Abstract:
:Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa inhibited PBL responsiveness to mitogenic (PHA) stimulation. The glycopeptides contained blood group I-antigenic determinants. These experiments demonstrate the presence of blood group I-active peptides in breast carcinoma that suppress peripheral blood lymphocyte functions. Further studies are in progress.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Dube VE,Kallio P,Hakim Adoi
10.3109/08820138809055715subject
Has Abstractpub_date
1988-03-01 00:00:00pages
19-24issue
1eissn
0882-0139issn
1532-4311journal_volume
17pub_type
杂志文章abstract::Seven commercially available intravenous immunoglobulins (IVIG) preparations, a gamma globulin prepared by ethanol fractionation, and an experimental IgG isolated by a chromatographic procedure were compared in several tests. Split products were present in preparations manufactured by procedures involving protease tre...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055724
更新日期:1988-04-01 00:00:00
abstract::The role of ICAM-1 in contact activation of the bronchial epithelial cells is elucidated. Direct contact between epithelial cells and leukocytes is required to change transepithelial electrical resistance (TER) of the epithelium. Migration of human neutrophils across the layers of cultured human airway epithelial cell...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130600745703
更新日期:2007-01-01 00:00:00
abstract::Identification and characterization of antigenic proteins of Setaria cervi (bovine filarial parasite) adults and microfilariae was done by immunoblotting technique using hyperimmune rabbit sera against S. cervi and Brugia malayi. The antigens recognized by these sera were detected by using 125I protein-A followed by a...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030571
更新日期:1987-04-01 00:00:00
abstract::Previous work had implicated T cells within the stimulating population as having a significant role in the MLR. We now report that depletion of T cells from the stimulators caused a reduction in proliferative response in mixed leukocyte reaction (MLR) by 50% or more. This response could be restored by adding T-enriche...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609042020
更新日期:1986-03-01 00:00:00
abstract::Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice wit...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1267203
更新日期:2017-04-01 00:00:00
abstract::The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130902846290
更新日期:2009-01-01 00:00:00
abstract::A well-characterized recombinant anti-idiotype to an anti-DNA antibody can be useful for studies of the regulation of anti-DNA-producing B cells. Using a hybridoma technique, a monoclonal anti-idiotypic antibody, designated O2F3, was obtained, and its scFv gene was constructed. O2F3 single chain Fv (scFv) was produced...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120016241
更新日期:2002-08-01 00:00:00
abstract::There has been a dramatic increase recently in the number of reports of septic episodes associated with both red cell and platelet concentrate transfusions. These reports suggest that transfusion-associated septic reactions may occur as often as 1 per 4000 platelet transfusions, however, the true incidence of the bact...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139509062770
更新日期:1995-01-01 00:00:00
abstract::Dengue viruses (DV) infection is an important public health issue all over the world. Although the pathogenesis remains unclear, the overwhelmingly triggered immune responses have been consistently observed. Recently, we and other researchers demonstrated that the natural hosts for DV are dendritic cells (DC), the pri...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-200038680
更新日期:2004-01-01 00:00:00
abstract::We examined the effect of various polyanions on mouse complement hemolytic activity, Fc receptor (FcR) subclass mediated antibody-dependent cellular cytotoxicity (ADCC) as well as binding by mouse peritoneal macrophages (M phi) of sheep erythrocyte targets. All the polyanions tested (dextran sulfate, carrageenan, poly...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909057755
更新日期:1989-06-01 00:00:00
abstract::Although cancer immunotherapy, which is able to target specifically cancer cells without detrimental effects to normal cell functions, would serve as an ideal therapeutic modality, most of the randomized clinical trials of cancer immunotherapy have not demonstrated a meaningful survival benefit to cancer patients over...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2013.857352
更新日期:2014-01-01 00:00:00
abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030567
更新日期:1987-04-01 00:00:00
abstract::Cortical (immature) thymocytes are widely reported to express intermediate to high levels of receptors for the lectin, peanut agglutinin (PNA). Light-scatter studies of murine fetal thymocytes stained with PNA or anti-mouse CD4 and CD8 monoclonal antibodies indicated, however, that the most immature CD4-8- (DN) thymoc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309084180
更新日期:1993-12-01 00:00:00
