Effect of anti-Ig on rabbit B cell function and Ig expression.

Abstract:

:We have examined the effect which xenogeneic anti-Ig has on rabbit B cell function and Ig expression in an effort to understand the phenomenon of antibody mediated suppression. Treatment of rabbit lymphocyte cultures with xenogeneic anti-rabbit Ig causes 2.5-3.8 fold decrease in the level of Ig secreting cells with little or no long-term effect on surface Ig. This suppression in B cell secretory function is not the result of suppression of Ig gene expression since xenogeneic anti-rabbit Ig treatment causes a 1.7-2.7 fold increase in Ig L and H chain mRNA levels. Collectively, these data are consistent with the hypothesis that antibody mediated suppression of B cell function occurs at a post-transcriptional level involving either the secretory pathway of Ig expression and/or blockage in B cell differentiation.

journal_name

Immunol Invest

authors

Ives N,Asundi V,Dreher K

doi

10.3109/08820139109054924

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

45-53

issue

1

eissn

0882-0139

issn

1532-4311

journal_volume

20

pub_type

杂志文章
  • Generation and Characterization of Human Single-Chain Antibodies Against Polycyclic Aromatic Hydrocarbons.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2015.1043669

    authors: Ustinov VA,Studennikov AE,Vavilov VA,Tyumentseva MA,Morozova VV,Tikunova NV,Glushkov AN

    更新日期:2015-01-01 00:00:00

  • Depressed natural killer cell activity in schizophrenic patients.

    abstract::Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the cont...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139409066822

    authors: Abdeljaber MH,Nair MP,Schork MA,Schwartz SA

    更新日期:1994-08-01 00:00:00

  • Enhanced maturation and function of dendritic cells using hydrogel coated plate and antigen electroporation.

    abstract::Dendritic cells (DCs) are potent antigen-presenting cells that can be matured in vitro from immature dendritic cells (iDCs) in the presence of several biological agents such as cytokine cocktail, CD40L, TNF-a and antigen loading, which are necessary and achieved using various protocols, such as lipofection, passive pu...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2012.757234

    authors: Son CH,Bae JH,Shin DY,Lee HR,Choi YH,Yang K,Park YS

    更新日期:2013-01-01 00:00:00

  • Meta-Analysis of the Relationship between TNF-α (-308G/A) and IL-10 (-819C/T) Gene Polymorphisms and Susceptibility to Dengue.

    abstract:OBJECTIVE:This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS:a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. ...

    journal_title:Immunological investigations

    pub_type: 杂志文章,meta分析

    doi:10.1080/08820139.2016.1248560

    authors: Santos AC,de Moura EL,Ferreira JM,Santos BR,Alves VM,de Farias KF,de Souza Figueiredo EV

    更新日期:2017-02-01 00:00:00

  • Impact of Helicobacter pylori infection on the humoral immune response to MUC1 peptide in patients with chronic gastric diseases and gastric cancer.

    abstract::Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in pati...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130601109727

    authors: Klaamas K,Kurtenkov O,von Mensdorff-Pouilly S,Shljapnikova L,Miljukhina L,Brjalin V,Lipping A

    更新日期:2007-01-01 00:00:00

  • Analysis of human peripheral blood T lymphocytes proliferating in response to sensitizing antigens: effect of interleukin-2 (IL-2)-responsive bystander cells.

    abstract::The contribution of interleukin-2 (IL-2)-responsive bystander cells to the proliferative responses of human peripheral blood T lymphocytes to antigens used for sensitization such as Purified Protein Derivative (PPD), Tetanus toxoid (T T) and Influenza virus was investigated. Marked proliferation of the unfractionated ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809055720

    authors: Sia DY,Chou JL

    更新日期:1988-03-01 00:00:00

  • Multiparameter flow cytometric approach for simultaneous evaluation of proliferation and cytokine-secreting activity in T cells responding to allo-stimulation.

    abstract::We report a method combining mixed lymphocyte reaction (MLR) using a carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeling technique, intracellular cytokine immunofluorescence staining (ICIS), and multiparameter flow cytometry for simultaneous determination of proliferation and cytokine-secreting activity in...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-120038079

    authors: Tanaka Y,Ohdan H,Onoe T,Asahara T

    更新日期:2004-08-01 00:00:00

  • Characteristics of nitric oxide-induced apoptosis and its target cells in mitogen-stimulated peripheral blood mononuclear cells from HIV+ subjects.

