Cross-binding between Plasmodium falciparum CTL epitopes and HLA class I molecules.

Abstract:

:Plasmodium falciparum CTL epitope minigenes containing HLA-A2 and HLA-B7 subtype supermotifs were cloned into a plasmid expression vector; this expression was measured in eight human HLA class I molecule specific cell lines. Three assays for in vitro antigen presentation analysis were developed to examine the cross-binding between CTL epitopes and HLA class I molecules, including cell surface peptide-MHC class I binding assay, binding stabilization assay and MHC class I assembling assay. The results demonstrated that the HLA-B51 restricted CTL epitope of Plasmodium falciparum could be presented by other HLA class I molecules; however, no other presentation was found for HLA-A2.1 CTL epitope. This work suggests the possibility for improved vaccine-coverage rates by development of a CTL vaccine which contains epitopes capable of cross-binding among different MHC class I alleles.

journal_name

Immunol Invest

authors

Tang Y,Lin Y,Mao Y,Dong M,Wang H

doi

10.1081/imm-120019206

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

31-41

issue

1-2

eissn

0882-0139

issn

1532-4311

journal_volume

32

pub_type

杂志文章
  • A multi-laboratory evaluation of an enzyme-linked immunoassay quantitating human antibodies to Streptococcus pneumoniae polysaccharides.

    abstract::An enzyme-linked immunoassay (EIA) is described and evaluated which quantitates human antibodies to serotype specific S. pneumoniae polysaccharide (PnPs) in human sera. Based on the observations previously described by Koskela (1), native PnPs are used as coating antigens and sera are absorbed with a soluble pneumococ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-100105064

    authors: Quataert S,Martin D,Anderson P,Giebink GS,Henrichsen J,Leinonen M,Granoff DM,Russell H,Siber G,Faden H,Barnes D,Madore DV

    更新日期:2001-08-01 00:00:00

  • Association between Monocyte Chemoattractant Protein-1 -2518 (A/G) Single Nucleotide Polymorphism and Chronic Periodontitis in End-stage Renal Disease Patients - A Case-control Study.

    abstract::Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the  MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1702052

    authors: Ksiazek K,Buraczynska M

    更新日期:2020-11-01 00:00:00

  • Identification of individuals at increased risk for AIDS among clinically asymptomatic homosexuals and abusers of intravenous drugs.

    abstract::Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells we...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809055726

    authors: Mannhalter JW,Wolf HM,Pum M,Banekovich M,Hutterer J,Brandstätter R,Eibl MM

    更新日期:1988-04-01 00:00:00

  • Association of CTLA-4 and CD28 Gene Polymorphisms with Type 1 Diabetes in South Indian Population.

    abstract::Each functional gene illustrates the complexity of genetic predisposition to disease; however, it is difficult to bring out these traits with reference to autoimmune diseases like type 1 diabetes (T1D). To find out the genetic contribution of CTLA-4 + 49A/G, CTLA-4 -318C/T and CD28 + 17T/C polymorphisms toward T1D, th...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1590395

    authors: Gunavathy N,Asirvatham A,Chitra A,Jayalakshmi M

    更新日期:2019-08-01 00:00:00

  • Adsorption and helical coiling of amphipathic peptides on lipid vesicles leads to negligible protection from cathepsin B or cathepsin D.

    abstract::The processing of antigenic peptides for presentation by MHC molecules to T cells, may depend upon the function of a second, consensus sequence in or near the T cell-presented epitope. One such processing-regulating sequence appears to be composed of amino acids Leu, Ile, Val, Phe, and Met recurring in a fashion to fo...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139309066191

    authors: Goldschmidt TG,Reyes VE,You G,Nelson DJ,Reisert PS,Anderson J,Mole J,Humphreys RE

    更新日期:1993-02-01 00:00:00

  • Immunomodulation of RAW 264.7 murine macrophage functions and antioxidant activities of 11 plant extracts.

    abstract::A group of 11 medicinal plants, including Lavandula pubescens, Trigonella foenugricium, Salsola schweinforthi, Calligonum comosum, Silene succulenta, Silene villosa, Bogonvillea glabra, Cakile maritime, Gomphrene celesoids, Mirabilis jalaba, and Silene nocturna growing in Egypt, were extracted and examined for their i...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2014.988720

    authors: Ghonime M,Emara M,Shawky R,Soliman H,El-Domany R,Abdelaziz A

    更新日期:2015-01-01 00:00:00

  • Association between CD226 polymorphism and soluble levels in rheumatoid arthritis: Relationship with clinical activity.

    abstract:OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1423570

    authors: Mosaad YM,El-Toraby EE,Tawhid ZM,Abdelsalam AI,Enin AF,Hasson AM,Shafeek GM

    更新日期:2018-04-01 00:00:00

  • BK virus terminates tolerance to dsDNA and histone antigens in vivo.

    abstract::In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139009042033

    authors: Fredriksen K,Traavik T,Flaegstad T,Rekvig OP

    更新日期:1990-04-01 00:00:00

  • A rapid, quantitative enzyme-linked immunosorbent assay (ELISA) for the immunodiagnosis of Chagas' disease.

