Immunological mechanisms affecting angiogenesis and their relation to porcine pregnancy success.

Abstract:

:Prenatal mortality due to loss of lymphocyte-promoted endometrial angiogenesis is being investigated as a major cause of litter reductions during pregnancy in pigs. This review discusses immune mechanisms influencing porcine endometrial angiogenesis as well as additional signalling molecules that may play important roles in the compromise of peri-implantation and mid-gestation fetal pig survival. These include dendritic cells, signalling molecules such as toll-like receptors, chemokines and ficolins. Together these cells and molecules regulate immune responses and, ideally, protect the mother and prevent immune-based conceptus losses. Dendritic cells were recently shown to be angiogenic. Their tolerogenic role at the maternal-fetal interface coupled with the ability to secrete and respond to angiogenic factors suggests that dendritic cells are the key coordinators of angiogenesis at the porcine maternal-fetal interface. Chemokines coordinate the localization of immune effector and endothelial cells. The balance between pro-angiogenic and anti-angiogenic chemokines is addressed in relation to conceptus viability. Ficolins, components of the lectin-mediated complement activation pathway, are used for self/non-self recognition. Together, these components of the immune system could regulate lymphocyte- and non-lymphocyte-promoted endometrial angiogenesis to determine conceptus survival.

journal_name

Immunol Invest

authors

Linton NF,Wessels JM,Cnossen SA,Croy BA,Tayade C

doi

10.1080/08820130802191540

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

611-29

issue

5

eissn

0882-0139

issn

1532-4311

pii

901776989

journal_volume

37

pub_type

杂志文章,评审
  • Immunoglobulins for intravenous use inhibit TNF alpha cytotoxicity in vitro.

    abstract::Intravenous immunoglobulins (IVIg) have been used as an immunomodulatory therapy in a variety of diseases. Several mechanisms of action have been proposed, one of which is interference with the cytokine network. We have investigated the effect of IVIg on the cytotoxicity of human TNF alpha. IVIg was capable of protect...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139709088541

    authors: Stangel M,Schumacher HC,Ruprecht K,Boegner F,Marx P

    更新日期:1997-08-01 00:00:00

  • Increased Circulating Osteoprotegerin Levels in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis Based on Observational Studies.

    abstract::Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone me...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1710531

    authors: Duan CC,Ma C,Tang HQ

    更新日期:2021-02-01 00:00:00

  • Heterogeneity of drug susceptibility of mouse active anaphylactic shock.

    abstract::To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139609055732

    authors: Kimura S,Watanabe A,Nagata M,Niinomi Y,Harada M

    更新日期:1996-09-01 00:00:00

  • Adjuvant properties of AcF1, an immunostimulant fraction of Alchornea cordifolia extract.

    abstract::As a result of strong experimental data supporting effectiveness and safety, herb-based immunomodulators are paving way as alternative sources of potent adjuvants for vaccines. In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluate...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820130903496793

    authors: Nworu CS,Esimone CO,Tenbusch M,Nabi G,Proksch P,Uberla K,Temchura VV

    更新日期:2010-01-01 00:00:00

  • Role of Different CD40 Polymorphisms in Graves' Disease and Hashimoto's Thyroiditis.

    abstract::Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was t...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1319382

    authors: Wang D,Chen J,Zhang H,Zhang F,Yang L,Mou Y

    更新日期:2017-08-01 00:00:00

  • A high frequency of peripheral blood NKG2D+NK and NKT cells in euthyroid patients with new onset hashimoto's thyroiditis--a pilot study.

    abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2013.854377

    authors: Guo H,Xu B,Yang X,Wang Y,Liu X,Cui C,Jiang Y

    更新日期:2014-01-01 00:00:00

  • The Association between Interleukin-6 Gene Polymorphisms and Risk of Systemic Lupus Erythematosus: A Meta-analysis with Trial Sequential Analysis.

    abstract:BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of th...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1769646

    authors: Liu J,Liao MQ,Cao DF,Yang Y,Yang Y,Liu YH,Zeng FF,Chen XH

    更新日期:2021-02-01 00:00:00

  • Impairment of Leishmania mexicana phagocytosis in peritoneal macrophages induced by Amaranthus leucocarpus lectin.

    abstract::The lectin from Amaranthus leucocarpus (ALL) is specific for N-acetyl-D-galactosamine and inhibits phagocytosis of Leishmania mexicana promastigotes in Balb/c mice peritoneal macrophages by 38%. The lipophosphoglycan (LPG) purified from L. mexicana inhibits penetration of promastigotes into peritoneal macrophages by 3...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:

    authors: Gorocica P,Hernández P,Perez A,Chávez R,Baez R,Zenteno E,Lascurain R

    更新日期:2000-11-01 00:00:00

  • Effect of anti-Ig on rabbit B cell function and Ig expression.

