Abstract:
BACKGROUND:Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. OBJECTIVE:We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures. METHODS:Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs), and 36 polychlorinated biphenyls (PCBs) were measured before conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-SD increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal prepregnancy body mass index (kilograms per meter squared) and other confounders, and all models included an interaction term between infant sex and each chemical. RESULTS:Among girls (n = 117), birth weight was significantly lower (range, 84-195 g) in association with a 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183, and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs 138, 153, 167, 170, 195, and 209 and perfluorooctane sulfonamide) and paternal (PCBs 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range, 98-170 g), whereas paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures. CONCLUSIONS:Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Robledo CA,Yeung E,Mendola P,Sundaram R,Maisog J,Sweeney AM,Barr DB,Louis GMdoi
10.1289/ehp.1308016subject
Has Abstractpub_date
2015-01-01 00:00:00pages
88-94issue
1eissn
0091-6765issn
1552-9924journal_volume
123pub_type
杂志文章abstract::Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.877581
更新日期:1987-11-01 00:00:00
abstract::U.S. chemical plants currently have potentially catastrophic vulnerabilities as terrorist targets. The possible consequences of these vulnerabilities echo from the tragedies of the Bhopal incident in 1984 to the terrorist attacks on 11 September 2001 and, most recently, Hurricanes Katrina and Rita. Findings from a 200...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8762
更新日期:2006-09-01 00:00:00
abstract::The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8351189
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307309
更新日期:2014-05-01 00:00:00
abstract::Many naturally occurring and man-made chemicals present in the environment possess estrogenic activity. Examples include plant and fungal products, pesticides, plasticizers, and other agricultural and industrial chemicals. These environmental estrogens as well as endogenous ovarian estrogens are thought to initiate th...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s729
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants and are becoming a ubiquitous environmental contaminant. Adverse effects in the developing brain are of great health concern. OBJECTIVE:We investigated the effect of PBDEs/hydroxylated PBDEs (OH-PBDEs) on thyroid hormone (TH) receptor...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002065
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11927
更新日期:2009-01-01 00:00:00
abstract::Reproduction is essential for the continuation of the species and for life itself. In biological terms, living and reproducing are essentially one and the same. There is, therefore, no sharp division between identifying factors harmful to reproduction and identifying factors harmful to life or vice versa. Detection of...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s219
更新日期:1993-07-01 00:00:00
abstract::A wide range of chemicals with diverse structures derived from plant and environmental origins are reported to have hormonal activity. The potential for appreciable exposure of humans to such substances prompts the need to develop sensitive screening methods to quantitate and evaluate the risk to the public. Yeast cel...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105734
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains a global public health problem. Health risks persist after As exposure has ended, suggesting epigenetic dysregulation as a mechanistic link between exposure and health outcomes. OBJECTIVES:We investigated the association between tota...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6263
更新日期:2020-06-01 00:00:00
abstract::Over 250 adults and children were exposed to chlordane when the wooden building surfaces and soil around an apartment complex were sprayed in 1987. Two hundred-sixteen adults had neurobehavioral functions measured and completed questionnaires for symptom frequency, mood status, confounding factors, and medical, rheuma...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103690
更新日期:1995-07-01 00:00:00
abstract::Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.111-1241299
更新日期:2003-01-01 00:00:00
abstract::Previous studies in our laboratory demonstrated that high-performance liquid chromatography (HPLC) analysis of ground corncob bedding extracts characterized two components (peak I and peak II) that disrupted endocrine function in male and female rats and stimulated breast and prostate cancer cell proliferation in vitr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8231
更新日期:2005-12-01 00:00:00
abstract::It was considered that the fall in lung function seen after exposure to cotton dust may be attributable in part to the activity of arachidonic acid metabolites, such as leucotrienes as well as to the more established release of histamine by cotton dust. However, we found that cotton and barley dusts elicited poor rele...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866687
更新日期:1986-04-01 00:00:00