    abstract::A rapid, quantitative enzyme-linked immunosorbent assay (ELISA) for the immunodiagnosis of Chagas' disease is described. The ELISA was standardized with the Falcon assay screening test (F.A.S.T.) system using a purified Trypanosoma cruzi epimastigote fraction (PEF) obtained by ion exchange chromatography. The ELISA te...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139809070892

    authors: Partel CD,Rossi CL

    更新日期:1998-01-01 00:00:00

  • Effects of corticosterone on responses of murine splenic B and T cells to phytohemagglutinin, concanavalin A, and lipopolysaccharide.

    abstract::Spleen cells of C57BL/6 mice injected with corticosterone were compared with cells from mice injected with saline in their ability to respond to the mitogens PHA, Con A, and LPS. Both unseparated cells and cells separated into T-enriched and B-enriched fractions were studied. After either seven daily injections or fou...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909045782

    authors: Stevenson JR,Kreiling JA,Taylor R

    更新日期:1989-10-01 00:00:00

  • Identification of antigenic proteins of setaria cervi by immunoblotting technique.

    abstract::Identification and characterization of antigenic proteins of Setaria cervi (bovine filarial parasite) adults and microfilariae was done by immunoblotting technique using hyperimmune rabbit sera against S. cervi and Brugia malayi. The antigens recognized by these sera were detected by using 125I protein-A followed by a...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709030571

    authors: Kaushal NA,Kaushal DC,Ghatak S

    更新日期:1987-04-01 00:00:00

  • Immunohistochemical analysis of experimental autoimmune uveoretinitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) in the rat.

    abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709055713

    authors: Chan CC,Nussenblatt RB,Wiggert B,Redmond TM,Fujikawa LS,Chader GJ,Gery I

    更新日期:1987-03-01 00:00:00

  • Impairment of Leishmania mexicana phagocytosis in peritoneal macrophages induced by Amaranthus leucocarpus lectin.

    abstract::The lectin from Amaranthus leucocarpus (ALL) is specific for N-acetyl-D-galactosamine and inhibits phagocytosis of Leishmania mexicana promastigotes in Balb/c mice peritoneal macrophages by 38%. The lipophosphoglycan (LPG) purified from L. mexicana inhibits penetration of promastigotes into peritoneal macrophages by 3...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:

    authors: Gorocica P,Hernández P,Perez A,Chávez R,Baez R,Zenteno E,Lascurain R

    更新日期:2000-11-01 00:00:00

  • Characteristics of nitric oxide-induced apoptosis and its target cells in mitogen-stimulated peripheral blood mononuclear cells from HIV+ subjects.

    abstract::The phenomenon of apoptosis observed in lymphoid cells from HIV+ subjects is an important factor contributing to their massive depletion. Several studies have identified nitric oxide (NO) as one of the molecules involved in the apoptosis phenomenon observed during HIV infection. It has been shown that HIV-derived gp12...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-100108163

    authors: García M,del Llano AM,Cruz-Colón E,Saavedra S,Lavergne JA

    更新日期:2001-11-01 00:00:00

  • A high frequency of peripheral blood NKG2D+NK and NKT cells in euthyroid patients with new onset hashimoto's thyroiditis--a pilot study.

    abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2013.854377

    authors: Guo H,Xu B,Yang X,Wang Y,Liu X,Cui C,Jiang Y

    更新日期:2014-01-01 00:00:00

  • Flow cytometric quantification of T cell proliferation and division kinetics in woodchuck model of hepatitis B.

    abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:

    authors: Gujar SA,Michalak TI

    更新日期:2005-01-01 00:00:00

  • Polymorphism in the promoter region of the CD14 gene and susceptibility to Brucellosis.

    abstract::A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130600634568

    authors: Haidari M,Hajilooi M,Rezazadeh M,Rafiei A,Alavi SA,Keramat F

    更新日期:2006-01-01 00:00:00

  • Two Novel Technologies for the Detection of Anti-cardiolipin and Anti β2-Glycoprotein Antibodies in the Real Life: Chemiluminescent in Comparison to the Addressable Laser Bead Immunoassays.

    abstract::In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1647233

    authors: Grossi V,Infantino M,Benucci M,Li Gobbi F,Bandinelli F,Damiani A,Bodio C,Borghi MO,Mahler M,Aure MA,Bentow C,Manfredi M

    更新日期:2020-02-01 00:00:00

  • Effect of immunization or cyclophosphamide treatment on growth of EL-4 leukemia cells in syngenic C57BL/6 mice.

    abstract::Prolonged survival of C57BL/6 (B6) mice bearing syngenic EL-4 leukemia cells resulted from immunization with irradiated EL-4 cells on the day of inoculation of live leukemia cells. No prolongation of survival was observed if the irradiated cells were injected 6 or 13 days after live cell inoculation. Protection also w...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509022676

    authors: Abeyounis CJ,Bekierkunst A,Milgrom F

    更新日期:1985-12-01 00:00:00

  • Differential activation of dendritic cells by Mycobacterium tuberculosis Beijing genotype.

