml for water-soluble salts (NiCl2, NiSO4, Ni(CH3COO)2). The Ni(OH)2, NiCO3, and sulfides (Ni3S2, Ni7S6, "amorphous NiS") exhibited similar toxicities (LC50's of 2 t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s369
更新日期:1994-09-01 00:00:00
abstract::The consideration of ethical issues relating to pediatric environmental health is a recent phenomenon. Discussions of biomedical ethics, research on children, and environmental health research have a longer history. In the late 1990s, researchers at the Kennedy Krieger Institute in Baltimore, Maryland, undertook a stu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9000
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health, but current regulations may not be protective of sensitive populations. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits in rodent and primate models; however, the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6652
更新日期:2020-11-01 00:00:00
abstract::We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s41041
更新日期:1998-08-01 00:00:00
abstract::Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wis...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.834993
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Endocrine-disrupting chemicals have been shown to have broad effects on development, but their mutagenic actions that can lead to cancer have been less clearly demonstrated. Physiological levels of estrogen have been shown to stimulate DNA damage in breast epithelial cells through mechanisms mediated by estr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5221
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in laboratory animals. However, the association between PAHs and breast cancer in women is unclear. Vehicular traffic is a major ambient source of PAH exposure. OBJEC...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307736
更新日期:2016-01-01 00:00:00
abstract::The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...
journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.7544
更新日期:2005-05-01 00:00:00
abstract::Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and lymphoproliferative malignancies and related disorders (HLD). In a follow-up study of 74,828 benzene-exposed workers and a...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.961041353
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Exposure to inorganic arsenic is associated with numerous adverse health outcomes, with susceptibility differing by sex. Although evidence from in vitro studies suggests that arsenic alters post-translational histone modifications (PTHMs), evidence in humans is limited. OBJECTIVES:The objectives were to det...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1510412
更新日期:2016-08-01 00:00:00
abstract::This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/1. in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7928261
更新日期:1979-02-01 00:00:00
abstract::The N-oxidation of carcinogenic arylamines to form N-hydroxy arylamines has long been regarded as a necessary metabolic step for conversion to proximate carcinogenic derivatives. In contrast, arylamine ring-oxidation has been generally considered to be an important detoxification mechanism. Both enzymatic reactions ar...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9087233
更新日期:1990-07-01 00:00:00
abstract::Sulfur trioxide in the exhaust gas of an internal combustion engine is removed and concentrated by absorption in a solution of 80% isopropyl alcohol, which quantitatively absorbs it and inhibits the oxidation of any sulfur dioxide which may be absorbed. The absorbed sulfur trioxide (sulfuric acid) is determined by an ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7510117
更新日期:1975-04-01 00:00:00
abstract::Prostaglandin-H synthase is unique among enzymes of the plant and animal kingdom in its ability to biosynthesize and metabolize hydroperoxides. Its cyclooxygenase activity oxygenates polyunsaturated fatty acids to hydroperoxy endoperoxides, and its peroxidase activity reduces the hydroperoxy group to hydroxy groups. H...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.90885
更新日期:1990-08-01 00:00:00
abstract::The natural occurrence of palladium (Pd) is rare. It is obtained as a by-product during the extraction of platinum and, until the present time, its uses were small in number--principally in the manufacture of jewelry, dental alloys, chemical catalysts, and electrical contacts. Interest in Pd toxicology has been limite...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.751241
更新日期:1975-12-01 00:00:00
abstract::Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.898181
更新日期:1989-05-01 00:00:00