Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada.

Abstract:

:The association between ambient air pollution and adverse health effects, such as emergency room visits, hospitalizations, and mortality from respiratory and cardiovascular diseases, has been studied extensively in many countries, including Canada. Recently, studies conducted in China, the Czech Republic, and the United States have related ambient air pollution to adverse pregnancy outcomes. In this study, we examined association between preterm birth, low birth weight, and intrauterine growth retardation (IUGR) among singleton live births and ambient concentrations of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone in Vancouver, Canada, for 1985-1998. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for such effects. Low birth weight was associated with exposure to SO2 during the first month of pregnancy (OR = 1.11, 95% CI, 1.01-1.22, for a 5.0 ppb increase). Preterm birth was associated with exposure to SO2 (OR = 1.09, 95% CI, 1.01-1.19, for a 5.0 ppb increase) and to CO (OR = 1.08, 95% CI, 1.01-1.15, for a 1.0 ppm increase) during the last month of pregnancy. IUGR was associated with exposure to SO2 (OR = 1.07, 95% CI, 1.01-1.13, for a 5.0 ppb increase), to NO2 (OR = 1.05, 95% CI, 1.01-1.10, for a 10.0 ppb increase), and to CO (OR = 1.06, 95% CI, 1.01-1.10, for a 1.0 ppm increase) during the first month of pregnancy. In conclusion, relatively low concentrations of gaseous air pollutants are associated with adverse effects on birth outcomes in populations experiencing diverse air pollution profiles.

authors

Liu S,Krewski D,Shi Y,Chen Y,Burnett RT

doi

10.1289/ehp.6251

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1773-8

issue

14

eissn

0091-6765

issn

1552-9924

journal_volume

111

pub_type

杂志文章
  • Role of alveolar macrophages in precipitation of mineral elements inhaled as soluble aerosols.

    abstract::The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lys...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9297145

    authors: Galle P,Berry JP,Galle C

    更新日期:1992-07-01 00:00:00

  • Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakstan: high levels of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in agricultural villages of southern Kazakstan.

    abstract::To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in breast milk samples collected in 1994 according to the World Health Organization protocol from 92 donors...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.98106797

    authors: Hooper K,Petreas MX,Chuvakova T,Kazbekova G,Druz N,Seminova G,Sharmanov T,Hayward D,She J,Visita P,Winkler J,McKinney M,Wade TJ,Grassman J,Stephens RD

    更新日期:1998-12-01 00:00:00

  • In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment.

    abstract:BACKGROUND:Millions of people worldwide consume arsenic-contaminated rice; however, little is known about the uptake and bioavailability of arsenic species after arsenic-contaminated rice ingestion. OBJECTIVES:In this study, we assessed arsenic speciation in greenhouse-grown and supermarket-bought rice, and determined...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9322

    authors: Juhasz AL,Smith E,Weber J,Rees M,Rofe A,Kuchel T,Sansom L,Naidu R

    更新日期:2006-12-01 00:00:00

  • The U.S. EPA Conference on Preventable Causes of Cancer in Children: a research agenda.

    abstract::On 15-16 September 1997, the U.S. Environmental Protection Agency sponsored the Conference on Preventable Causes of Cancer in Children. The conference was convened to examine rising trends in reported incidence of childhood cancer and the association of these trends with environmental exposures. This paper summarizes ...

    journal_title:Environmental health perspectives

    pub_type:

    doi:10.1289/ehp.98106867

    authors: Carroquino MJ,Galson SK,Licht J,Amler RW,Perera FP,Claxton LD,Landrigan PJ

    更新日期:1998-06-01 00:00:00

  • Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of Shanghai women and men.

    abstract:BACKGROUND:Exposure to certain phenols is ubiquitous because of their use in many consumer and personal care products. However, predictors of exposure have not been well characterized in most populations. OBJECTIVES:We sought to identify predictors of exposure and to assess the reproducibility of phenol concentrations...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1306830

    authors: Engel LS,Buckley JP,Yang G,Liao LM,Satagopan J,Calafat AM,Matthews CE,Cai Q,Ji BT,Cai H,Engel SM,Wolff MS,Rothman N,Zheng W,Xiang YB,Shu XO,Gao YT,Chow WH

    更新日期:2014-07-01 00:00:00

  • Comparison of gas-phase free-radical populations in tobacco smoke and model systems by HPLC.

