Abstract:
:A. actinomycetemcomitans is a facultative Gram-negative coccobacillus which has been implicated in the etiology and pathogenesis of localized juvenile periodontitis and has also been recognized for its potential to cause serious extraoral infections, particularly endocarditis. The polymorphonuclear neutrophil has been suggested to play a key role in host resistance to periodontopathic organisms, as indicated by the association between defective production or function of these phagocytic cells and severe periodontal disease. This association has engendered interest in the study of the interaction between neutrophils and A. actinomycetemcomitans, as well as the role of immunoglobulin and complement in facilitating this interaction. The objective of this review is to summarize current knowledge of the nature and consequences of the interaction between A. actinomycetemcomitans and the host defense triad consisting of neutrophils, complement and immunoglobulin.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Wilson ME,Genco RJdoi
10.3109/08820138909112237subject
Has Abstractpub_date
1989-01-01 00:00:00pages
187-209issue
1-4eissn
0882-0139issn
1532-4311journal_volume
18pub_type
杂志文章,评审abstract::Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139809070903
更新日期:1998-07-01 00:00:00
abstract::This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the intestinal tract. It is associated with elevated levels of various inflammatory mediators, including interleukin (IL)-1β, IL-6, tumor necrosis fa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2016.1168830
更新日期:2016-07-01 00:00:00
abstract::Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the cont...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066822
更新日期:1994-08-01 00:00:00
abstract::Th17 cells of the intestine and colon can produce several important cytokines during mucosal inflammation. However, few studies have focused on the role of IL-26 in intestinal inflammations. Colonic epithelial cells express receptors for IL-26, and this cytokine has been shown to induce the HT-29 colonic epithelial ce...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1594247
更新日期:2019-11-01 00:00:00
abstract::The transferrin receptor (TR), the HLA DR antigen (DR), and the antigen binding OKT10 (T10) are present on activated lymphocyte populations. The authors have studied their expression and that of antigens defined by eight commercial monoclonal antibodies on peripheral blood lymphocytes of 50 healthy hospital workers ag...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709087089
更新日期:1987-06-01 00:00:00
abstract::Prolonged survival of C57BL/6 (B6) mice bearing syngenic EL-4 leukemia cells resulted from immunization with irradiated EL-4 cells on the day of inoculation of live leukemia cells. No prolongation of survival was observed if the irradiated cells were injected 6 or 13 days after live cell inoculation. Protection also w...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138509022676
更新日期:1985-12-01 00:00:00
abstract::Many proteins of various origins are able to form complexes with Immunoglobulin G using reaction sites formed by residues of constant domains. Studies of IgG complexes of non-immune nature are important as biologically active proteins could escape from the circulation forming complexes with IgG as well as with other s...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701854339
更新日期:2008-01-01 00:00:00
abstract::Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder caused by genetic, environmental and immunological factors. It is known that neural development processes are affected by immune functions. The aim of this study is to evaluate the relationship between cytokines IL6 and IL1B gene polymorphisms...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1870489
更新日期:2021-01-12 00:00:00
abstract::The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820131003615498
更新日期:2010-01-01 00:00:00
abstract::Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909050768
更新日期:1989-08-01 00:00:00
abstract::Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609052952
更新日期:1986-06-01 00:00:00
abstract::We have examined the effect which xenogeneic anti-Ig has on rabbit B cell function and Ig expression in an effort to understand the phenomenon of antibody mediated suppression. Treatment of rabbit lymphocyte cultures with xenogeneic anti-rabbit Ig causes 2.5-3.8 fold decrease in the level of Ig secreting cells with li...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109054924
更新日期:1991-02-01 00:00:00
abstract::Conventional plate ML-ELISA technique for diagnosis of recent cases of amoebiasis was converted into a simple polyvinyl chloride strip multilayer-enzyme linked immunosorbent assay (PVC strip ML-ELISA). This report details the development and preliminary characterization of the PVC strip ML-ELISA method for Entamoeba h...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109026242
更新日期:1991-12-01 00:00:00
abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909045785
更新日期:1989-10-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1043669
更新日期:2015-01-01 00:00:00
abstract::Thrombocytopenia as a complicating event in human immunodeficiency infection is a rather common hematological disorder and in many aspects resembles idiopathic(immune) thrombocytopenic purpura (ITP). Consequently, treatment of severe cases is similar to treating ITP, but steroids should be administered with particular...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139109050791
更新日期:1991-04-01 00:00:00
abstract::Prenatal mortality due to loss of lymphocyte-promoted endometrial angiogenesis is being investigated as a major cause of litter reductions during pregnancy in pigs. This review discusses immune mechanisms influencing porcine endometrial angiogenesis as well as additional signalling molecules that may play important ro...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820130802191540
更新日期:2008-01-01 00:00:00
abstract::Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells we...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055726
更新日期:1988-04-01 00:00:00
abstract::IL-3-like activity (IL-3-LA) is a growth factor that stimulates stem cell maturation. We examined the production of IL-3-LA by peripheral blood mononuclear cells of 10 patients with relapsing-remitting multiple sclerosis (MS) following one year of treatment with intravenous immunoglobulins (IVIG). The results were com...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509060704
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Adult chronic immune thrombocytopenic purpura (chronic ITP) is an autoimmune multifactorial bleeding disorder that occurs because of enhanced peripheral platelet destruction. Treatment decisions can be challenging because the goal of treatment is to prevent severe bleeding, but the risk of bleeding can be di...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1064948
更新日期:2015-01-01 00:00:00
abstract::Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1180302
更新日期:2016-08-01 00:00:00
abstract::An enzyme-linked immunoassay (EIA) is described and evaluated which quantitates human antibodies to serotype specific S. pneumoniae polysaccharide (PnPs) in human sera. Based on the observations previously described by Koskela (1), native PnPs are used as coating antigens and sera are absorbed with a soluble pneumococ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100105064
更新日期:2001-08-01 00:00:00
abstract::In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009042033
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1416398
更新日期:2018-04-01 00:00:00
abstract::Two monoclonal antibodies, D2A1 and D5G3 were elicited by immunization with a preparation of chicken egg riboflavin carrier protein which had been reduced and carboxymethylated. Epitopes recognised by the monoclonal antibodies were mapped using the Pepscan method. Epitopic determinants for D2A1 as well as D5G3 were id...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139809022708
更新日期:1998-12-01 00:00:00
abstract::Electroeluted outer membrane proteins [(EOmp), (35-37 KDa, porins)] were highly immunogenic in New Zealand White rabbits. An ELISA peak titer of 51,200 to EOmp as compared to 6,400 for non-eluted outer membrane protein (Omp) was demonstrated. EOmp enhanced the antigenicity of Omp possibly due to epitopes which were ma...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409087802
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4+ and CD8+ T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myel...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1367008
更新日期:2018-01-01 00:00:00
abstract::The susceptibility of cataract Shionogi (CTS) mice as young as 8 to 10 weeks of age to passive anaphylactic shock mediated by anti-benzylpenicilloyl IgE and IgG1 monoclonal antibodies was compared with those of other strains of the same age including sister strains such as nonobese-diabetic (NOD) and nonobese-nondiabe...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109026232
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:The pathological mechanisms associated with the occurrence and development of Behcet's disease (BD) are not yet known. Two large genome-wide association surveys revealed an association between interleukin (IL)-23R single nucleotide polymorphism and BD. This study aimed to investigate the association between ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1698600
更新日期:2020-08-01 00:00:00
abstract::VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear poly N-acetyl lactosamine chains. Since the anti-carbohydrate response i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1015682
更新日期:2015-01-01 00:00:00