Is it worth a dam?

abstract：:An increased gastrointestinal cancer risk is associated with occupational exposure to asbestos fiber. Examination of tissues obtained from extrapulmonary organs of exposed workmen demonstrates the presence of asbestos fibers and bodies. The amount of fiber present in these tissues is many magnitudes less than encounte...

journal_title：Environmental health perspectives

authors： Langer AM

更新日期：1974-12-01 00:00:00

abstract：:To elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one concerning the possible association of broiled fish consumption with cancer and the other concerning the cancer mortality ...

journal_title：Environmental health perspectives

authors： Kuratsune M,Ikeda M,Hayashi T

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...

journal_title：Environmental health perspectives

authors： van den Hooven EH,de Kluizenaar Y,Pierik FH,Hofman A,van Ratingen SW,Zandveld PY,Lindemans J,Russcher H,Steegers EA,Miedema HM,Jaddoe VW

更新日期：2012-05-01 00:00:00

abstract：:It is necessary but not sufficient to develop laboratory animal models in sensory behavioral toxicology for screening toxic substances and for the analysis of sensory impairment at threshold levels of stimulation. It is important to develop more thorough and quantitative tests of impairment which in their greater comp...

journal_title：Environmental health perspectives

authors： Stebbins WC

更新日期：1982-04-01 00:00:00

abstract：:The capacity of in vitro bioassays to detect the potential carcinogenicity of metal compounds is reviewed. The in vitro bioassays discussed include: bacterial reversion analysis to determine the capacity of metal salts to revert Salmonella typhimurium histidine auxotrophs or to revert Escherichia coli WP 2 tryp- to tr...

journal_title：Environmental health perspectives

authors： Sirover MA

更新日期：1981-08-01 00:00:00

abstract：:Data from experiments on the induction of specific-locus mutations in model systems are used in genetic risk assessment to estimate potential adverse effects in the human population. In such assessments with radiation or chemical mutagens, the following information is required: a) spontaneous and induced forward-mutat...

journal_title：Environmental health perspectives

authors： de Serres FJ

更新日期：1994-01-01 00:00:00

abstract：:Phthalates are a group of multifunctional chemicals used in consumer and personal care products, plastics, and medical devices. Laboratory studies show that some phthalates are reproductive and developmental toxicants. Recently, human studies have shown measurable levels of several phthalates in most of the U.S. gener...

journal_title：Environmental health perspectives

authors： Hauser R,Duty S,Godfrey-Bailey L,Calafat AM

更新日期：2004-05-01 00:00:00

abstract：:To study the effect of processing on polybrominated biphenyl (PBB) levels, milk from four dairy herds containing less than 0.3 ppm (fat basis) of physiologically incorporated PBBs was presented individually into cream, skim milk, butter, and stirred curd cheese. Pasteurized and freeze-dried whole milk, skim milk, and ...

journal_title：Environmental health perspectives

authors： Zabik ME,Johnson TM,Smith S

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:There is general concern that persistent organic pollutants (POPs) found in the environment, wildlife, food, water, house dust, human tissues, and fluids may alter normal human physiologic activities (e.g., fetal development, immune and endocrine systems). Although the levels of some POPs [polychlorinated bi...

journal_title：Environmental health perspectives

authors： Doucet J,Tague B,Arnold DL,Cooke GM,Hayward S,Goodyer CG

更新日期：2009-04-01 00:00:00

abstract：:Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure...

journal_title：Environmental health perspectives

authors： Luster MI,Faith RE,Moore JA

更新日期：1978-04-01 00:00:00

abstract：:Although most people are thought to receive their highest acute exposures to gasoline while refueling, relatively little is actually known about personal, nonoccupational exposures to gasoline during refueling activities. This study was designed to measure exposures associated with the use of an oxygenated fuel under ...

journal_title：Environmental health perspectives

authors： Backer LC,Egeland GM,Ashley DL,Lawryk NJ,Weisel CP,White MC,Bundy T,Shortt E,Middaugh JP

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) is a known neuro-toxicant. Emerging evidence indicates it may have adverse effects on the neuro-logic and other body systems at common low levels of exposure. Impacts of MeHg exposure could vary by individual susceptibility or be confounded by beneficial nutrients in fish containing MeHg...

journal_title：Environmental health perspectives

authors： Karagas MR,Choi AL,Oken E,Horvat M,Schoeny R,Kamai E,Cowell W,Grandjean P,Korrick S

更新日期：2012-06-01 00:00:00

abstract：:Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...

journal_title：Environmental health perspectives

authors： Medinsky MA,Sabourin PJ,Henderson RF,Lucier G,Birnbaum LS

更新日期：1989-07-01 00:00:00

abstract：:The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...

journal_title：Environmental health perspectives

authors： Skerfving S

更新日期：1978-08-01 00:00:00

abstract：:A patient with massive exposure to tetrachloroethylene fumes presented with coma and severe pulmonary edema. Sequential blood gases, chest x-rays, and clinical findings showed dramatic improvement with conventional but aggressive management and the patient recovered completely. There was no evidence of permanent renal...

