Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis.

Abstract:

:IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was examined. The significant decreased IL-2 production by PB MNC from the patients with RA (p < 0.05) and OAD (p < 0.05) were observed when compared with normal controls, and no statistical difference was found although IL-2 levels in RA PB were lower than in OAD PB. However, significant statistical difference (p < 0.01) was found when the IL-2 production by RA SF was compared with OAD SF. Serum IL-2 inhibitory factor was examined by IL-2-dependent mouse helper T cell line (HT-2). Significantly higher inhibitory activity was found in RA patients (p = 0.001) compared to OAD and normal control patients. Mycobacterium tuberculosis (MT) antigen was also examined from patients with RA and OAD, and 55.5% of SF from RA patients were positive for MT antigens and none was detected in OAD by a highly specific and sensitive double-antibody sandwich ELISA. However, no correlation between MT antigens, IL-2 levels and IL-2 inhibitory activities were found in patients with RA. Our results and other indicate that rheumatoid SF MNC, IL-2 inhibitor and MT antigen may play important roles in the pathogenesis of RA.

journal_name

Immunol Invest

authors

Wu CH,Jeng KC,Lan JL

doi

10.3109/08820139509060720

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

957-64

issue

6

eissn

0882-0139

issn

1532-4311

journal_volume

24

pub_type

杂志文章
  • Generation and Characterization of Human Single-Chain Antibodies Against Polycyclic Aromatic Hydrocarbons.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2015.1043669

    authors: Ustinov VA,Studennikov AE,Vavilov VA,Tyumentseva MA,Morozova VV,Tikunova NV,Glushkov AN

    更新日期:2015-01-01 00:00:00

  • The role of RANTES in a murine model of food allergy.

    abstract::Food allergy is an important and common health issue, and there is a need to identify and characterize the sensitizing mechanisms. One of the common causes of food allergy is ovalbumin (OVA), a dietary antigen from eggs. We hypothesized that OVA-induced food allergy in the gut involves the activation of the chemokine ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-120027682

    authors: Lee JB,Matsumoto T,Shin YO,Yang HM,Min YK,Timothy O,Bae SJ,Quan FS

    更新日期:2004-02-01 00:00:00

  • Changes in the Level of Immunoglobulins and CD4/CD8 Ratio in Young and Aged Mice with Estradiol Deficiency.

    abstract::Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice wit...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2016.1267203

    authors: Shao MJ,Zhu YJ,Qiu YE,Hu M,He YQ

    更新日期:2017-04-01 00:00:00

  • Impaired antigen presenting function of macrophages from aged mice.

    abstract::Using antigen-induced proliferation assay the presence of macrophages was found to be essential for the development of the T cell response. Decreased ability of antigen presentation by macrophages from aged A/J mice was detected. ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509042005

    authors: Vĕtvicka V,Tlaskalová-Hogenová H,Pospísil M

    更新日期:1985-04-01 00:00:00

  • Sulfated radix Cyathulae officinalis polysaccharides act as adjuvant via promoting the dendritic cell maturation and suppressing Treg frequency.

    abstract::This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, I...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2015.1009546

    authors: Feng H,Fan J,Du X,Song Z,Wang Z,Han X,Zhao B,Liu J

    更新日期:2015-01-01 00:00:00

  • T cell receptor V-segment frequencies in peripheral CD8+ T cells in aging.

    abstract::Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139809070903

    authors: Esparza B,Rodriguez A,Puente M,Sabino E,Merino F

    更新日期:1998-07-01 00:00:00

  • Anti-Inflammatory Effects of Modified Adenoviral Vectors for Gene Therapy: A View through Animal Models Tested.

    abstract::The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139.2016.1168831

    authors: Castañeda-Lopez ME,Garza-Veloz I,Lopez-Hernandez Y,Barbosa-Cisneros OY,Martinez-Fierro ML

    更新日期:2016-07-01 00:00:00

  • Interleukin-4 and Interleukin-10 Gene Polymorphisms in Patients with Inflammatory Bowel Disease.

    abstract:BACKGROUND:Changes in cytokine expression have been frequently found in patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within cytokine genes. OBJECTIVE:The present study was designed to investigate the possible association betwee...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1360343

    authors: Ebrahimi Daryani N,Saghazadeh A,Moossavi S,Sadr M,Shahkarami S,Soltani S,Farhadi E,Rezaei N

    更新日期:2017-10-01 00:00:00

  • Direct effects of conjugated linoleic acid isomers on P815 mast cells in vitro.

    abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.647187

    authors: Krishnan S,Russell J,Bodziak M,Koury S,Masso-Welch P

    更新日期:2012-01-01 00:00:00

  • Immune Profiling of T Cells Infiltrating Vitreous Humor in Tubercular Uveitis.

    abstract:PURPOSE:To assess cellular composition and local cytokine response in vitreous humor of tubercular uveitis. METHODS:Cells were collected from vitreous cassettes and peripheral blood of 8 tubercular uveitis and 5 control subjects, undergoing vitrectomy and analyzed by flow cytometry for cellular composition, activation...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1470640

    authors: Sharma RK M.Sc,Gupta V M.S,Bansal R M.S,Sharma K M.D,Gupta A M.S,Sachdeva N Ph.D

    更新日期:2018-08-01 00:00:00

  • Two Novel Technologies for the Detection of Anti-cardiolipin and Anti β2-Glycoprotein Antibodies in the Real Life: Chemiluminescent in Comparison to the Addressable Laser Bead Immunoassays.

    abstract::In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1647233

    authors: Grossi V,Infantino M,Benucci M,Li Gobbi F,Bandinelli F,Damiani A,Bodio C,Borghi MO,Mahler M,Aure MA,Bentow C,Manfredi M

    更新日期:2020-02-01 00:00:00

  • Efficacy of recombinant human mannose binding lectin alone and in combination with itraconazole against murine Candida albicans vaginitis.

    abstract::Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida albicans. In these studies we assessed the utility of recombinant human MBL (rhMBL) as a therapeutic against experimental C. albicans vaginitis. After intravenous treatment of uninfected mice ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.569627

    authors: Clemons KV,Martinez M,Axelsen M,Thiel S,Stevens DA

    更新日期:2011-01-01 00:00:00

  • Evaluation of IL1B rs1143634 and IL6 rs1800796 Polymorphisms with Autism Spectrum Disorder in the Turkish Children.

    abstract::Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder caused by genetic, environmental and immunological factors. It is known that neural development processes are affected by immune functions. The aim of this study is to evaluate the relationship between cytokines IL6 and IL1B gene polymorphisms...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1870489

    authors: Pekkoc Uyanik KC,Kalayci Yigin A,Dogangun B,Seven M

    更新日期:2021-01-12 00:00:00

  • The Ernest Witebsky memorial lecture. Red but not dead: not a hapless sac of hemoglobin.

    abstract::The purpose of this presentation was to demonstrate that the red blood cell is not a hapless sac of hemoglobin and that much research is still needed for better understanding of its complexities. After a brief historical introduction the following subjects are presented: 1). Phosphofructokinase is the rate limiting st...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139509062760

    authors: Greenwalt TJ

    更新日期:1995-01-01 00:00:00

  • High Interleukin-10 Expression in Type 2 T Helper Cells in Septic Patients.

    abstract::Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 3...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1288237

    authors: Wu HP,Chu CM,Kao KC,Huang SH,Chuang DY

    更新日期:2017-05-01 00:00:00

  • Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls.

    abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1480030

    authors: Spacek J,Vocka M,Netikova I,Skalova H,Dundr P,Konopasek B,Zavadova E,Lubos P

    更新日期:2018-10-01 00:00:00

  • TLR4 and IL-18 gene variants in chronic periodontitis: impact on disease susceptibility and severity.

    abstract::The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130902846290

    authors: Noack B,Görgens H,Lorenz K,Schackert HK,Hoffmann T

    更新日期:2009-01-01 00:00:00

  • Reduction in CD16/CD56 and CD16/CD3/CD56 Natural Killer Cells in Coronary Artery Disease.

    abstract:BACKGROUND:Natural killer (NK) cells are the potential modulators of inflammatory reactions that exert several unique biological effects and could lead to future adverse events of coronary artery disease (CAD). HYPOTHESIS:The purpose of this study was to find out the possible association of modulation in NK cell, TNK ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1306866

    authors: Jabir NR,Firoz CK,Ahmed F,Kamal MA,Hindawi S,Damanhouri GA,Almehdar HA,Tabrez S

    更新日期:2017-07-01 00:00:00

  • Immune responses induced by heterologous boosting of recombinant bacillus Calmette-Guerin with Ag85B-ESAT6 fusion protein in levamisole-based adjuvant.

