Dose-dependent fate of vinyl chloride and its possible relationship to oncogenicity in rats.

abstract：:The U.S. Environmental Protection Agency is under a congressional mandate to revise its current standard for arsenic in drinking water. We present a risk assessment for cancers of the bladder, liver, and lung from exposure to arsenic in water, based on data from 42 villages in an arseniasis-endemic region of Taiwan. W...

journal_title：Environmental health perspectives

authors： Morales KH,Ryan L,Kuo TL,Wu MM,Chen CJ

更新日期：2000-07-01 00:00:00

abstract：:We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...

journal_title：Environmental health perspectives

authors： Wilhelm M,Ritz B

更新日期：2005-09-01 00:00:00

abstract：:The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of e...

journal_title：Environmental health perspectives

authors： Krewski D,Withey JR,Ku LF,Andersen ME

更新日期：1994-12-01 00:00:00

abstract：:Several examples of categorized data from epidemiological studies are analyzed to illustrate that more informative analysis than tests of independence can be performed by fitting models. All of the analyses fit into a unified conceptual framework that can be performed by weighted least squares. The methods presented s...

journal_title：Environmental health perspectives

authors： Grizzle JE,Koch GG

更新日期：1979-10-01 00:00:00

abstract：:Reproduction is essential for the continuation of the species and for life itself. In biological terms, living and reproducing are essentially one and the same. There is, therefore, no sharp division between identifying factors harmful to reproduction and identifying factors harmful to life or vice versa. Detection of...

journal_title：Environmental health perspectives

authors： Palmer AK

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain devel...

journal_title：Environmental health perspectives

authors： Chevrier J,Gunier RB,Bradman A,Holland NT,Calafat AM,Eskenazi B,Harley KG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particl...

journal_title：Environmental health perspectives

authors： Puett RC,Hart JE,Yanosky JD,Paciorek C,Schwartz J,Suh H,Speizer FE,Laden F

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in ...

journal_title：Environmental health perspectives

authors： Halldorsson TI,Rytter D,Haug LS,Bech BH,Danielsen I,Becher G,Henriksen TB,Olsen SF

更新日期：2012-05-01 00:00:00

abstract：:The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics ...

journal_title：Environmental health perspectives

authors： Danzo BJ

更新日期：1997-03-01 00:00:00

abstract：:Stable associations of syntrophic fermentative organisms and populations that consume fermentation products play key roles in the anaerobic biodegradation of chlorinated organic contaminants. The involvement of these syntrophic populations is essential for mineralization of chlorinated aromatic compounds under methano...

journal_title：Environmental health perspectives

authors： Becker JG,Berardesco G,Rittmann BE,Stahl DA

更新日期：2005-03-01 00:00:00

abstract：:A brief overview is given of the sources, characteristics, and toxic constituents of municipal solid wastes. Several methods are presented for handling, treating, and disposal of solid wastes. Monitoring the landfill site is necessary; there has been a trend to recognize that municipal solid wastes may be hazardous an...

journal_title：Environmental health perspectives

authors： Stone R

更新日期：1978-12-01 00:00:00

abstract：:The formamidines, a relatively new group of acaricide-insecticides, are novel both in their range of biological activities and in their mode of action, which is presently unknown. This paper is a review of the historical development, properties, structures, uses, and chemistry of this group of pesticides, with particu...

journal_title：Environmental health perspectives

authors： Hollingworth RM

更新日期：1976-04-01 00:00:00

abstract：:The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...

journal_title：Environmental health perspectives

authors： Rosenkranz HS

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a...

journal_title：Environmental health perspectives

authors： Liu Y,Wu F

更新日期：2010-06-01 00:00:00

abstract：:Dietary components express a wide range of activities that can affect carcinogenesis. Naturally occurring substances in foods have been shown in laboratory experiments to serve as dietary antimutagens, either as bioantimutagens or as desmutagens. Dietary desmutagens may function as chemical inactivaters, enzymatic ind...

journal_title：Environmental health perspectives

authors： Kohlmeier L,Simonsen N,Mottus K

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The Marcellus Shale is a vast natural gas field underlying parts of Pennsylvania, New York, West Virginia, Virginia, and Maryland. Rapid development of this field has been enabled by advances in hydrofracking techniques that include injection of chemical and physical agents deep underground. Response to publ...

journal_title：Environmental health perspectives

authors： Goldstein BD,Kriesky J,Pavliakova B

更新日期：2012-04-01 00:00:00

abstract：:Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are...

