A high frequency of peripheral blood NKG2D+NK and NKT cells in euthyroid patients with new onset hashimoto's thyroiditis--a pilot study.

abstract：:To investigate whether phospholipase D1 (PLD1) is involved in autoimmune damage to the eyes, we used Western blotting and immunohistochemistry to examine the expression and distribution of PLD1 in the retinas of Lewis rats with experimental autoimmune uveoretinitis (EAU). Western blot analysis showed that the level of...

journal_title：Immunological investigations

authors： Kang J,Ahn M,Moon C,Min DS,Matsumoto Y,Shin T

更新日期：2005-01-01 00:00:00

abstract：:Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...

journal_title：Immunological investigations

authors： Estes MK,Conner ME,Gilger MA,Graham DY

更新日期：1989-01-01 00:00:00

abstract：:Many proteins of various origins are able to form complexes with Immunoglobulin G using reaction sites formed by residues of constant domains. Studies of IgG complexes of non-immune nature are important as biologically active proteins could escape from the circulation forming complexes with IgG as well as with other s...

journal_title：Immunological investigations

authors： Nezlin R,Bengtsson AA

更新日期：2008-01-01 00:00:00

abstract：:A colorimetric microadhesion assay that allows the quantitative determination of carcinoembryonic antigen (CEA)-mediated homophilic cell adhesion to CEA immobilized on 96-well polyvinyl chloride plates is described. Chinese hamster ovary (CHO) cells transfected with a full-length CEA cDNA were used as indicator cells....

journal_title：Immunological investigations

authors： Kuwahara M,Kuroki M,Haruno M,Murakami M,Arakawa F,Oikawa S,Nakazato H,Matsuoka Y

更新日期：1994-11-01 00:00:00

abstract：:Conventional plate ML-ELISA technique for diagnosis of recent cases of amoebiasis was converted into a simple polyvinyl chloride strip multilayer-enzyme linked immunosorbent assay (PVC strip ML-ELISA). This report details the development and preliminary characterization of the PVC strip ML-ELISA method for Entamoeba h...

journal_title：Immunological investigations

authors： Agarwal RK,Rawat R,Malaviya B,Das SR

更新日期：1991-12-01 00:00:00

abstract：:Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...

journal_title：Immunological investigations

authors： Watson CL,Furlong SJ,Hoskin DW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Cancer immunotherapies have achieved much success and have become the forefront treatment of cancers previously associated with poor prognosis. However, a major challenge in cancer immunotherapies remains the heterogeneity of the immunoregulatory capacities of cancers, and not all patients of a given cancer ...

journal_title：Immunological investigations

authors： Andersen MM,Larsen J,Hansen M,Pedersen AE,Gad M

更新日期：2020-06-23 00:00:00

abstract：:The occurrence of apoptosis in cultured blood cells from HIV+ patients is well-documented. However, the relationship of this process to cytokine production is still undefined. We measured the production of TNF-beta by mitogen-stimulated PBLs from 33 HIV+ patients, while simultaneously assessing their development of ap...

journal_title：Immunological investigations

authors： Lavergne JA,Zorrilla C,del Llano AM

更新日期：1996-07-01 00:00:00

abstract：:Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...

journal_title：Immunological investigations

authors： Nydegger UE,Castelli D

更新日期：1991-04-01 00:00:00

abstract：:The phenomenon of apoptosis observed in lymphoid cells from HIV+ subjects is an important factor contributing to their massive depletion. Several studies have identified nitric oxide (NO) as one of the molecules involved in the apoptosis phenomenon observed during HIV infection. It has been shown that HIV-derived gp12...

journal_title：Immunological investigations

authors： García M,del Llano AM,Cruz-Colón E,Saavedra S,Lavergne JA

更新日期：2001-11-01 00:00:00

abstract：:CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...

journal_title：Immunological investigations

authors： Reid SD,Pockley AG

更新日期：2000-08-01 00:00:00

abstract：:Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate c...

journal_title：Immunological investigations

authors： Amirifar P,Mozdarani H,Yazdani R,Kiaei F,Moeini Shad T,Shahkarami S,Abolhassani H,Delavari S,Sohani M,Rezaei A,Hassanpour G,Akrami SM,Aghamohammadi A

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS:a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. ...

journal_title：Immunological investigations

authors： Santos AC,de Moura EL,Ferreira JM,Santos BR,Alves VM,de Farias KF,de Souza Figueiredo EV

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular les...

journal_title：Immunological investigations

authors： Poomarimuthu M,Elango S,Solomon PR,Soundrapandian S,Mariakuttikan J

更新日期：2018-10-01 00:00:00

abstract：:Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...

journal_title：Immunological investigations

authors： Skitzki JJ,Muhitch JB,Evans SS

更新日期：2007-01-01 00:00:00

abstract：:The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-...

journal_title：Immunological investigations

authors： Noack B,Görgens H,Lorenz K,Schackert HK,Hoffmann T

更新日期：2009-01-01 00:00:00

abstract：:Peripheral blood lymphocytes of a patient with myasthenia gravis (MG) were fused to the non-secreting human lymphoblastoid line HuNSI to produce human x human hybridomas that secrete monoclonal antibodies (mAb) to acetylcholine receptor (AChR). Screening of hybridomas for antibody production involved an enzyme-linked ...

