Abstract:
:Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular caution in patients suffering from AIDS. Alternatives to steroids are considered in the present article with emphasis on intravenous immunoglobulin as a means to favourably influence the pathogenic events on the platelet surface.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Nydegger UE,Castelli Ddoi
10.3109/08820139109050791subject
Has Abstractpub_date
1991-04-01 00:00:00pages
223-9issue
2eissn
0882-0139issn
1532-4311journal_volume
20pub_type
杂志文章,评审abstract::Each functional gene illustrates the complexity of genetic predisposition to disease; however, it is difficult to bring out these traits with reference to autoimmune diseases like type 1 diabetes (T1D). To find out the genetic contribution of CTLA-4 + 49A/G, CTLA-4 -318C/T and CD28 + 17T/C polymorphisms toward T1D, th...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1590395
更新日期:2019-08-01 00:00:00
abstract::The antiviral activity of cell-associated, non-elutable recombinant human gamma interferon (rHuIFN-gamma) was neutralized by antibody. The neutralization of cell-associated rHuIFN-gamma was maximal through 2 h (60-100%) and declined through 8 h (20-40%). Concomitantly, the antiviral activity of cell-associated [Met-Gl...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009052977
更新日期:1990-10-01 00:00:00
abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030567
更新日期:1987-04-01 00:00:00
abstract::The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055720
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1423570
更新日期:2018-04-01 00:00:00
abstract::Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139809070903
更新日期:1998-07-01 00:00:00
abstract::Cortical (immature) thymocytes are widely reported to express intermediate to high levels of receptors for the lectin, peanut agglutinin (PNA). Light-scatter studies of murine fetal thymocytes stained with PNA or anti-mouse CD4 and CD8 monoclonal antibodies indicated, however, that the most immature CD4-8- (DN) thymoc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309084180
更新日期:1993-12-01 00:00:00
abstract::Mice were immunized with 14 free (i.e. not conjugated to any carrier) synthetic peptides representing the entire human hemoglobin alpha-chain. Antibodies against each peptide were determined using solid phase radioimmunoassay, both with free peptides and peptides coupled to a protein carrier as the coating antigen. It...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909050764
更新日期:1989-08-01 00:00:00
abstract::Alveolar macrophages (AM) freshly obtained by bronchoalveolar lavage suppressed significantly, in a dose-dependent fashion, lung interstitial lymphocytes cytotoxicity against the NK-sensitive target cells, YAC-1. Kinetic experiments revealed that AM-mediated suppression of NK activity was seen following short-term inc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009042023
更新日期:1990-02-01 00:00:00
abstract::Champedak (Artocarpus integer) lectin-M is a lectin with high specificity and affinity for the core-mannosyl residues of the N-linked oligosaccharides of glycoproteins. We have studied the interaction of the champedak seed lectin with human serum glycoproteins that were resolved by 2-dimensional (2-D) gel electrophore...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100104021
更新日期:2001-05-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709055713
更新日期:1987-03-01 00:00:00
abstract::Hematological disorders like Aplastic anemia are quite frequent in Pakistan. Human leukocyte antigen (HLA) system, have been implicated in the development of Aplastic anemia in various population-based studies, The aim of this study was to determine the role of the HLA Class I and Class II alleles in genetic susceptib...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820130903271415
更新日期:2009-01-01 00:00:00
abstract::DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.622828
更新日期:2012-01-01 00:00:00
abstract::Anti-α-galactoside antibody (anti-Gal) from human plasma that bound to α-galactoside-bearing guar galactomannan gel and was eluted with specific sugar (affinity-purified anti-Gal ; APAG) invariably contained apo(a) and apo B subunits in a proportion close to that in plasma lipoprotein(a) [Lp(a)]. Since LDL does not co...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.764316
更新日期:2013-01-01 00:00:00
abstract::The role of innate immunity, e.g., complement activation and cytokine release in the hemodynamic alterations in the course of human septic shock is largely unknown. We prospectively studied 14 consecutive septic shock patients with a pulmonary artery catheter in place. For 3 days after admission, hemodynamic variables...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2010.502949
