Abstract:
:The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed using Con A stimulated blast cells as the target. It was found that Dang Gui increased and GB decreased the production of IL-2. In the control experiments for immuno-modulating effect, prostaglandin E2 (PGE2) was found to suppress and indomethacin to increase IL-2 production. The stimulatory effect of Dang Gui was totally abrogated by PGE2.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Weng XC,Zhang P,Gong SS,Xiai SWdoi
10.3109/08820138709030565subject
Has Abstractpub_date
1987-04-01 00:00:00pages
79-86issue
2eissn
0882-0139issn
1532-4311journal_volume
16pub_type
杂志文章abstract::Spleen cells of C57BL/6 mice injected with corticosterone were compared with cells from mice injected with saline in their ability to respond to the mitogens PHA, Con A, and LPS. Both unseparated cells and cells separated into T-enriched and B-enriched fractions were studied. After either seven daily injections or fou...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909045782
更新日期:1989-10-01 00:00:00
abstract:PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1470640
更新日期:2018-08-01 00:00:00
abstract::Each functional gene illustrates the complexity of genetic predisposition to disease; however, it is difficult to bring out these traits with reference to autoimmune diseases like type 1 diabetes (T1D). To find out the genetic contribution of CTLA-4 + 49A/G, CTLA-4 -318C/T and CD28 + 17T/C polymorphisms toward T1D, th...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1590395
更新日期:2019-08-01 00:00:00
abstract::This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the intestinal tract. It is associated with elevated levels of various inflammatory mediators, including interleukin (IL)-1β, IL-6, tumor necrosis fa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2016.1168830
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD). METHODS:Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conduct...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.3109/08820139.2014.988721
更新日期:2015-01-01 00:00:00
abstract::Adjuvant interleukin (IL)-2 immunotherapy has been used in the treatment of different malignant dieseases. However, clinical results have been rather disappointing. Therefore, further investigations on IL-2-induced mediators of cytotoxicity seem to be necessary in order to possibly create cytokine cocktails which coul...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120030916
更新日期:2004-05-01 00:00:00
abstract::There is a continuing need for alternatives to current human adjuvants. Recombinant protein vaccines, which target antigen to human Fc gamma receptor type I (hFcgammaRI) on hFcgammaRI-expressing antigen presenting cells, provide one potential alternative. Using a recombinant anti-hFcgammaRI-antigen fusion protein and ...
journal_title:Immunological investigations
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doi:10.1080/08820130500265372
更新日期:2005-01-01 00:00:00
abstract::DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.622828
更新日期:2012-01-01 00:00:00
abstract::Alveolar macrophages (AM) freshly obtained by bronchoalveolar lavage suppressed significantly, in a dose-dependent fashion, lung interstitial lymphocytes cytotoxicity against the NK-sensitive target cells, YAC-1. Kinetic experiments revealed that AM-mediated suppression of NK activity was seen following short-term inc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009042023
更新日期:1990-02-01 00:00:00
abstract::A colorimetric microadhesion assay that allows the quantitative determination of carcinoembryonic antigen (CEA)-mediated homophilic cell adhesion to CEA immobilized on 96-well polyvinyl chloride plates is described. Chinese hamster ovary (CHO) cells transfected with a full-length CEA cDNA were used as indicator cells....
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066832
更新日期:1994-11-01 00:00:00
abstract::Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909050768
更新日期:1989-08-01 00:00:00
abstract::Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609052952
更新日期:1986-06-01 00:00:00
abstract::Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate c...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1723104
更新日期:2021-02-01 00:00:00
abstract::Corneal transplant is the most common solid tissue transplant in humans. Advances in microsurgical techniques, eye banking and the use of corticosteroids have improved the success of corneal transplants. Over 65,000 corneal transplants are being performed worldwide annually. Most of these transplants are performed in ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2014.910024
更新日期:2014-01-01 00:00:00
abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Identification and characterization of antigenic proteins of Setaria cervi (bovine filarial parasite) adults and microfilariae was done by immunoblotting technique using hyperimmune rabbit sera against S. cervi and Brugia malayi. The antigens recognized by these sera were detected by using 125I protein-A followed by a...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030571
更新日期:1987-04-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Matrix metalloproteinases (MMPs) play an important role in breakdown of blood-brain barrier, transmigration, and invasion of immune cells and formation of MS lesions. The aim of present study was to investigate the influence of MMP-...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1180303
更新日期:2016-08-01 00:00:00
abstract::Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055715
更新日期:1988-03-01 00:00:00
abstract::This research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE2, and TNF-alpha and also on inducible nitric...
journal_title:Immunological investigations
pub_type: 杂志文章,收录出版
doi:10.1080/08820130600992115
更新日期:2007-01-01 00:00:00
abstract::Dengue viruses (DV) infection is an important public health issue all over the world. Although the pathogenesis remains unclear, the overwhelmingly triggered immune responses have been consistently observed. Recently, we and other researchers demonstrated that the natural hosts for DV are dendritic cells (DC), the pri...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-200038680
更新日期:2004-01-01 00:00:00
abstract::Jeevaneeya rasayana is an ayurvedic polyherbal formulation, with antirheumatic potential. The present study investigates the therapeutic efficacy of isolated total alkaloid fraction of Jeevaneeya Rasayana (AJR) in treating rheumatoid arthritis in a rat model of Adjuvant-induced arthritis (AIA). Paw swelling, inflammat...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.936937
更新日期:2015-01-01 00:00:00
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journal_title:Immunological investigations
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doi:10.3109/08820139.2015.1043669
更新日期:2015-01-01 00:00:00
abstract::Cortical (immature) thymocytes are widely reported to express intermediate to high levels of receptors for the lectin, peanut agglutinin (PNA). Light-scatter studies of murine fetal thymocytes stained with PNA or anti-mouse CD4 and CD8 monoclonal antibodies indicated, however, that the most immature CD4-8- (DN) thymoc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309084180
更新日期:1993-12-01 00:00:00
abstract::Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701555035
更新日期:2008-01-01 00:00:00
abstract::Anti-galactocerebroside (GalC) antibodies have been reported to inhibit myelin formation, cause demyelination, and block HIV-I infection of neural cells. We examined the binding of 3 monoclonal and polyclonal anti-GalC antibodies to a panel of purified glycolipids by ELISA and by an immunospot assay on nitrocellulose ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509066860
更新日期:1995-05-01 00:00:00
abstract::The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2016.1168831
更新日期:2016-07-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.647187
更新日期:2012-01-01 00:00:00
abstract::The role of innate immunity, e.g., complement activation and cytokine release in the hemodynamic alterations in the course of human septic shock is largely unknown. We prospectively studied 14 consecutive septic shock patients with a pulmonary artery catheter in place. For 3 days after admission, hemodynamic variables...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2010.502949
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...
journal_title:Immunological investigations
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doi:10.1080/08820139.2018.1423570
更新日期:2018-04-01 00:00:00
abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.854377
更新日期:2014-01-01 00:00:00