journal_title：Immunological investigations

authors： Blair DA,Richman DP,Taves CJ,Koethe S

更新日期：1986-06-01 00:00:00

abstract：:Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...

journal_title：Immunological investigations

authors： Kamal A,Gamal SM,Elgengehy FT,Alkemary AK,Siam I

更新日期：2016-08-01 00:00:00

abstract：:Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida albicans. In these studies we assessed the utility of recombinant human MBL (rhMBL) as a therapeutic against experimental C. albicans vaginitis. After intravenous treatment of uninfected mice ...

journal_title：Immunological investigations

authors： Clemons KV,Martinez M,Axelsen M,Thiel S,Stevens DA

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to evaluate the possible association of IL12B gene polymorphisms with serum levels of IL-12p40, IL-23 and genetic susceptibility to rheumatoid arthritis (RA) in the Bulgarian population. Genotyping for IL12Bpro (rs17860508) and IL12B A/C - 3' UTR (rs3212227) polymorphisms was performed by pol...

journal_title：Immunological investigations

authors： Manolova I,Ivanova M,Vasilev G,Stoilov R,Miteva L,Stanilova S

更新日期：2020-02-01 00:00:00

abstract：:We investigated the functional and subset surface marker characteristics of supramammary lymph node T cell populations at sites proximal and distal to the mammary region of goats repeatedly injected with heat-treated Staphylococcus aureus antigen (HK-SAC). Flow cytometric studies showed quantitative differences in CD4...

journal_title：Immunological investigations

authors： Dobrzanski MJ,Yang TJ

更新日期：1992-04-01 00:00:00

abstract：:As a result of strong experimental data supporting effectiveness and safety, herb-based immunomodulators are paving way as alternative sources of potent adjuvants for vaccines. In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluate...

journal_title：Immunological investigations

authors： Nworu CS,Esimone CO,Tenbusch M,Nabi G,Proksch P,Uberla K,Temchura VV

更新日期：2010-01-01 00:00:00

abstract：:Background: Polymorphisms in T-cell immunoglobulin and mucin domain 3 (TIM-3) gene have been implicated in susceptibility to autoimmune diseases (ADs) with inconsistent results. The aim of this study was to perform meta-analyses for clarifying the relationship between them. Methods: All relevant case-control studies w...

journal_title：Immunological investigations

authors： Zhang R,Li H,Bai L,Duan J

更新日期：2019-08-01 00:00:00

abstract：:Using antigen-induced proliferation assay the presence of macrophages was found to be essential for the development of the T cell response. Decreased ability of antigen presentation by macrophages from aged A/J mice was detected. ...

journal_title：Immunological investigations

authors： Vĕtvicka V,Tlaskalová-Hogenová H,Pospísil M

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...

journal_title：Immunological investigations

authors： Jing X,Luan Z,Liu B

更新日期：2021-01-17 00:00:00

abstract：:Background: Immunosuppressive agents are necessary to enhance allograft tolerance after transplantation and the treatment of autoimmune disorders. Regulatory T cells (Tregs) play a pivotal role in improving allograft tolerance and determining the fate of transplanted organs. Therefore, the aim of this study was to inv...

journal_title：Immunological investigations

authors： Keyhanmehr N,Motedayyen H,Eskandari N

更新日期：2019-07-01 00:00:00

abstract：:In the last 15 years, it has become apparent that ovarian cancer is recognized by the immune system, taking into account that T cell infiltration can be associated with increased overall survival. Several studies indicate that a correct combination of cluster of differentiation 8 and cluster of differentiation 4 T cel...

journal_title：Immunological investigations

authors： Singh M,Loftus T,Webb E,Benencia F

更新日期：2016-11-01 00:00:00

abstract：:Identification and characterization of antigenic proteins of Setaria cervi (bovine filarial parasite) adults and microfilariae was done by immunoblotting technique using hyperimmune rabbit sera against S. cervi and Brugia malayi. The antigens recognized by these sera were detected by using 125I protein-A followed by a...

journal_title：Immunological investigations

authors： Kaushal NA,Kaushal DC,Ghatak S

更新日期：1987-04-01 00:00:00

abstract：:The loading of dendritic cells (DCs) with whole tumor cell lysates may circumvent the facts that few tumor-specific antigens have been identified in human solid tumors. The present study was designed to investigate whether ovarian cancer cells lysate-pulsed DCs activate T cell responses against autologous ovarian tumo...

journal_title：Immunological investigations

authors： Zhao X,Wei YQ,Peng ZL

更新日期：2001-02-01 00:00:00

abstract：:Although cancer immunotherapy, which is able to target specifically cancer cells without detrimental effects to normal cell functions, would serve as an ideal therapeutic modality, most of the randomized clinical trials of cancer immunotherapy have not demonstrated a meaningful survival benefit to cancer patients over...

journal_title：Immunological investigations

authors： Kim SJ,Ha GH,Kim SH,Kang CD

更新日期：2014-01-01 00:00:00