    abstract::We have examined the effect which xenogeneic anti-Ig has on rabbit B cell function and Ig expression in an effort to understand the phenomenon of antibody mediated suppression. Treatment of rabbit lymphocyte cultures with xenogeneic anti-rabbit Ig causes 2.5-3.8 fold decrease in the level of Ig secreting cells with li...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109054924

    authors: Ives N,Asundi V,Dreher K

    更新日期:1991-02-01 00:00:00

  • An improved PVC strip ML-ELISA technique for diagnosis of recent cases of amoebiasis.

    abstract::Conventional plate ML-ELISA technique for diagnosis of recent cases of amoebiasis was converted into a simple polyvinyl chloride strip multilayer-enzyme linked immunosorbent assay (PVC strip ML-ELISA). This report details the development and preliminary characterization of the PVC strip ML-ELISA method for Entamoeba h...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109026242

    authors: Agarwal RK,Rawat R,Malaviya B,Das SR

    更新日期:1991-12-01 00:00:00

  • Interferon-gamma alone triggers the production of nitric oxide from serum-starved BNL CL.2, murine embryonic liver cells.

    abstract::A previous study has demonstrated that both interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) were needed to induce the production of nitric oxide (NO) in BNL CL.2 cells, murine embryonic liver cells. We here demonstrate that when BNL CL.2 cells were cultured with serum-free medium, they were induced to produc...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139909061144

    authors: Pae HO,Yoo JC,Choi BM,Paik SG,Kim YH,Jin HS,Chung HT

    更新日期:1999-03-01 00:00:00

  • Bacterial contamination of blood products and the value of pre-transfusion testing.

    abstract::There has been a dramatic increase recently in the number of reports of septic episodes associated with both red cell and platelet concentrate transfusions. These reports suggest that transfusion-associated septic reactions may occur as often as 1 per 4000 platelet transfusions, however, the true incidence of the bact...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139509062770

    authors: Blajchman MA

    更新日期:1995-01-01 00:00:00

  • Immunohistochemical analysis of experimental autoimmune uveoretinitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) in the rat.

    abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709055713

    authors: Chan CC,Nussenblatt RB,Wiggert B,Redmond TM,Fujikawa LS,Chader GJ,Gery I

    更新日期:1987-03-01 00:00:00

  • The role of RANTES in a murine model of food allergy.

    abstract::Food allergy is an important and common health issue, and there is a need to identify and characterize the sensitizing mechanisms. One of the common causes of food allergy is ovalbumin (OVA), a dietary antigen from eggs. We hypothesized that OVA-induced food allergy in the gut involves the activation of the chemokine ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-120027682

    authors: Lee JB,Matsumoto T,Shin YO,Yang HM,Min YK,Timothy O,Bae SJ,Quan FS

    更新日期:2004-02-01 00:00:00

  • Employing XIAP to enhance the duration of antigen expression and immunity against an avian influenza H5 DNA vaccine.

    abstract::DNA vaccine represents a powerful approach for prevention of avian H5N1 influenza infection. Yet, DNA vaccine-induced immune responses might be limited by the short duration of antigen expression. As a strategy to enhance adaptive immune responses elicited by a hemagglutinin 5 (H5) DNA vaccine, we explored the effect ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2014.988718

    authors: Tabatabaeizadeh SE,Bassami MR,Haghparast A,Dehghani H

    更新日期:2015-01-01 00:00:00

  • Two Novel Technologies for the Detection of Anti-cardiolipin and Anti β2-Glycoprotein Antibodies in the Real Life: Chemiluminescent in Comparison to the Addressable Laser Bead Immunoassays.

    abstract::In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1647233

    authors: Grossi V,Infantino M,Benucci M,Li Gobbi F,Bandinelli F,Damiani A,Bodio C,Borghi MO,Mahler M,Aure MA,Bentow C,Manfredi M

    更新日期:2020-02-01 00:00:00

  • Association between CARD8 rs2043211 polymorphism and inflammatory bowel disease: a meta-analysis.

    abstract:OBJECTIVE:The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD). METHODS:Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conduct...

    journal_title:Immunological investigations

    pub_type: 杂志文章,meta分析

    doi:10.3109/08820139.2014.988721

    authors: Liu J,Liu YY,Liu J,Li BZ,Cen H,Xu WD,Leng RX,Pan HF,Ye DQ

    更新日期:2015-01-01 00:00:00

  • Are the mast cells antigen presenting cells?

