Bacterial mutagenicity of pyrolysis tars produced from chloro-organic fuels.

abstract：:Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensi...

journal_title：Environmental health perspectives

authors： Benowitz NL

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg. OBJECTIVES:We investigated the protective effect of isothiocyanates, which are kno...

journal_title：Environmental health perspectives

authors： Toyama T,Shinkai Y,Yasutake A,Uchida K,Yamamoto M,Kumagai Y

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES:We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS:A total of 186 incide...

journal_title：Environmental health perspectives

authors： Pastor-Barriuso R,Fernández MF,Castaño-Vinyals G,Whelan D,Pérez-Gómez B,Llorca J,Villanueva CM,Guevara M,Molina-Molina JM,Artacho-Cordón F,Barriuso-Lapresa L,Tusquets I,Dierssen-Sotos T,Aragonés N,Olea N,Kogevinas M,Pollá

更新日期：2016-10-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...

journal_title：Environmental health perspectives

authors： Perera FP,Tang D,Rauh V,Lester K,Tsai WY,Tu YH,Weiss L,Hoepner L,King J,Del Priore G,Lederman SA

更新日期：2005-08-01 00:00:00

abstract：:A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...

journal_title：Environmental health perspectives

authors： Ernst M,Flesch-Janys D,Morgenstern I,Manz A

更新日期：1998-04-01 00:00:00

abstract：:In this study, we evaluated the impact of long-term occupational exposure to elemental mercury vapor (Hg0) on the personality traits of ex-mercury miners. Study groups included 53 ex-miners previously exposed to Hg0 and 53 age-matched controls. Miners and controls completed the self-reporting Eysenck Personality Quest...

journal_title：Environmental health perspectives

authors： Kobal Grum D,Kobal AB,Arneric N,Horvat M,Zenko B,Dzeroski S,Osredkar J

更新日期：2006-02-01 00:00:00

abstract：:The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...

journal_title：Environmental health perspectives

authors： Calabrese EJ

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Discoveries that emerging and re-emerging pathogens have their origin in environmental change has created an urgent need to understand how these environmental changes impact disease burden. In this article we present a framework that provides a context from which to examine the relationship between environme...

journal_title：Environmental health perspectives

authors： Eisenberg JN,Desai MA,Levy K,Bates SJ,Liang S,Naumoff K,Scott JC

更新日期：2007-08-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. However, results from our laboratory and others indicate that AChE has an extrasynaptic, noncholinergic role during neural development. This article is a review of our findi...

journal_title：Environmental health perspectives

authors： Bigbee JW,Sharma KV,Gupta JJ,Dupree JL

更新日期：1999-02-01 00:00:00

abstract：:Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...

journal_title：Environmental health perspectives

authors： Medinsky MA,Sabourin PJ,Henderson RF,Lucier G,Birnbaum LS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Exposure mixtures frequently occur in data across many domains, particularly in the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer questions about exposure mixtures, including methods such as weighted quantile sum (WQS) regression that estimate a joint effect o...

journal_title：Environmental health perspectives

authors： Keil AP,Buckley JP,O'Brien KM,Ferguson KK,Zhao S,White AJ

更新日期：2020-04-01 00:00:00

abstract：:The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...

journal_title：Environmental health perspectives

authors： Morris RD,Naumova EN

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied. OBJECTIVES:We investigated the prevalence, risk factors, and dri...

journal_title：Environmental health perspectives

authors： Li J,Bi Z,Ma S,Chen B,Cai C,He J,Schwarz S,Sun C,Zhou Y,Yin J,Hulth A,Wang Y,Shen Z,Wang S,Wu C,Nilsson LE,Walsh TR,Börjesson S,Shen J,Sun Q,Wang Y

更新日期：2019-10-01 00:00:00

abstract：:An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental...

journal_title：Environmental health perspectives

authors： Faustman EM,Silbernagel SM,Fenske RA,Burbacher TM,Ponce RA

更新日期：2000-03-01 00:00:00

abstract：:To evaluate the effectiveness of mass screening for uterine cancer in Japan, we compared the changes in the age-adjusted rates of potential years of life lost (PYLL) due to uterine cancer between 1969 and 1972 to 1973 through 1977 between the high coverage-rate (intensively screened) areas and the comparable control a...

journal_title：Environmental health perspectives

authors： Kuroishi T,Hirose K,Tominaga S

更新日期：1990-07-01 00:00:00

abstract：:Over the past decade much information has been published on the analysis of organics extracted from treated water. Certain of these organics have been shown to be by-products of the chlorination disinfection process and to possess harmful effects at high concentrations. This has resulted in increased interest in alter...