    abstract::Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains can affect their interaction with the immune system. Beijing genotype has attracted attention because of its high prevalence and mu...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2014.880120

    authors: Reyes-Martínez JE,Nieto-Patlán E,Nieto-Patlán A,Gonzaga-Bernachi J,Santos-Mendoza T,Serafín-López J,Chávez-Blanco A,Sandoval-Montes C,Flores-Romo L,Estrada-Parra S,Estrada-García I,Chacón-Salinas R

    更新日期:2014-01-01 00:00:00

  • Adjuvant properties of AcF1, an immunostimulant fraction of Alchornea cordifolia extract.

    abstract::As a result of strong experimental data supporting effectiveness and safety, herb-based immunomodulators are paving way as alternative sources of potent adjuvants for vaccines. In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluate...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820130903496793

    authors: Nworu CS,Esimone CO,Tenbusch M,Nabi G,Proksch P,Uberla K,Temchura VV

    更新日期:2010-01-01 00:00:00

  • Comparison of peptide-coating conditions in solid phase plate assays for detection of anti-peptide antibodies.

    abstract::Mice were immunized with 14 free (i.e. not conjugated to any carrier) synthetic peptides representing the entire human hemoglobin alpha-chain. Antibodies against each peptide were determined using solid phase radioimmunoassay, both with free peptides and peptides coupled to a protein carrier as the coating antigen. It...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909050764

    authors: Oshima M,Atassi MZ

    更新日期:1989-08-01 00:00:00

  • Safety aspects of intravenous immunoglobulins.

    abstract::Seven commercially available intravenous immunoglobulins (IVIG) preparations, a gamma globulin prepared by ethanol fractionation, and an experimental IgG isolated by a chromatographic procedure were compared in several tests. Split products were present in preparations manufactured by procedures involving protease tre...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809055724

    authors: Medgyesi GA,Kovács J,Füst G,Merétey K

    更新日期:1988-04-01 00:00:00

  • Effect of immuno-modulating agents on murine IL-2 production.

    abstract::The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709030565

    authors: Weng XC,Zhang P,Gong SS,Xiai SW

    更新日期:1987-04-01 00:00:00

  • miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-κB Pathway.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2021.1874977

    authors: Jing X,Luan Z,Liu B

    更新日期:2021-01-17 00:00:00

  • Association between Vascular Endothelial Growth Factor Gene Polymorphisms and Pre-Eclampsia Susceptibility: An Updated Meta-Analysis.

    abstract::Objectives: The aim of this study was to assess the genetic association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of pre-eclampsia (PE).Methods: A systematic literature search of several databases (PubMed, Embase, and the China National Knowledge Infrastructure (CNKI)) was condu...

    journal_title:Immunological investigations

    pub_type: 杂志文章,meta分析

    doi:10.1080/08820139.2019.1659812

    authors: Wang X,Sun T,Chen G,Gao H

    更新日期:2020-02-01 00:00:00

  • PNA lectin-based separation of thymocytes into mature and immature subpopulations: CD4-8- double negative cells display characteristics of PNAlo mature thymocytes.

    abstract::Cortical (immature) thymocytes are widely reported to express intermediate to high levels of receptors for the lectin, peanut agglutinin (PNA). Light-scatter studies of murine fetal thymocytes stained with PNA or anti-mouse CD4 and CD8 monoclonal antibodies indicated, however, that the most immature CD4-8- (DN) thymoc...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139309084180

    authors: Holladay S,Blaylock B,Smith B,Luster M

    更新日期:1993-12-01 00:00:00

  • Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.

    abstract::Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate c...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1723104

    authors: Amirifar P,Mozdarani H,Yazdani R,Kiaei F,Moeini Shad T,Shahkarami S,Abolhassani H,Delavari S,Sohani M,Rezaei A,Hassanpour G,Akrami SM,Aghamohammadi A

    更新日期:2021-02-01 00:00:00

  • Effects of immunization with B. macacae on induced periodontitis--preliminary findings.

    abstract::This preliminary study examined the effects of immunization with Bacteroides macacae, the monkey equivalent of the human species of B. gingivalis on ligature-induced periodontitis. During a 12 week immunization period, 8 out of the 12 Macacae fasicularis monkeys were immunized weekly with B. macacae washed cells and 4...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909112239

    authors: Nisengard R,Blann D,Zelonis L,McHenry K,Reynolds H,Zambon J

    更新日期:1989-01-01 00:00:00

  • Influence of high altitude exposure on the immune system: a review.

    abstract::High altitude may be defined as elevations as low as 1500 meters to those as high as 8800 meters. Very few studies have been conducted so far at high altitude for the specific purpose of monitoring different immune parameters in humans. Military personnel and mountaineers may be required to perform in environmental ex...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820131003681144

    authors: Mishra KP,Ganju L

    更新日期:2010-01-01 00:00:00