abstract::The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055720
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Cancer immunotherapies have achieved much success and have become the forefront treatment of cancers previously associated with poor prognosis. However, a major challenge in cancer immunotherapies remains the heterogeneity of the immunoregulatory capacities of cancers, and not all patients of a given cancer ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1778024
更新日期:2020-06-23 00:00:00
abstract::Endomyocardial biopsy is generally used to quantify heart allograft rejection and guide immunotherapy. Biopsy, however, is invasive, costly, and risky. Since rejection requires lymphocyte activation, the purpose of this study was to assess alternative methods to evaluate rejection dynamics by investigating serum level...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609059287
更新日期:1996-01-01 00:00:00
abstract::This preliminary study examined the effects of immunization with Bacteroides macacae, the monkey equivalent of the human species of B. gingivalis on ligature-induced periodontitis. During a 12 week immunization period, 8 out of the 12 Macacae fasicularis monkeys were immunized weekly with B. macacae washed cells and 4...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909112239
更新日期:1989-01-01 00:00:00
abstract::In the last 15 years, it has become apparent that ovarian cancer is recognized by the immune system, taking into account that T cell infiltration can be associated with increased overall survival. Several studies indicate that a correct combination of cluster of differentiation 8 and cluster of differentiation 4 T cel...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820139.2016.1186689
更新日期:2016-11-01 00:00:00
abstract::Regulatory T cells (Tregs) play pivotal roles in limiting the duration and magnitude of immune response against infectious agents and self-antigens. This is accomplished through contact-dependent and -independent mechanisms that involve crosstalk between Treg cells and other immune and tissue-specific cell types. The ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820139.2016.1197242
更新日期:2016-11-01 00:00:00
abstract::Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1702052
更新日期:2020-11-01 00:00:00
abstract::Champedak (Artocarpus integer) lectin-M is a lectin with high specificity and affinity for the core-mannosyl residues of the N-linked oligosaccharides of glycoproteins. We have studied the interaction of the champedak seed lectin with human serum glycoproteins that were resolved by 2-dimensional (2-D) gel electrophore...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100104021
更新日期:2001-05-01 00:00:00
abstract::Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909050768
更新日期:1989-08-01 00:00:00
abstract::We examined the blocking ability of poly(vinyl alcohol) (PVA) in enzyme immunoassays by coating polystyrene microtiter wells with PVA of different molecular weights (MW) and percent hydrolysis (%Hyd). Blocking ability was measured by the differences in non-specific binding of an anti-rabbit IgG-horseradish peroxidase ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066836
更新日期:1994-11-01 00:00:00
abstract::Peripheral blood lymphocytes of a patient with myasthenia gravis (MG) were fused to the non-secreting human lymphoblastoid line HuNSI to produce human x human hybridomas that secrete monoclonal antibodies (mAb) to acetylcholine receptor (AChR). Screening of hybridomas for antibody production involved an enzyme-linked ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609052954
更新日期:1986-06-01 00:00:00
abstract::Intravenous immunoglobulins (IVIg) have been used as an immunomodulatory therapy in a variety of diseases. Several mechanisms of action have been proposed, one of which is interference with the cytokine network. We have investigated the effect of IVIg on the cytotoxicity of human TNF alpha. IVIg was capable of protect...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139709088541
更新日期:1997-08-01 00:00:00
abstract::DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.622828
更新日期:2012-01-01 00:00:00
abstract::Conventional plate ML-ELISA technique for diagnosis of recent cases of amoebiasis was converted into a simple polyvinyl chloride strip multilayer-enzyme linked immunosorbent assay (PVC strip ML-ELISA). This report details the development and preliminary characterization of the PVC strip ML-ELISA method for Entamoeba h...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109026242
更新日期:1991-12-01 00:00:00
abstract::Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701712867
更新日期:2007-01-01 00:00:00
abstract::The transferrin receptor (TR), the HLA DR antigen (DR), and the antigen binding OKT10 (T10) are present on activated lymphocyte populations. The authors have studied their expression and that of antigens defined by eight commercial monoclonal antibodies on peripheral blood lymphocytes of 50 healthy hospital workers ag...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709087089
更新日期:1987-06-01 00:00:00
abstract::The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820131003615498
更新日期:2010-01-01 00:00:00