Abstract:
:In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2K alleles is transcriptionally suppressed in both of these clones. In addition the IC-9 clone does not transcribe also the H-2Dk allele. Our data rule out the possibility that this suppression results from enhanced RNA degradation, impaired polyadenylation, DNA rearrangement, or changes in DNA methylation within these genes. Interferons (IFN) are known to enhance MHC expression by acting on a consensus IFN responsive element present in the promoter region of MHC genes. However, IFN-gamma, which is the most potent IFN in this respect, failed to activate the expression of the silent MHC genes in our cells. This finding may reflect a defect within the promoter region of these genes or changes in their chromatin structure.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Aboud M,Amitai H,Huleihel M,Har-vardi I,Gopas J,Segal Sdoi
10.3109/08820139109082628subject
Has Abstractpub_date
1991-08-01 00:00:00pages
475-85issue
5-6eissn
0882-0139issn
1532-4311journal_volume
20pub_type
杂志文章abstract::CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820130009060867
更新日期:2000-08-01 00:00:00
abstract::Anti-α-galactoside antibody (anti-Gal) from human plasma that bound to α-galactoside-bearing guar galactomannan gel and was eluted with specific sugar (affinity-purified anti-Gal ; APAG) invariably contained apo(a) and apo B subunits in a proportion close to that in plasma lipoprotein(a) [Lp(a)]. Since LDL does not co...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.764316
更新日期:2013-01-01 00:00:00
abstract::In the last 10 years many of the superantigens of the microbial world have been defined and the mechanisms of cellular interaction between lymphocytes and antigen presenting cells has been elucidated in great detail. The consequences of superantigen stimulation of the immune system, though less well defined, can be co...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139709048933
更新日期:1997-01-01 00:00:00
abstract::VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear poly N-acetyl lactosamine chains. Since the anti-carbohydrate response i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1015682
更新日期:2015-01-01 00:00:00
abstract::This research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE2, and TNF-alpha and also on inducible nitric...
journal_title:Immunological investigations
pub_type: 杂志文章,收录出版
doi:10.1080/08820130600992115
更新日期:2007-01-01 00:00:00
abstract::Prenatal mortality due to loss of lymphocyte-promoted endometrial angiogenesis is being investigated as a major cause of litter reductions during pregnancy in pigs. This review discusses immune mechanisms influencing porcine endometrial angiogenesis as well as additional signalling molecules that may play important ro...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820130802191540
更新日期:2008-01-01 00:00:00
abstract::The complement system which is a critical mediator of innate immunity plays diverse roles in the neuropathogenesis of HIV-1 infection such as clearing HIV-1 and promoting productive HIV-1 replication. In the development of HIV-1 associated neurological disorders (HAND), there may be an imbalance between complement act...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1371891
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Rheumatic fever (RF) and its sequel rheumatic heart disease (RHD) is an autoimmune disease caused by an abnormal host immune response to group A streptococcus (GAS) infection. The HLA class II molecules are entailed in immune-mediated infectious, inflammatory, and autoimmune diseases including RHD. However, ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1822864
更新日期:2020-09-23 00:00:00
abstract::The role of ICAM-1 in contact activation of the bronchial epithelial cells is elucidated. Direct contact between epithelial cells and leukocytes is required to change transepithelial electrical resistance (TER) of the epithelium. Migration of human neutrophils across the layers of cultured human airway epithelial cell...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130600745703
更新日期:2007-01-01 00:00:00
abstract::We tested by Western blot several thousand antibody-secreting human cell lines immortalized by hybridoma fusion or Epstein-Barr virus transformation of peripheral blood lymphocytes from patients with systemic lupus erythematosus or mixed connective tissue disease. The blots utilized total human Jurkat cell extract as ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809041420
更新日期:1988-06-01 00:00:00
abstract::IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were com...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509060704
更新日期:1995-08-01 00:00:00
abstract::Th17 cells of the intestine and colon can produce several important cytokines during mucosal inflammation. However, few studies have focused on the role of IL-26 in intestinal inflammations. Colonic epithelial cells express receptors for IL-26, and this cytokine has been shown to induce the HT-29 colonic epithelial ce...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1594247
更新日期:2019-11-01 00:00:00
abstract::The induction of immune tolerance is the most common consequence of protein feeding, i.e., "oral tolerance". In this study we investigated the genetic basis of oral tolerance using various kinds of recombinant and congenic mice, and the cells involved in the development of this phenomenon in mice. The footpad swelling...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309063423
