Abstract:
:Prenatal mortality due to loss of lymphocyte-promoted endometrial angiogenesis is being investigated as a major cause of litter reductions during pregnancy in pigs. This review discusses immune mechanisms influencing porcine endometrial angiogenesis as well as additional signalling molecules that may play important roles in the compromise of peri-implantation and mid-gestation fetal pig survival. These include dendritic cells, signalling molecules such as toll-like receptors, chemokines and ficolins. Together these cells and molecules regulate immune responses and, ideally, protect the mother and prevent immune-based conceptus losses. Dendritic cells were recently shown to be angiogenic. Their tolerogenic role at the maternal-fetal interface coupled with the ability to secrete and respond to angiogenic factors suggests that dendritic cells are the key coordinators of angiogenesis at the porcine maternal-fetal interface. Chemokines coordinate the localization of immune effector and endothelial cells. The balance between pro-angiogenic and anti-angiogenic chemokines is addressed in relation to conceptus viability. Ficolins, components of the lectin-mediated complement activation pathway, are used for self/non-self recognition. Together, these components of the immune system could regulate lymphocyte- and non-lymphocyte-promoted endometrial angiogenesis to determine conceptus survival.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Linton NF,Wessels JM,Cnossen SA,Croy BA,Tayade Cdoi
10.1080/08820130802191540subject
Has Abstractpub_date
2008-01-01 00:00:00pages
611-29issue
5eissn
0882-0139issn
1532-4311pii
901776989journal_volume
37pub_type
杂志文章,评审abstract::Intravenous immunoglobulins (IVIg) have been used as an immunomodulatory therapy in a variety of diseases. Several mechanisms of action have been proposed, one of which is interference with the cytokine network. We have investigated the effect of IVIg on the cytotoxicity of human TNF alpha. IVIg was capable of protect...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139709088541
更新日期:1997-08-01 00:00:00
abstract::Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone me...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1710531
更新日期:2021-02-01 00:00:00
abstract::To determine the main mediators for mouse anaphylactic shock, the suppression of active anaphylactic shock by cyproheptadine, an antagonist of histamine/serotonin, and CV-6209, an antagonist of platelet-activating factor (PAF), was systematically evaluated using various mouse strains. The suppression was quite heterog...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609055732
更新日期:1996-09-01 00:00:00
abstract::As a result of strong experimental data supporting effectiveness and safety, herb-based immunomodulators are paving way as alternative sources of potent adjuvants for vaccines. In this study, the immunostimulatory and adjuvant properties of AcF1, a flavonoids-rich fraction of Alchornea cordifolia extract, was evaluate...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820130903496793
更新日期:2010-01-01 00:00:00
abstract::Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was t...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1319382
更新日期:2017-08-01 00:00:00
abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.854377
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of th...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2020.1769646
更新日期:2021-02-01 00:00:00
abstract::The lectin from Amaranthus leucocarpus (ALL) is specific for N-acetyl-D-galactosamine and inhibits phagocytosis of Leishmania mexicana promastigotes in Balb/c mice peritoneal macrophages by 38%. The lipophosphoglycan (LPG) purified from L. mexicana inhibits penetration of promastigotes into peritoneal macrophages by 3...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::We have examined the effect which xenogeneic anti-Ig has on rabbit B cell function and Ig expression in an effort to understand the phenomenon of antibody mediated suppression. Treatment of rabbit lymphocyte cultures with xenogeneic anti-rabbit Ig causes 2.5-3.8 fold decrease in the level of Ig secreting cells with li...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109054924
更新日期:1991-02-01 00:00:00
abstract::Conventional plate ML-ELISA technique for diagnosis of recent cases of amoebiasis was converted into a simple polyvinyl chloride strip multilayer-enzyme linked immunosorbent assay (PVC strip ML-ELISA). This report details the development and preliminary characterization of the PVC strip ML-ELISA method for Entamoeba h...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109026242
更新日期:1991-12-01 00:00:00
abstract::A previous study has demonstrated that both interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) were needed to induce the production of nitric oxide (NO) in BNL CL.2 cells, murine embryonic liver cells. We here demonstrate that when BNL CL.2 cells were cultured with serum-free medium, they were induced to produc...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139909061144
更新日期:1999-03-01 00:00:00
