Abstract:
BACKGROUND:Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. OBJECTIVE:We investigated the relationship between phthalate exposure and preterm birth. METHODS:Within a large Mexican birth cohort study, we compared third-trimester urinary phthalate metabolite concentrations in 30 women who delivered preterm (< 37 weeks of gestation) with those of 30 controls (> or = 37 weeks of gestation). RESULTS:Concentrations of most of the metabolites were similar to those reported among U.S. females, although in the present study mono-n-butyl phthalate (MBP) concentrations were higher and monobenzyl phthalate (MBzP) concentrations lower. In a crude comparison before correcting for urinary dilution, geometric mean urinary concentrations were higher for the phthalate metabolites MBP, MBzP, mono(3-carboxylpropyl) phthalate, and four metabolites of di(2-ethyl-hexyl) phthalate among women who subsequently delivered preterm. These differences remained, but were somewhat lessened, after correction by specific gravity or creatinine. In multivariate logistic regression analysis adjusted for potential confounders, elevated odds of having phthalate metabolite concentrations above the median level were found. CONCLUSIONS:We found that phthalate exposure is prevalent among this group of pregnant women in Mexico and that some phthalates may be associated with preterm birth.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Meeker JD,Hu H,Cantonwine DE,Lamadrid-Figueroa H,Calafat AM,Ettinger AS,Hernandez-Avila M,Loch-Caruso R,Téllez-Rojo MMdoi
10.1289/ehp.0800522subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1587-92issue
10eissn
0091-6765issn
1552-9924journal_volume
117pub_type
杂志文章abstract::The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8980199
更新日期:1989-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866861
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journal_title:Environmental health perspectives
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更新日期:2015-05-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.8041
更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-06-01 00:00:00
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8774229
更新日期:1987-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352177
更新日期:1983-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1985-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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更新日期:2016-06-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.761855
更新日期:1976-12-01 00:00:00
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更新日期:2005-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00