Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren.

Abstract:

BACKGROUND:The biological mechanisms involved in inflammatory response to air pollution are not clearly understood. OBJECTIVE:In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function. METHODS:We studied a cohort of 158 asthmatic and 50 nonasthmatic school-age children, followed an average of 22 weeks. We conducted spirometric tests, measurements of fractional exhaled nitric oxide (Fe(NO)), interleukin-8 (IL-8) in nasal lavage, and pH of exhaled breath condensate every 15 days during follow-up. Data were analyzed using linear mixed-effects models. RESULTS:An increase of 17.5 microg/m(3) in the 8-hr moving average of PM(2.5) levels (interquartile range) was associated with a 1.08-ppb increase in Fe(NO) [95% confidence interval (CI), 1.01-1.16] and a 1.07-pg/mL increase in IL-8 (95% CI 0.98-1.19) in asthmatic children and a 1.16 pg/ml increase in IL-8 (95% CI, 1.00-1.36) in nonasthmatic children. The 5-day accumulated average of exposure to particulate matter <2.5 microm in aerodynamic diamter (PM(2.5)) was significantly inversely associated with forced expiratory volume in 1 sec (FEV(1)) (p=0.048) and forced vital capacity (FVC) (p=0.012) in asthmatic children and with FVC (p=0.021) in nonasthmatic children. Fe(NO) and FEV(1) were inversely associated (p=0.005) in asthmatic children. CONCLUSIONS:Exposure to PM(2.5) resulted in acute airway inflammation and decrease in lung function in both asthmatic and nonasthmatic children.

authors

Barraza-Villarreal A,Sunyer J,Hernandez-Cadena L,Escamilla-Nuñez MC,Sienra-Monge JJ,Ramírez-Aguilar M,Cortez-Lugo M,Holguin F,Diaz-Sánchez D,Olin AC,Romieu I

doi

10.1289/ehp.10926

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

832-8

issue

6

eissn

0091-6765

issn

1552-9924

journal_volume

116

pub_type

杂志文章
  • Reactions of carbanions with triplet and singlet molecular oxygen.

    abstract::The gas phase reactions of carbanions with molecular oxygen in both its ground state (X3 sigma g-) and first electronically excited state (a1 delta g) have been studied by the flowing afterglow technique. Reactions include cleavage processes, charge transfer, hydride transfer, formation of hydroxide ion and processes ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8036119

    authors: Bierbaum VM,Schmitt RJ,DePuy CH

    更新日期:1980-06-01 00:00:00

  • State-of-the-science workshop report: issues and approaches in low-dose-response extrapolation for environmental health risk assessment.

    abstract::Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component of the risk assessment process. At a workshop held in Baltimore, Maryland, on 23-24 April 2007, sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences and Public Policy Ins...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11502

    authors: White RH,Cote I,Zeise L,Fox M,Dominici F,Burke TA,White PD,Hattis DB,Samet JM

    更新日期:2009-02-01 00:00:00

  • Opportunities and Challenges for Personal Heat Exposure Research.

    abstract:BACKGROUND:Environmental heat exposure is a public health concern. The impacts of environmental heat on mortality and morbidity at the population scale are well documented, but little is known about specific exposures that individuals experience. OBJECTIVES:The first objective of this work was to catalyze discussion o...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP556

    authors: Kuras ER,Richardson MB,Calkins MM,Ebi KL,Hess JJ,Kintziger KW,Jagger MA,Middel A,Scott AA,Spector JT,Uejio CK,Vanos JK,Zaitchik BF,Gohlke JM,Hondula DM

    更新日期:2017-08-01 00:00:00

  • The characterization of upper-room ultraviolet germicidal irradiation in inactivating airborne microorganisms.

    abstract::In this study, we explored the efficacy of upper-room ultraviolet germicidal irradiation (UVGI) in reducing the concentration of Serratia marcescens and Mycobacterium bovis bacille Calmette-Guérin (BCG) aerosols in enclosed places. We constructed a facility (4.5 m x 3 m x 2.9 m) in which both ceiling- and wall-mounted...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0211095

    authors: Ko G,First MW,Burge HA

    更新日期:2002-01-01 00:00:00

  • Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis.

    abstract::Occupational exposures to mineral particles cause pneumoconiosis and other diseases, including cancer. Recent studies have suggested that reactive oxygen species (ROS) may play a key role in the mechanisms of disease initiation and progression following exposure to these particles. ROS-induced primary stimuli result i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.98106s51151

    authors: Vallyathan V,Shi X,Castranova V

    更新日期:1998-10-01 00:00:00

  • Differential cytotoxic effects of arsenic on human and animal cells.

    abstract::Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102s3101

    authors: Lee TC,Ho IC

    更新日期:1994-09-01 00:00:00

  • The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality.