    abstract::We used an improved method for trapping carbon-centered radicals (.R) from the gas-phase to compare radical suites trapped from various tobacco smoke and model smoke systems. Using a nitroxide trap, 3-amino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (3AP), on solid support, we trapped radicals directly from the gas phase, ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109765

    authors: Flicker TM,Green SA

    更新日期:2001-08-01 00:00:00

  • Pesticide-induced immunotoxicity: are Great Lakes residents at risk?

    abstract::Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s955

    authors: Thomas PT

    更新日期:1995-12-01 00:00:00

  • Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies.

    abstract:BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.10108

    authors: Bell ML,Kim JY,Dominici F

    更新日期:2007-11-01 00:00:00

  • Contribution of lead in dust to children's blood lead.

    abstract::The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8350371

    authors: Duggan MJ

    更新日期:1983-04-01 00:00:00

  • Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy.

    abstract::It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.011091237

    authors: Recio R,Robbins WA,Borja-Aburto V,Morán-Martínez J,Froines JR,Hernández RM,Cebrián ME

    更新日期:2001-12-01 00:00:00

  • Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat.

    abstract:OBJECTIVE:The aim of this study was to assess whether the joint effects of three androgen receptor antagonists (vinclozolin, flutamide, procymidone) on male sexual differentiation after in utero and postnatal exposures can be predicted based on dose-response data of the individual chemicals. METHODS:Test chemicals and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9360

    authors: Hass U,Scholze M,Christiansen S,Dalgaard M,Vinggaard AM,Axelstad M,Metzdorff SB,Kortenkamp A

    更新日期:2007-12-01 00:00:00

  • Size-fractionated particle number concentrations and daily mortality in a Chinese city.

    abstract:BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1206398

    authors: Meng X,Ma Y,Chen R,Zhou Z,Chen B,Kan H

    更新日期:2013-10-01 00:00:00

  • Proliferative lesions of the exocrine pancreas in male F344/N rats.

    abstract::While the rat pancreas is susceptible to experimental cancer induction, the spontaneous incidence of pancreatic cancer in this species is reported to be very low. However, we observed unusually high incidences of focal acinar hyperplasia and acinar adenoma in vehicle control male F344/N rats of some NCI/NTP 2-year tox...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8456213

    authors: Boorman GA,Eustis SL

    更新日期:1984-06-01 00:00:00

  • Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.

    abstract:BACKGROUND:Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density-lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein an...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1003296

    authors: Ayotte P,Carrier A,Ouellet N,Boiteau V,Abdous B,Sidi EA,Château-Degat ML,Dewailly É

    更新日期:2011-08-01 00:00:00

  • Expanded operational concept of high risk groups and its role in standard setting.

    abstract::The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8352257

    authors: Calabrese EJ

    更新日期:1983-10-01 00:00:00

  • A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter.

    abstract::Epidemiologic studies demonstrate that infection, specifically pneumonia, contributes substantially to the increased morbidity and mortality among elderly individuals following exposure to ambient particulate matter (PM). This laboratory has previously demonstrated that a single inhalation exposure of Streptococcus pn...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110s5871

    authors: Zelikoff JT,Schermerhorn KR,Fang K,Cohen MD,Schlesinger RB

    更新日期:2002-10-01 00:00:00

  • Sampling strategies in nested case-control studies.

    abstract::A stratified version of nested case-control sampling which we call "countermatching" is presented. This design uses data available for all cohort members to obtain a sample for collecting additional information in a case-control substudy. Hitherto the only stratified sampling design for such studies has involved match...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102s847

    authors: Langholz B,Clayton D

    更新日期:1994-11-01 00:00:00

  • Endocrine disruptors and human health--is there a problem? An update.

    abstract::It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic varia...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108487

    authors: Safe SH

    更新日期:2000-06-01 00:00:00

  • Weather variability, tides, and Barmah Forest virus disease in the Gladstone region, Australia.

    abstract::In this study we examined the impact of weather variability and tides on the transmission of Barmah Forest virus (BFV) disease and developed a weather-based forecasting model for BFV disease in the Gladstone region, Australia. We used seasonal autoregressive integrated moving-average (SARIMA) models to determine the c...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8568

    authors: Naish S,Hu W,Nicholls N,Mackenzie JS,McMichael AJ,Dale P,Tong S

    更新日期:2006-05-01 00:00:00

  • Angiotensin-converting enzyme: II. Pulmonary endothelial cells in culture.

