Oxidant effects on epithelial Na,K-ATPase gene expression and promoter function.

abstract：BACKGROUND:Developmental exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term auditory deficits. However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function. OBJECTIVE:We developmentally exposed...

journal_title：Environmental health perspectives

authors： Powers BE,Poon E,Sable HJ,Schantz SL

更新日期：2009-07-01 00:00:00

abstract：:Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

journal_title：Environmental health perspectives

authors： Lee TC,Ho IC

更新日期：1994-09-01 00:00:00

abstract：:Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median aerodynamic diameter < 10 microm (PM10) is associated with an increase in respiratory-related disease. However, there is a growing consensus that particles < 2.5 microm (PM2.5), including many in the ultrafine (< 0.1 microm) size...

journal_title：Environmental health perspectives

authors： Smith KR,Kim S,Recendez JJ,Teague SV,Ménache MG,Grubbs DE,Sioutas C,Pinkerton KE

更新日期：2003-06-01 00:00:00

abstract：:Consideration of needs for public health interventions and new research requires comparative assessments of the health benefits that are likely to result from alternative uses of limited regulatory and technical resources. This paper briefly examines regulatory and research priorities in the light of recent informatio...

journal_title：Environmental health perspectives

authors： Hattis D

更新日期：1981-10-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. OBJECTIVE:The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. METHODS:Cancers among 20,984 consented participants ...

journal_title：Environmental health perspectives

authors： Solan S,Wallenstein S,Shapiro M,Teitelbaum SL,Stevenson L,Kochman A,Kaplan J,Dellenbaugh C,Kahn A,Biro FN,Crane M,Crowley L,Gabrilove J,Gonsalves L,Harrison D,Herbert R,Luft B,Markowitz SB,Moline J,Niu X,Sacks H,

更新日期：2013-06-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and 3A families. We fo...

journal_title：Environmental health perspectives

authors： Tabb MM,Kholodovych V,Grün F,Zhou C,Welsh WJ,Blumberg B

更新日期：2004-02-01 00:00:00

abstract：:Locating geographic hot spots of cancer may lead to new causal hypotheses and ultimately to new knowledge of cancer-causing factors. The Cape Cod region of Massachusetts has experienced elevated incidence of breast cancer compared with statewide averages. The origins of the excess remain largely unexplained, even afte...

journal_title：Environmental health perspectives

authors： Paulu C,Aschengrau A,Ozonoff D

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:We evaluated the association between drinking-water disinfection by-products and preterm births using improved exposure assessment and more appropriate analysis methods than used in prior studies. METHODS:During 1999-2001, vital record data were obtained for a large, racially diverse population residing in ...

journal_title：Environmental health perspectives

authors： Lewis C,Suffet IH,Hoggatt K,Ritz B

更新日期：2007-02-01 00:00:00

abstract：:Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to ben...

journal_title：Environmental health perspectives

authors： Wan J,Shi J,Hui L,Wu D,Jin X,Zhao N,Huang W,Xia Z,Hu G

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg. OBJECTIVES:We investigated the protective effect of isothiocyanates, which are kno...

journal_title：Environmental health perspectives

authors： Toyama T,Shinkai Y,Yasutake A,Uchida K,Yamamoto M,Kumagai Y

更新日期：2011-08-01 00:00:00

abstract：:Enhanced transport of trace metal in porous media can occur in the presence of a ligand or "carrier" that has a high affinity for binding the pollutant, is dispersed and mobile in the soil environment, is recalcitrant with respect to microbial degradation, and is acceptable to the public. These aspects of the facilita...

journal_title：Environmental health perspectives

authors： Chen JH,Czajka DR,Lion LW,Shuler ML,Ghiorse WC

更新日期：1995-02-01 00:00:00

abstract：:In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrin...

journal_title：Environmental health perspectives

authors： Mossman BT,Faux S,Janssen Y,Jimenez LA,Timblin C,Zanella C,Goldberg J,Walsh E,Barchowsky A,Driscoll K

更新日期：1997-09-01 00:00:00

abstract：:Among the issues dealing with identifying potential adverse immunologic effects (i.e., suppression, hypersensitivity, or autoimmunity) associated with xenobiotic exposure, general agreement exists among the regulatory and pharmaceutical communities that predictive tests for autoimmunity are in most need of development...

journal_title：Environmental health perspectives

authors： Luster MI,Simeonova PP,Gallucci R,Matheson J

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Tetraethyl lead was phased out of gasoline in Uganda in 2005. Recent mitigation of an important source of lead exposure suggests examination and re-evaluation of the prevalence of childhood lead poisoning in this country. Ongoing concerns persist about exposure from the Kiteezi landfill in Kampala, the count...

journal_title：Environmental health perspectives

authors： Graber LK,Asher D,Anandaraja N,Bopp RF,Merrill K,Cullen MR,Luboga S,Trasande L

更新日期：2010-06-01 00:00:00

abstract：:There is widespread concern regarding the safety of silver-mercury amalgam dental restorations, yet little evidence to support their harm or safety. We examined whether mercury dental amalgams are adversely associated with cognitive functioning in a cross-sectional sample of healthy working adults. We studied 550 adul...