    abstract::Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7234

    authors: Meeker JD,Ryan L,Barr DB,Herrick RF,Bennett DH,Bravo R,Hauser R

    更新日期:2004-12-01 00:00:00

  • A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study.

    abstract:BACKGROUND:The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES:We aimed to a) determine whether BPA showed effects on the developin...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP6301

    authors: Montévil M,Acevedo N,Schaeberle CM,Bharadwaj M,Fenton SE,Soto AM

    更新日期:2020-05-01 00:00:00

  • Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype.

    abstract::Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109833

    authors: Ahsan H,Wang LY,Chen CJ,Tsai WY,Santella RM

    更新日期:2001-08-01 00:00:00

  • The pyrethroid pesticide esfenvalerate suppresses the afternoon rise of luteinizing hormone and delays puberty in female rats.

    abstract:BACKGROUND:One of the most widely used classes of insecticides is the synthetic pyrethroids. Although pyrethroids are less acutely toxic to humans than to insects, in vitro studies have suggested that pyrethroids may be estrogenic. OBJECTIVES:We assessed pubertal effects by orally administering 0.5, 1.0, and 5.0 mg/kg...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11119

    authors: Pine MD,Hiney JK,Lee B,Dees WL

    更新日期:2008-09-01 00:00:00

  • Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study.

    abstract:BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9662

    authors: Lee WJ,Alavanja MC,Hoppin JA,Rusiecki JA,Kamel F,Blair A,Sandler DP

    更新日期:2007-04-01 00:00:00

  • Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy.

    abstract:BACKGROUND:Benzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Oc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0901531

    authors: Xing C,Marchetti F,Li G,Weldon RH,Kurtovich E,Young S,Schmid TE,Zhang L,Rappaport S,Waidyanatha S,Wyrobek AJ,Eskenazi B

    更新日期:2010-06-01 00:00:00

  • Nutritional considerations in designing animal models of metal toxicity in man.

    abstract::In recent years, exposure of man to increasing amounts of metals has occurred rather generally from industrial contamination and variably from intake of dietary mineral supplements. Adverse effects of individual metals can be markedly altered by dietary levels of other essential and nonessential inorganic elements, es...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7825137

    authors: Fox MR

    更新日期:1978-08-01 00:00:00

  • Personality traits in miners with past occupational elemental mercury exposure.

    abstract::In this study, we evaluated the impact of long-term occupational exposure to elemental mercury vapor (Hg0) on the personality traits of ex-mercury miners. Study groups included 53 ex-miners previously exposed to Hg0 and 53 age-matched controls. Miners and controls completed the self-reporting Eysenck Personality Quest...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7863

    authors: Kobal Grum D,Kobal AB,Arneric N,Horvat M,Zenko B,Dzeroski S,Osredkar J

    更新日期:2006-02-01 00:00:00

  • Aluminum in the environment and human health.

    abstract::The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7483

    authors: Sorenson JR,Campbell IR,Tepper LB,Lingg RD

    更新日期:1974-08-01 00:00:00

  • Physiological attributes of microbial BTEX degradation in oxygen-limited environments.

    abstract::Our work has focused on the determination of physiological traits that may facilitate in situ degradation of xenobiotic compounds by indigenous microorganisms. For this our interests center on the following questions: What are the ambient conditions in a benzene, toluene, ethylbenzene, and xylene (BTEX)-contaminated a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s449

    authors: Olsen RH,Mikesell MD,Kukor JJ,Byrne AM

    更新日期:1995-06-01 00:00:00

  • The role of specimen banking in risk assessment.

    abstract::The risk assessment process is described with a focus on the hazard identification and dose-response components. Many of the scientific questions and uncertainties associated with these components are discussed, and the role for biomarkers and specimen banking in supporting these activities are assessed. Under hazard ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.95103s39

    authors: Zenick H,Griffith J

    更新日期:1995-04-01 00:00:00

  • A study of acute respiratory disease in families exposed to different levels of Air pollution in the Great Salt Lake basin, Utah, 1971-1972 and 1972-1973.

    abstract::The reported incidence of acute respiratory illness in families exposed to different concentrations of air pollution was studied during two consecutive school years. The purpose of the study was to determine the effect of increased exposure to sulfur dioxide and suspended particulate matter. In each of four study comm...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8244165

    authors: Love GJ,Lan SP,Shy CM

    更新日期:1982-04-01 00:00:00

  • Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes.

    abstract:BACKGROUND:C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure. The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11922

    authors: Folkmann JK,Risom L,Jacobsen NR,Wallin H,Loft S,Møller P

    更新日期:2009-05-01 00:00:00

  • Bisphenol A and Dental Sealants: Olea's Response.

