当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Protective immunity provided by HLA-A2 epitopes for fusion and hemagglutinin proteins of measles virus.

Protective immunity provided by HLA-A2 epitopes for fusion and hemagglutinin proteins of measles virus.

Abstract：

:Natural infection and vaccination with a live-attenuated measles virus (MV) induce CD8(+) T-cell-mediated immune responses that may play a central role in controlling MV infection. In this study, we show that newly identified human HLA-A2 epitopes from MV hemagglutinin (H) and fusion (F) proteins induced protective immunity in HLA-A2 transgenic mice challenged with recombinant vaccinia viruses expressing F or H protein. HLA-A2 epitopes were predicted and synthesized. Five and four peptides from H and F, respectively, bound to HLA-A2 molecules in a T2-binding assay, and four from H and two from F could induce peptide-specific CD8+ T cell responses in HLA-A2 transgenic mice. Further experiments proved that three peptides from H (H9-567, H10-250, and H10-516) and one from F protein (F9-57) were endogenously processed and presented on HLA-A2 molecules. All peptides tested in this study are common to 5 different strains of MV including Edmonston. In both A2K(b) and HHD-2 mice, the identified peptide epitopes induced protective immunity against recombinant vaccinia viruses expressing H or F. Because F and H proteins induce neutralizing antibodies, they are major components of new vaccine strategies, and therefore data from this study will contribute to the development of new vaccines against MV infection.

journal_name

Virology

journal_title

Virology

authors

Oh S,Stegman B,Pendleton CD,Ota MO,Pan CH,Griffin DE,Burke DS,Berzofsky JA

doi

10.1016/j.virol.2006.04.040

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

390-9

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(06)00304-7

journal_volume

352

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA.

    abstract：:The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR. Analysis of the nucleotide sequence revealed the presence of a long open reading frame of 1944 nucleotides that is capable of encoding...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90147-3

    authors： Cohen M,Powers M,O'Connell C,Kato N

    更新日期：1985-12-01 00:00:00

  • Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line.

    abstract：:Hepatitis C virus (HCV) core protein is a multifunctional protein interacting with cellular and viral proteins and promoters. A tetracycline-regulated system was used to generate a HepG2 Tet-Off cell line allowing regulated expression of a full-length (191 aa) and an N(c)-truncated core protein (160 aa). In this syste...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1227

    authors： Erhardt A,Hassan M,Heintges T,Häussinger D

    更新日期：2002-01-20 00:00:00

  • The predicted primary structure of the measles virus hemagglutinin.

    abstract：:The complete nucleotide sequence of cloned cDNAs corresponding to the full length of the mRNA encoding the measles virus hemagglutinin (H) protein has been determined. the mRNA contains a single large open reading frame which is capable of encoding a protein of 617 amino acids with a molecular mass of 69,250 Da. The d...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90312-0

    authors： Alkhatib G,Briedis DJ

    更新日期：1986-04-30 00:00:00

  • Assembly of influenza ribonucleoprotein in vitro using recombinant nucleoprotein.

    abstract：:The influenza A virus nucleoprotein previously expressed in Escherichia coli after fusion to 32 heterologous amino acids has now been purified and tested for its ability to form complexes with RNA in vitro. By using a simple filter binding assay, we show that ribonucleoprotein (RNP) complexes form readily with single-...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90419-3

    authors： Kingsbury DW,Jones IM,Murti KG

    更新日期：1987-02-01 00:00:00

  • Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G(2) arrest of the cell cycle.

    abstract：:The HIV-1 accessory gene product Vpr can inhibit cell proliferation via cell cycle arrest at the G(2) phase, and it can induce apoptosis after G(2) arrest. We found recently that C81, a carboxy-terminally truncated form of Vpr, induced apoptosis via G(1) arrest but did not induce G(2) arrest of the cell cycle. Thus, i...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0534

    authors： Nishizawa M,Kamata M,Mojin T,Nakai Y,Aida Y

    更新日期：2000-10-10 00:00:00

  • Foot-and-mouth disease virus protease 3C inhibits cellular transcription and mediates cleavage of histone H3.