journal_title：Environmental health perspectives

authors： Factor-Litvak P,Hasselgren G,Jacobs D,Begg M,Kline J,Geier J,Mervish N,Schoenholtz S,Graziano J

更新日期：2003-05-01 00:00:00

abstract：:Two remote maritime populations were evaluated for their biological exposure to organochlorines in 1989-1990. Because of their high intake of seafood, these two populations have high biological levels. One hundred nine breast milk samples from Inuit women from Arctic Québec were analyzed to determine levels of polychl...

journal_title：Environmental health perspectives

authors： Dewailly E,Ryan JJ,Laliberté C,Bruneau S,Weber JP,Gingras S,Carrier G

更新日期：1994-01-01 00:00:00

abstract：:Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period...

journal_title：Environmental health perspectives

authors： Durant JL,Chen J,Hemond HF,Thilly WG

更新日期：1995-09-01 00:00:00

abstract：:The role of cell-specific metabolism in benzene toxicity was examined in both murine and human bone marrow. Hemopoietic progenitor cells and stromal cells are important control points for regulation of hemopoiesis. We show that the selective toxicity of hydroquinone at the level of the macrophage in murine bone marrow...

journal_title：Environmental health perspectives

authors： Ross D,Siegel D,Schattenberg DG,Sun XM,Moran JL

更新日期：1996-12-01 00:00:00

abstract：:Laboratory and room-scale experiments were conducted with natural and synthetic polymers: cotton, paper, wood, wool, acetate, acrylic, nylon, and urethane. Smoke and off-gases from single materials were generated in a dual-compartment 110-liter exposure chamber. Multicomponent, composite fuel loads were burned within ...

journal_title：Environmental health perspectives

authors： Wright PL,Adams CH

更新日期：1976-10-01 00:00:00

abstract：:[This corrects the article DOI: https://doi.org/10.1289/EHP507.]. ...

journal_title：Environmental health perspectives

authors： Fann N,Kim SY,Olives C,Sheppard L

更新日期：2018-02-20 00:00:00

abstract：:Martineau et al. (2002) reported that St. Lawrence beluga (SLB) have high cancer rates. Unfortunately, errors in their interpretation of the data have led them to overstate the importance of cancer and its links to environmental sources. ...

journal_title：Environmental health perspectives

authors： Hammill MO,Lesage V,Kingsley MC

更新日期：2003-02-01 00:00:00

abstract：:A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...

journal_title：Environmental health perspectives

authors： Macek KJ

更新日期：1980-02-01 00:00:00

abstract：:Recent investigations have demonstrated the ability of leukocytes to metabolize promutagens or procarcinogens into their genotoxic forms. As a possible explanation for the association between inflammation and cancer, we and others have hypothesized that local accumulations of leukocytes could take up nearby promutagen...

journal_title：Environmental health perspectives

authors： Isola VJ,Hartman TC,Trumble SJ,Ruzek MC,Gentile JM

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess whether the joint effects of three androgen receptor antagonists (vinclozolin, flutamide, procymidone) on male sexual differentiation after in utero and postnatal exposures can be predicted based on dose-response data of the individual chemicals. METHODS:Test chemicals and...

journal_title：Environmental health perspectives

authors： Hass U,Scholze M,Christiansen S,Dalgaard M,Vinggaard AM,Axelstad M,Metzdorff SB,Kortenkamp A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Few studies have been conducted to identify risk factors for balance and vestibular dysfunction in general populations, but previous studies have reported evidence of adverse effects of lead and cadmium on balance control in high-risk groups. OBJECTIVE:We evaluated the relationship between blood lead and ca...

journal_title：Environmental health perspectives

authors： Min KB,Lee KJ,Park JB,Min JY

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Extreme heat events (EHEs) are increasing in frequency in large U.S. cities and are responsible for a greater annual number of climate-related fatalities, on average, than any other form of extreme weather. In addition, low-density, sprawling patterns of urban development have been associated with enhanced s...

journal_title：Environmental health perspectives

authors： Stone B,Hess JJ,Frumkin H

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Understanding the potential links between extreme weather events and human health in India is important in the context of vulnerability and adaptation to climate change. Research exploring such linkages in India is sparse. OBJECTIVES:We evaluated the association between extreme precipitation and gastrointes...

journal_title：Environmental health perspectives

authors： Bush KF,O'Neill MS,Li S,Mukherjee B,Hu H,Ghosh S,Balakrishnan K

更新日期：2014-03-01 00:00:00

abstract：:We developed a series of articles concerning epidemiologic research on potential health effects of electric and magnetic fields. Our goal was to identify methodological issues that have arisen through past studies of cancer, reproduction, and neurobehavioral outcomes in order to suggest strategies to extend knowledge....

journal_title：Environmental health perspectives

authors： Savitz DA

更新日期：1993-12-01 00:00:00

abstract：:The presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. In a recently published report, the National Academy of Sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-...

journal_title：Environmental health perspectives

authors： Crump KS,Gibbs JP

更新日期：2005-08-01 00:00:00