Depressed natural killer cell activity in schizophrenic patients.

Abstract:

:Factors that suppress natural killer (NK) cell activity were examined in a random sample of 73 schizophrenic patients. NK activity in these patients were compared with 25 healthy age, sex and race matched controls. The mean percent of NK activity was 21% in the schizophrenic group compared with 30% percent in the controls. The difference between these two groups was statistically significant. The mean percent of NK activity in the chronic undifferentiated schizophrenic subgroup and schizoaffective subgroup were 20% and 22% respectively. The degree of suppression of NK activity in the chronic undifferentiated subgroup was higher than in the schizoaffective one, but the difference was not statistically significant. The two subgroups were comparable regarding other immune related variables such as total white cell count, neutrophils, lymphocytes, total protein, albumin, globulin, immunoglobulins and stress. The lower impairment of NK activity in the schizoaffective subgroup may be due to their exposure to lithium which can enhance immune functions. Factors associated with significant suppression of NK activity in schizophrenic patients were physical restraint, number of psychotropic medications, number of chronic non-psychiatric diagnoses and race. Psychosocial stressors were associated with suppression of NK activity but it was not statistically significant. Our results identify factors associated with reduced NK activity observed in certain schizophrenic patients and NK activity in these patients may be the result of interaction between various factors.

journal_name

Immunol Invest

authors

Abdeljaber MH,Nair MP,Schork MA,Schwartz SA

doi

10.3109/08820139409066822

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

259-68

issue

4-5

eissn

0882-0139

issn

1532-4311

journal_volume

23

pub_type

杂志文章
  • Benign monoclonal gammopathy: a reassessment of the problem.

    abstract::Disease associations of clonally restricted serum immunoglobulin (Ig) abnormalities were examined using methods for detecting and characterizing homogeneous Ig that are approximately forty times more sensitive than either cellulose acetate zone electrophoresis or immunoelectrophoresis. Medical records of three hundred...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509076143

    authors: Kelly RH,Hardy TJ,Shah PM

    更新日期:1985-06-01 00:00:00

  • Association of Interleukin-23R Gene Polymorphisms with Behcet's Disease Susceptibility: A Meta-Analysis of Case-control Studies.

    abstract:BACKGROUND:The pathological mechanisms associated with the occurrence and development of Behcet's disease (BD) are not yet known. Two large genome-wide association surveys revealed an association between interleukin (IL)-23R single nucleotide polymorphism and BD. This study aimed to investigate the association between ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1698600

    authors: Gong HB,Wu XJ,Pu XM,Kang XJ

    更新日期:2020-08-01 00:00:00

  • Associations between Gene Polymorphisms in Pro-inflammatory Cytokines and the Risk of Inflammatory Bowel Disease: A Meta-analysis.

    abstract::The relationships between polymorphisms in pro-inflammatory cytokines and the risk of inflammatory bowel disease (IBD) remain discrepant. Therefore, the authors conducted a meta-analysis to robustly explore relationships between polymorphisms in pro-inflammatory cytokines and the risk of IBD by integrating the results...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1787438

    authors: Liu W,Wang C,Tang L,Yang H

    更新日期:2020-08-26 00:00:00

  • Flow cytometric quantification of T cell proliferation and division kinetics in woodchuck model of hepatitis B.

    abstract::Woodchucks infected with woodchuck hepatitis virus (WHV) represent the closest natural animal model to study the immunopathogenesis of liver injury caused by essentially noncytopathic, highly human specific hepatitis B virus (HBV). The importance of antiviral T cell response in induction of hepatitis and in control of...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:

    authors: Gujar SA,Michalak TI

    更新日期:2005-01-01 00:00:00

  • Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls.

    abstract:BACKGROUND:The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS:Blood samples were collected from 22 colorectal patients and 25 healthy controls before the sta...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2018.1480030

    authors: Spacek J,Vocka M,Netikova I,Skalova H,Dundr P,Konopasek B,Zavadova E,Lubos P

    更新日期:2018-10-01 00:00:00

  • The Effect of IL-26 on TNF-α-Induced CXCL8 Responses by Colonic Epithelial Cell Lines.

    abstract::Th17 cells of the intestine and colon can produce several important cytokines during mucosal inflammation. However, few studies have focused on the role of IL-26 in intestinal inflammations. Colonic epithelial cells express receptors for IL-26, and this cytokine has been shown to induce the HT-29 colonic epithelial ce...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1594247

    authors: Weishaar IM,Young RS,Wiles BM,McGee DW

    更新日期:2019-11-01 00:00:00

  • Lavandula angustifolia Mill. Essential Oil Exerts Antibacterial and Anti-Inflammatory Effect in Macrophage Mediated Immune Response to Staphylococcus aureus.