    abstract::In the present study, we evaluated the effectiveness of a levamisole-based adjuvant (ADL) to enhance the ability of the Ag85B-ESAT6 fusion protein to boost immune responses after primary vaccination with recombinant bacillus Calmette-Guerin (rBCG) in Balb/c mice. The results were compared with that of the control adju...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2012.658940

    authors: You Q,Wu Y,Jiang D,Wu Y,Wang C,Wei W,Yu X,Zhang X,Kong W,Jiang C

    更新日期:2012-01-01 00:00:00

  • A high frequency of peripheral blood NKG2D+NK and NKT cells in euthyroid patients with new onset hashimoto's thyroiditis--a pilot study.

    abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2013.854377

    authors: Guo H,Xu B,Yang X,Wang Y,Liu X,Cui C,Jiang Y

    更新日期:2014-01-01 00:00:00

  • Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population.

    abstract:BACKGROUND:IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular les...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1493053

    authors: Poomarimuthu M,Elango S,Solomon PR,Soundrapandian S,Mariakuttikan J

    更新日期:2018-10-01 00:00:00

  • Immunological mechanisms affecting angiogenesis and their relation to porcine pregnancy success.

    abstract::Prenatal mortality due to loss of lymphocyte-promoted endometrial angiogenesis is being investigated as a major cause of litter reductions during pregnancy in pigs. This review discusses immune mechanisms influencing porcine endometrial angiogenesis as well as additional signalling molecules that may play important ro...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.1080/08820130802191540

    authors: Linton NF,Wessels JM,Cnossen SA,Croy BA,Tayade C

    更新日期:2008-01-01 00:00:00

  • Suppression of MAPKs/NF-κB Activation Induces Intestinal Anti-Inflammatory Action of Ginsenoside Rf in HT-29 and RAW264.7 Cells.

    abstract::This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the intestinal tract. It is associated with elevated levels of various inflammatory mediators, including interleukin (IL)-1β, IL-6, tumor necrosis fa...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2016.1168830

    authors: Ahn S,Siddiqi MH,Aceituno VC,Simu SY,Yang DC

    更新日期:2016-07-01 00:00:00

  • Effect of Cytokine Genes in the Pathogenesis and on the Clinical Parameters for the Treatment of Multiple Myeloma.

    abstract::In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2016.1208219

    authors: Haydaroglu H,Oguzkan Balcı S,Pehlıvan S,Ozdıllı K,Gundogan E,Okan V,Nursal AF,Pehlıvan M

    更新日期:2017-01-01 00:00:00

  • Effect of immunization or cyclophosphamide treatment on growth of EL-4 leukemia cells in syngenic C57BL/6 mice.

    abstract::Prolonged survival of C57BL/6 (B6) mice bearing syngenic EL-4 leukemia cells resulted from immunization with irradiated EL-4 cells on the day of inoculation of live leukemia cells. No prolongation of survival was observed if the irradiated cells were injected 6 or 13 days after live cell inoculation. Protection also w...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509022676

    authors: Abeyounis CJ,Bekierkunst A,Milgrom F

    更新日期:1985-12-01 00:00:00

  • Presence of IgG-CD4 complexes in the circulation.

    abstract::Many proteins of various origins are able to form complexes with Immunoglobulin G using reaction sites formed by residues of constant domains. Studies of IgG complexes of non-immune nature are important as biologically active proteins could escape from the circulation forming complexes with IgG as well as with other s...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130701854339

    authors: Nezlin R,Bengtsson AA

    更新日期:2008-01-01 00:00:00

  • Heterogeneity of drug susceptibility of mouse active anaphylactic shock.

    abstract::To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139609055732

    authors: Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

    更新日期:1996-09-01 00:00:00

  • Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells.

    abstract::The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated in T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) as the main cell type that expresses a diverse range of tissue-restricted antigens (TRAs). The TECs of a common autoimmu...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130801967841

    authors: Chen J,Yang W,Yu C,Li Y

    更新日期:2008-01-01 00:00:00

  • Analysis of human peripheral blood T lymphocytes proliferating in response to sensitizing antigens: effect of interleukin-2 (IL-2)-responsive bystander cells.

    abstract::The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809055720

    authors: Sia DY,Chou JL

    更新日期:1988-03-01 00:00:00

  • MHC-restricted presentation of a single repeat of MUC1 mucin.

    abstract::Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented b...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130601187384

    authors: Orr MK,Burnside JS,Phillips CA,Philip R,Dombrowski KE,Wright SE

    更新日期:2007-01-01 00:00:00