Abstract:
:The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatment of inflammatory diseases. The main targets are cytokines, co-stimulatory molecules, and different types of cells from hematological and mesenchymal sources. In this review, we focus on molecules with anti-inflammatory effects used for in vivo gene therapy mediated by adenoviral gene transfer in the treatment of immune-mediated inflammatory diseases, with particular emphasis on autoinflammatory and autoimmune diseases.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Castañeda-Lopez ME,Garza-Veloz I,Lopez-Hernandez Y,Barbosa-Cisneros OY,Martinez-Fierro MLdoi
10.3109/08820139.2016.1168831subject
Has Abstractpub_date
2016-07-01 00:00:00pages
450-70issue
5eissn
0882-0139issn
1532-4311journal_volume
45pub_type
杂志文章,评审abstract:BACKGROUND:Loquat leaf is an herb that is commonly used in traditional Chinese medicine (TCM) for its anti-inflammatory properties. Numerous studies have demonstrated that Th17 cells play a fundamental role in mediating SLE pathological deterioration. In our study, we investigated the inhibitory effect of pentacyclic t...
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abstract::Plasmodium falciparum CTL epitope minigenes containing HLA-A2 and HLA-B7 subtype supermotifs were cloned into a plasmid expression vector; this expression was measured in eight human HLA class I molecule specific cell lines. Three assays for in vitro antigen presentation analysis were developed to examine the cross-bi...
journal_title:Immunological investigations
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abstract::Background: Polymorphisms in T-cell immunoglobulin and mucin domain 3 (TIM-3) gene have been implicated in susceptibility to autoimmune diseases (ADs) with inconsistent results. The aim of this study was to perform meta-analyses for clarifying the relationship between them. Methods: All relevant case-control studies w...
journal_title:Immunological investigations
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abstract::The role of ICAM-1 in contact activation of the bronchial epithelial cells is elucidated. Direct contact between epithelial cells and leukocytes is required to change transepithelial electrical resistance (TER) of the epithelium. Migration of human neutrophils across the layers of cultured human airway epithelial cell...
journal_title:Immunological investigations
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abstract:BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...
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abstract:BACKGROUND:Rheumatic fever (RF) and its sequel rheumatic heart disease (RHD) is an autoimmune disease caused by an abnormal host immune response to group A streptococcus (GAS) infection. The HLA class II molecules are entailed in immune-mediated infectious, inflammatory, and autoimmune diseases including RHD. However, ...
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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journal_title:Immunological investigations
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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doi:10.3109/08820139.2012.757234
更新日期:2013-01-01 00:00:00
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doi:10.1080/08820139.2019.1622561
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