Polymorphism in the promoter region of the CD14 gene and susceptibility to Brucellosis.

Abstract:

:A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic. The CD14 genotype was determined in 228 patients with brucellosis from a rural area and 129 healthy volunteers from the same area. The prevalence of genotype TT was significantly higher in the patients while the controls showed higher prevalence of genotype CC (34.5% vs 15.5%, 15.4% vs 25.6%, P = 0.009). Multiple logistic regression analysis after adjustment for gender demonstrated that the patients who were homozygous for allele T of promoter of CD14 gene had a significantly higher risk for developing brucellosis with odds ratio of 3.03 (95% CI, 5.2, 1.75 P = 0.0004). The existence of homozygous genotype of allele T of CD14 was an independent determinant for occurrence of arthritis among the patients with brucellosis (odds ratio of 3.92 (95% CI, 2.93, 5.88, P = 0.001).Our findings provide suggestive evidence of association of the CD14 gene polymorphism with susceptibility to development of brucellosis in Iranian populations.

journal_name

Immunol Invest

authors

Haidari M,Hajilooi M,Rezazadeh M,Rafiei A,Alavi SA,Keramat F

doi

10.1080/08820130600634568

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

239-45

issue

2

eissn

0882-0139

issn

1532-4311

pii

R1G1713755117G6X

journal_volume

35

pub_type

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