journal_title：Environmental health perspectives

authors： Watts CD,Crathorne B,Fielding M,Killops SD

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:When conducting research with American Indian tribes, informed consent beyond conventional institutional review board (IRB) review is needed because of the potential for adverse consequences at a community or governmental level that are unrecognized by academic researchers. OBJECTIVES:In this article, we re...

journal_title：Environmental health perspectives

authors： Harding A,Harper B,Stone D,O'Neill C,Berger P,Harris S,Donatuto J

更新日期：2012-01-01 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...

journal_title：Environmental health perspectives

authors： Johnson MD,Housey GM,O'Brian CA,Kirschmeier PT,Weinstein IB

更新日期：1987-12-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Exposure to flame retardants has been associated with negative health outcomes including metabolic effects. As polybrominated diphenyl ether flame retardants were pulled from commerce, human exposure to new flame retardants such as Firemaster® 550 (FM550) has increased. Although previous studies in murine sy...

journal_title：Environmental health perspectives

authors： Tung EWY,Peshdary V,Gagné R,Rowan-Carroll A,Yauk CL,Boudreau A,Atlas E

更新日期：2017-09-14 00:00:00

abstract：:Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to ...

journal_title：Environmental health perspectives

authors： Wartenberg D,Reyner D,Scott CS

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Exposure to organophosphate (OP) pesticides is an occupational hazard for farmworkers and affects their children through the take-home pathway. OBJECTIVES:We examined the effectiveness of a randomized community intervention to reduce pesticide exposure among farmworkers and their children. METHODS:We condu...

journal_title：Environmental health perspectives

authors： Thompson B,Coronado GD,Vigoren EM,Griffith WC,Fenske RA,Kissel JC,Shirai JH,Faustman EM

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:National disparities in asbestos use will likely lead to an unequal burden of asbestos diseases. OBJECTIVES:As economic status may be linked to asbestos use, we assessed, globally, the relationship between indicators of national economic development and asbestos use. METHODS:For the 135 countries that have...

journal_title：Environmental health perspectives

authors： Le GV,Takahashi K,Karjalainen A,Delgermaa V,Hoshuyama T,Miyamura Y,Furuya S,Higashi T,Pan G,Wagner G

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Nearly all China's rural residents and a shrinking fraction of urban residents use solid fuels (biomass and coal) for household cooking and/or heating. Consequently, global meta-analyses of epidemiologic studies indicate that indoor air pollution from solid fuel use in China is responsible for approximately 4...

journal_title：Environmental health perspectives

authors： Zhang JJ,Smith KR

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...

journal_title：Environmental health perspectives

authors： Lassen TH,Frederiksen H,Jensen TK,Petersen JH,Joensen UN,Main KM,Skakkebaek NE,Juul A,Jørgensen N,Andersson AM

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Adapting to extreme heat is becoming more critical as our climate changes. Previous research reveals that very few communities in the United States have programs to sufficiently prevent health problems during hot weather. OBJECTIVE:Our goal was to examine county-level local heat preparedness and response in...

journal_title：Environmental health perspectives

authors： White-Newsome JL,Ekwurzel B,Baer-Schultz M,Ebi KL,O'Neill MS,Anderson GB

更新日期：2014-06-01 00:00:00

abstract：:A series of experiments is described in which operant methodology is used to study the effects of drugs on "learning." Emphasis is placed on the technique of repeated acquisition as a behavioral baseline for studying this type of transition state. In this technique, each subject is required to learn a new discriminati...

journal_title：Environmental health perspectives

authors： Thompson DM,Moerschbaecher JM

更新日期：1978-10-01 00:00:00

abstract：:An association between human illness and exposure to Pfiesteria was first observed among laboratory personnel working with the microorganism. In 1997, in the setting of Pfiesteria activity on the Pocomoke River in Maryland, difficulties with learning and memory were epidemiologically associated with high-level exposur...

journal_title：Environmental health perspectives

authors： Morris JG Jr

更新日期：2001-10-01 00:00:00

abstract：:The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no p...

journal_title：Environmental health perspectives

authors： Radford EP

更新日期：1981-12-01 00:00:00

abstract：:Principles and practices of pediatric neurotoxicology are reviewed here with the purpose of guiding the design and execution of the planned National Children's Study. The developing human central nervous system is the target organ most vulnerable to environmental chemicals. An investigation of the effects of environme...

journal_title：Environmental health perspectives

authors： Dietrich KN,Eskenazi B,Schantz S,Yolton K,Rauh VA,Johnson CB,Alkon A,Canfield RL,Pessah IN,Berman RF

更新日期：2005-10-01 00:00:00