A comparison of two dissimilar monoclonal antibodies that are directed to a common epitope in the reduced and carboxymethylated chicken riboflavin carrier protein.

abstract：:The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...

journal_title：Immunological investigations

authors： Castañeda-Lopez ME,Garza-Veloz I,Lopez-Hernandez Y,Barbosa-Cisneros OY,Martinez-Fierro ML

更新日期：2016-07-01 00:00:00

abstract：:The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...

journal_title：Immunological investigations

authors： Sia DY,Chou JL

更新日期：1988-03-01 00:00:00

abstract：:In this study we examined a panel of CD4+ antigen specific/MHC restricted T cell clones for their ability to secrete IL-2, IL-4, and IFN-gamma upon stimulation with con A, three lymphokines which are diagnostic for the TH1 and TH2 subtypes of helper T cells. Eight of the twelve clones we analyzed did not fit the class...

journal_title：Immunological investigations

authors： Hatfield SM,Rodgers GH,Marder P,Roehm NW

更新日期：1991-02-01 00:00:00

abstract：:We examined the blocking ability of poly(vinyl alcohol) (PVA) in enzyme immunoassays by coating polystyrene microtiter wells with PVA of different molecular weights (MW) and percent hydrolysis (%Hyd). Blocking ability was measured by the differences in non-specific binding of an anti-rabbit IgG-horseradish peroxidase ...

journal_title：Immunological investigations

authors： Rodda DJ,Yamazaki H

更新日期：1994-11-01 00:00:00

abstract：:In a previous study, we noticed that some ascitic cells isolated from melanoma patients survive, proliferate, and differentiate into giant phagocytes after the other cells died. Similar phenomena were observed in the primary cultures of mouse lung and liver cells. In the present study, the effects of dying cells on ab...

journal_title：Immunological investigations

authors： Yuan X,Li X,Zhang Q,Zhang C,Yang Z,Li D

更新日期：2013-01-01 00:00:00

abstract：:Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa...

journal_title：Immunological investigations

authors： Dube VE,Kallio P,Hakim A

更新日期：1988-03-01 00:00:00

abstract：:In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...

journal_title：Immunological investigations

authors： Fredriksen K,Traavik T,Flaegstad T,Rekvig OP

更新日期：1990-04-01 00:00:00

abstract：:Disease associations of clonally restricted serum immunoglobulin (Ig) abnormalities were examined using methods for detecting and characterizing homogeneous Ig that are approximately forty times more sensitive than either cellulose acetate zone electrophoresis or immunoelectrophoresis. Medical records of three hundred...

journal_title：Immunological investigations

authors： Kelly RH,Hardy TJ,Shah PM

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Loquat leaf is an herb that is commonly used in traditional Chinese medicine (TCM) for its anti-inflammatory properties. Numerous studies have demonstrated that Th17 cells play a fundamental role in mediating SLE pathological deterioration. In our study, we investigated the inhibitory effect of pentacyclic t...

journal_title：Immunological investigations

authors： Zhou X,Chen H,Wei F,Zhao Q,Su Q,Lei Y,Yin M,Tian X,Liu Z,Yu B,Bai C,He X,Huang Z

更新日期：2020-08-01 00:00:00

abstract：:Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was t...

journal_title：Immunological investigations

authors： Wang D,Chen J,Zhang H,Zhang F,Yang L,Mou Y

更新日期：2017-08-01 00:00:00

abstract：:A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....

journal_title：Immunological investigations

authors： Haidari M,Hajilooi M,Rezazadeh M,Rafiei A,Alavi SA,Keramat F

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...

journal_title：Immunological investigations

authors： Sharma RK M.Sc,Gupta V M.S,Bansal R M.S,Sharma K M.D,Gupta A M.S,Sachdeva N Ph.D

更新日期：2018-08-01 00:00:00

abstract：:Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...

journal_title：Immunological investigations

authors： Gujar SA,Michalak TI

更新日期：2005-01-01 00:00:00

abstract：:IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was...

journal_title：Immunological investigations

authors： Wu CH,Jeng KC,Lan JL

更新日期：1995-11-01 00:00:00

abstract：:In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...

journal_title：Immunological investigations

authors： Grossi V,Infantino M,Benucci M,Li Gobbi F,Bandinelli F,Damiani A,Bodio C,Borghi MO,Mahler M,Aure MA,Bentow C,Manfredi M

更新日期：2020-02-01 00:00:00

abstract：:To investigate whether phospholipase D1 (PLD1) is involved in autoimmune damage to the eyes, we used Western blotting and immunohistochemistry to examine the expression and distribution of PLD1 in the retinas of Lewis rats with experimental autoimmune uveoretinitis (EAU). Western blot analysis showed that the level of...

