Abstract:
:IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was examined. The significant decreased IL-2 production by PB MNC from the patients with RA (p < 0.05) and OAD (p < 0.05) were observed when compared with normal controls, and no statistical difference was found although IL-2 levels in RA PB were lower than in OAD PB. However, significant statistical difference (p < 0.01) was found when the IL-2 production by RA SF was compared with OAD SF. Serum IL-2 inhibitory factor was examined by IL-2-dependent mouse helper T cell line (HT-2). Significantly higher inhibitory activity was found in RA patients (p = 0.001) compared to OAD and normal control patients. Mycobacterium tuberculosis (MT) antigen was also examined from patients with RA and OAD, and 55.5% of SF from RA patients were positive for MT antigens and none was detected in OAD by a highly specific and sensitive double-antibody sandwich ELISA. However, no correlation between MT antigens, IL-2 levels and IL-2 inhibitory activities were found in patients with RA. Our results and other indicate that rheumatoid SF MNC, IL-2 inhibitor and MT antigen may play important roles in the pathogenesis of RA.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Wu CH,Jeng KC,Lan JLdoi
10.3109/08820139509060720subject
Has Abstractpub_date
1995-11-01 00:00:00pages
957-64issue
6eissn
0882-0139issn
1532-4311journal_volume
24pub_type
杂志文章abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1043669
更新日期:2015-01-01 00:00:00
abstract::Food allergy is an important and common health issue, and there is a need to identify and characterize the sensitizing mechanisms. One of the common causes of food allergy is ovalbumin (OVA), a dietary antigen from eggs. We hypothesized that OVA-induced food allergy in the gut involves the activation of the chemokine ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120027682
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abstract::Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice wit...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1267203
更新日期:2017-04-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138509042005
更新日期:1985-04-01 00:00:00
abstract::This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, I...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1009546
更新日期:2015-01-01 00:00:00
abstract::Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139809070903
更新日期:1998-07-01 00:00:00
abstract::The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2016.1168831
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Changes in cytokine expression have been frequently found in patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within cytokine genes. OBJECTIVE:The present study was designed to investigate the possible association betwee...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1360343
更新日期:2017-10-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.647187
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1470640
更新日期:2018-08-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1647233
更新日期:2020-02-01 00:00:00
abstract::Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida albicans. In these studies we assessed the utility of recombinant human MBL (rhMBL) as a therapeutic against experimental C. albicans vaginitis. After intravenous treatment of uninfected mice ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.569627
更新日期:2011-01-01 00:00:00
abstract::Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder caused by genetic, environmental and immunological factors. It is known that neural development processes are affected by immune functions. The aim of this study is to evaluate the relationship between cytokines IL6 and IL1B gene polymorphisms...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1870489
更新日期:2021-01-12 00:00:00
abstract::The purpose of this presentation was to demonstrate that the red blood cell is not a hapless sac of hemoglobin and that much research is still needed for better understanding of its complexities. After a brief historical introduction the following subjects are presented: 1). Phosphofructokinase is the rate limiting st...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139509062760
更新日期:1995-01-01 00:00:00
abstract::Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 3...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1288237
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1480030
更新日期:2018-10-01 00:00:00
abstract::The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130902846290
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Natural killer (NK) cells are the potential modulators of inflammatory reactions that exert several unique biological effects and could lead to future adverse events of coronary artery disease (CAD). HYPOTHESIS:The purpose of this study was to find out the possible association of modulation in NK cell, TNK ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1306866
更新日期:2017-07-01 00:00:00
abstract::In the present study, we evaluated the effectiveness of a levamisole-based adjuvant (ADL) to enhance the ability of the Ag85B-ESAT6 fusion protein to boost immune responses after primary vaccination with recombinant bacillus Calmette-Guerin (rBCG) in Balb/c mice. The results were compared with that of the control adju...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2012.658940
更新日期:2012-01-01 00:00:00
abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.854377
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular les...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1493053
更新日期:2018-10-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820130802191540
更新日期:2008-01-01 00:00:00
abstract::This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the intestinal tract. It is associated with elevated levels of various inflammatory mediators, including interleukin (IL)-1β, IL-6, tumor necrosis fa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2016.1168830
更新日期:2016-07-01 00:00:00
abstract::In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1208219
更新日期:2017-01-01 00:00:00
abstract::Prolonged survival of C57BL/6 (B6) mice bearing syngenic EL-4 leukemia cells resulted from immunization with irradiated EL-4 cells on the day of inoculation of live leukemia cells. No prolongation of survival was observed if the irradiated cells were injected 6 or 13 days after live cell inoculation. Protection also w...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138509022676
更新日期:1985-12-01 00:00:00
abstract::Many proteins of various origins are able to form complexes with Immunoglobulin G using reaction sites formed by residues of constant domains. Studies of IgG complexes of non-immune nature are important as biologically active proteins could escape from the circulation forming complexes with IgG as well as with other s...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701854339
更新日期:2008-01-01 00:00:00
abstract::To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609055732
更新日期:1996-09-01 00:00:00
abstract::The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130801967841
更新日期:2008-01-01 00:00:00
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journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055720
更新日期:1988-03-01 00:00:00
abstract::Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented b...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130601187384
更新日期:2007-01-01 00:00:00