abstract::The gas phase reactions of carbanions with molecular oxygen in both its ground state (X3 sigma g-) and first electronically excited state (a1 delta g) have been studied by the flowing afterglow technique. Reactions include cleavage processes, charge transfer, hydride transfer, formation of hydroxide ion and processes ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8036119
更新日期:1980-06-01 00:00:00
abstract::Chlorination has been the major strategy for disinfection of drinking water in the United States. Concern about the potential health effects of the reaction by-products of chlorine has prompted use of alternative strategies. One such method is chloramination, a treatment process that does not appear to have carcinogen...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8669275
更新日期:1986-11-01 00:00:00
abstract::Animal studies and small studies in humans have shown that uranium is nephrotoxic. However, more information about its renal effects in humans following chronic exposure through drinking water is required. We measured uranium concentrations in drinking water and urine in 325 persons who had used drilled wells for drin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110337
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901200
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Understanding the potential links between extreme weather events and human health in India is important in the context of vulnerability and adaptation to climate change. Research exploring such linkages in India is sparse. OBJECTIVES:We evaluated the association between extreme precipitation and gastrointes...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1306807
更新日期:2014-03-01 00:00:00
abstract::Martineau et al. (2002) reported that St. Lawrence beluga (SLB) have high cancer rates. Unfortunately, errors in their interpretation of the data have led them to overstate the importance of cancer and its links to environmental sources. ...
journal_title:Environmental health perspectives
pub_type: 评论,信件
doi:10.1289/ehp.111-a77c
更新日期:2003-02-01 00:00:00
abstract::The Lower North Shore region of the St. Lawrence River is home to a fish-eating population that displays an unusually high body burden of several organochlorines, including polychlorinated biphenyls (PCBs) and dioxin-like compounds (DLCs). We measured biomarkers indicative of liver enzyme induction and investigated th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7970
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6334
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:In the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates. OBJECTIVES:We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9337
更新日期:2006-10-01 00:00:00
abstract::Organophosphate (OP) pesticides are commonly used in the United States, and farmworkers are at risk for chronic exposure. Using a sample of 218 farmworkers in 24 communities and labor camps in eastern Washington State, we examined the association between agricultural crop and OP pesticide metabolite concentrations in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8620
更新日期:2006-07-01 00:00:00
abstract::Carbon monoxide is widely distributed in the environment, and acute or chronic toxic effects may be of considerable public health significance. A review of the basis for current ambient standards is given. Mortality and morbidity studies have been negative or equivocal in relating carbon monoxide levels to health effe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352131
更新日期:1983-10-01 00:00:00
abstract::The current Good Manufacturing Practice (cGMP) and effluent emission (use and disposal) regulations of the U.S. Food and Drug Administration (FDA) and manufacturing effluent discharge and emission regulations of the U.S. Environmental Protection Agency (U.S. EPA) require contained manufacture, use, and disposal of pha...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110213
更新日期:2002-03-01 00:00:00
abstract::We conducted a 1-year epidemiologic study in Boston, Massachusetts, beginning May 1997, to examine the associations between environmental factors and office workers' health. We recruited 98 subjects (81 females and 17 males) in 21 offices in four office buildings. We conducted environmental sampling every 6 weeks and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5697
更新日期:2003-07-01 00:00:00
abstract::A co-culture clonal survival assay was developed to measure the cytotoxicity of test chemical treatments to BALB/c-3T3 cells because the standard clonal survival assay using 200 wild type (WT) cells frequently overestimates chemical cytotoxicity when compared with identical treatment doses in high-density cultures. Th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s2311
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to identify mental, behavioral, and cognitive disorders that may be triggered or exacerbated during heat waves, predisposing individuals to heat-related morbidity and mortality. DESIGN:Using health outcome data from Adelaide, South Australia, for 1993-2006, we estimated the effect ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11339
更新日期:2008-10-01 00:00:00
abstract::We tested the hypothesis that exposure of healthy volunteers to concentrated ambient air particles (CAPS) between 0.1 and 2.5 microm in diameter is associated with modulation of human alveolar macrophage (AM) function, cytokine production, and immune phenotype in both blood and lung. Thirty-eight volunteers were expos...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s4599
更新日期:2001-08-01 00:00:00