abstract::There has been a dramatic increase recently in the number of reports of septic episodes associated with both red cell and platelet concentrate transfusions. These reports suggest that transfusion-associated septic reactions may occur as often as 1 per 4000 platelet transfusions, however, the true incidence of the bact...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139509062770
更新日期:1995-01-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709055713
更新日期:1987-03-01 00:00:00
abstract::Food allergy is an important and common health issue, and there is a need to identify and characterize the sensitizing mechanisms. One of the common causes of food allergy is ovalbumin (OVA), a dietary antigen from eggs. We hypothesized that OVA-induced food allergy in the gut involves the activation of the chemokine ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120027682
更新日期:2004-02-01 00:00:00
abstract::DNA vaccine represents a powerful approach for prevention of avian H5N1 influenza infection. Yet, DNA vaccine-induced immune responses might be limited by the short duration of antigen expression. As a strategy to enhance adaptive immune responses elicited by a hemagglutinin 5 (H5) DNA vaccine, we explored the effect ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2014.988718
更新日期:2015-01-01 00:00:00
abstract::In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1647233
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD). METHODS:Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conduct...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.3109/08820139.2014.988721
更新日期:2015-01-01 00:00:00
abstract::Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation. In rats, 10% of mast cells i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909050768
更新日期:1989-08-01 00:00:00
abstract::IL-2 production by the phytohemaglutinin (PHA)-stimulated mononuclear cells (MNC) of peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA), other arthritic diseases (OAD) and age-matched normal controls were studied, and the activity of IL-2 inhibitor in sera of studied subject was...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139509060720
更新日期:1995-11-01 00:00:00
abstract::Champedak (Artocarpus integer) lectin-M is a lectin with high specificity and affinity for the core-mannosyl residues of the N-linked oligosaccharides of glycoproteins. We have studied the interaction of the champedak seed lectin with human serum glycoproteins that were resolved by 2-dimensional (2-D) gel electrophore...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100104021
更新日期:2001-05-01 00:00:00
abstract::Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701555035
更新日期:2008-01-01 00:00:00
abstract::Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109026231
更新日期:1991-06-01 00:00:00
abstract::The effect of two Chinese traditional drugs, Dang Gui injection prepared from Angelica sinensis and C 21 Ester glucoside (GB) extracted from Cynanchus auriculatus on in vitro production of IL-2 has been studied. The IL-2 was produced by Con A stimulation of mouse spleen mononuclear cells. The IL-2 activity was assayed...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030565
更新日期:1987-04-01 00:00:00
abstract::There is a continuing need for alternatives to current human adjuvants. Recombinant protein vaccines, which target antigen to human Fc gamma receptor type I (hFcgammaRI) on hFcgammaRI-expressing antigen presenting cells, provide one potential alternative. Using a recombinant anti-hFcgammaRI-antigen fusion protein and ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130500265372
更新日期:2005-01-01 00:00:00
abstract::A disintegrin and metalloproteinases (ADAMs) are believed to be involved in the pathogenesis of many fibrosis-related diseases. However, little is known regarding the significance of ADAM17 as a biomarker for interstitial lung disease (ILD). In this study, by using the RT-PCR, western blotting and ELISA, we detected t...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1660367
更新日期:2020-02-01 00:00:00
abstract::Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). Previous studies have shown that HCV NS5A protein induces expression of the proinflammatory interleukin-8 (IL-8) and this may affect the therapeutic outcome. The aim of the present study ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2010.508192
更新日期:2011-01-01 00:00:00
abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030567
更新日期:1987-04-01 00:00:00
abstract::Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820138909112264
更新日期:1989-01-01 00:00:00
abstract::Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that inhibit anti-tumor immunity through a variety of mechanisms. Malignant gliomas are heavily infiltrated by myeloid cells, some of which appear to share biological functions of MDSCs. Our data with mouse de novo gliomas indicate critic...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2012.689591
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4+ and CD8+ T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myel...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1367008
更新日期:2018-01-01 00:00:00