    abstract::Comments on "Determination of bisphenol A and related aromatic compounds released from Bis-GMA-based composites and sealants by high performance liquid chromatography." by ulgar R, Olea-Serrano MF, Novillo-Fertrell A, Rivas A, Pazos P, Pedraza V, Navajas J-M, Olea N. Environ Health Perspect 108:21-27 (2000). ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.108-a546a

    authors: Olea N

    更新日期:2000-12-01 00:00:00

  • Impact of current good manufacturing practices and emission regulations and guidances on the discharge of pharmaceutical chemicals into the environment from manufacturing, use, and disposal.

    abstract::The current Good Manufacturing Practice (cGMP) and effluent emission (use and disposal) regulations of the U.S. Food and Drug Administration (FDA) and manufacturing effluent discharge and emission regulations of the U.S. Environmental Protection Agency (U.S. EPA) require contained manufacture, use, and disposal of pha...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.02110213

    authors: Velagaleti R,Burns PK,Gill M,Prothro J

    更新日期:2002-03-01 00:00:00

  • Pulmonary toxicity of bleomycin.

    abstract::Diffuse pulmonary fibrosis is associated with bleomycin administration to humans. The sequential reactions of lung cells to this drug have now been investigated in mice following injection of 20 mg/kg bleomycin twice per week for 4 to 8 weeks. Cytoplasmic and subendothelial edema was first observed in large vessels an...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7616119

    authors: Adamson IY

    更新日期:1976-08-01 00:00:00

  • Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity.

    abstract::The role of cell-specific metabolism in benzene toxicity was examined in both murine and human bone marrow. Hemopoietic progenitor cells and stromal cells are important control points for regulation of hemopoiesis. We show that the selective toxicity of hydroquinone at the level of the macrophage in murine bone marrow...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.961041177

    authors: Ross D,Siegel D,Schattenberg DG,Sun XM,Moran JL

    更新日期:1996-12-01 00:00:00

  • Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study.

    abstract:BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP39

    authors: Béranger R,Garlantézec R,Le Maner-Idrissi G,Lacroix A,Rouget F,Trowbridge J,Warembourg C,Monfort C,Le Gléau F,Jourdin M,Multigner L,Cordier S,Chevrier C

    更新日期:2017-04-01 00:00:00

  • Use of geographic information system technology to aid Health Department decision making about childhood lead poisoning prevention activities.

    abstract::The Centers for Disease Control and Prevention recommend that local public health agencies use local data to identify children at risk for lead exposure to ensure that they receive preventive services. The objective of this study was to demonstrate the usefulness of a geographic information system (GIS) in identifying...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0110989

    authors: Reissman DB,Staley F,Curtis GB,Kaufmann RB

    更新日期:2001-01-01 00:00:00

  • Mechanisms associated with human alveolar macrophage stimulation by particulates.

    abstract::Asbestos and silica are well-known fibrogenic dusts. However, there is no comprehensive understanding of the molecular and cellular events that lead to fibrosis as a consequence of asbestos or silica inhalation. Previous studies have shown that asbestos stimulates superoxide anion production in alveolar macrophages th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102s1069

    authors: Holian A,Kelley K,Hamilton RF Jr

    更新日期:1994-12-01 00:00:00

  • Different slopes for different folks: socioeconomic and racial/ethnic disparities in asthma and hay fever among 173,859 U.S. men and women.

    abstract::Although allergic diseases such as asthma and hay fever are a major cause of morbidity in industrialized countries, most studies have focused on patterns of prevalence among children and adolescents, with relatively few studies on variations in prevalence by race/ethnicity and socioeconomic position among adults. Our ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110s2211

    authors: Chen JT,Krieger N,Van Den Eeden SK,Quesenberry CP

    更新日期:2002-04-01 00:00:00

  • Annoyance from transportation noise: relationships with exposure metrics DNL and DENL and their confidence intervals.

    abstract::We present a model of the distribution of noise annoyance with the mean varying as a function of the noise exposure. Day-night level (DNL) and day-evening-night level (DENL) were used as noise descriptors. Because the entire annoyance distribution has been modeled, any annoyance measure that summarizes this distributi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109409

    authors: Miedema HM,Oudshoorn CG

    更新日期:2001-04-01 00:00:00

  • Occurrence of cadmium in crabs (Cancer pagurus) and the isolation and properties of cadmium metallothionein.

    abstract::The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8665101

    authors: Overnell J

    更新日期:1986-03-01 00:00:00

  • Predictors of Indoor Radon Concentrations in Pennsylvania, 1989-2013.

    abstract:BACKGROUND:Radon is the second-leading cause of lung cancer worldwide. Most indoor exposure occurs by diffusion of soil gas. Radon is also found in well water, natural gas, and ambient air. Pennsylvania has high indoor radon concentrations; buildings are often tested during real estate transactions, with results report...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409014

    authors: Casey JA,Ogburn EL,Rasmussen SG,Irving JK,Pollak J,Locke PA,Schwartz BS

    更新日期:2015-11-01 00:00:00