A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada.

abstract：BACKGROUND:Although it is well established that air pollutants can exacerbate asthma, the link with new asthma onset in children is less clear. OBJECTIVE:We assessed the association between the onset of childhood asthma with both time of birth and time-varying exposures to outdoor air pollutants. METHOD:An open cohor...

journal_title：Environmental health perspectives

authors： Tétreault LF,Doucet M,Gamache P,Fournier M,Brand A,Kosatsky T,Smargiassi A

更新日期：2016-08-01 00:00:00

abstract：:The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been ob...

journal_title：Environmental health perspectives

authors： Anderson MW,Reynolds SH,You M,Maronpot RM

更新日期：1992-11-01 00:00:00

abstract：:Organophosphate (OP) pesticides are commonly used in the United States, and farmworkers are at risk for chronic exposure. Using a sample of 218 farmworkers in 24 communities and labor camps in eastern Washington State, we examined the association between agricultural crop and OP pesticide metabolite concentrations in ...

journal_title：Environmental health perspectives

authors： Coronado GD,Vigoren EM,Thompson B,Griffith WC,Faustman EM

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Trying to publish a paper in a top-rated peer-reviewed journal can be a difficult and frustrating experience for authors. It is important that authors understand the general review process before submitting manuscripts for publication. OBJECTIVES:Editors-in-chief and associate editors from top-tier journals...

journal_title：Environmental health perspectives

authors： Lee BM

更新日期：2011-07-01 00:00:00

abstract：:The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of e...

journal_title：Environmental health perspectives

authors： Krewski D,Withey JR,Ku LF,Andersen ME

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Pregnancy is a sensitive condition during which adverse environmental exposures should be monitored thoroughly and minimized whenever possible. In particular, the hormone balance during gestation is delicate, and disturbance may cause acute or chronic long-term health effects. A potential endocrine disruptio...

journal_title：Environmental health perspectives

authors： Warth B,Preindl K,Manser P,Wick P,Marko D,Buerki-Thurnherr T

更新日期：2019-10-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are widespread, low-level environmental pollutants associated with adverse health effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, inclu...

journal_title：Environmental health perspectives

authors： Bergeron JM,Crews D,McLachlan JA

更新日期：1994-09-01 00:00:00

abstract：:The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...

journal_title：Environmental health perspectives

authors： Regoli F,Orlando E

更新日期：1994-09-01 00:00:00

abstract：:Previous NIOSH studies demonstrated the embryo- and fetotoxicity and teratogenicity of ethylene glycol monoethyl ether (EGEE) applied to the shaved skin of pregnant rats. In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glycol monoethyl ether ...

journal_title：Environmental health perspectives

authors： Hardin BD,Goad PT,Burg JR

更新日期：1984-08-01 00:00:00

abstract：:1,3-Butadiene is a major monomer in the rubber and plastics industry and is one of the highest-production industrial chemicals in the United States. Although not highly acutely toxic to rodents, inhalation of concentrations as low as 6.25 ppm causes tumors in mice. Butadiene is oncogenic in rats, but much higher expos...

journal_title：Environmental health perspectives

authors： Birnbaum LS

更新日期：1993-12-01 00:00:00

abstract：:Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...

journal_title：Environmental health perspectives

authors： Schecter A,Lucier GW,Cunningham ML,Abdo KM,Blumenthal G,Silver AG,Melnick R,Portier C,Barr DB,Barr JR,Stanfill SB,Patterson DG Jr,Needham LL,Stopford W,Masten S,Mignogna J,Tung KC

更新日期：2004-05-01 00:00:00

abstract：:Metallothioneins (MTs) are encoded by a multigene family in man. We have isolated those genes and analyzed the structure of some of them. The MT-II variant is encoded by a single functional gene: MT-IIA. The MT-IIB gene is a processed pseudogene derived from a reverse transcript of MT-II mRNA. On the other hand, the M...

journal_title：Environmental health perspectives

authors： Karin M,Richards RI

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...

journal_title：Environmental health perspectives

authors： Shao K,Shapiro AJ

更新日期：2018-01-11 00:00:00

abstract：:There is a need to identify specific biological indicator(s) of cadmium exposure so that the renal damage can be prevented. Towards this end, we have examined the usefulness of urinary metallothionein as an indicator of cadmium body burden. It is found that, in both animals and humans, urinary metallothionein level is...

journal_title：Environmental health perspectives

authors： Shaikh ZA,Tohyama C

更新日期：1984-03-01 00:00:00

abstract：:N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. De...