    abstract：:Foot-and-mouth disease virus protease 3C is essential for the processing of the viral precursor polyprotein. It is shown here to also inhibit gene expression in baby hamster kidney cells after transient expression from transfected cDNA fragments. Protease 3C could not be detected by indirect immunofluorescence in cont...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90090-e

    authors： Tesar M,Marquardt O

    更新日期：1990-02-01 00:00:00

  • Outer nuclear membrane fusion of adjacent nuclei in varicella-zoster virus-induced syncytia.

    abstract：:Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.09.002

    authors： Wang W,Yang L,Huang X,Fu W,Pan D,Cai L,Ye J,Liu J,Xia N,Cheng T,Zhu H

    更新日期：2017-12-01 00:00:00

  • Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques.

    abstract：:The vaginal and rectal mucosae are the first line of cellular immune defense to sexually transmitted human immunodeficiency virus type 1 (HIV-1) entry. Thus, intraepithelial lymphocytes (IELs) may be important in the immune response to HIV infection. Here we investigated whether functional IELs in mucosal compartments...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.08.046

    authors： Stevceva L,Moniuszko M,Alvarez X,Lackner AA,Franchini G

    更新日期：2004-02-20 00:00:00

  • Distinctive kinetics of the antibody-forming cell response to Sendai virus infection of mice in different anatomical compartments.

    abstract：:The single-cell ELISPOT assay was used to determine the frequency and isotype commitment of virus-specific antibody-forming cells (AFC) at different anatomical locations following intranasal Sendai virus infection of C57BL/6 and 129/Sv mice. AFC responses in the mediastinal and cervical lymph nodes showed sharp increa...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1079

    authors： Sangster M,Hyland L,Sealy R,Coleclough C

    更新日期：1995-02-20 00:00:00

  • Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome.

    abstract：:Viral functions essential for the establishment of latent infection in murine sensory neurons in vivo were investigated by employing a herpes simplex virus type 1 (HSV-1) variant (KD6/B11) deleted for expression of the ICP4 gene and therefore unable to replicate. Since the viral DNA persisted in these cells, the laten...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1089

    authors： Sedarati F,Margolis TP,Stevens JG

    更新日期：1993-02-01 00:00:00

  • Maintenance of human cytomegalovirus genome in human diploid fibroblast cells.

    abstract：:Human embryo lung cells pretreated with a combination of human leukocyte interferon and acyclovir were infected with human cytomegalovirus (HCMV) and treated daily for 14 days with the same inhibitor combination. After removal of the inhibitors, the incubation temperature was maintained at either 37 or 40.5 degrees. I...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90139-3

    authors： Bucher LJ,Wigdahl B,Rapp F

    更新日期：1983-10-15 00:00:00

  • Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particles.

    abstract：:The protruding (P) domain of norovirus VP1 is responsible for immune recognition and host receptor interaction. Our previous studies have demonstrated that a modification of the ends of the P domain affects the conformation and/or function of the P protein. An expression of the P domain with or without the hinge, or w...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.11.017

    authors： Tan M,Fang PA,Xia M,Chachiyo T,Jiang W,Jiang X

    更新日期：2011-02-20 00:00:00

  • Cooperative interactions between bacteriophage P2 integrase and its accessory factors IHF and Cox.

    abstract：:Bacteriophage P2 integrase (Int) mediates site-specific recombination leading to integration or excision of the phage genome in or out of the bacterial chromosome. Int belongs to the large family of tyrosine recombinases that have two different DNA recognition motifs binding to the arm and core sites, respectively, wh...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.11.015

    authors： Frumerie C,Sylwan L,Ahlgren-Berg A,Haggård-Ljungquist E

    更新日期：2005-02-05 00:00:00

  • Finding our roots and celebrating our shoots: Plant virology in Virology, 1955-1964.

    abstract：:To celebrate the sixtieth anniversary of Virology a survey is made of the plant viruses, virologists and their institutions, and tools and technology described in the first decade of plant virus publications in Virology. This was a period when plant viruses increasingly became tools of discovery as epistemic objects a...

    journal_title：Virology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.virol.2015.03.019

    authors： Scholthof KB

    更新日期：2015-05-01 00:00:00

  • Complete nucleotide sequences of 5'- and 3'-noncoding regions of both genome segments of different strains of infectious bursal disease virus.

