Abstract:
BACKGROUND:Methylmercury (MeHg) may affect fetal growth; however, prior research often lacked assessment of mercury speciation, confounders, and interactions. OBJECTIVE:Our objective was to assess the relationship between MeHg and fetal growth as well as the potential for confounding or interaction of this relationship from speciated mercury, fatty acids, selenium, and sex. METHODS:This cross-sectional study includes 271 singletons born in Baltimore, Maryland, 2004-2005. Umbilical cord blood was analyzed for speciated mercury, serum omega-3 highly unsaturated fatty acids (n-3 HUFAs), and selenium. Multivariable linear regression models controlled for gestational age, birth weight, maternal age, parity, prepregnancy body mass index, smoking, hypertension, diabetes, selenium, n-3 HUFAs, and inorganic mercury (IHg). RESULTS:Geometric mean cord blood MeHg was 0.94 μg/L (95% CI: 0.84, 1.07). In adjusted models for ponderal index, βln(MeHg) = -0.045 (g/cm(3)) × 100 (95% CI: -0.084, -0.005). There was no evidence of a MeHg × sex interaction with ponderal index. Contrastingly, there was evidence of a MeHg × n-3 HUFAs interaction with birth length [among low n-3 HUFAs, βln(MeHg) = 0.40 cm, 95% CI: -0.02, 0.81; among high n-3 HUFAs, βln(MeHg) = -0.15, 95% CI: -0.54, 0.25; p-interaction = 0.048] and head circumference [among low n-3 HUFAs, βln(MeHg) = 0.01 cm, 95% CI: -0.27, 0.29; among high n-3 HUFAs, βln(MeHg) = -0.37, 95% CI: -0.63, -0.10; p-interaction = 0.042]. The association of MeHg with birth weight and ponderal index was affected by n-3 HUFAs, selenium, and IHg. For birth weight, βln(MeHg) without these variables was -16.8 g (95% CI: -75.0, 41.3) versus -29.7 (95% CI: -93.9, 34.6) with all covariates. Corresponding values for ponderal index were -0.030 (g/cm(3)) × 100 (95% CI: -0.065, 0.005) and -0.045 (95% CI: -0.084, -0005). CONCLUSION:We observed an association of increased MeHg with decreased ponderal index. There is evidence for interaction between MeHg and n-3 HUFAs; infants with higher MeHg and n-3 HUFAs had lower birth length and head circumference. These results should be verified with additional studies.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Wells EM,Herbstman JB,Lin YH,Jarrett J,Verdon CP,Ward C,Caldwell KL,Hibbeln JR,Witter FR,Halden RU,Goldman LRdoi
10.1289/ehp.1408596subject
Has Abstractpub_date
2016-03-01 00:00:00pages
373-9issue
3eissn
0091-6765issn
1552-9924journal_volume
124pub_type
杂志文章abstract::The marriage of toxicology and genomics has created not only opportunities but also novel informatics challenges. As with the larger field of gene expression analysis, toxicogenomics faces the problems of probe annotation and data comparison across different array platforms. Toxicogenomics studies are generally built ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.6697
更新日期:2004-03-01 00:00:00
abstract::The combination of cigarette smoke and high-level occupational asbestos exposure produces a synergistic increase in the incidence of lung cancer; however, smoking does not affect the incidence of mesothelioma. Here we present the results of tests of two theories that have been proposed to explain this phenomenon; name...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101326
更新日期:1993-09-01 00:00:00
abstract::This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106801
更新日期:1998-06-01 00:00:00
abstract::High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA) ] with no known historical cadmium contamination, we investiga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8763
更新日期:2006-06-01 00:00:00
abstract::Reproduction is essential for the continuation of the species and for life itself. In biological terms, living and reproducing are essentially one and the same. There is, therefore, no sharp division between identifying factors harmful to reproduction and identifying factors harmful to life or vice versa. Detection of...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s219
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Cadmium is a commonly occurring toxic food contaminant, but health consequences of early-life exposure are poorly understood. OBJECTIVES:We evaluated the associations between cadmium exposure and neurobehavioral development in preschool children. METHODS:In our population-based mother-child cohort study in...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104431
更新日期:2012-10-01 00:00:00
abstract::Population monitoring using methods of molecular epidemiology combined with reliable data on exposure is an extremely powerful approach to determine the effect of mutagens on human populations. Although human blood and urine have traditionally been used for biomonitoring, an increase in the use of placental and buccal...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.104-1469653
更新日期:1996-05-01 00:00:00
abstract::It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091237
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications. OBJECTIVE:We prospectively evaluated the associations of maternal air pollution exposure with markers of placental growth and function among 7,801 pregnant women in the Netherlands...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1204918
更新日期:2012-12-01 00:00:00
abstract::Risk assessment is a process often divided into the following steps: a) hazard identification, b) dose-response assessment, c) exposure assessment, and d) risk characterization. Regulatory toxicity studies usually are aimed at providing data for the first two steps. Human case reports, environmental research, and in v...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s1131
更新日期:1998-02-01 00:00:00
abstract::Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.877335