    abstract::The phenomenon of apoptosis observed in lymphoid cells from HIV+ subjects is an important factor contributing to their massive depletion. Several studies have identified nitric oxide (NO) as one of the molecules involved in the apoptosis phenomenon observed during HIV infection. It has been shown that HIV-derived gp12...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-100108163

    authors: García M,del Llano AM,Cruz-Colón E,Saavedra S,Lavergne JA

    更新日期:2001-11-01 00:00:00

  • Analysis of responsive cells in tolerance by the oral administration of ovalbumin.

    abstract::The induction of immune tolerance is the most common consequence of protein feeding, i.e., "oral tolerance". In this study we investigated the genetic basis of oral tolerance using various kinds of recombinant and congenic mice, and the cells involved in the development of this phenomenon in mice. The footpad swelling...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139309063423

    authors: Ishii N,Moriguchi N,Sugita Y,Nakajima H,Tanaka S,Aoki I

    更新日期:1993-08-01 00:00:00

  • Polymorphism in the promoter region of the CD14 gene and susceptibility to Brucellosis.

    abstract::A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130600634568

    authors: Haidari M,Hajilooi M,Rezazadeh M,Rafiei A,Alavi SA,Keramat F

    更新日期:2006-01-01 00:00:00

  • Association of VDR ApaI and TaqI Gene Polymorphisms with the Risk of Scleroderma and Behçet's Disease.

    abstract::Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma i...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2016.1180302

    authors: Kamal A,Gamal SM,Elgengehy FT,Alkemary AK,Siam I

    更新日期:2016-08-01 00:00:00

  • Tracking the elusive lymphocyte: methods of detection during adoptive immunotherapy.

    abstract::Adoptive immunotherapy is an attractive cancer treatment modality due to its capacity to target primary and metastatic lesions with large numbers of tumor-reactive, cytotoxic lymphocytes. The inability of fully armed lymphocytes to traffic into sites of tumor has been proposed as a causal factor for the minimal succes...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130701712867

    authors: Skitzki JJ,Muhitch JB,Evans SS

    更新日期:2007-01-01 00:00:00

  • Interferon-gamma can remain on the cell surface during the induction of the antiviral state.

    abstract::The antiviral activity of cell-associated, non-elutable recombinant human gamma interferon (rHuIFN-gamma) was neutralized by antibody. The neutralization of cell-associated rHuIFN-gamma was maximal through 2 h (60-100%) and declined through 8 h (20-40%). Concomitantly, the antiviral activity of cell-associated [Met-Gl...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139009052977

    authors: Langford MP,Gates WG,Kaiwar R

    更新日期:1990-10-01 00:00:00

  • Modulation of B cell stimulation by maternal serum.

    abstract::Anti-IgM stimulation of B cells is decreased in the presence of maternal serum as compared to control media. This inhibiting influence of maternal serum is observed during the priming of the B cells. The progression of B cells into cellular proliferation was not influenced by maternal serum. At the level of the immuno...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109026231

    authors: Vanderbeeken YE,Duchateau J,Gregoire M,Vandermeersch B,Collet H,Lucas A

    更新日期:1991-06-01 00:00:00

  • Direct effects of conjugated linoleic acid isomers on P815 mast cells in vitro.

    abstract::Conjugated linoleic acid (CLA) is a dietary fatty acid which causes extensive remodeling and mast cell recruitment in the mouse mammary gland. Two CLA isomers, 9,11- and 10,12-CLA, have differing effects in vivo, with only 10,12-CLA increasing mast cell number. The purpose of this project is to test the hypothesis tha...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.647187

    authors: Krishnan S,Russell J,Bodziak M,Koury S,Masso-Welch P

    更新日期:2012-01-01 00:00:00

  • Impaired antigen presenting function of macrophages from aged mice.

    abstract::Using antigen-induced proliferation assay the presence of macrophages was found to be essential for the development of the T cell response. Decreased ability of antigen presentation by macrophages from aged A/J mice was detected. ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509042005

    authors: Vĕtvicka V,Tlaskalová-Hogenová H,Pospísil M

    更新日期:1985-04-01 00:00:00

  • Flow cytometric quantification of T cell proliferation and division kinetics in woodchuck model of hepatitis B.

    abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:

    authors: Gujar SA,Michalak TI

    更新日期:2005-01-01 00:00:00

  • A major peritoneal reservoir of precursors for intestinal IgA plasma cells.