    abstract：:The terminal sequences of both genomic dsRNA segments of different strains of infectious bursal disease virus were determined. Analysis of the linear sequences revealed in the 5'-noncoding region of both segments the presence of a 32-nucleotide sequence with motifs conserved between segments and serotypes. The 3'-nonc...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1226

    authors： Mundt E,Müller H

    更新日期：1995-05-10 00:00:00

  • Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivo.

    abstract：:The envelope (E) protein of dengue virus (DENV) is composed of three domains (EDI, EDII, EDIII) and is the main target of neutralizing antibodies. Many monoclonal antibodies that bind EDIII strongly neutralize DENV. However in vitro studies indicate that anti-EDIII antibodies contribute little to the neutralizing pote...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2012.03.003

    authors： Williams KL,Wahala WM,Orozco S,de Silva AM,Harris E

    更新日期：2012-07-20 00:00:00

  • The herpes simplex virus type 2 equivalent of the herpes simplex virus type 1 US7 gene and its flanking sequences.

    abstract：:Nucleotide sequencing studies (D. J. McGeoch, A. Dolan, S. Donald, and F. Rixon, 1985, J. Mol. Biol. 181, 1-14) have indicated that herpes simplex virus type 1 (HSV-1) has a coding sequence, referred to as US7, between the genes for the glycoproteins D and E (gD and gE). Northern blot analysis and nucleotide sequencin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90002-4

    authors： Hodgman TC,Minson AC

    更新日期：1986-08-01 00:00:00

  • Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.

    abstract：:Many tumors, including cervical carcinoma, show dysregulated expression of the microRNA processing machinery, specifically DROSHA and DICER. Some cervical cancers exhibit chromosome 5p amplifications and DROSHA is the most significantly upregulated transcript and is observed in all tumors with 5p gain. DROSHA and DICE...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.04.022

    authors： Harden ME,Munger K

    更新日期：2017-07-01 00:00:00

  • Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.

    abstract：:Herpes simplex virus mutant KG111 contains a nonsense mutation at codon 44 of the viral thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide. We tested mutant KG111 and related viruses that specify varying amounts of similar truncated tk polypeptides for their sensitivities to antiviral nu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90261-4

    authors： Coen DM,Irmiere AF,Jacobson JG,Kerns KM

    更新日期：1989-02-01 00:00:00

  • High-affinity Rep-binding is not required for the replication of a geminivirus DNA and its satellite.

    abstract：:The 682-nt satellite DNA (sat-DNA) of Tomato leaf curl virus (TLCV) depends on the helper virus for its replication. In contrast to the strict specificity that exists in each geminivirus for its cognate replication associated protein (Rep), TLCV sat-DNA can utilize Rep encoded by distinct geminiviruses. We have used a...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1671

    authors： Lin B,Akbar Behjatnia SA,Dry IB,Randles JW,Rezaian MA

    更新日期：2003-01-20 00:00:00

  • Herpes simplex virus immediate early gene expression in the absence of transinduction by Vmw65 varies during the cell cycle.

    abstract：:The requirement for the herpes simplex virus type 1 (HSV-1) protein Vmw65 (VP16) for activation of immediate early (IE) gene expression was examined in synchronized HeLa cells. Analyses of IE RNA levels were conducted during infection with a viral Vmw65 mutant, in1814. The results revealed an increased requirement for...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90695-l

    authors： Daksis JI,Preston CM

    更新日期：1992-07-01 00:00:00

  • Identification of a new neutralization epitope on VP7 of human serotype 2 rotavirus and evidence for electropherotype differences caused by single nucleotide substitutions.

    abstract：:Neutralizing monoclonal antibodies 2F1 and 1C10, which are specific for VP7 of serotype 2 rotaviruses (G2), were used to select neutralization escape variants of the human serotype 2 rotavirus, DS-1. Neutralization survival patterns generated by monoclonal antibodies 2F1, 1C10, and RV5:3 indicated that 2F1 and 1C10 di...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1601

    authors： Dunn SJ,Ward RL,McNeal MM,Cross TL,Greenberg HB

    更新日期：1993-11-01 00:00:00

  • High-level expression of the measles virus nucleocapsid protein by using a replication-deficient adenovirus vector: induction of an MHC-1-restricted CTL response and protection in a murine model.