    abstract::Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells i...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909050768

    authors: Banovac K,Neylan D,Leone J,Ghandur-Mnaymneh L,Rabinovitch A

    更新日期:1989-08-01 00:00:00

  • Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis.

    abstract::IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139509060720

    authors: Wu CH,Jeng KC,Lan JL

    更新日期:1995-11-01 00:00:00

  • The application of Artocarpus integer seed lectin-M in the detection and isolation of selective human serum acute-phase proteins and immunoglobulins.

    abstract::Champedak (Artocarpus integer) lectin-M is a lectin with high specificity and affinity for the core-mannosyl residues of the N-linked oligosaccharides of glycoproteins. We have studied the interaction of the champedak seed lectin with human serum glycoproteins that were resolved by 2-dimensional (2-D) gel electrophore...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-100104021

    authors: Hashim OH,Ahmad F,Shuib AS

    更新日期:2001-05-01 00:00:00

  • Impaired interleukin-2 synthesis and T cell proliferation following antibody-mediated CD3 and CD2 or CD28 cross-linking in trans: evidence that T cell activation requires the engagement of costimulatory molecules within the immunological synapse.

    abstract::Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130701555035

    authors: Watson CL,Furlong SJ,Hoskin DW

    更新日期:2008-01-01 00:00:00

  • Modulation of B cell stimulation by maternal serum.

    abstract::Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109026231

    authors: Vanderbeeken YE,Duchateau J,Gregoire M,Vandermeersch B,Collet H,Lucas A

    更新日期:1991-06-01 00:00:00

  • Effect of immuno-modulating agents on murine IL-2 production.

    abstract::The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709030565

    authors: Weng XC,Zhang P,Gong SS,Xiai SW

    更新日期:1987-04-01 00:00:00

  • Enhanced antigen-specific antibody and cytokine responses when targeting antigen to human FcGAMMA receptor type I using an anti-human FcGAMMA receptor type I-streptavidin fusion protein in an adjuvant-free system.

    abstract::There is a continuing need for alternatives to current human adjuvants. Recombinant protein vaccines, which target antigen to human Fc gamma receptor type I (hFcgammaRI) on hFcgammaRI-expressing antigen presenting cells, provide one potential alternative. Using a recombinant anti-hFcgammaRI-antigen fusion protein and ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130500265372

    authors: Adamova E,Walsh MC,Gosselin DR,Hale K,Preissler MT,Graziano RF,Gosselin EJ

    更新日期:2005-01-01 00:00:00

  • Association of ADAM17 Expression Levels in Patients with Interstitial Lung Disease.

    abstract::A disintegrin and metalloproteinases (ADAMs) are believed to be involved in the pathogenesis of many fibrosis-related diseases. However, little is known regarding the significance of ADAM17 as a biomarker for interstitial lung disease (ILD). In this study, by using the RT-PCR, western blotting and ELISA, we detected t...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1660367

    authors: Ge J,Tang L,Mu P,Zhu F,Xie L,Tang Y

    更新日期:2020-02-01 00:00:00

  • Evaluation of interleukin-8 in hepatitis C virus infection: relation to combined peg-interferon ribavirin response and genotype 4.

    abstract::Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). Previous studies have shown that HCV NS5A protein induces expression of the proinflammatory interleukin-8 (IL-8) and this may affect the therapeutic outcome. The aim of the present study ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2010.508192

    authors: El Sayed ZM,Mansour FA,Ghal MF,Abou-Zahra SB

    更新日期:2011-01-01 00:00:00

  • A quantitative relationship between antibody affinity and antibody avidity.

    abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709030567

    authors: Griswold WR

    更新日期:1987-04-01 00:00:00

  • Molecular biology and immunology of rotavirus infections.

    abstract::Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820138909112264

    authors: Estes MK,Conner ME,Gilger MA,Graham DY

    更新日期:1989-01-01 00:00:00

  • Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development.

    abstract::Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that inhibit anti-tumor immunity through a variety of mechanisms. Malignant gliomas are heavily infiltrated by myeloid cells, some of which appear to share biological functions of MDSCs. Our data with mouse de novo gliomas indicate critic...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820139.2012.689591

    authors: Kohanbash G,Okada H

    更新日期:2012-01-01 00:00:00

  • Inconsistence between number and function of autoreactive T cells in the course of experimental autoimmune encephalomyelitis.

    abstract:BACKGROUND:Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4+ and CD8+ T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myel...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1367008

    authors: Wan X,Pei W,Zhang Y,Zhang L,Shahzad KA,Xu T,Shen C

    更新日期:2018-01-01 00:00:00