Changes in the Level of Immunoglobulins and CD4/CD8 Ratio in Young and Aged Mice with Estradiol Deficiency.

abstract：:Peripheral blood lymphocytes of a patient with myasthenia gravis (MG) were fused to the non-secreting human lymphoblastoid line HuNSI to produce human x human hybridomas that secrete monoclonal antibodies (mAb) to acetylcholine receptor (AChR). Screening of hybridomas for antibody production involved an enzyme-linked ...

journal_title：Immunological investigations

authors： Blair DA,Richman DP,Taves CJ,Koethe S

更新日期：1986-06-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains can affect their interaction with the immune system. Beijing genotype has attracted attention because of its high prevalence and mu...

journal_title：Immunological investigations

authors： Reyes-Martínez JE,Nieto-Patlán E,Nieto-Patlán A,Gonzaga-Bernachi J,Santos-Mendoza T,Serafín-López J,Chávez-Blanco A,Sandoval-Montes C,Flores-Romo L,Estrada-Parra S,Estrada-García I,Chacón-Salinas R

更新日期：2014-01-01 00:00:00

abstract：:In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2...

journal_title：Immunological investigations

authors： Aboud M,Amitai H,Huleihel M,Har-vardi I,Gopas J,Segal S

更新日期：1991-08-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...

journal_title：Immunological investigations

authors： Ustinov VA,Studennikov AE,Vavilov VA,Tyumentseva MA,Morozova VV,Tikunova NV,Glushkov AN

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Adult chronic immune thrombocytopenic purpura (chronic ITP) is an autoimmune multifactorial bleeding disorder that occurs because of enhanced peripheral platelet destruction. Treatment decisions can be challenging because the goal of treatment is to prevent severe bleeding, but the risk of bleeding can be di...

journal_title：Immunological investigations

authors： El Ghannam D,Fawzy IM,Azmy E,Hakim H,Eid I

更新日期：2015-01-01 00:00:00

abstract：:We examined the effect of various polyanions on mouse complement hemolytic activity, Fc receptor (FcR) subclass mediated antibody-dependent cellular cytotoxicity (ADCC) as well as binding by mouse peritoneal macrophages (M phi) of sheep erythrocyte targets. All the polyanions tested (dextran sulfate, carrageenan, poly...

journal_title：Immunological investigations

authors： Mocharla R,Mocharla H,Leu RW

更新日期：1989-06-01 00:00:00

abstract：:Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells i...

journal_title：Immunological investigations

authors： Banovac K,Neylan D,Leone J,Ghandur-Mnaymneh L,Rabinovitch A

更新日期：1989-08-01 00:00:00

abstract：:Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone me...

journal_title：Immunological investigations

authors： Duan CC,Ma C,Tang HQ

更新日期：2021-02-01 00:00:00

abstract：:An enzyme-linked immunoassay (EIA) is described and evaluated which quantitates human antibodies to serotype specific S. pneumoniae polysaccharide (PnPs) in human sera. Based on the observations previously described by Koskela (1), native PnPs are used as coating antigens and sera are absorbed with a soluble pneumococ...

journal_title：Immunological investigations

authors： Quataert S,Martin D,Anderson P,Giebink GS,Henrichsen J,Leinonen M,Granoff DM,Russell H,Siber G,Faden H,Barnes D,Madore DV

更新日期：2001-08-01 00:00:00

abstract：:In the last 15 years, it has become apparent that ovarian cancer is recognized by the immune system, taking into account that T cell infiltration can be associated with increased overall survival. Several studies indicate that a correct combination of cluster of differentiation 8 and cluster of differentiation 4 T cel...

journal_title：Immunological investigations

authors： Singh M,Loftus T,Webb E,Benencia F

更新日期：2016-11-01 00:00:00

abstract：:Studies presented examine the origin of IgA plasma cells in B lineage chimeric mice constructed by reconstituting lethally irradiated mice with a mixture of syngeneic bone marrow cells and peritoneal cells from Ig heavy chain allotype congenic donors. In these mice, essentially all B cells in spleen and Peyer's patche...

journal_title：Immunological investigations

authors： Kroese FG,Butcher EC,Stall AM,Herzenberg LA

更新日期：1989-01-01 00:00:00

abstract：:The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...

journal_title：Immunological investigations

authors： Griswold WR

更新日期：1987-04-01 00:00:00

abstract：:Champedak (Artocarpus integer) lectin-M is a lectin with high specificity and affinity for the core-mannosyl residues of the N-linked oligosaccharides of glycoproteins. We have studied the interaction of the champedak seed lectin with human serum glycoproteins that were resolved by 2-dimensional (2-D) gel electrophore...

journal_title：Immunological investigations

authors： Hashim OH,Ahmad F,Shuib AS

更新日期：2001-05-01 00:00:00

abstract：:The complement system which is a critical mediator of innate immunity plays diverse roles in the neuropathogenesis of HIV-1 infection such as clearing HIV-1 and promoting productive HIV-1 replication. In the development of HIV-1 associated neurological disorders (HAND), there may be an imbalance between complement act...

journal_title：Immunological investigations

authors： Mahajan SD,Aalinkeel R,Parikh NU,Jacob A,Cwiklinski K,Sandhu P,Le K,Loftus AW,Schwartz SA,Quigg RJ,Alexander JJ

更新日期：2017-11-01 00:00:00

abstract：:IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was...