    abstract::Studies presented examine the origin of IgA plasma cells in B lineage chimeric mice constructed by reconstituting lethally irradiated mice with a mixture of syngeneic bone marrow cells and peritoneal cells from Ig heavy chain allotype congenic donors. In these mice, essentially all B cells in spleen and Peyer's patche...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909112226

    authors: Kroese FG,Butcher EC,Stall AM,Herzenberg LA

    更新日期:1989-01-01 00:00:00

  • Cytokines and cell surface markers in prediction of cardiac allograft rejection.

    abstract::Endomyocardial biopsy is generally used to quantify heart allograft rejection and guide immunotherapy. Biopsy, however, is invasive, costly, and risky. Since rejection requires lymphocyte activation, the purpose of this study was to assess alternative methods to evaluate rejection dynamics by investigating serum level...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139609059287

    authors: Chang DM,Ding YA,Kuo SY,Chang ML,Wei J

    更新日期:1996-01-01 00:00:00

  • Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes.

    abstract::In recent studies, using a swine model of single lung transplantation, we demonstrated that IRI alone increased MHC II expression in the host's peripheral T lymphocytes. The inhibition of increased MHC II expression with TCV-309, a specific platelet-activating factor (PAF) antagonist suggested that PAF might play a ro...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139909060857

    authors: Nikbakht-Sangari M,Qayumi AK,Keown P,Duronio V,Horley K

    更新日期:1999-07-01 00:00:00

  • Immunohistochemical analysis of experimental autoimmune uveoretinitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) in the rat.

    abstract::Experimental autoimmune uveoretinitis (EAU) was induced in rats by immunization with bovine interphotoreceptor retinoid-binding protein (IRBP) and studied by immunohistochemistry. In general, the IRBP induction of inflammatory cellular components and expression of immune-related antigens on various non-lymphoid cells ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138709055713

    authors: Chan CC,Nussenblatt RB,Wiggert B,Redmond TM,Fujikawa LS,Chader GJ,Gery I

    更新日期:1987-03-01 00:00:00

  • Studies on in vitro production of Paul-Bunnell antibodies.

    abstract::Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138609052952

    authors: Wasik M,Milgrom F

    更新日期:1986-06-01 00:00:00

  • Cytokine regulation of CD44 expression on rat intestinal epithelial cells.

    abstract::CD44 comprises a family of type I transmembrane glycoproteins that is expressed on a wide range of cells including those of epithelial, lymphoid and myeloid lineage. Although expression of CD44 in the small intestine is typically localised in the crypts of Lieberkuhn, we have reported the expression of CD44 on mature,...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820130009060867

    authors: Reid SD,Pockley AG

    更新日期:2000-08-01 00:00:00

  • Anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis.

    abstract::The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (+/-4.02) years and...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130802438057

    authors: Habib HM,Mosaad YM,Youssef HM

    更新日期:2008-01-01 00:00:00

  • Antigen presentation by non-immune B-cell hybridoma clones: presentation of synthetic antigenic sites reveals clones that exhibit no specificity and clones that present only one epitope.

    abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909045785

    authors: Cohly HH,Morrison DR,Atassi MZ

    更新日期:1989-10-01 00:00:00

  • Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population.

    abstract:BACKGROUND:Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a co...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2017.1416398

    authors: Allam G,Nasr A,Talaat IM,Abuelsaad ASA,Bakheit AM,Nemenqani D,Alsulaimani AA

    更新日期:2018-04-01 00:00:00

  • Effect of Cytokine Genes in the Pathogenesis and on the Clinical Parameters for the Treatment of Multiple Myeloma.

    abstract::In this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2016.1208219

    authors: Haydaroglu H,Oguzkan Balcı S,Pehlıvan S,Ozdıllı K,Gundogan E,Okan V,Nursal AF,Pehlıvan M

    更新日期:2017-01-01 00:00:00

  • Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls.

    abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1480030

    authors: Spacek J,Vocka M,Netikova I,Skalova H,Dundr P,Konopasek B,Zavadova E,Lubos P

    更新日期:2018-10-01 00:00:00

  • Molecular biology and immunology of rotavirus infections.

    abstract::Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820138909112264

    authors: Estes MK,Conner ME,Gilger MA,Graham DY

    更新日期:1989-01-01 00:00:00

  • BK virus terminates tolerance to dsDNA and histone antigens in vivo.

    abstract::In order to characterize the immune response to BK virus, a human polyomavirus containing dsDNA and host cell histones, we followed the appearance of antibodies in five outbred rabbits after intravenous inoculation with purified infectious BK virus without any adjuvant. The animals were followed for 15 weeks after the...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139009042033

    authors: Fredriksen K,Traavik T,Flaegstad T,Rekvig OP

    更新日期:1990-04-01 00:00:00