Abstract:
:Studies presented examine the origin of IgA plasma cells in B lineage chimeric mice constructed by reconstituting lethally irradiated mice with a mixture of syngeneic bone marrow cells and peritoneal cells from Ig heavy chain allotype congenic donors. In these mice, essentially all B cells in spleen and Peyer's patches are derived from the bone marrow donor; however Ly-1 B lineage cells which have been mainly detected in the peritoneum are derived from the peritoneal cell donor. Surprisingly, roughly half of the IgA plasma cells in the lamina propria of the gut are also derived from the peritoneal cell donor, suggesting an important role for peritoneally-derived B cells in the mucosal immune response.
journal_name
Immunol Investjournal_title
Immunological investigationsauthors
Kroese FG,Butcher EC,Stall AM,Herzenberg LAdoi
10.3109/08820138909112226subject
Has Abstractpub_date
1989-01-01 00:00:00pages
47-58issue
1-4eissn
0882-0139issn
1532-4311journal_volume
18pub_type
杂志文章abstract::Antigen (HSA) bound in immune complexes at equivalence with syngeneic anti-HSA antibodies elicit much stronger humoral immune response then soluble HSA. On the other hand, administration of immune complexes formed with xenogeneic (rabbit) anti-HSA antibodies suppressed humoral immune response against HSA, but not agai...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139209069398
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE:To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical pr...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1237525
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD). METHODS:Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conduct...
journal_title:Immunological investigations
pub_type: 杂志文章,meta分析
doi:10.3109/08820139.2014.988721
更新日期:2015-01-01 00:00:00
abstract::Regulatory T cells (Tregs) play pivotal roles in limiting the duration and magnitude of immune response against infectious agents and self-antigens. This is accomplished through contact-dependent and -independent mechanisms that involve crosstalk between Treg cells and other immune and tissue-specific cell types. The ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.1080/08820139.2016.1197242
更新日期:2016-11-01 00:00:00
abstract::Two cell lines secreting Paul-Bunnell antibodies were established by means of Epstein-Barr virus-induced immortalization of B lymphocytes from patients with infectious mononucleosis. Progressive loss of antibody production, most probably due to a shutdown of antibody secretion by individual cells was, however, observe...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609052952
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:Adult chronic immune thrombocytopenic purpura (chronic ITP) is an autoimmune multifactorial bleeding disorder that occurs because of enhanced peripheral platelet destruction. Treatment decisions can be challenging because the goal of treatment is to prevent severe bleeding, but the risk of bleeding can be di...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1064948
更新日期:2015-01-01 00:00:00
abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138909045785
更新日期:1989-10-01 00:00:00
abstract::This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, I...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2015.1009546
更新日期:2015-01-01 00:00:00
abstract::The relationship between antibody avidity, measured by the dissociation of the antigen-antibody bond in antigen excess, and antibody affinity was studied. Complexes of radiolabelled antigen and antibody of known affinity were prepared in vitro and allowed to stand for seven days to reach equilibrium. Then nonlabelled ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030567
更新日期:1987-04-01 00:00:00
abstract::The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatme...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820139.2016.1168831
更新日期:2016-07-01 00:00:00
abstract::Although the T cell costimulatory molecules CD2 and CD28 are enriched within the immunological synapse (IS), it has been suggested that costimulatory molecules need not be localized to the contact site between a T cell and an antigen-presenting cell (APC) in order to costimulate T cell activation. To determine whether...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130701555035
更新日期:2008-01-01 00:00:00
abstract::To investigate whether phospholipase D1 (PLD1) is involved in autoimmune damage to the eyes, we used Western blotting and immunohistochemistry to examine the expression and distribution of PLD1 in the retinas of Lewis rats with experimental autoimmune uveoretinitis (EAU). Western blot analysis showed that the level of...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This study investigated the intestinal anti-inflammatory action of ginsenoside Rf in inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease that affects the intestinal tract. It is associated with elevated levels of various inflammatory mediators, including interleukin (IL)-1β, IL-6, tumor necrosis fa...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2016.1168830
更新日期:2016-07-01 00:00:00
abstract::Hashimoto's thyroiditis (HT) is a T cell-mediated autoimmune disease. However, little is known about the role of different subsets of natural killer (NK) and natural killer T (NKT) cells at the early stage of the HT process. A total of 45 euthyroid patients with new onset HT and 40 age/gender-matched healthy controls ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2013.854377
更新日期:2014-01-01 00:00:00