    abstract：:Replication-deficient adenovirus (Ad) vectors provide an efficient technology for direct DNA delivery to cells both in vitro and in vivo. We have inserted the measles virus nucleoprotein (N) gene under the control of the strong constitutive CMV major IE promoter into an Ad type 5 E1- vector to produce the recombinant ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1362

    authors： Fooks AR,Schadeck E,Liebert UG,Dowsett AB,Rima BK,Steward M,Stephenson JR,Wilkinson GW

    更新日期：1995-07-10 00:00:00

  • Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase.

    abstract：:The retroviral integrase (IN) is a virus-encoded enzyme that is essential for insertion of viral DNA into the host chromosome. In order to map and define the properties of a minimal functional domain for this unique viral enzyme, a series of N- and C-terminal deletions of both Rous sarcoma virus (RSV) and human immuno...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(95)80060-3

    authors： Kulkosky J,Katz RA,Merkel G,Skalka AM

    更新日期：1995-01-10 00:00:00

  • Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China.

    abstract：:Among 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.03.049

    authors： Lau SK,Woo PC,Wong BH,Wong AY,Tsoi HW,Wang M,Lee P,Xu H,Poon RW,Guo R,Li KS,Chan KH,Zheng BJ,Yuen KY

    更新日期：2010-08-15 00:00:00

  • The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.

    abstract：:The cellular protein MDM2 can bind to the tumor suppressor gene product p53 and abrogate its transcriptional activity. In addition, p53 can regulate expression of the mdm2 gene. We and others have previously shown that p53 is present at high levels in adenovirus-transformed cells which express the larger E1B protein. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1349

    authors： Grand RJ,Lecane PS,Owen D,Grant ML,Roberts S,Levine AJ,Gallimore PH

    更新日期：1995-07-10 00:00:00

  • Isoprenylation of large hepatitis delta antigen is necessary but not sufficient for hepatitis delta virus assembly.

    abstract：:Hepatitis delta virus (HDV) encodes two proteins, the small hepatitis delta antigen (SHDAg) and large hepatitis delta antigen (LHDAg). Both proteins are identical except for the presence of additional 19 amino acids at the C terminus of LHDAg. While SHDAg is required for HDV RNA replication, LHDAg inhibits replication...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1109

    authors： Lee CZ,Chen PJ,Lai MM,Chen DS

    更新日期：1994-02-15 00:00:00

  • A subtype of human papillomavirus 5 (HPV-5b) and its subgenomic segment amplified in a carcinoma: nucleotide sequences and genomic organizations.

    abstract：:A subtype of human papillomavirus 5 (HPV-5b) is closely associated with carcinomas in the disease epidermodysplasia verruciformis (EV). The complete genome was cloned from virus particles in benign lesions of a patient with EV and sequenced: it was 7779 nucleotides long and consisted of six open reading frames (ORFs) ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)91013-7

    authors： Yabe Y,Sakai A,Hitsumoto T,Kato H,Ogura H

    更新日期：1991-08-01 00:00:00

  • Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 genome.

    abstract：:We have shown that polyamide nucleic acids (PNAs) targeted to the PBS (PNA(PBS)) and A-loop (PNA(A-loop)) sequences, when transfected into cells, inhibit HIV-1 replication by blocking the initiation of reverse transcription via destabilizing tRNA(3)(Lys) primer from the viral genome. Here we demonstrate that both PNA(...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.01.016

    authors： Tripathi S,Chaubey B,Barton BE,Pandey VN

    更新日期：2007-06-20 00:00:00

  • Expression and purification of a recombinant tobacco etch virus NIa proteinase: biochemical analyses of the full-length and a naturally occurring truncated proteinase form.

    abstract：:The tobacco etch virus 27-kDa nuclear inclusion a (NIa) proteinase was expressed in Escherichia coli as a recombinant fusion protein containing a seven-histidine tag at the amino-terminus. Catalytically active and inactive (by virtue of a single amino acid change) forms of the proteinase were purified to homogeneity i...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1995.1331

    authors： Parks TD,Howard ED,Wolpert TJ,Arp DJ,Dougherty WG

    更新日期：1995-06-20 00:00:00