Abstract:
:To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterogeneic depending on the mouse strain and method for sensitization. When sensitization was done with bovine serum albumin (BSA) plus Bordetella pertussis organisms, anaphylactic shock in C57BL/6N mice was suppressed by cyproheptadine but not by CV-6209. In contrast, shock in C3H/HeN and WBB6F1-W/Wv mice was suppressed by CV-6209 but not by cyproheptadine. Shock in BALB/c mice was suppressed by both agents but that in WBB6F1-(+)/+ mice was not at all by either one. DS and BDF1 mice showed differences due to the length of the sensitization period; shock was not suppressed by cyproheptadine with a shorter sensitization (9 to 11 days) but clearly suppressed with prolonged sensitization of 14 to 15 days. Shock in DS, WBB6F1-(+)/+ and BDF1 mice, which was not suppressed by either agent alone, was strongly suppressed by the combination of the two agents. In animals which had been sensitized with BSA emulsified with Freund's complete adjuvant (FCA) and given DL-propranolol as a shock potentiator, a similar pattern of drug susceptibility as that in the pertussis-vaccinated animals was obtained in general, although a discrepancy was seen with regard to the suppression of CV-6209 in C3H/HeN and BDF1 mice. Synergistic suppression by CV-6209 and cyproheptadine was also very clear with the WBB6F1-(+)/+ mice sensitized using FCA. In addition, results quite similar to those with cyproheptadine were obtained with the other two antihistamines, triprolidine almost devoid of antiserotonin activity and oxatomide, in testing with BDF1 mice sensitized using Bordetella pertussis organisms. From these findings, the conclusion is that histamine and PAF play major roles solely or in combination in mouse active anaphylactic shock.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada Mdoi
10.3109/08820139609055732subject
Has Abstractpub_date
1996-09-01 00:00:00pages
425-34issue
5-6eissn
0882-0139issn
1532-4311journal_volume
25pub_type
杂志文章abstract::Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa...
journal_title:Immunological investigations
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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journal_title:Immunological investigations
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3109/08820139.2015.1009546
更新日期:2015-01-01 00:00:00
abstract::Jeevaneeya rasayana is an ayurvedic polyherbal formulation, with antirheumatic potential. The present study investigates the therapeutic efficacy of isolated total alkaloid fraction of Jeevaneeya Rasayana (AJR) in treating rheumatoid arthritis in a rat model of Adjuvant-induced arthritis (AIA). Paw swelling, inflammat...
journal_title:Immunological investigations
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更新日期:2015-01-01 00:00:00
abstract::The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...
journal_title:Immunological investigations
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journal_title:Immunological investigations
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doi:10.3109/08820139.2015.1043669
更新日期:2015-01-01 00:00:00
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doi:10.1080/08820130701854339
更新日期:2008-01-01 00:00:00
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journal_title:Immunological investigations
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doi:10.3109/08820139.2012.658940
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journal_title:Immunological investigations
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doi:10.3109/08820139409087802
更新日期:1994-04-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139509062760
更新日期:1995-01-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055720
更新日期:1988-03-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139109050791
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journal_title:Immunological investigations
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abstract::Lymphotoxin beta receptor (LTBR) is essential for development and organization of the secondary lymphoid tissues. To investigate whether LTBR polymorphisms are associated with IgA nephropathy (IgAN) in Korean children, One hundred ninety nine patients with IgAN and 289 controls were recruited. Two promoter single nucl...
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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更新日期:1999-07-01 00:00:00