journal_title：Immunological investigations

authors： Wu CH,Jeng KC,Lan JL

更新日期：1995-11-01 00:00:00

abstract：:The objective of this study was to analyze how Staphylococcus epidermidis SCV and WT strains manipulate the PI3K/Akt/mTOR signaling pathway. Six S. epidermidis strains with normal phenotype (WT) and six S. epidermidis strains with SCV phenotype were isolated in parallel from six patients with the prosthetic hip joint ...

journal_title：Immunological investigations

authors： Magryś A,Bogut A,Kiełbus M,Olender A

更新日期：2018-04-01 00:00:00

abstract：:Jeevaneeya rasayana is an ayurvedic polyherbal formulation, with antirheumatic potential. The present study investigates the therapeutic efficacy of isolated total alkaloid fraction of Jeevaneeya Rasayana (AJR) in treating rheumatoid arthritis in a rat model of Adjuvant-induced arthritis (AIA). Paw swelling, inflammat...

journal_title：Immunological investigations

authors： Shyni GL,Sindhu G,Helen A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...

journal_title：Immunological investigations

authors： Mosaad YM,El-Toraby EE,Tawhid ZM,Abdelsalam AI,Enin AF,Hasson AM,Shafeek GM

更新日期：2018-04-01 00:00:00

abstract：:Functional defects of polymorphonuclear leukocytes can lead to clinical immunodeficiency. Understanding these conditions requires a knowledge of normal polymorph physiology and the means to analyse various aspects of polymorph function. Primary diseases of polymorph function are rare, whereas disorders secondary to ot...

journal_title：Immunological investigations

authors： Thompson RA

更新日期：1988-04-01 00:00:00

abstract：:To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

journal_title：Immunological investigations

authors： Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

更新日期：1996-09-01 00:00:00

abstract：:The purpose of this presentation was to demonstrate that the red blood cell is not a hapless sac of hemoglobin and that much research is still needed for better understanding of its complexities. After a brief historical introduction the following subjects are presented: 1). Phosphofructokinase is the rate limiting st...

journal_title：Immunological investigations

authors： Greenwalt TJ

更新日期：1995-01-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the  MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic ...

journal_title：Immunological investigations

authors： Ksiazek K,Buraczynska M

更新日期：2020-11-01 00:00:00

abstract：:Previous work had implicated T cells within the stimulating population as having a significant role in the MLR. We now report that depletion of T cells from the stimulators caused a reduction in proliferative response in mixed leukocyte reaction (MLR) by 50% or more. This response could be restored by adding T-enriche...

journal_title：Immunological investigations

authors： Roy C,Brown DL,Kaplan JG

更新日期：1986-03-01 00:00:00

abstract：:CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...

journal_title：Immunological investigations

authors： Reid SD,Pockley AG

更新日期：2000-08-01 00:00:00

abstract：:Hematological disorders like Aplastic anemia are quite frequent in Pakistan. Human leukocyte antigen (HLA) system, have been implicated in the development of Aplastic anemia in various population-based studies, The aim of this study was to determine the role of the HLA Class I and Class II alleles in genetic susceptib...

journal_title：Immunological investigations

authors： Rehman S,Saba N,Khalilullah,Munir S,Ahmed P,Mehmood T

更新日期：2009-01-01 00:00:00

abstract：:A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....

journal_title：Immunological investigations

authors： Haidari M,Hajilooi M,Rezazadeh M,Rafiei A,Alavi SA,Keramat F

更新日期：2006-01-01 00:00:00

abstract：:Human tumors often progress and spread in spite of the presence of large numbers of CD4+ and CD8+ T cells with activated or memory cell phenotypes. The T cells in the microenvironment of human lung tumors fail to be activated in response to stimulation via the T cell receptor and CD28 under conditions that fully activ...

journal_title：Immunological investigations

authors： Broderick L,Bankert RB

更新日期：2006-01-01 00:00:00

abstract：:Whole-body hyperthermia (WBH) has been used as an adjunct approach to radio-/ chemotherapy for tumor therapy for many years. However, the molecular mechanism underlying the enhancement of tumor control is not clearly understood. It has been hypothesized that WBH might activate immune system by inducing the expression ...

journal_title：Immunological investigations

authors： Zhang H,Wang W,Zhang S,Huang W

更新日期：2005-01-01 00:00:00

abstract：:We tested by Western blot several thousand antibody-secreting human cell lines immortalized by hybridoma fusion or Epstein-Barr virus transformation of peripheral blood lymphocytes from patients with systemic lupus erythematosus or mixed connective tissue disease. The blots utilized total human Jurkat cell extract as ...

journal_title：Immunological investigations

authors： Vanderslice WE,Takeda Y,Chen J,Sharp GC,Pettersson I,Rosen A,Wigzell H,Wang RJ

更新日期：1988-06-01 00:00:00

abstract：:The aim of this study was to evaluate the possible association of IL12B gene polymorphisms with serum levels of IL-12p40, IL-23 and genetic susceptibility to rheumatoid arthritis (RA) in the Bulgarian population. Genotyping for IL12Bpro (rs17860508) and IL12B A/C - 3' UTR (rs3212227) polymorphisms was performed by pol...

journal_title：Immunological investigations

authors： Manolova I,Ivanova M,Vasilev G,Stoilov R,Miteva L,Stanilova S

更新日期：2020-02-01 00:00:00