    abstract::Different studies described the antibacterial properties of Lavandula angustifolia (Mill.) essential oil and its anti-inflammatory effects. Besides, no data exist on its ability to activate human macrophages during the innate response against Staphylococcus aureus. The discovery of promising regulators of macrophage-m...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2015.1085392

    authors: Giovannini D,Gismondi A,Basso A,Canuti L,Braglia R,Canini A,Mariani F,Cappelli G

    更新日期:2016-01-01 00:00:00

  • Antigen presentation by non-immune B-cell hybridoma clones: presentation of synthetic antigenic sites reveals clones that exhibit no specificity and clones that present only one epitope.

    abstract::Recently, we reported the preparation and antigen-presenting properties of hybridoma B-cell clones obtained after fusing non-secreting, non-antigen presenting Balb/c 653-myeloma cells with non-immune SJL spleen cells. It was found that antigen presentation at the clonal level can be specific or non-specific, depending...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909045785

    authors: Cohly HH,Morrison DR,Atassi MZ

    更新日期:1989-10-01 00:00:00

  • Tolerogenic DNA vaccine for prevention of autoimmune ovarian disease.

    abstract::DNA vaccines have been widely used to induce immune responses against molecular targets. In this study, we explored the possibility of using DNA vaccine combined with the immunosuppressant FK506 (tacrolimus) to antigen-specifically suppress unwanted immune responses and prevent autoimmune ovarian disease. To that end,...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.622828

    authors: Kang Y,Zheng G,Chen A,Wang J,Hu Y,Li J,Zhang J,Gao W,Fu H,Xia G,Wang B

    更新日期:2012-01-01 00:00:00

  • Meta-Analysis of the Relationship between TNF-α (-308G/A) and IL-10 (-819C/T) Gene Polymorphisms and Susceptibility to Dengue.

    abstract:OBJECTIVE:This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS:a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. ...

    journal_title:Immunological investigations

    pub_type: 杂志文章,meta分析

    doi:10.1080/08820139.2016.1248560

    authors: Santos AC,de Moura EL,Ferreira JM,Santos BR,Alves VM,de Farias KF,de Souza Figueiredo EV

    更新日期:2017-02-01 00:00:00

  • Human plasma anti-α-galactoside antibody forms immune complex with autologous lipoprotein(a).

    abstract::Anti-α-galactoside antibody (anti-Gal) from human plasma that bound to α-galactoside-bearing guar galactomannan gel and was eluted with specific sugar (affinity-purified anti-Gal ; APAG) invariably contained apo(a) and apo B subunits in a proportion close to that in plasma lipoprotein(a) [Lp(a)]. Since LDL does not co...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2013.764316

    authors: Mandagini G,Subramanian SP,Vasantha K,Appukuttan PS

    更新日期:2013-01-01 00:00:00

  • Differential transcriptional control of the H-2K and H-2D loci of the major histocompatibility complex in fibrosarcoma cells.

    abstract::In this study we demonstrate a differential transcription of H-2K and H-2D class-I genes in two different tumor cell clones; one is highly metastatic (IE-7) and the other is not metastatic (IC-9), both derived from the same fibrosarcoma, T-10, induced in an (H-2b x H-2k)F1 mouse. The expression of the two parental H-2...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109082628

    authors: Aboud M,Amitai H,Huleihel M,Har-vardi I,Gopas J,Segal S

    更新日期:1991-08-01 00:00:00

  • Effect of immunization or cyclophosphamide treatment on growth of EL-4 leukemia cells in syngenic C57BL/6 mice.

    abstract::Prolonged survival of C57BL/6 (B6) mice bearing syngenic EL-4 leukemia cells resulted from immunization with irradiated EL-4 cells on the day of inoculation of live leukemia cells. No prolongation of survival was observed if the irradiated cells were injected 6 or 13 days after live cell inoculation. Protection also w...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138509022676

    authors: Abeyounis CJ,Bekierkunst A,Milgrom F

    更新日期:1985-12-01 00:00:00

  • Effects of immunization with B. macacae on induced periodontitis--preliminary findings.

    abstract::This preliminary study examined the effects of immunization with Bacteroides macacae, the monkey equivalent of the human species of B. gingivalis on ligature-induced periodontitis. During a 12 week immunization period, 8 out of the 12 Macacae fasicularis monkeys were immunized weekly with B. macacae washed cells and 4...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138909112239

    authors: Nisengard R,Blann D,Zelonis L,McHenry K,Reynolds H,Zambon J

    更新日期:1989-01-01 00:00:00

  • Dysregulated proteolysis in AIDS.

