Abstract:
:The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmune (non-obese diabetic [NOD]) mouse model express much lower levels of an autoimmune regulator (Aire) and TRAs than normal (Balb/c) TECs. Transfection of an Aire plasmid led to increased levels of TRA expression in cultured TECs from Balb/c and NOD mice; an increase that was enhanced by the presence of thymocytes. These data show that Aire initiates promiscuous gene expression in TECs, and that this function might be under thymocyte control.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Chen J,Yang W,Yu C,Li Ydoi
10.1080/08820130801967841subject
Has Abstractpub_date
2008-01-01 00:00:00pages
203-14issue
3eissn
0882-0139issn
1532-4311pii
791932056journal_volume
37pub_type
杂志文章abstract::Spleen cells of C57BL/6 mice injected with corticosterone were compared with cells from mice injected with saline in their ability to respond to the mitogens PHA, Con A, and LPS. Both unseparated cells and cells separated into T-enriched and B-enriched fractions were studied. After either seven daily injections or fou...
journal_title:Immunological investigations
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