更新日期:1987-08-01 00:00:00
abstract::A biodosimetric approach to determine alpha-particle dose to the respiratory tract epithelium from known exposures to radon has been developed in the rat. Cytotoxicity assays have been used to obtain dose-conversion factors for cumulative exposures typical of those encountered by underground uranium miners. However, t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s4913
更新日期:1997-06-01 00:00:00
abstract::The National Center for Health Statistics (NCHS) conducts a variety of surveys designed to provide cross-sectional estimates of the prevalence of various factors measuring the health of Americans. When these cross-sectional estimates are put together and plotted over time, they provide a picture of the trends in the h...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8562267
更新日期:1985-10-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are important environmental contaminants, and their toxicity to wildlife and humans are of major concern. PCBs form persistent and abundant metabolites, PCB methyl sulfones, that accumulate in biota. We now report that certain hydroxylated PCB metabolites show a strong and selective ac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102464
更新日期:1994-05-01 00:00:00
abstract::The lymphocyte micronucleus assay was used to measure the average frequency of micronuclei in a population and thus assess genotoxic effects. Data from 174 persons give an average value of 16.4 +/- 7.3, and a slight age-dependence was observed. To detect combined environmental mutagen injuries the micronucleus assay w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.101-1521140
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104802
更新日期:2012-07-01 00:00:00
abstract::Although broad links between climatic factors and coccidioidomycosis have been established, the identification of simple and robust relationships linking climatic controls to seasonal timing and outbreaks of the disease has remained elusive. Using an adaptive data-oriented method for estimating date of exposure, in th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7786
更新日期:2005-06-01 00:00:00
abstract::The chlorinated hydrocarbons chloroform (CHCl3), 1,1-dichlorethane (1,1-DCE) and 1,2-dichloroethane (1,2-DCE) have been detected in finished drinking water. When administered to B6C3F1 mice by gavage in corn oil, these compounds have been shown to induce hepatic tumors. The present study examines the effect on liver t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866989
更新日期:1986-11-01 00:00:00
abstract::With the "graying of America," the prevalence of neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD) will make increasingly greater demands on Medicare/Medicaid resources, which will greatly strain the national economy. It is imperative that prevention and intervention strategies for t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::A previously healthy woman developed hypersensitivity pneumonitis of such severity that she required chronic systemic corticosteroid therapy for symptom control. Detailed investigation of her workplace and home environments revealed fungi in her typical suburban home, to which she had specific serum precipitating anti...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109979
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Accordingly, these agents may differ in their effects on specific brain circuits. OBJECTIVES:We gave parathion to neonatal rats [postnatal days (PNDs) 1-4], at daily...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11451
更新日期:2008-10-01 00:00:00
abstract::Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104s3489
更新日期:1996-05-01 00:00:00
abstract::Previously, we found that exposure of neonatal rats to chlorpyrifos (CPF) produced brain cell damage and loss, with resultant abnormalities of synaptic development. We used the same biomarkers to examine prenatal CPF treatment so as to define the critical period of vulnerability. One group of pregnant rats received CP...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.021101097
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206398
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stres...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0900907
更新日期:2010-01-01 00:00:00
abstract::Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s19
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Radon is the second-leading cause of lung cancer worldwide. Most indoor exposure occurs by diffusion of soil gas. Radon is also found in well water, natural gas, and ambient air. Pennsylvania has high indoor radon concentrations; buildings are often tested during real estate transactions, with results report...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409014
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Animal feeding practices in the United States have changed considerably over the past century. As large-scale, concentrated production methods have become the predominant model for animal husbandry, animal feeds have been modified to include ingredients ranging from rendered animals and animal waste to antibi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9760
更新日期:2007-05-01 00:00:00
abstract::Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.845725
更新日期:1984-08-01 00:00:00
abstract::Microarrays provide an unprecedented opportunity for comprehensive concurrent analysis of thousands of genes. The global analysis of the response of genes to a toxic insult (toxicogenomics), as opposed to the historical method of examining a few select genes, provides a more complete picture of toxicologically signifi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6709
更新日期:2004-03-01 00:00:00