journal_title：Environmental health perspectives

authors： Patel R,Janakiraman N,Towne WD

更新日期：1977-12-01 00:00:00

abstract：:Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...

journal_title：Environmental health perspectives

authors： Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AH

更新日期：2005-09-01 00:00:00

abstract：:The nasal cavity is susceptible to chemically induced injury as a result of exposure to inhaled irritants. Some responses of the nasal mucosa to inhaled toxicants are species specific. These species-related differences in response may be due to variations in structural, physiologic, and biochemical factors, such as gr...

journal_title：Environmental health perspectives

authors： Harkema JR

更新日期：1990-04-01 00:00:00

abstract：:Some have hypothesized that community water containing sodium silicofluoride and hydrofluosilicic acid may increase blood lead (PbB) concentrations in children by leaching of lead from water conduits and by increasing absorption of lead from water. Our analysis aimed to evaluate the relation between water fluoridation...

journal_title：Environmental health perspectives

authors： Macek MD,Matte TD,Sinks T,Malvitz DM

更新日期：2006-01-01 00:00:00

abstract：:In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA d...

journal_title：Environmental health perspectives

authors： Mangipudy RS,Rao PS,Mehendale HM

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized. OBJECTIVES:We aimed to characterize within-day, between-da...

journal_title：Environmental health perspectives

authors： Vernet C,Philippat C,Calafat AM,Ye X,Lyon-Caen S,Siroux V,Schisterman EF,Slama R

更新日期：2018-03-16 00:00:00

abstract：:Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced...

journal_title：Environmental health perspectives

authors： Stowers SJ,Maronpot RR,Reynolds SH,Anderson MW

更新日期：1987-11-01 00:00:00

abstract：:In this study, we explored the efficacy of upper-room ultraviolet germicidal irradiation (UVGI) in reducing the concentration of Serratia marcescens and Mycobacterium bovis bacille Calmette-Guérin (BCG) aerosols in enclosed places. We constructed a facility (4.5 m x 3 m x 2.9 m) in which both ceiling- and wall-mounted...

journal_title：Environmental health perspectives

authors： Ko G,First MW,Burge HA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Despite experimental evidence, most epidemiologic studies to date have not supported an association between exposure to persistent organic pollutants (POP) and breast cancer incidence in humans. This may be attributable to difficulties in estimating blood/tissue POP concentration at critical time periods of ...

journal_title：Environmental health perspectives

authors： Verner MA,Charbonneau M,López-Carrillo L,Haddad S

更新日期：2008-07-01 00:00:00

abstract：:Microarrays provide an unprecedented opportunity for comprehensive concurrent analysis of thousands of genes. The global analysis of the response of genes to a toxic insult (toxicogenomics), as opposed to the historical method of examining a few select genes, provides a more complete picture of toxicologically signifi...

journal_title：Environmental health perspectives

authors： Newton RK,Aardema M,Aubrecht J

更新日期：2004-03-01 00:00:00

abstract：:The Children's Post-Pesticide Application Exposure Study (CPPAES) was conducted to look at the distribution of chlorpyrifos within a home environment for 2 weeks after a routine professional crack-and-crevice application and to determine the amount of the chlorpyrifos that is absorbed by a child living within the home...

journal_title：Environmental health perspectives

authors： Hore P,Robson M,Freeman N,Zhang J,Wartenberg D,Ozkaynak H,Tulve N,Sheldon L,Needham L,Barr D,Lioy PJ

更新日期：2005-02-01 00:00:00

abstract：:Grafting experiments show that the enhanced sensitivity of the SENCAR mouse to skin carcinogenesis by initiation and promotion is a property of the skin itself, suggesting the usefulness of in vitro studies to elucidate the mechanism. Such studies have indicated that cultured epidermal cells of SENCAR mice and the res...

journal_title：Environmental health perspectives

authors： Strickland JE,Allen PT,Sauder DN,Kawamura H,Fong MC,Yuspa SH

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified...

journal_title：Environmental health perspectives

authors： Donoghue LJ,Neufeld TI,Li Y,Arao Y,Coons LA,Korach KS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:In the United States, most of the treated sewage sludge (biosolids) is applied to farmland as a soil amendment. Critics suggest that rules regulating sewage sludge treatment and land application may be insufficient to protect public health and the environment. Neighbors of land application sites report illne...

journal_title：Environmental health perspectives

authors： Lowman A,McDonald MA,Wing S,Muhammad N

更新日期：2013-05-01 00:00:00

abstract：:N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. De...

journal_title：Environmental health perspectives

authors： King CM,Glowinski IB

更新日期：1983-03-01 00:00:00

abstract：:Although allergic diseases such as asthma and hay fever are a major cause of morbidity in industrialized countries, most studies have focused on patterns of prevalence among children and adolescents, with relatively few studies on variations in prevalence by race/ethnicity and socioeconomic position among adults. Our ...

journal_title：Environmental health perspectives

authors： Chen JT,Krieger N,Van Den Eeden SK,Quesenberry CP

更新日期：2002-04-01 00:00:00