    abstract::Plasmin activity induced by different concentrations of added urokinase (UK) in serum from 20 patients with AIDS (P) and 10 healthy control (HC) subjects was measured using the fibrin plate assay. 125I-fibrin coated 24 well plates were exposed to UK (0.34-6.8 ng/ml) or to trypsin (T) (2.5 micrograms/ml) in the presenc...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139209069370

    authors: Auci DL,Durkin HG,Murali MR

    更新日期:1992-07-01 00:00:00

  • An improved PVC strip ML-ELISA technique for diagnosis of recent cases of amoebiasis.

    abstract::Conventional plate ML-ELISA technique for diagnosis of recent cases of amoebiasis was converted into a simple polyvinyl chloride strip multilayer-enzyme linked immunosorbent assay (PVC strip ML-ELISA). This report details the development and preliminary characterization of the PVC strip ML-ELISA method for Entamoeba h...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139109026242

    authors: Agarwal RK,Rawat R,Malaviya B,Das SR

    更新日期:1991-12-01 00:00:00

  • Two Novel Technologies for the Detection of Anti-cardiolipin and Anti β2-Glycoprotein Antibodies in the Real Life: Chemiluminescent in Comparison to the Addressable Laser Bead Immunoassays.

    abstract::In the present study, we evaluated two novel technologies, the chemiluminescent immunoassay (CIA) QUANTA Flash on BIO-FLASH (Inova Diagnostics, San Diego, CA, USA) and the addressable laser bead immunoassay (ALBIA) on BioPlex™ 2200 (Bio-Rad, Hercules, CA, USA) for the detection of anti-cardiolipin IgG/IgM (aCL) and an...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1647233

    authors: Grossi V,Infantino M,Benucci M,Li Gobbi F,Bandinelli F,Damiani A,Bodio C,Borghi MO,Mahler M,Aure MA,Bentow C,Manfredi M

    更新日期:2020-02-01 00:00:00

  • Polymorphism in the promoter region of the CD14 gene and susceptibility to Brucellosis.

    abstract::A single-nucleotide polymorphism in the promoter region of the CD14 gene at position 159 has been implicated in susceptibility to infectious diseases. We sought to determine the association between CD14 C-159 T functional promoter polymorphism and brucellosis in Western Iranian population where the disease is endemic....

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130600634568

    authors: Haidari M,Hajilooi M,Rezazadeh M,Rafiei A,Alavi SA,Keramat F

    更新日期:2006-01-01 00:00:00

  • Multiple antigen recognition by individual human monoclonal antibodies of rheumatic disease patient origin.

    abstract::We tested by Western blot several thousand antibody-secreting human cell lines immortalized by hybridoma fusion or Epstein-Barr virus transformation of peripheral blood lymphocytes from patients with systemic lupus erythematosus or mixed connective tissue disease. The blots utilized total human Jurkat cell extract as ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820138809041420

    authors: Vanderslice WE,Takeda Y,Chen J,Sharp GC,Pettersson I,Rosen A,Wigzell H,Wang RJ

    更新日期:1988-06-01 00:00:00

  • Differential activation of dendritic cells by Mycobacterium tuberculosis Beijing genotype.

    abstract::Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains can affect their interaction with the immune system. Beijing genotype has attracted attention because of its high prevalence and mu...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2014.880120

    authors: Reyes-Martínez JE,Nieto-Patlán E,Nieto-Patlán A,Gonzaga-Bernachi J,Santos-Mendoza T,Serafín-López J,Chávez-Blanco A,Sandoval-Montes C,Flores-Romo L,Estrada-Parra S,Estrada-García I,Chacón-Salinas R

    更新日期:2014-01-01 00:00:00

  • The Effects of Silymarin and Cyclosporine A on the Proliferation and Cytokine Production of Regulatory T Cells.

    abstract::Background: Immunosuppressive agents are necessary to enhance allograft tolerance after transplantation and the treatment of autoimmune disorders. Regulatory T cells (Tregs) play a pivotal role in improving allograft tolerance and determining the fate of transplanted organs. Therefore, the aim of this study was to inv...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2019.1571506

    authors: Keyhanmehr N,Motedayyen H,Eskandari N

    更新日期:2019-07-01 00:00:00

  • Generation and Characterization of Human Single-Chain Antibodies Against Polycyclic Aromatic Hydrocarbons.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including humans. BP is one of the most...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2015.1043669

    authors: Ustinov VA,Studennikov AE,Vavilov VA,Tyumentseva MA,Morozova VV,Tikunova NV,Glushkov AN