    abstract::Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8035171

    authors: Ryan US,Ryan JW

    更新日期:1980-04-01 00:00:00

  • Health status and PCBs in blood of workers exposed to PCBs and of their children.

    abstract::A follow-up study of capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs) and their children was conducted since 1973. PCB levels in whole blood of workers as well as in breast milk of the exposed lactating mothers were approximately 10 to 100 times those of nonexposed Japanese. Blood PCB levels...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.59-1568101

    authors: Hara I

    更新日期:1985-02-01 00:00:00

  • Sensitivity of health endpoints: effect on conclusions of studies.

    abstract::The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no p...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.814245

    authors: Radford EP

    更新日期:1981-12-01 00:00:00

  • Acute sensory responses of nonsmokers at very low environmental tobacco smoke concentrations in controlled laboratory settings.

    abstract::The objective of this study was to provide a basis for effectively protecting nonsmokers from acute sensory impacts and for preventing deterioration of indoor air quality caused by environmental tobacco smoke (ETS) emissions. With an olfactory experiment we determined odor detection thresholds (OT) of sidestream ETS (...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.011091045

    authors: Junker MH,Danuser B,Monn C,Koller T

    更新日期:2001-10-01 00:00:00

  • In vitro techniques for the assessment of neurotoxicity.

    abstract::Risk assessment is a process often divided into the following steps: a) hazard identification, b) dose-response assessment, c) exposure assessment, and d) risk characterization. Regulatory toxicity studies usually are aimed at providing data for the first two steps. Human case reports, environmental research, and in v...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.98106s1131

    authors: Harry GJ,Billingsley M,Bruinink A,Campbell IL,Classen W,Dorman DC,Galli C,Ray D,Smith RA,Tilson HA

    更新日期:1998-02-01 00:00:00

  • Research recommendations for selected IARC-classified agents.

    abstract:OBJECTIVES:There are some common occupational agents and exposure circumstances for which evidence of carcinogenicity is substantial but not yet conclusive for humans. Our objectives were to identify research gaps and needs for 20 agents prioritized for review based on evidence of widespread human exposures and potenti...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.0901828

    authors: Ward EM,Schulte PA,Straif K,Hopf NB,Caldwell JC,Carreón T,DeMarini DM,Fowler BA,Goldstein BD,Hemminki K,Hines CJ,Pursiainen KH,Kuempel E,Lewtas J,Lunn RM,Lynge E,McElvenny DM,Muhle H,Nakajima T,Robertson LW,Rothma

    更新日期:2010-10-01 00:00:00

  • Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells.

    abstract:BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5862

    authors: Li Z,Lyu C,Ren Y,Wang H

    更新日期:2020-02-01 00:00:00

  • Human DNA adduct measurements: state of the art.

    abstract::Human DNA adduct formation (covalent modification of DNA with chemical carcinogens) is a promising biomarker for elucidating the molecular epidemiology of cancer. Classes of compounds for which human DNA adducts have been observed include polycyclic aromatic hydrocarbons (PAHs), nitrosamines, mycotoxins, aromatic amin...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.96104s5883

    authors: Poirier MC,Weston A

    更新日期:1996-10-01 00:00:00

  • Measurement variability associated with KXRF bone lead measurement in young adults.

    abstract::In vivo bone lead measurement using K X-ray fluorescence (KXRF) has been used to estimate long-term lead exposure, especially in adults. Relatively few studies have been conducted on young subjects with this technique. To explore the measurement variability of KXRF bone lead measurements in young subjects, the tibiae ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108239

    authors: Hoppin JA,Aro A,Hu H,Ryan PB

    更新日期:2000-03-01 00:00:00

  • DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay.

    abstract::32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were exposed occupationally to a mixture of polycyclic aromatic hydrocarbons (PAHs). Preliminary results reported here are from...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9399307

    authors: Schoket B,Phillips DH,Poirier MC,Vincze I

    更新日期:1993-03-01 00:00:00

  • Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects.

    abstract::The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compou...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s2157

    authors: Birnbaum LS

    更新日期:1995-03-01 00:00:00