journal_title：Immunological investigations

authors： Kang J,Ahn M,Moon C,Min DS,Matsumoto Y,Shin T

更新日期：2005-01-01 00:00:00

abstract：:Flow cytometric analyses of immune cell proliferation, differentiation, and function are limited by the number of different fluorochromes that can be resolved simultaneously. Additional colors to expand functional analytic capability will facilitate higher dimensional analyses of heterogeneous cell populations by basi...

journal_title：Immunological investigations

authors： Bantly AD,Gray BD,Breslin E,Weinstein EG,Muirhead KA,Ohlsson-Wilhelm BM,Moore JS

更新日期：2007-01-01 00:00:00

abstract：:Studies presented examine the origin of IgA plasma cells in B lineage chimeric mice constructed by reconstituting lethally irradiated mice with a mixture of syngeneic bone marrow cells and peritoneal cells from Ig heavy chain allotype congenic donors. In these mice, essentially all B cells in spleen and Peyer's patche...

journal_title：Immunological investigations

authors： Kroese FG,Butcher EC,Stall AM,Herzenberg LA

更新日期：1989-01-01 00:00:00

abstract：:Hematological disorders like Aplastic anemia are quite frequent in Pakistan. Human leukocyte antigen (HLA) system, have been implicated in the development of Aplastic anemia in various population-based studies, The aim of this study was to determine the role of the HLA Class I and Class II alleles in genetic susceptib...

journal_title：Immunological investigations

authors： Rehman S,Saba N,Khalilullah,Munir S,Ahmed P,Mehmood T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of th...

journal_title：Immunological investigations

authors： Liu J,Liao MQ,Cao DF,Yang Y,Yang Y,Liu YH,Zeng FF,Chen XH

更新日期：2021-02-01 00:00:00

abstract：:Background: Polymorphisms in T-cell immunoglobulin and mucin domain 3 (TIM-3) gene have been implicated in susceptibility to autoimmune diseases (ADs) with inconsistent results. The aim of this study was to perform meta-analyses for clarifying the relationship between them. Methods: All relevant case-control studies w...

journal_title：Immunological investigations

authors： Zhang R,Li H,Bai L,Duan J

更新日期：2019-08-01 00:00:00

abstract：:Antigen (HSA) bound in immune complexes at equivalence with syngeneic anti-HSA antibodies elicit much stronger humoral immune response then soluble HSA. On the other hand, administration of immune complexes formed with xenogeneic (rabbit) anti-HSA antibodies suppressed humoral immune response against HSA, but not agai...

journal_title：Immunological investigations

authors： Marusić M,Marusić-Galesić S,Pokrić B

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:The pathological mechanisms associated with the occurrence and development of Behcet's disease (BD) are not yet known. Two large genome-wide association surveys revealed an association between interleukin (IL)-23R single nucleotide polymorphism and BD. This study aimed to investigate the association between ...

journal_title：Immunological investigations

authors： Gong HB,Wu XJ,Pu XM,Kang XJ

更新日期：2020-08-01 00:00:00

abstract：:The phenomenon of apoptosis observed in lymphoid cells from HIV+ subjects is an important factor contributing to their massive depletion. Several studies have identified nitric oxide (NO) as one of the molecules involved in the apoptosis phenomenon observed during HIV infection. It has been shown that HIV-derived gp12...

journal_title：Immunological investigations

authors： García M,del Llano AM,Cruz-Colón E,Saavedra S,Lavergne JA

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...

journal_title：Immunological investigations

authors： Mosaad YM,El-Toraby EE,Tawhid ZM,Abdelsalam AI,Enin AF,Hasson AM,Shafeek GM

更新日期：2018-04-01 00:00:00

abstract：:Results of recent studies indicated that a monoclonal ART18 antibody recognizes the receptor sites or closely related structures for IL-2 on activated rat T-cells. The major histocompatibility complex (MHC) class II (Ia) antigens (RT1B and RT1D in rat), detected with OX6 antibody, and OX17 antibody, may be present on ...

journal_title：Immunological investigations

authors： Chan CC,Caspi R,Mochizuki M,Diamantstein T,Gery I,Nussenblatt RB

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE:To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical pr...

journal_title：Immunological investigations

authors： Skare TL,Nisihara R,Cieslinski JZ,Zeni JO,Rasera HN,Messias-Reason I,Utiyama SR

更新日期：2017-02-01 00:00:00

abstract：:DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...

journal_title：Immunological investigations

authors： Kang Y,Zheng G,Chen A,Wang J,Hu Y,Li J,Zhang J,Gao W,Fu H,Xia G,Wang B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic smoking-related lung disease associated with higher mortality and morbidity. Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. METHODS:GEO database was applied to fil...

journal_title：Immunological investigations

authors： Jing X,Luan Z,Liu B

更新日期：2021-01-17 00:00:00

abstract：:In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma ...

journal_title：Immunological investigations

authors： Haydaroglu H,Oguzkan Balcı S,Pehlıvan S,Ozdıllı K,Gundogan E,Okan V,Nursal AF,Pehlıvan M

更新日期：2017-01-01 00:00:00