    更新日期:2015-01-01 00:00:00

  • Development of an In Vitro Assay to Assess Pharmacological Compounds and Reversion of Tumor-Derived Immunosuppression of Dendritic Cells.

    abstract:BACKGROUND:Cancer immunotherapies have achieved much success and have become the forefront treatment of cancers previously associated with poor prognosis. However, a major challenge in cancer immunotherapies remains the heterogeneity of the immunoregulatory capacities of cancers, and not all patients of a given cancer ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1778024

    authors: Andersen MM,Larsen J,Hansen M,Pedersen AE,Gad M

    更新日期:2020-06-23 00:00:00

  • Efficacy of recombinant human mannose binding lectin alone and in combination with itraconazole against murine Candida albicans vaginitis.

    abstract::Mannan binding lectin (MBL) deficiency has been associated with increased susceptibility to vaginitis in humans due to Candida albicans. In these studies we assessed the utility of recombinant human MBL (rhMBL) as a therapeutic against experimental C. albicans vaginitis. After intravenous treatment of uninfected mice ...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.569627

    authors: Clemons KV,Martinez M,Axelsen M,Thiel S,Stevens DA

    更新日期:2011-01-01 00:00:00

  • Presence of IgG-CD4 complexes in the circulation.

    abstract::Many proteins of various origins are able to form complexes with Immunoglobulin G using reaction sites formed by residues of constant domains. Studies of IgG complexes of non-immune nature are important as biologically active proteins could escape from the circulation forming complexes with IgG as well as with other s...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820130701854339

    authors: Nezlin R,Bengtsson AA

    更新日期:2008-01-01 00:00:00

  • The Association between Interleukin-6 Gene Polymorphisms and Risk of Systemic Lupus Erythematosus: A Meta-analysis with Trial Sequential Analysis.

    abstract:BACKGROUND:Molecular epidemiological studies have sought associations between interleukin-6 (IL-6) polymorphisms and the risk of systemic lupus erythematosus (SLE); however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of th...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1080/08820139.2020.1769646

    authors: Liu J,Liao MQ,Cao DF,Yang Y,Yang Y,Liu YH,Zeng FF,Chen XH

    更新日期:2021-02-01 00:00:00

  • Influence of high altitude exposure on the immune system: a review.

    abstract::High altitude may be defined as elevations as low as 1500 meters to those as high as 8800 meters. Very few studies have been conducted so far at high altitude for the specific purpose of monitoring different immune parameters in humans. Military personnel and mountaineers may be required to perform in environmental ex...

    journal_title:Immunological investigations

    pub_type: 杂志文章,评审

    doi:10.3109/08820131003681144

    authors: Mishra KP,Ganju L

    更新日期:2010-01-01 00:00:00

  • Association between lymphotoxin beta receptor gene polymorphisms and IgA nephropathy in Korean children.

    abstract::Lymphotoxin beta receptor (LTBR) is essential for development and organization of the secondary lymphoid tissues. To investigate whether LTBR polymorphisms are associated with IgA nephropathy (IgAN) in Korean children, One hundred ninety nine patients with IgAN and 289 controls were recruited. Two promoter single nucl...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139.2011.649438

    authors: Kim SK,Lee JY,Jeong Park H,Chung JH,Suh JS,Hahn WH,Cho BS,Kim MJ

    更新日期:2012-01-01 00:00:00

  • Modulation of lung-associated natural killer activity by resident and activated alveolar macrophages.

    abstract::Alveolar macrophages (AM) freshly obtained by bronchoalveolar lavage suppressed significantly, in a dose-dependent fashion, lung interstitial lymphocytes cytotoxicity against the NK-sensitive target cells, YAC-1. Kinetic experiments revealed that AM-mediated suppression of NK activity was seen following short-term inc...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.3109/08820139009042023

    authors: Lemaire I,St-Jean M

    更新日期:1990-02-01 00:00:00

  • Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.

    abstract::Dengue viruses (DV) infection is an important public health issue all over the world. Although the pathogenesis remains unclear, the overwhelmingly triggered immune responses have been consistently observed. Recently, we and other researchers demonstrated that the natural hosts for DV are dendritic cells (DC), the pri...

    journal_title:Immunological investigations

    pub_type: 杂志文章

    doi:10.1081/imm-200038680

    authors: Ho LJ,Shaio MF,Chang DM,Liao CL,Lai JH

    更新日期:2004-01-01 00:00:00