The hemodynamics of human septic shock relate to circulating innate immunity factors.

abstract：:The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...

journal_title：Immunological investigations

authors： Castañeda-Lopez ME,Garza-Veloz I,Lopez-Hernandez Y,Barbosa-Cisneros OY,Martinez-Fierro ML

更新日期：2016-07-01 00:00:00

abstract：:The loading of dendritic cells (DCs) with whole tumor cell lysates may circumvent the facts that few tumor-specific antigens have been identified in human solid tumors. The present study was designed to investigate whether ovarian cancer cells lysate-pulsed DCs activate T cell responses against autologous ovarian tumo...

journal_title：Immunological investigations

authors： Zhao X,Wei YQ,Peng ZL

更新日期：2001-02-01 00:00:00

abstract：:The induction of immune tolerance is the most common consequence of protein feeding, i.e., "oral tolerance". In this study we investigated the genetic basis of oral tolerance using various kinds of recombinant and congenic mice, and the cells involved in the development of this phenomenon in mice. The footpad swelling...

journal_title：Immunological investigations

authors： Ishii N,Moriguchi N,Sugita Y,Nakajima H,Tanaka S,Aoki I

更新日期：1993-08-01 00:00:00

abstract：:Antisera to the chemically synthesized trisaccharide, Gal beta 1-3(GlcNAc beta 1-6)GalNAc, and disaccharide, GlcNAc beta 1-6GalNAc, were developed using the diazophenyl bovine serum albumin derivatives. The binding specificity of the antisera were analyzed by enzyme immunoassays with structurally related, chemically s...

journal_title：Immunological investigations

authors： Matta KL,Piskorz CF,Abbas SA,Diakun KR

更新日期：1991-08-01 00:00:00

abstract：:The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical ...

journal_title：Immunological investigations

authors： Durrant DM,Metzger DW

更新日期：2010-01-01 00:00:00

abstract：:Rapid and accurate diagnosis of cytomegalovirus (CMV) infection is imperative with the advent of effective antiviral therapy (gangiclovir, foscarnet, CMV hyperimmune globin). Applications of conventional cell culture (CC), shell vial assay (SV), serological testing, antigenemia assay (AG) as well as molecular methods ...

journal_title：Immunological investigations

authors： Myers JB,Amsterdam D

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae is a major pathogen accounting for a large number of pneumococcal disease in worldwide. Due to the mucosal immune pathway induces both systemic and mucosal immune responses, the potential strategy to prevent pneumococcal disease may be to develop a mucosal vaccine. METHOD:In this st...

journal_title：Immunological investigations

authors： Wang D,Lu J,Yu J,Hou H,Leenhouts K,Van Roosmalen ML,Gu T,Jiang C,Kong W,Wu Y

更新日期：2018-05-01 00:00:00

abstract：:Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa...

journal_title：Immunological investigations

authors： Dube VE,Kallio P,Hakim A

更新日期：1988-03-01 00:00:00

abstract：:The objective of this study was to analyze how Staphylococcus epidermidis SCV and WT strains manipulate the PI3K/Akt/mTOR signaling pathway. Six S. epidermidis strains with normal phenotype (WT) and six S. epidermidis strains with SCV phenotype were isolated in parallel from six patients with the prosthetic hip joint ...

journal_title：Immunological investigations

authors： Magryś A,Bogut A,Kiełbus M,Olender A

更新日期：2018-04-01 00:00:00

abstract：:Adenoid hypertrophy is the most common cause of upper airway obstruction and sleep-disordered breathing in children, yet its pathogenesis remains unclear. The identification of the novel helper T cell subsets, Th17 cells and regulatory T cells (Tregs) could provide new insight into our understanding of the mechanisms ...

journal_title：Immunological investigations

authors： Sade K,Fishman G,Kivity S,DeRowe A,Langier S

更新日期：2011-01-01 00:00:00

abstract：:In recent studies, using a swine model of single lung transplantation, we demonstrated that IRI alone increased MHC II expression in the host's peripheral T lymphocytes. The inhibition of increased MHC II expression with TCV-309, a specific platelet-activating factor (PAF) antagonist suggested that PAF might play a ro...

journal_title：Immunological investigations

authors： Nikbakht-Sangari M,Qayumi AK,Keown P,Duronio V,Horley K

更新日期：1999-07-01 00:00:00

abstract：:The processing of antigenic peptides for presentation by MHC molecules to T cells, may depend upon the function of a second, consensus sequence in or near the T cell-presented epitope. One such processing-regulating sequence appears to be composed of amino acids Leu, Ile, Val, Phe, and Met recurring in a fashion to fo...

journal_title：Immunological investigations

authors： Goldschmidt TG,Reyes VE,You G,Nelson DJ,Reisert PS,Anderson J,Mole J,Humphreys RE

更新日期：1993-02-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...

journal_title：Immunological investigations

authors： Krishnan S,Russell J,Bodziak M,Koury S,Masso-Welch P

更新日期：2012-01-01 00:00:00

abstract：:White cell infiltration of solid tumors is an important prognostic indicator in malignant disease. Although macrophage infiltration is associated with good outcome in colorectal cancer, a high macrophage content is associated with poor prognosis in breast cancer. Suppressor macrophages prevent T cell activation in nor...

journal_title：Immunological investigations

authors： Toomey D,Harmey J,Condron C,Kay E,Bouchier-Hayes D

更新日期：1999-01-01 00:00:00

abstract：:To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

journal_title：Immunological investigations

authors： Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

更新日期：1996-09-01 00:00:00

abstract：:The occurrence of apoptosis in cultured blood cells from HIV+ patients is well-documented. However, the relationship of this process to cytokine production is still undefined. We measured the production of TNF-beta by mitogen-stimulated PBLs from 33 HIV+ patients, while simultaneously assessing their development of ap...