更新日期:2010-01-01 00:00:00
abstract::Seven commercially available intravenous immunoglobulins (IVIG) preparations, a gamma globulin prepared by ethanol fractionation, and an experimental IgG isolated by a chromatographic procedure were compared in several tests. Split products were present in preparations manufactured by procedures involving protease tre...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055724
更新日期:1988-04-01 00:00:00
abstract::Exposure to laboratory animals poses a hazard for development of occupational allergy. Identification of antigenic determinants of allergenic proteins may be valuable for immunotherapeutic purposes. Overlapping peptides of the major allergen in rat urine, Rat n 1.02, corresponding to the protein alpha2u-globulin were ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139909062266
更新日期:1999-09-01 00:00:00
abstract::A colorimetric microadhesion assay that allows the quantitative determination of carcinoembryonic antigen (CEA)-mediated homophilic cell adhesion to CEA immobilized on 96-well polyvinyl chloride plates is described. Chinese hamster ovary (CHO) cells transfected with a full-length CEA cDNA were used as indicator cells....
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066832
更新日期:1994-11-01 00:00:00
abstract::The occurrence of apoptosis in cultured blood cells from HIV+ patients is well-documented. However, the relationship of this process to cytokine production is still undefined. We measured the production of TNF-beta by mitogen-stimulated PBLs from 33 HIV+ patients, while simultaneously assessing their development of ap...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609059311
更新日期:1996-07-01 00:00:00
abstract::Neutrophil chemotactic defects have been reported previously in patients with hyper-IgE syndrome. Bi-allelic mutations in dedicator of cytokinesis 8 (DOCK8) gene usually cause an autosomal recessive hyper-IgE syndrome phenotype. Data are lacking about expression of DOCK8 protein in neutrophils or the possible role of ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1567533
更新日期:2019-05-01 00:00:00
abstract::To investigate whether phospholipase D1 (PLD1) is involved in autoimmune damage to the eyes, we used Western blotting and immunohistochemistry to examine the expression and distribution of PLD1 in the retinas of Lewis rats with experimental autoimmune uveoretinitis (EAU). Western blot analysis showed that the level of...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were com...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509060704
更新日期:1995-08-01 00:00:00
abstract::Adenoid hypertrophy is the most common cause of upper airway obstruction and sleep-disordered breathing in children, yet its pathogenesis remains unclear. The identification of the novel helper T cell subsets, Th17 cells and regulatory T cells (Tregs) could provide new insight into our understanding of the mechanisms ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.575426
更新日期:2011-01-01 00:00:00
abstract::Jeevaneeya rasayana is an ayurvedic polyherbal formulation, with antirheumatic potential. The present study investigates the therapeutic efficacy of isolated total alkaloid fraction of Jeevaneeya Rasayana (AJR) in treating rheumatoid arthritis in a rat model of Adjuvant-induced arthritis (AIA). Paw swelling, inflammat...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.936937
更新日期:2015-01-01 00:00:00
abstract::The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2016.1168831
更新日期:2016-07-01 00:00:00
abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909045785
更新日期:1989-10-01 00:00:00
abstract::In this study we examined a panel of CD4+ antigen specific/MHC restricted T cell clones for their ability to secrete IL-2, IL-4, and IFN-gamma upon stimulation with con A, three lymphokines which are diagnostic for the TH1 and TH2 subtypes of helper T cells. Eight of the twelve clones we analyzed did not fit the class...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109054925
更新日期:1991-02-01 00:00:00
abstract::A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130600634568
更新日期:2006-01-01 00:00:00
abstract::Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone me...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1710531
更新日期:2021-02-01 00:00:00
abstract::The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (+/-4.02) years and...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130802438057
更新日期:2008-01-01 00:00:00