journal_title：Environmental health perspectives

authors： Rais-Bahrami K,Nunez S,Revenis ME,Luban NL,Short BL

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

journal_title：Environmental health perspectives

authors： Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Millions of people worldwide consume arsenic-contaminated rice; however, little is known about the uptake and bioavailability of arsenic species after arsenic-contaminated rice ingestion. OBJECTIVES:In this study, we assessed arsenic speciation in greenhouse-grown and supermarket-bought rice, and determined...

journal_title：Environmental health perspectives

authors： Juhasz AL,Smith E,Weber J,Rees M,Rofe A,Kuchel T,Sansom L,Naidu R

更新日期：2006-12-01 00:00:00

abstract：:Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

journal_title：Environmental health perspectives

authors： Buffler PA,Crane M,Key MM

更新日期：1985-10-01 00:00:00

abstract：:Inspection of the available literature reveals that a detailed investigation of the aqueous organic chemistry of chlorine dioxide and systematic identification of products formed during water disinfection has not been considered. This must be done before an informed assessment can be made of the relative safety of usi...

journal_title：Environmental health perspectives

authors： Stevens AA

更新日期：1982-12-01 00:00:00

abstract：:Possible effects of Chernobyl fallout on outcome of pregnancy in Finland were evaluated in a nationwide follow-up study. The outcomes were the rate of live births and stillbirths, pregnancy loss, and induced abortions by municipality. Exposure was assessed based on nationwide surveys of radiation dose rate from the Ch...

journal_title：Environmental health perspectives

authors： Auvinen A,Vahteristo M,Arvela H,Suomela M,Rahola T,Hakama M,Rytömaa T

更新日期：2001-02-01 00:00:00

abstract：:Cooking, heat processing, or pyrolysis of protein-rich foods induce the formation of a series of structurally related heterocyclic aromatic bases that have been found to be mutagens. The primary genetic assay utilized to detect and isolate these mutagens has been the his reversion assay in Salmonella typhimurium. The ...

journal_title：Environmental health perspectives

authors： Hatch FT

更新日期：1986-08-01 00:00:00

abstract：:High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA) ] with no known historical cadmium contamination, we investiga...

journal_title：Environmental health perspectives

authors： Akesson A,Bjellerup P,Lundh T,Lidfeldt J,Nerbrand C,Samsioe G,Skerfving S,Vahter M

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Extreme heat events (EHEs) are increasing in frequency in large U.S. cities and are responsible for a greater annual number of climate-related fatalities, on average, than any other form of extreme weather. In addition, low-density, sprawling patterns of urban development have been associated with enhanced s...

journal_title：Environmental health perspectives

authors： Stone B,Hess JJ,Frumkin H

更新日期：2010-10-01 00:00:00

abstract：:This paper addresses the subject of the use of selected toxicology information resources in assessing relationships between chemical structure and specific biological end points. To assist the researcher in how to access the primary literature of genetic toxicology, teratogenesis, and carcinogenesis, three specific sp...

journal_title：Environmental health perspectives

authors： Wassom JS

更新日期：1985-09-01 00:00:00

abstract：:Pavlovian conditioning processes may contribute to some symptoms of multiple chemical sensitivity (MCS). This review summarizes the potential relevance of the literature on conditional taste and olfactory aversions, conditional sensitization, and conditional immunomodulation to understanding MCS. A conditioning-based ...

journal_title：Environmental health perspectives

authors： Siegel S,Kreutzer R

更新日期：1997-03-01 00:00:00

abstract：:Restriction-fragment-length polymorphism analysis was performed on several different types of human cancers, including carcinoma of the uterine cervix, neuroblastoma, hepatocellular carcinoma, pheochromocytoma, stomach cancer, and small-cell lung carcinoma (SCLC), to determine the chromosomal loci of putative tumor-su...

journal_title：Environmental health perspectives

authors： Yokota J,Sugimura T,Terada M

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise polluti...

journal_title：Environmental health perspectives

authors： Hammer MS,Swinburn TK,Neitzel RL

更新日期：2014-02-01 00:00:00

abstract：:Previously, we found that exposure of neonatal rats to chlorpyrifos (CPF) produced brain cell damage and loss, with resultant abnormalities of synaptic development. We used the same biomarkers to examine prenatal CPF treatment so as to define the critical period of vulnerability. One group of pregnant rats received CP...

journal_title：Environmental health perspectives

authors： Qiao D,Seidler FJ,Padilla S,Slotkin TA

更新日期：2002-11-01 00:00:00