journal_title：Immunological investigations

authors： Lavergne JA,Zorrilla C,del Llano AM

更新日期：1996-07-01 00:00:00

abstract：:In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2...

journal_title：Immunological investigations

authors： Aboud M,Amitai H,Huleihel M,Har-vardi I,Gopas J,Segal S

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Changes in cytokine expression have been frequently found in patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within cytokine genes. OBJECTIVE:The present study was designed to investigate the possible association betwee...

journal_title：Immunological investigations

authors： Ebrahimi Daryani N,Saghazadeh A,Moossavi S,Sadr M,Shahkarami S,Soltani S,Farhadi E,Rezaei N

更新日期：2017-10-01 00:00:00

abstract：:Prolonged survival of C57BL/6 (B6) mice bearing syngenic EL-4 leukemia cells resulted from immunization with irradiated EL-4 cells on the day of inoculation of live leukemia cells. No prolongation of survival was observed if the irradiated cells were injected 6 or 13 days after live cell inoculation. Protection also w...

journal_title：Immunological investigations

authors： Abeyounis CJ,Bekierkunst A,Milgrom F

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular les...

journal_title：Immunological investigations

authors： Poomarimuthu M,Elango S,Solomon PR,Soundrapandian S,Mariakuttikan J

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD). METHODS:Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conduct...

journal_title：Immunological investigations

authors： Liu J,Liu YY,Liu J,Li BZ,Cen H,Xu WD,Leng RX,Pan HF,Ye DQ

更新日期：2015-01-01 00:00:00

abstract：:In the present study, we evaluated the effectiveness of a levamisole-based adjuvant (ADL) to enhance the ability of the Ag85B-ESAT6 fusion protein to boost immune responses after primary vaccination with recombinant bacillus Calmette-Guerin (rBCG) in Balb/c mice. The results were compared with that of the control adju...

journal_title：Immunological investigations

authors： You Q,Wu Y,Jiang D,Wu Y,Wang C,Wei W,Yu X,Zhang X,Kong W,Jiang C

更新日期：2012-01-01 00:00:00

abstract：:Dendritic cells (DCs) are potent antigen-presenting cells that can be matured in vitro from immature dendritic cells (iDCs) in the presence of several biological agents such as cytokine cocktail, CD40L, TNF-a and antigen loading, which are necessary and achieved using various protocols, such as lipofection, passive pu...

journal_title：Immunological investigations

authors： Son CH,Bae JH,Shin DY,Lee HR,Choi YH,Yang K,Park YS

更新日期：2013-01-01 00:00:00

abstract：:Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 3...

journal_title：Immunological investigations

authors： Wu HP,Chu CM,Kao KC,Huang SH,Chuang DY

更新日期：2017-05-01 00:00:00

abstract：:Drug abuse has become a global health concern. Understanding how drug abuse modulates the immune system and how the immune system responds to pathogens associated with drug abuse, such hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1), can be assessed by an integrated approach comparing proteomic analys...

journal_title：Immunological investigations

authors： Reynolds JL,Mahajan SD,Aalinkeel R,Nair B,Sykes DE,Schwartz SA

更新日期：2009-01-01 00:00:00

abstract：:We report a method combining mixed lymphocyte reaction (MLR) using a carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeling technique, intracellular cytokine immunofluorescence staining (ICIS), and multiparameter flow cytometry for simultaneous determination of proliferation and cytokine-secreting activity in...

journal_title：Immunological investigations

authors： Tanaka Y,Ohdan H,Onoe T,Asahara T

更新日期：2004-08-01 00:00:00

abstract：:As a result of strong experimental data supporting effectiveness and safety, herb-based immunomodulators are paving way as alternative sources of potent adjuvants for vaccines. In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluate...

journal_title：Immunological investigations

authors： Nworu CS,Esimone CO,Tenbusch M,Nabi G,Proksch P,Uberla K,Temchura VV

更新日期：2010-01-01 00:00:00

abstract：:In this study we examined a panel of CD4+ antigen specific/MHC restricted T cell clones for their ability to secrete IL-2, IL-4, and IFN-gamma upon stimulation with con A, three lymphokines which are diagnostic for the TH1 and TH2 subtypes of helper T cells. Eight of the twelve clones we analyzed did not fit the class...

journal_title：Immunological investigations

authors： Hatfield SM,Rodgers GH,Marder P,Roehm NW

更新日期：1991-02-01 00:00:00

abstract：:The antiviral activity of cell-associated, non-elutable recombinant human gamma interferon (rHuIFN-gamma) was neutralized by antibody. The neutralization of cell-associated rHuIFN-gamma was maximal through 2 h (60-100%) and declined through 8 h (20-40%). Concomitantly, the antiviral activity of cell-associated [Met-Gl...

journal_title：Immunological investigations

authors： Langford MP,Gates WG,Kaiwar R

更新日期：1990-10-01 00:00:00

abstract：:The rat small intestinal epithelial cell (enterocyte) has an average life span of 48h. Undifferentiated stem cells in the lower crypt region undergo division and differentiation into enterocytes as the cell moves on a basement membrane up the villus to reach the tip and be extruded into the lumen. The mechanism of thi...

journal_title：Immunological investigations

authors： Weiser MM,Ryzowicz S,Soroka CJ,Albini B

更新日期：1989-01-01 00:00:00