Abstract:
:The type II cell plays an important role in the response of the alveolar epithelium after lung injury through its synthesis and secretion of pulmonary surfactant, and by acting as the stem cell for the replacement of damaged type I epithelial cells. The nonciliated bronchiolar epithelial (Clara) cell is thought to play a similar role during repair of the bronchiolar epithelium. Recent evidence has suggested that epithelial cells may participate in aspects of the inflammatory response and regulation of fibroblast growth during pulmonary fibrosis through the production of and response to specific growth factors and cytokines. The cellular and molecular responses of epithelial cells and how they lead to the progression of events that defines the pulmonary parenchymal response to a class of particles is unclear. We used particles differing in size, chemical composition, and fibrogenicity in vivo and in vitro to elucidate early changes in proinflammatory and profibrotic cytokine and antioxidant gene expression in lung cells. Early increases in mRNA and protein for the proinflammatory cytokines interleukin (IL)-1 beta, IL-6, and tumor necrosis factor alpha have been observed in epithelial cells following exposure. These are accompanied by changes in specific epithelial genes including surfactant protein C and Clara cell secretory protein. The data indicate that effects on the epithelium are due to direct interactions with particles, not a result of macrophage-derived mediators, and suggest a more significant role in the overall pulmonary response than previously suspected. These results suggest that type II cell growth factor production may be significant in the pathogenesis of pulmonary fibrosis.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Finkelstein JN,Johnston C,Barrett T,Oberdörster Gdoi
10.1289/ehp.97105s51179subject
Has Abstractpub_date
1997-09-01 00:00:00pages
1179-82eissn
0091-6765issn
1552-9924journal_volume
105 Suppl 5pub_type
杂志文章abstract::In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six ...
journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.8870
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pub_type: 杂志文章
doi:10.1289/ehp.7234
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pub_type: 杂志文章
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.85-1568334
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pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-04-01 00:00:00
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doi:10.1289/ehp.02110871
更新日期:2002-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8774153
更新日期:1987-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.845725
更新日期:1984-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8564309
更新日期:1985-12-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.98106127
更新日期:1998-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.761457
更新日期:1976-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.101-1521147
更新日期:1993-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.0900918
更新日期:2010-03-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1985-09-01 00:00:00
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更新日期:2014-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11927
更新日期:2009-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782337
更新日期:1978-04-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2008-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11922
更新日期:2009-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s3335
更新日期:1994-09-01 00:00:00
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更新日期:2016-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800121
更新日期:2009-04-01 00:00:00