Abstract:
BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of the associations. METHODS:Published literatures reporting the relationships of two IL-6 polymorphisms (G-174C and G-572C) and SLE risk were retrieved from electronic databases such as PubMed and EMBASE. The most appropriate genetic model was chosen for each polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Trial sequential analysis (TSA) was introduced to assess the information size and the positive results. RESULTS:With 17 studies (2780 cases and 3100 controls) included, a dominant association (CC+GC vs. GG) was suggested for G-174C polymorphism, and compared with the GG genotype, the CC+GC genotype of G-174C was associated with a decreased SLE risk (OR = 0.71; 95% CI = 0.56-0.88, P =.02). No association was found for G-572C under all genetic models (e.g. OR and 95%CI for CC+GC vs. GG: 0.89, 0.73-1.08, P =.22). Subgroup analyses indicated that SLE risk decreased in G-174C polymorphism by subgroups of Caucasian population, publications after 2010, studies with high quality, and studies complied with Hardy-Weinberg equilibrium (HWE). TSA suggested that the sample sizes used for G-572C were insufficient. CONCLUSION:We found that the minor allele C of IL6G-174C polymorphism is a protective factor in SLE. Further studies with a larger sample size are needed to confirm the null association for G-572C.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Liu J,Liao MQ,Cao DF,Yang Y,Yang Y,Liu YH,Zeng FF,Chen XHdoi
10.1080/08820139.2020.1769646subject
Has Abstractpub_date
2021-02-01 00:00:00pages
259-272issue
2-3eissn
0882-0139issn
1532-4311journal_volume
50pub_type
杂志文章abstract:OBJECTIVE:The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD). METHODS:Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conduct...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.3109/08820139.2014.988721
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-200038680
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abstract::The transferrin receptor (TR), the HLA DR antigen (DR), and the antigen binding OKT10 (T10) are present on activated lymphocyte populations. The authors have studied their expression and that of antigens defined by eight commercial monoclonal antibodies on peripheral blood lymphocytes of 50 healthy hospital workers ag...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709087089
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abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...
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doi:10.3109/08820138909045785
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journal_title:Immunological investigations
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journal_title:Immunological investigations
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doi:10.3109/08820138809055724
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journal_title:Immunological investigations
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doi:10.3109/08820139509066864
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journal_title:Immunological investigations
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更新日期:2010-01-01 00:00:00
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journal_title:Immunological investigations
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doi:10.3109/08820139009052977
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abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030567
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...
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pub_type: 杂志文章
doi:10.1080/08820139.2018.1423570
更新日期:2018-04-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139809070892
更新日期:1998-01-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.575426
更新日期:2011-01-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309066191
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doi:10.3109/08820139809070903
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章,评审
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doi:10.3109/08820138809055726
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更新日期:2005-01-01 00:00:00
abstract::The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed...
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doi:10.3109/08820138709030565
更新日期:1987-04-01 00:00:00