Abstract:
:We have examined the effect which xenogeneic anti-Ig has on rabbit B cell function and Ig expression in an effort to understand the phenomenon of antibody mediated suppression. Treatment of rabbit lymphocyte cultures with xenogeneic anti-rabbit Ig causes 2.5-3.8 fold decrease in the level of Ig secreting cells with little or no long-term effect on surface Ig. This suppression in B cell secretory function is not the result of suppression of Ig gene expression since xenogeneic anti-rabbit Ig treatment causes a 1.7-2.7 fold increase in Ig L and H chain mRNA levels. Collectively, these data are consistent with the hypothesis that antibody mediated suppression of B cell function occurs at a post-transcriptional level involving either the secretory pathway of Ig expression and/or blockage in B cell differentiation.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Ives N,Asundi V,Dreher Kdoi
10.3109/08820139109054924subject
Has Abstractpub_date
1991-02-01 00:00:00pages
45-53issue
1eissn
0882-0139issn
1532-4311journal_volume
20pub_type
杂志文章abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1043669
更新日期:2015-01-01 00:00:00
abstract::Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the cont...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139409066822
更新日期:1994-08-01 00:00:00
abstract::Dendritic cells (DCs) are potent antigen-presenting cells that can be matured in vitro from immature dendritic cells (iDCs) in the presence of several biological agents such as cytokine cocktail, CD40L, TNF-a and antigen loading, which are necessary and achieved using various protocols, such as lipofection, passive pu...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2012.757234
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS:a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. ...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.1080/08820139.2016.1248560
更新日期:2017-02-01 00:00:00
abstract::Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in pati...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130601109727
更新日期:2007-01-01 00:00:00
abstract::The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138809055720
更新日期:1988-03-01 00:00:00
abstract::We report a method combining mixed lymphocyte reaction (MLR) using a carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeling technique, intracellular cytokine immunofluorescence staining (ICIS), and multiparameter flow cytometry for simultaneous determination of proliferation and cytokine-secreting activity in...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-120038079
更新日期:2004-08-01 00:00:00
abstract::The phenomenon of apoptosis observed in lymphoid cells from HIV+ subjects is an important factor contributing to their massive depletion. Several studies have identified nitric oxide (NO) as one of the molecules involved in the apoptosis phenomenon observed during HIV infection. It has been shown that HIV-derived gp12...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100108163
更新日期:2001-11-01 00:00:00
abstract::The induction of immune tolerance is the most common consequence of protein feeding, i.e., "oral tolerance". In this study we investigated the genetic basis of oral tolerance using various kinds of recombinant and congenic mice, and the cells involved in the development of this phenomenon in mice. The footpad swelling...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139309063423
更新日期:1993-08-01 00:00:00
abstract::A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130600634568
更新日期:2006-01-01 00:00:00
abstract::Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1180302
更新日期:2016-08-01 00:00:00
abstract::Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701712867
更新日期:2007-01-01 00:00:00
abstract::The antiviral activity of cell-associated, non-elutable recombinant human gamma interferon (rHuIFN-gamma) was neutralized by antibody. The neutralization of cell-associated rHuIFN-gamma was maximal through 2 h (60-100%) and declined through 8 h (20-40%). Concomitantly, the antiviral activity of cell-associated [Met-Gl...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009052977
更新日期:1990-10-01 00:00:00
abstract::Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139109026231
更新日期:1991-06-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.647187
更新日期:2012-01-01 00:00:00
abstract::Using antigen-induced proliferation assay the presence of macrophages was found to be essential for the development of the T cell response. Decreased ability of antigen presentation by macrophages from aged A/J mice was detected. ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138509042005
更新日期:1985-04-01 00:00:00
abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Studies presented examine the origin of IgA plasma cells in B lineage chimeric mice constructed by reconstituting lethally irradiated mice with a mixture of syngeneic bone marrow cells and peritoneal cells from Ig heavy chain allotype congenic donors. In these mice, essentially all B cells in spleen and Peyer's patche...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909112226
更新日期:1989-01-01 00:00:00
abstract::Endomyocardial biopsy is generally used to quantify heart allograft rejection and guide immunotherapy. Biopsy, however, is invasive, costly, and risky. Since rejection requires lymphocyte activation, the purpose of this study was to assess alternative methods to evaluate rejection dynamics by investigating serum level...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139609059287
更新日期:1996-01-01 00:00:00
abstract::In recent studies, using a swine model of single lung transplantation, we demonstrated that IRI alone increased MHC II expression in the host's peripheral T lymphocytes. The inhibition of increased MHC II expression with TCV-309, a specific platelet-activating factor (PAF) antagonist suggested that PAF might play a ro...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139909060857
更新日期:1999-07-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709055713
更新日期:1987-03-01 00:00:00
abstract::Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609052952
更新日期:1986-06-01 00:00:00
abstract::CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820130009060867
更新日期:2000-08-01 00:00:00
abstract::The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (+/-4.02) years and...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130802438057
更新日期:2008-01-01 00:00:00
abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909045785
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1416398
更新日期:2018-04-01 00:00:00
abstract::In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1208219
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1480030
更新日期:2018-10-01 00:00:00
abstract::Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820138909112264
更新日期:1989-01-01 00:00:00
abstract::In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139009042033
更新日期:1990-04-01 00:00:00