abstract::Many investigators have demonstrated alteration of gastric mucins in H. pylori infected individuals. The inflammatory environment induced by H. pylori leading to aberrant glycosylation of MUC1 and demasking of core peptide MUC1 epitope could enhance immune responses to MUC1. IgG and IgM immune response to MUC1 in pati...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130601109727
更新日期:2007-01-01 00:00:00
abstract::White cell infiltration of solid tumors is an important prognostic indicator in malignant disease. Although macrophage infiltration is associated with good outcome in colorectal cancer, a high macrophage content is associated with poor prognosis in breast cancer. Suppressor macrophages prevent T cell activation in nor...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139909022721
更新日期:1999-01-01 00:00:00
abstract::Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 3...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2017.1288237
更新日期:2017-05-01 00:00:00
abstract::A. actinomycetemcomitans is a facultative Gram-negative coccobacillus which has been implicated in the etiology and pathogenesis of localized juvenile periodontitis and has also been recognized for its potential to cause serious extraoral infections, particularly endocarditis. The polymorphonuclear neutrophil has been...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820138909112237
更新日期:1989-01-01 00:00:00
abstract::Identification and characterization of antigenic proteins of Setaria cervi (bovine filarial parasite) adults and microfilariae was done by immunoblotting technique using hyperimmune rabbit sera against S. cervi and Brugia malayi. The antigens recognized by these sera were detected by using 125I protein-A followed by a...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138709030571
更新日期:1987-04-01 00:00:00
abstract::Champedak (Artocarpus integer) lectin-M is a lectin with high specificity and affinity for the core-mannosyl residues of the N-linked oligosaccharides of glycoproteins. We have studied the interaction of the champedak seed lectin with human serum glycoproteins that were resolved by 2-dimensional (2-D) gel electrophore...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100104021
更新日期:2001-05-01 00:00:00
abstract::Drug abuse has become a global health concern. Understanding how drug abuse modulates the immune system and how the immune system responds to pathogens associated with drug abuse, such hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1), can be assessed by an integrated approach comparing proteomic analys...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130902874110
更新日期:2009-01-01 00:00:00
abstract::Peripheral blood lymphocytes of a patient with myasthenia gravis (MG) were fused to the non-secreting human lymphoblastoid line HuNSI to produce human x human hybridomas that secrete monoclonal antibodies (mAb) to acetylcholine receptor (AChR). Screening of hybridomas for antibody production involved an enzyme-linked ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820138609052954
更新日期:1986-06-01 00:00:00
abstract::Rapid and accurate diagnosis of cytomegalovirus (CMV) infection is imperative with the advent of effective antiviral therapy (gangiclovir, foscarnet, CMV hyperimmune globin). Applications of conventional cell culture (CC), shell vial assay (SV), serological testing, antigenemia assay (AG) as well as molecular methods ...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139709022694
更新日期:1997-04-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Matrix metalloproteinases (MMPs) play an important role in breakdown of blood-brain barrier, transmigration, and invasion of immune cells and formation of MS lesions. The aim of present study was to investigate the influence of MMP-...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2016.1180303
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals. METHODS:The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism w...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2018.1423570
更新日期:2018-04-01 00:00:00
abstract::DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.3109/08820139.2011.622828
更新日期:2012-01-01 00:00:00
abstract::Rotaviruses were first recognized about 15 years ago in association with diarrhea in children and animals. Since then, rotaviruses have been determined to be the most important viral agent that causes clinically significant diarrhea in children and a need for an effective vaccination program has been recognized. This ...
journal_title:Immunological investigations
pub_type: 杂志文章,评审
doi:10.3109/08820138909112264
更新日期:1989-01-01 00:00:00
abstract::The role of ICAM-1 in contact activation of the bronchial epithelial cells is elucidated. Direct contact between epithelial cells and leukocytes is required to change transepithelial electrical resistance (TER) of the epithelium. Migration of human neutrophils across the layers of cultured human airway epithelial cell...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820130600745703
更新日期:2007-01-01 00:00:00
abstract::A disintegrin and metalloproteinases (ADAMs) are believed to be involved in the pathogenesis of many fibrosis-related diseases. However, little is known regarding the significance of ADAM17 as a biomarker for interstitial lung disease (ILD). In this study, by using the RT-PCR, western blotting and ELISA, we detected t...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1080/08820139.2019.1660367
更新日期:2020-02-01 00:00:00
abstract::The loading of dendritic cells (DCs) with whole tumor cell lysates may circumvent the facts that few tumor-specific antigens have been identified in human solid tumors. The present study was designed to investigate whether ovarian cancer cells lysate-pulsed DCs activate T cell responses against autologous ovarian tumo...
journal_title:Immunological investigations
pub_type: 杂志文章
doi:10.1081/imm-100103689
更新日期:2001-02-01 00:00:00