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Changes in cytokine expression have been frequently found in patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within cytokine genes. OBJECTIVE:The present study was designed to investigate the possible association betwee...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1360343
更新日期:2017-10-01 00:00:00
abstract::In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009042033
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine the association of three functional IRF5 rs10954213, rs3757385, and rs41298401 polymorphisms with susceptibility to unexplained recurrent pregnancy loss (RPL) among Iranian women from south of Iran. METHODS:176 women with unexplained RPL and 173 healthy postmenopausal controls wer...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1225759
更新日期:2017-01-01 00:00:00
abstract::As a result of strong experimental data supporting effectiveness and safety, herb-based immunomodulators are paving way as alternative sources of potent adjuvants for vaccines. In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluate...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820130903496793
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Natural killer (NK) cells are the potential modulators of inflammatory reactions that exert several unique biological effects and could lead to future adverse events of coronary artery disease (CAD). HYPOTHESIS:The purpose of this study was to find out the possible association of modulation in NK cell, TNK ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1306866
更新日期:2017-07-01 00:00:00
abstract::Competitive binding to polystyrene-bound antigens showed that human rye Group I (rye I)-specific IgG recognize the same three distinct epitopes of rye I as three monoclonal antibodies directed against the same antigens. Anti-idiotypic antibodies against one of the monoclonal antibodies (290A-167) inhibit completely th...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609036364
更新日期:1986-12-01 00:00:00
abstract::Electroeluted outer membrane proteins [(EOmp), (35-37 KDa, porins)] were highly immunogenic in New Zealand White rabbits. An ELISA peak titer of 51,200 to EOmp as compared to 6,400 for non-eluted outer membrane protein (Omp) was demonstrated. EOmp enhanced the antigenicity of Omp possibly due to epitopes which were ma...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409087802
更新日期:1994-04-01 00:00:00
abstract::A simple and rapid method of ABH phenotyping baboons has been developed which takes advantage of the fact that blood group antigens are expressed on epithelial cells. Use of readily available monoclonal antibodies and phycoerythrin-conjugated second antibody permits rapid identification of ABH phenotypes directly on b...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709055712
更新日期:1987-03-01 00:00:00
abstract::We examined the effect of various polyanions on mouse complement hemolytic activity, Fc receptor (FcR) subclass mediated antibody-dependent cellular cytotoxicity (ADCC) as well as binding by mouse peritoneal macrophages (M phi) of sheep erythrocyte targets. All the polyanions tested (dextran sulfate, carrageenan, poly...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909057755
更新日期:1989-06-01 00:00:00
abstract::The processing of antigenic peptides for presentation by MHC molecules to T cells, may depend upon the function of a second, consensus sequence in or near the T cell-presented epitope. One such processing-regulating sequence appears to be composed of amino acids Leu, Ile, Val, Phe, and Met recurring in a fashion to fo...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309066191
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE:To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical pr...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1237525
更新日期:2017-02-01 00:00:00
abstract::Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139809070903
更新日期:1998-07-01 00:00:00
abstract::Plasmodium falciparum CTL epitope minigenes containing HLA-A2 and HLA-B7 subtype supermotifs were cloned into a plasmid expression vector; this expression was measured in eight human HLA class I molecule specific cell lines. Three assays for in vitro antigen presentation analysis were developed to examine the cross-bi...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120019206
更新日期:2003-02-01 00:00:00
abstract::Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1180302
更新日期:2016-08-01 00:00:00
abstract::Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains can affect their interaction with the immune system. Beijing genotype has attracted attention because of its high prevalence and mu...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.880120
更新日期:2014-01-01 00:00:00
abstract::A previous study has demonstrated that both interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) were needed to induce the production of nitric oxide (NO) in BNL CL.2 cells, murine embryonic liver cells. We here demonstrate that when BNL CL.2 cells were cultured with serum-free medium, they were induced to produc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139909061144
更新日期:1999-03-01 00:00:00
abstract::Human tumors often progress and spread in spite of the presence of large numbers of CD4+ and CD8+ T cells with activated or memory cell phenotypes. The T cells in the microenvironment of human lung tumors fail to be activated in response to stimulation via the T cell receptor and CD28 under conditions that fully activ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820130600755066
更新日期:2006-01-01 00:00:00