journal_title：Environmental health perspectives

authors： King CM,Glowinski IB

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Environmental exposures to phthalates, particularly high-molecular-weight (HMW) phthalates, are suspected to contribute to allergy. OBJECTIVE:We assessed whether phthalate metabolites are associated with allergic symptoms and sensitization in a large nationally representative sample. METHODS:We used data o...

journal_title：Environmental health perspectives

authors： Hoppin JA,Jaramillo R,London SJ,Bertelsen RJ,Salo PM,Sandler DP,Zeldin DC

更新日期：2013-10-01 00:00:00

abstract：:Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...

journal_title：Environmental health perspectives

authors： Harbison RD

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies--and fewer epidemiologic investigations--have examined the potential effects of prenatal exposure. OBJECTIVES:We assessed the association between adverse birth outcomes and urinary biomarkers of prenatal atr...

journal_title：Environmental health perspectives

authors： Chevrier C,Limon G,Monfort C,Rouget F,Garlantézec R,Petit C,Durand G,Cordier S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes withi...

journal_title：Environmental health perspectives

authors： Steinmaus C,Pearl M,Kharrazi M,Blount BC,Miller MD,Pearce EN,Valentin-Blasini L,DeLorenze G,Hoofnagle AN,Liaw J

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Bacterial meningitis causes a high burden of disease in the African meningitis belt, with regular seasonal hyperendemicity and sporadic short, but intense, localized epidemics during the late dry season occurring at a small spatial scale [i.e., below the district level, in individual health centers (HCs)]. I...

journal_title：Environmental health perspectives

authors： Woringer M,Martiny N,Porgho S,Bicaba BW,Bar-Hen A,Mueller JE

更新日期：2018-09-01 00:00:00

abstract：:Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...

journal_title：Environmental health perspectives

authors： Barrett JC,Lamb PW,Wiseman RW

更新日期：1989-05-01 00:00:00

abstract：:Stable associations of syntrophic fermentative organisms and populations that consume fermentation products play key roles in the anaerobic biodegradation of chlorinated organic contaminants. The involvement of these syntrophic populations is essential for mineralization of chlorinated aromatic compounds under methano...

journal_title：Environmental health perspectives

authors： Becker JG,Berardesco G,Rittmann BE,Stahl DA

更新日期：2005-03-01 00:00:00

abstract：:Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...

journal_title：Environmental health perspectives

authors： Morgan MS

更新日期：1997-02-01 00:00:00

abstract：:Occupational exposures to mineral particles cause pneumoconiosis and other diseases, including cancer. Recent studies have suggested that reactive oxygen species (ROS) may play a key role in the mechanisms of disease initiation and progression following exposure to these particles. ROS-induced primary stimuli result i...

journal_title：Environmental health perspectives

authors： Vallyathan V,Shi X,Castranova V

更新日期：1998-10-01 00:00:00

abstract：:The binary, ternary, quaternary, and quintary interactions of a five-component mixture of carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response surface analyses are described. Initially, lung tumor dose-response curves in strain A/J mice for each of the individual PAHs benzo[a]pyrene (B[a]P...

journal_title：Environmental health perspectives

authors： Nesnow S,Mass MJ,Ross JA,Galati AJ,Lambert GR,Gennings C,Carter WH Jr,Stoner GD

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes. OBJECTIVES:We examined quantitative aspects of occupational pesticide exposure associa...

journal_title：Environmental health perspectives

authors： Moisan F,Spinosi J,Delabre L,Gourlet V,Mazurie JL,Bénatru I,Goldberg M,Weisskopf MG,Imbernon E,Tzourio C,Elbaz A

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB ...

journal_title：Environmental health perspectives

authors： Goncharov A,Pavuk M,Foushee HR,Carpenter DO,Anniston Environmental Health Reseach Consortium.

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00

abstract：:Airway mucus is a complex airway secretion whose primary function as part of the mucociliary transport mechanism is to to serve as renewable and transportable barrier against inhaled particulates and toxic agents. The rheologic properties necessary for this function are imparted by glycoproteins, or mucins. Some respi...

journal_title：Environmental health perspectives

authors： Samet JM,Cheng PW

更新日期：1994-06-01 00:00:00

abstract：:Adults eating a Western diet digest and absorb ingested food containing approximately 100 g fat, 350 g carbohydrate, and 75 g protein daily. Normal fat absorption requires adequate gastric, pancreatic, liver-biliary, mucosal, and lymphatic function. Carbohydrate and protein absorption is much less dependent on liver-b...

journal_title：Environmental health perspectives

authors： Heizer WD

更新日期：1979-12-01 00:00:00